N J Wareham

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Cardiovascular risk assessment scores for people with diabetes: a systematic review
    P Chamnan
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:2001-14. 2009
  2. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
  3. pmc Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study
    Anne M May
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, PO Box 85500, 3508, GA, Utrecht, The Netherlands
    BMC Med Res Methodol 12:148. 2012
  4. pmc Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition
    Sabine Rohrmann
    Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, 8001 Zurich, Switzerland
    BMC Med 11:63. 2013
  5. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
  6. pmc Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening
    D R Webb
    Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester, UK
    Trials 11:16. 2010
  7. pmc Assessing the impact of road traffic on cycling for leisure and cycling to work
    Charlie E Foster
    Department of Public Health, University of Oxford, UK
    Int J Behav Nutr Phys Act 8:61. 2011
  8. pmc Validation of the historical adulthood physical activity questionnaire (HAPAQ) against objective measurements of physical activity
    Herve Besson
    Medical Research Council Epidemiology Unit, IMS, Cambridge, UK
    Int J Behav Nutr Phys Act 7:54. 2010
  9. pmc Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study
    A Sandbaek
    Department of General Practice, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Diabetologia 51:1127-34. 2008
  10. pmc Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care
    Simon J Griffin
    MRC Epidemiology Unit, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    BMC Public Health 11:211. 2011

Collaborators

Detail Information

Publications201 found, 100 shown here

  1. pmc Cardiovascular risk assessment scores for people with diabetes: a systematic review
    P Chamnan
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:2001-14. 2009
    ..However, due to the uncertainty in estimation of true risk, care is needed when using scores to communicate absolute CVD risk to individuals...
  2. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
    ....
  3. pmc Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study
    Anne M May
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, PO Box 85500, 3508, GA, Utrecht, The Netherlands
    BMC Med Res Methodol 12:148. 2012
    ....
  4. pmc Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition
    Sabine Rohrmann
    Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, 8001 Zurich, Switzerland
    BMC Med 11:63. 2013
    ..The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)...
  5. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
    ..We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the model have not yet been established...
  6. pmc Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening
    D R Webb
    Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester, UK
    Trials 11:16. 2010
    ..Here we describe the rationale and methods of a systematic community screening programme and randomised controlled trial of cardiovascular risk management within a UK multiethnic setting (ADDITION-Leicester)...
  7. pmc Assessing the impact of road traffic on cycling for leisure and cycling to work
    Charlie E Foster
    Department of Public Health, University of Oxford, UK
    Int J Behav Nutr Phys Act 8:61. 2011
    ..To explore the relationship between leisure and commuter cycling with objectively measured levels of road traffic and whether any relationship was affected by traffic levels directly outside of home or in local neighbourhood...
  8. pmc Validation of the historical adulthood physical activity questionnaire (HAPAQ) against objective measurements of physical activity
    Herve Besson
    Medical Research Council Epidemiology Unit, IMS, Cambridge, UK
    Int J Behav Nutr Phys Act 7:54. 2010
    ..abstract:..
  9. pmc Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study
    A Sandbaek
    Department of General Practice, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Diabetologia 51:1127-34. 2008
    ..This paper describes the baseline characteristics of the study population, their estimated risk of coronary heart disease and the extent to which that risk is potentially modifiable...
  10. pmc Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care
    Simon J Griffin
    MRC Epidemiology Unit, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    BMC Public Health 11:211. 2011
    ..The ADDITION-Plus trial was designed to address these issues among recently diagnosed patients in primary care over one year...
  11. pmc Socioeconomic position and risk of short-term weight gain: prospective study of 14,619 middle-aged men and women
    Lisa R Purslow
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Public Health 8:112. 2008
    ..The association between socioeconomic position in middle age and risk of subsequent, short-term weight gain is unknown. We therefore assessed this association in a prospective population based cohort study in Norfolk, UK...
  12. pmc Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: environmental Determinants in Young people)
    Esther M F van Sluijs
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    BMC Public Health 8:388. 2008
    ..We present here the analyses of the PA, dietary and anthropometry data...
  13. pmc A translational framework for public health research
    David Ogilvie
    Medical Research Council Epidemiology Unit and Centre for Diet and Activity Research, Cambridge, UK
    BMC Public Health 9:116. 2009
    ..We therefore outline a translational framework for public health research...
  14. pmc A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data
    Jian An Luan
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    BMC Proc 3:S115. 2009
    ..Linkage disequilibrium (LD) between the two FTO SNPs was strong (D' = 0.997, r2 = 0.875) but their haplotype was not significantly associated with either weight or BMI. The two SNPs near MC4R were in weak LD (D' = 0.487, r2 = 0.166)...
  15. pmc Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP diet and health study
    Tricia M Peters
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda, MD, USA
    BMC Cancer 9:349. 2009
    ..Despite strong evidence of an inverse association of physical activity with postmenopausal breast cancer risk, whether a certain intensity or time of life of physical activity is most effective for lowering breast cancer risk is not known...
  16. ncbi request reprint Epidemiological studies of physical activity and diabetes risk, and implications for diabetes prevention
    Nicholas J Wareham
    MRC Epidemiology Unit, Elsie Widdowson Laboratories, 120 Fulbourn Road, Cambridge, CB1 9NL, UK
    Appl Physiol Nutr Metab 32:778-82. 2007
    ..An appropriate balance between individually tailored approaches aimed at those at high risk and interventions aimed at trying to shift physical activity levels in entire populations remains to be determined...
  17. ncbi request reprint Is there really an epidemic of diabetes?
    N J Wareham
    Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratories, Cambridge CB1 9NL, UK
    Diabetologia 48:1454-5. 2005
  18. ncbi request reprint Physical activity and obesity prevention
    N Wareham
    MRC Epidemiology Unit, Elsie Widdowson Laboratories, Cambridge, UK
    Obes Rev 8:109-14. 2007
  19. ncbi request reprint Physical activity and obesity prevention: a review of the current evidence
    Nicholas J Wareham
    Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Proc Nutr Soc 64:229-47. 2005
    ..Whilst efforts should continue to enhance the evidence base it is wise, in the meantime, to stick to the consensus public health advice of advocating 45-60 min moderate intensity activity daily to prevent obesity...
  20. ncbi request reprint Fat consumption and HbA(1c) levels: the EPIC-Norfolk study
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Diabetes Care 24:1911-6. 2001
    ..They provide further support to efforts promoting modifications in the intake of dietary fat...
  21. ncbi request reprint Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer--Norfolk (EPIC-Norfolk) study: a population-based study
    L A Sargeant
    Department of Community Medicine, University of Cambridge, Institute of Public Health, UK
    Diabetes Care 23:726-32. 2000
    ..To examine the cross-sectional association between plasma vitamin C, self-reported diabetes, and HbA1c...
  22. ncbi request reprint Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study
    L A Sargeant
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Cambridge, UK
    Eur J Clin Nutr 55:342-8. 2001
    ....
  23. ncbi request reprint Cigarette smoking and glycaemia: the EPIC-Norfolk Study. European Prospective Investigation into Cancer
    L A Sargeant
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 30:547-54. 2001
    ..CONCLUSIONS: These results add support to the hypothesis that smoking has long-term effects on glucose homeostasis, an association that cannot be explained by confounding by dietary factors as measured in this study...
  24. ncbi request reprint The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK
    Atherosclerosis 127:35-42. 1996
    ....
  25. ncbi request reprint Family history of diabetes identifies a group at increased risk for the metabolic consequences of obesity and physical inactivity in EPIC-Norfolk: a population-based study. The European Prospective Investigation into Cancer
    L A Sargeant
    Department of Community Medicine, University of Cambridge, Institute of Public Health, UK
    Int J Obes Relat Metab Disord 24:1333-9. 2000
    ..To investigate the interaction of a family history of diabetes with obesity and physical inactivity on diabetes prevalence in middle-aged and elderly men and women...
  26. pmc Rate of weight gain predicts change in physical activity levels: a longitudinal analysis of the EPIC-Norfolk cohort
    R Golubic
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Int J Obes (Lond) 37:404-9. 2013
    ..To investigate the relationship of body weight and its changes over time with physical activity (PA)...
  27. pmc Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trial
    R K Simmons
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 51:787-94. 2008
    ....
  28. doi request reprint The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 53:624-31. 2010
    ..We sought to determine the effect of an aerobic exercise intervention on clustered metabolic risk and related outcomes in healthy older adults in a single-centre, explanatory randomised controlled trial...
  29. ncbi request reprint Cross-sectional but not longitudinal associations between non-esterified fatty acid levels and glucose intolerance and other features of the metabolic syndrome
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Diabet Med 16:1007-15. 1999
    ..However, the direction of causality in these studies is uncertain. The aim of this study was to examine whether NEFA levels predicted the development of glucose intolerance in a prospective population-based cohort study...
  30. ncbi request reprint Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study
    R W Jakes
    Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Cambridge, UK
    Eur J Clin Nutr 57:1089-96. 2003
    ..This study describes the associations between sedentary behaviour (television viewing) and participation in vigorous recreational activity with obesity and with biomarkers of cardiovascular disease (CVD) risk profile...
  31. doi request reprint Factor VII, blood lipids and fat intake: gene-nutrient interaction and risk of coronary heart disease with the factor VII R353Q polymorphism
    R Bowman
    MRC Dunn Human Nutrition Unit, Cambridge, UK
    Eur J Clin Nutr 63:771-7. 2009
    ..The relation between dietary fat, blood lipids, plasma factor VII coagulant activity (FVIIc) and risk of coronary heart disease (CHD) according to the R353Q polymorphism in the factor VII gene was assessed...
  32. ncbi request reprint How much might achievement of diabetes prevention behaviour goals reduce the incidence of diabetes if implemented at the population level?
    R K Simmons
    MRC Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Diabetologia 49:905-11. 2006
    ..We quantified the association between the achievement of behavioural goals for the prevention of diabetes and the incidence of diabetes in a population-based cohort study...
  33. ncbi request reprint Do simple questions about diet and physical activity help to identify those at risk of Type 2 diabetes?
    R K Simmons
    MRC Epidemiology Unit, Cambridge, UK
    Diabet Med 24:830-5. 2007
    ..We determined whether simple measures of physical activity and diet predicted incident diabetes and enhanced prediction by known risk factors including age, body mass index and family history...
  34. ncbi request reprint A common apolipoprotein B signal peptide polymorphism modifies the relation between plasma non-esterified fatty acids and triglyceride concentration in men
    D J Halsall
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, CB2 2QR, Cambridge, UK
    Atherosclerosis 152:9-17. 2000
    ....
  35. pmc Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:2345-9. 2009
    ..We sought to assess the usefulness of the LAR as a measure of insulin resistance in non-diabetic white adults...
  36. ncbi request reprint Hormone replacement therapy and glucose tolerance in EPIC-Norfolk: a population-based study
    L A Sargeant
    Department of Community Medicine, University of Cambridge, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Diabetes Metab Res Rev 16:20-5. 2000
    ..The objective was to examine the relationship of glycated haemoglobin (HbA(1C)) concentration with HRT use in non-diabetic postmenopausal women...
  37. pmc Dietary antioxidants and asthma in adults
    B D Patel
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, UK
    Thorax 61:388-93. 2006
    ..Several antioxidant nutrients have been reported to be inversely associated with asthma. A study was undertaken to assess the independent associations of these nutrients with asthma in adults...
  38. doi request reprint Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
    C Langenberg
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Cambridge CB2 0QQ, UK E mail
    Diabetologia 54:2272-82. 2011
    ..This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes...
  39. doi request reprint Psychological distress, major depressive disorder, and risk of stroke
    P G Surtees
    Strangeways Research Laboratory, University of Cambridge, Department of Public Health and Primary Care, Cambridge, CB1 8RN, UK
    Neurology 70:788-94. 2008
    ..We investigated this association based upon a large population-based prospective cohort study...
  40. pmc Effect of screening for Type 2 diabetes on population-level self-rated health outcomes and measures of cardiovascular risk: 13-year follow-up of the Ely cohort
    M Rahman
    General Practice and Primary Care Research Unit, University of Cambridge, Cambridge, UK
    Diabet Med 29:886-92. 2012
    ..We compared clinical measures, prescribed medication, cardiovascular morbidity and self-rated health in individuals without diabetes in a screened vs. an unscreened population...
  41. ncbi request reprint Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study
    N G Forouhi
    MRC Epidemiology Unit, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge, CB1 9NL, UK
    Diabetologia 50:949-56. 2007
    ..The aim of this study was to examine the association between baseline body iron stores and new-onset diabetes...
  42. ncbi request reprint Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity
    P W Franks
    Medical Research Council Epidemiology Unit, Cambridge, UK
    J Appl Physiol (1985) 102:1921-6. 2007
    ..Hyperleptinemia predicts a relative decline in PAEE and worsening insulin resistance, possibly via shared molecular pathways...
  43. ncbi request reprint Modifiable lifestyle behaviors and functional health in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Prev Med 44:109-16. 2007
    ..To examine the association between modifiable lifestyle behaviors and functional health...
  44. ncbi request reprint Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population
    Shubhada Sinha
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Cardiovasc Prev Rehabil 12:144-50. 2005
    ..Cigarette smoking is a well-recognized determinant of plasma fibrinogen however it remains unclear how fibrinogen levels relate to the degree and duration of smoking, or to time since smoking cessation...
  45. ncbi request reprint Does the association of habitual physical activity with the metabolic syndrome differ by level of cardiorespiratory fitness?
    Paul W Franks
    MRC Epidemiology Unit, Cambridge, UK
    Diabetes Care 27:1187-93. 2004
    ..The purpose of this study was, therefore, to describe the association between physical activity and the metabolic syndrome and to test whether fitness level modifies this relationship...
  46. pmc Change in HbA1c over 3 years does not improve the prediction of cardiovascular disease over and above HbA1c measured at a single time point
    P Chamnan
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Diabetologia 56:1004-11. 2013
    ..This study examined the association between change in HbA1c over time and cardiovascular risk in a non-diabetic British population...
  47. doi request reprint Fibre intake in relation to serum total cholesterol levels and CHD risk: a comparison of dietary assessment methods
    H A Ward
    MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Institute of Public Health, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 66:296-304. 2012
    ..The objective of this study was to compare FFQ and 7-day diet diary (7DD) measurements of fibre intake with the incidence of coronary heart disease (CHD)...
  48. doi request reprint Relationship between plasma fibrinogen and fiber intake in the EPIC-Norfolk cohort
    R N Freitas
    DENCS, School of Nutrition and NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil
    Eur J Clin Nutr 66:443-51. 2012
    ..Fiber-rich diets have been proposed to lower circulating levels of inflammatory makers. Our objective was to investigate cross-sectional relationships between fiber intake and plasma fibrinogen...
  49. ncbi request reprint Is the association between dietary fat intake and insulin resistance modified by physical activity?
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Metabolism 50:1186-92. 2001
    ..The findings provide further support for efforts to promote increases in overall physical activity and modifications in the pattern of dietary fat intake in the whole population...
  50. pmc Who attends a UK diabetes screening programme? Findings from the ADDITION-Cambridge study
    L A Sargeant
    MRC Epidemiology Unit, Cambridge, UK
    Diabet Med 27:995-1003. 2010
    ..We examined attendance and practice- and individual-level factors influencing uptake at each stage of a diabetes screening programme in general practice...
  51. pmc The association of intensity and overall level of physical activity energy expenditure with a marker of insulin resistance
    F K Assah
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 51:1399-407. 2008
    ..We examined the association of overall level and intensity of physical activity with fasting insulin level, a marker of insulin resistance...
  52. ncbi request reprint No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits
    Magdalena Szopa
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Am J Clin Nutr 92:252-7. 2010
    ....
  53. pmc Objectively measured sedentary time may predict insulin resistance independent of moderate- and vigorous-intensity physical activity
    Hendrik J F Helmerhorst
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Diabetes 58:1776-9. 2009
    ....
  54. doi request reprint Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  55. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  56. pmc Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
    A H Harding
    MRC Epidemiology Unit, Cambridge, UK
    Diabetologia 49:2642-8. 2006
    ..The present study aimed to replicate our previously reported association in a larger case-control study and to examine an additional five SREBF1c SNPs for their association with diabetes risk and plasma glucose concentrations...
  57. ncbi request reprint Habitual fish consumption and glycated haemoglobin: the EPIC-Norfolk study
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 58:277-84. 2004
    ..To investigate the association between habitual fish consumption and a continuous measure of glycaemia...
  58. pmc Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples
    M den Hoed
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 37:191-6. 2013
    ..Meta-analysis of case-control genome-wide association studies (GWAS) for early onset and morbid obesity identified four variants in/near the PRL, PTER, MAF and NPC1 genes...
  59. doi request reprint Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort
    R K Simmons
    MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 54:312-9. 2011
    ..The aim of this study was to assess the impact of invitation to screening for type 2 diabetes and related cardiovascular risk factors on population mortality...
  60. pmc The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals
    E H Young
    MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Int J Obes (Lond) 31:1437-41. 2007
    ..Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger studies are needed, however, to confirm this relation...
  61. ncbi request reprint Physical health-related quality of life predicts stroke in the EPIC-Norfolk
    P K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Neurology 69:2243-8. 2007
    ..To examine the relationship between Short Form (SF)-36 physical functional health-related quality of life and incident stroke...
  62. ncbi request reprint Does physical activity equally predict gain in fat mass among obese and nonobese young adults?
    U Ekelund
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Int J Obes (Lond) 31:65-71. 2007
    ..Differences in energy metabolism and physical activity (PA) may contribute to the long-term regulation of body weight (BW)...
  63. doi request reprint Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis
    C C Lee
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:1040-7. 2009
    ..We examined the association between serum C-reactive protein (CRP) and incident diabetes in a prospective study, and added these data to a literature-based meta-analysis to explore potential sources of heterogeneity between studies...
  64. ncbi request reprint Studies of the SIM1 gene in relation to human obesity and obesity-related traits
    C C C Hung
    University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 31:429-34. 2007
    ..SIM1-deficient mice have a hypocellular PVN and are severely obese with increased food intake...
  65. pmc Genetic predisposition to obesity leads to increased risk of type 2 diabetes
    S Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 54:776-82. 2011
    ..We examined the associations of 12 obesity susceptibility loci, individually and in combination, with risk of type 2 diabetes in the population-based European Prospective Investigation of Cancer (EPIC) Norfolk cohort...
  66. pmc Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    Calliope A Dendrou
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Nat Genet 41:1011-5. 2009
    ....
  67. pmc Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study
    Clara Kelliny
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, U K
    Diabetes 58:2939-45. 2009
    ..The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children...
  68. ncbi request reprint Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS)
    Karani S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Obesity (Silver Spring) 17:1453-7. 2009
    ..There was also no evidence of interaction between genotype and physical activity (P = 0.95). Despite an adequately powered study, our findings suggest that rs7566605 is not associated with obesity-related traits and lipids in the EYHS...
  69. ncbi request reprint Effect of age on the relationship of occupational social class with prevalence of modifiable cardiovascular risk factors and cardiovascular diseases. A population-based cross-sectional study from European Prospective Investigation into Cancer - Norfolk (E
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Gerontology 52:51-8. 2006
    ..Previous studies on cardiovascular risk profile in different socioeconomic status were focused on younger populations and many of them have not been able to take into account age and sex differences...
  70. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  71. ncbi request reprint Does early intensive multifactorial therapy reduce modelled cardiovascular risk in individuals with screen-detected diabetes? Results from the ADDITION-Europe cluster randomized trial
    J A Black
    MRC Epidemiology Unit, Cambridge University Biomedical Campus, Cambridge, UK
    Diabet Med 31:647-56. 2014
    ....
  72. ncbi request reprint Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study
    M F Yuyun
    Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK
    J Intern Med 255:247-56. 2004
    ..To examine the relationship between microalbuminuria and incident stroke in the general population...
  73. ncbi request reprint Respiratory function and self-reported functional health: EPIC-Norfolk population study
    P K Myint
    Room 311, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Eur Respir J 26:494-502. 2005
    ..00; 95% CI 0.82-1.22). In conclusion, forced expiratory volume in one second independently predicts self perceived physical well being in a general population across the whole normal distribution of respiratory function...
  74. pmc Does early intensive multifactorial treatment reduce total cardiovascular burden in individuals with screen-detected diabetes? Findings from the ADDITION-Europe cluster-randomized trial
    R K Simmons
    MRC Epidemiology Unit, Cambridge, UK
    Diabet Med 29:e409-16. 2012
    ....
  75. doi request reprint Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study
    A Moayyeri
    Department of Public Health and Primary Care, University of Cambridge MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    J Intern Med 271:472-80. 2012
    ..The aim of this study was to examine the association between percentage body fat (%BF) and prospective risk of fracture...
  76. doi request reprint No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach
    R Pfister
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 54:2561-9. 2011
    ..Using a Mendelian randomisation approach, we investigated whether there is evidence for a causal role of serum uric acid for development of type 2 diabetes...
  77. doi request reprint Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease
    R Pfister
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 54:2283-7. 2011
    ..Type 2 diabetes is a major risk factor for CHD. We hypothesised that diabetes genetic susceptibility variants might be associated with increased CHD risk...
  78. doi request reprint Effects of body size and sociodemographic characteristics on differences between self-reported and measured anthropometric data in middle-aged men and women: the EPIC-Norfolk study
    J Y Park
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 65:357-67. 2011
    ..To investigate the effects of body size and sociodemographic characteristics on differences between self-reported (SR) and measured anthropometric data in men and women...
  79. ncbi request reprint The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals
    N Kurokawa
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 32:1240-9. 2008
    ..The association between the Trp64Arg variant in the ADRB3 and body mass index (BMI) has been widely examined, but previous studies have been small and results have been inconsistent...
  80. doi request reprint A cross-sectional analysis of physical activity and obesity indicators in European participants of the EPIC-PANACEA study
    H Besson
    Medical Research Council, Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Int J Obes (Lond) 33:497-506. 2009
    ....
  81. doi request reprint Altered respiratory function is associated with increased metabolic risk, independently of adiposity, fitness and physical activity
    R M Steele
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabet Med 26:362-9. 2009
    ....
  82. ncbi request reprint The performance of a risk score in predicting undiagnosed hyperglycemia
    P J Park
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Diabetes Care 25:984-8. 2002
    ..The objective of this study was to assess the effectiveness of the Cambridge risk score in a large and representative population...
  83. pmc Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies
    Ines Barroso
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Diabetes 57:3161-5. 2008
    ..We aimed to investigate whether data from a large-scale mapping approach would replicate this association in novel Ashkenazi samples and in U.K. populations and whether these data would allow us to refine the association signal...
  84. ncbi request reprint Gene-lifestyle interaction on risk of type 2 diabetes
    Paul W Franks
    Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratories, 120 Fulbourn Road, Cambridge, CB1 9NL, UK
    Nutr Metab Cardiovasc Dis 17:104-24. 2007
    ....
  85. ncbi request reprint Combined work and leisure physical activity and risk of stroke in men and women in the European prospective investigation into Cancer-Norfolk Prospective Population Study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Neuroepidemiology 27:122-9. 2006
    ..70, 95% CI: 0.49-0.99, p = 0.024) compared to those who were inactive. This highlights the fact that efforts to increase physical activity in both the work place and in leisure time should be encouraged...
  86. ncbi request reprint How should peripheral neuropathy be assessed in people with diabetes in primary care? A population-based comparison of four measures
    M Rahman
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Diabet Med 20:368-74. 2003
    ..To test the accuracy of four measures of peripheral diabetic neuropathy in a primary care population...
  87. ncbi request reprint Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians
    B G Challis
    University Departments of Medicine and Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes Relat Metab Disord 28:442-6. 2004
    ..To investigate whether genetic variation at the loci encoding the corticotropin-releasing factor receptors-1 and -2 (CRF-R1 and CRF-R2) contributes to human obesity...
  88. ncbi request reprint Diabetes risk score: towards earlier detection of type 2 diabetes in general practice
    S J Griffin
    General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Diabetes Metab Res Rev 16:164-71. 2000
    ..We aimed to develop and evaluate a score based on routinely collected information to identify people at risk of having undetected diabetes...
  89. pmc Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis
    A J Cooper
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Eur J Clin Nutr 66:1082-92. 2012
    ..84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect...
  90. pmc Estimating the potential population impact of stepwise screening strategies for identifying and treating individuals at high risk of Type 2 diabetes: a modelling study
    P Chamnan
    MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Diabet Med 29:893-904. 2012
    ..5%). We estimated the potential population impact of different stepwise screening strategies to identify individuals at high risk who might be offered preventive interventions...
  91. doi request reprint Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies
    N G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 55:2173-82. 2012
    ..We conducted a systematic review and meta-analysis that included new data from previously unpublished studies...
  92. ncbi request reprint Increased PAI activity and PAI-1 antigen occurring with an oral fat load: associations with PAI-1 genotype and plasma active TGF-beta levels
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Atherosclerosis 140:45-53. 1998
    ..In conclusion, increased PAI and decreased TGF-beta activity occur during a fat tolerance test and this effect may be modulated by a common insertion/deletion polymorphism in the PAI-1 promoter...
  93. ncbi request reprint Association between serotonin 5-HT-2C receptor gene (HTR2C) polymorphisms and obesity- and mental health-related phenotypes in a large population-based cohort
    K S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Int J Obes (Lond) 34:1028-33. 2010
    ..We aimed to analyse whether variation in the HTR2C is associated with obesity- and mental health-related phenotypes in a large population-based cohort...
  94. ncbi request reprint How much might cardiovascular disease risk be reduced by intensive therapy in people with screen-detected diabetes?
    J B Echouffo-Tcheugui
    MRC Epidemiology Unit and General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Diabet Med 25:1433-9. 2008
    ..To assess the cardiovascular disease (CVD) risk of people with screen-detected Type 2 diabetes and to estimate the risk reduction achievable through early intensive pharmacological intervention...
  95. ncbi request reprint Obesity is associated with altered lung function independently of physical activity and fitness
    Rebekah M Steele
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Obesity (Silver Spring) 17:578-84. 2009
    ..These associations were independent of the degree of physical activity and aerobic fitness in this cohort...
  96. ncbi request reprint Comparison of PAEE from combined and separate heart rate and movement models in children
    Kirsten Corder
    Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
    Med Sci Sports Exerc 37:1761-7. 2005
    ....
  97. ncbi request reprint Population impact of strategies for identifying groups at high risk of type 2 diabetes
    Anne Helen Harding
    MRC Epidemiology Unit, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Prev Med 42:364-8. 2006
    ..To assess the incidence of diabetes among sub-groups of the population defined by the presence of one or more simple risk factors, and to investigate population stratification as a means of identifying groups at high risk of diabetes...
  98. ncbi request reprint Glycated hemoglobin and risk of stroke in people without known diabetes in the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study: a threshold relationship?
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Stroke 38:271-5. 2007
    ..The relationship between blood glucose concentration and stroke in people without established diabetes has been studied less extensively...
  99. ncbi request reprint Physical activity and mammographic breast density in the EPIC-Norfolk cohort study
    Tricia M Peters
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Epidemiol 167:579-85. 2008
    ..The lack of an association between physical activity and percentage breast density suggests that an association between physical activity and breast cancer risk is unlikely to be mediated through an effect on mammographic breast density...
  100. ncbi request reprint Correlated measurement error--implications for nutritional epidemiology
    N E Day
    Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, CB1 8RN, UK
    Int J Epidemiol 33:1373-81. 2004
    ..This paper describes the effect on multivariate regression coefficients of different levels of correlation, both between the variables themselves and between the errors of estimation of these variables...
  101. doi request reprint How much does screening bring forward the diagnosis of type 2 diabetes and reduce complications? Twelve year follow-up of the Ely cohort
    M Rahman
    General Practice and Primary Care Research Unit, University of Cambridge, Cambridge, UK
    Diabetologia 55:1651-9. 2012
    ....