N J Wareham

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action
    Ines Barroso
    Incyte, Palo Alto, California, USA
    PLoS Biol 1:E20. 2003
  2. pmc The association of education with body mass index and waist circumference in the EPIC-PANACEA study
    Silke Hermann
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    BMC Public Health 11:169. 2011
  3. pmc Social inequalities in self-rated health by age: cross-sectional study of 22,457 middle-aged men and women
    Emily McFadden
    Institute of Public Health, University of Cambridge, UK
    BMC Public Health 8:230. 2008
  4. pmc The ProActive trial protocol - a randomised controlled trial of the efficacy of a family-based, domiciliary intervention programme to increase physical activity among individuals at high risk of diabetes [ISRCTN61323766]
    Kate Williams
    General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    BMC Public Health 4:48. 2004
  5. pmc Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Endocr Disord 9:15. 2009
  6. pmc The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 10:563. 2010
  7. ncbi request reprint Establishing the role of gene-environment interactions in the etiology of type 2 diabetes
    Nicholas J Wareham
    University of Cambridge, Department of Public Health and Primary Care, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    Endocrinol Metab Clin North Am 31:553-66. 2002
  8. ncbi request reprint Glucose intolerance and physical inactivity: the relative importance of low habitual energy expenditure and cardiorespiratory fitness
    N J Wareham
    Department of Community Medicine, Institute of Public Health, University of Cambridge, United Kingdom
    Am J Epidemiol 152:132-9. 2000
  9. ncbi request reprint Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Nicholas J Wareham
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, CB2 2SR, UK
    Public Health Nutr 6:407-13. 2003
  10. ncbi request reprint Validity and repeatability of the EPIC-Norfolk Physical Activity Questionnaire
    Nicholas J Wareham
    Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 31:168-74. 2002

Collaborators

Detail Information

Publications147 found, 100 shown here

  1. pmc Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action
    Ines Barroso
    Incyte, Palo Alto, California, USA
    PLoS Biol 1:E20. 2003
    ..The absence of large single-gene effects and the detection of multiple small effects accentuate the need for the study of larger populations in order to reliably identify the size of effect we now expect for complex diseases...
  2. pmc The association of education with body mass index and waist circumference in the EPIC-PANACEA study
    Silke Hermann
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    BMC Public Health 11:169. 2011
    ..To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC)...
  3. pmc Social inequalities in self-rated health by age: cross-sectional study of 22,457 middle-aged men and women
    Emily McFadden
    Institute of Public Health, University of Cambridge, UK
    BMC Public Health 8:230. 2008
    ..We investigate the association between occupational social class and self-rated health (SRH) at different ages in men and women...
  4. pmc The ProActive trial protocol - a randomised controlled trial of the efficacy of a family-based, domiciliary intervention programme to increase physical activity among individuals at high risk of diabetes [ISRCTN61323766]
    Kate Williams
    General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    BMC Public Health 4:48. 2004
    ..While previous evaluations of interventions to increase physical activity have involved communities or individuals with established disease, less attention has been given to interventions for individuals at risk of disease...
  5. pmc Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Endocr Disord 9:15. 2009
    ..TRIAL REGISTRATION: Current Controlled Trials: ISRCTN60986572...
  6. pmc The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 10:563. 2010
    ..BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC)...
  7. ncbi request reprint Establishing the role of gene-environment interactions in the etiology of type 2 diabetes
    Nicholas J Wareham
    University of Cambridge, Department of Public Health and Primary Care, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    Endocrinol Metab Clin North Am 31:553-66. 2002
    ..Understanding how to detect these individuals and which environmental factors a program should attempt to manipulate is a major goal of studies that attempt to unravel gene-environment interaction...
  8. ncbi request reprint Glucose intolerance and physical inactivity: the relative importance of low habitual energy expenditure and cardiorespiratory fitness
    N J Wareham
    Department of Community Medicine, Institute of Public Health, University of Cambridge, United Kingdom
    Am J Epidemiol 152:132-9. 2000
    ..These data provide support for public health strategies aimed at increasing overall energy expenditure...
  9. ncbi request reprint Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Nicholas J Wareham
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, CB2 2SR, UK
    Public Health Nutr 6:407-13. 2003
    ....
  10. ncbi request reprint Validity and repeatability of the EPIC-Norfolk Physical Activity Questionnaire
    Nicholas J Wareham
    Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 31:168-74. 2002
    ..We report the repeatability of this instrument and its validity against repeated objective measures of fitness and energy expenditure undertaken throughout the time frame of reference of the questionnaire...
  11. ncbi request reprint A quantitative analysis of the relationship between habitual energy expenditure, fitness and the metabolic cardiovascular syndrome
    N J Wareham
    Department of Community Medicine, University of Cambridge, UK
    Br J Nutr 80:235-41. 1998
    ..Such quantitative epidemiological data provide the basis for planning and evaluating the expected benefit of population-level interventions...
  12. ncbi request reprint Quantifying the association between habitual energy expenditure and blood pressure
    N J Wareham
    Department of Community Medicine, University of Cambridge, Cambridge CB2 2SR, UK
    Int J Epidemiol 29:655-60. 2000
    ..Our aim was to employ these methods to assess the independent association between energy expenditure, cardio-respiratory fitness and blood pressure...
  13. ncbi request reprint Fasting proinsulin concentrations predict the development of type 2 diabetes
    N J Wareham
    Department of Community Medicine, University of Cambridge, England, U K
    Diabetes Care 22:262-70. 1999
    ..This study was established to examine whether the concentration of this molecule predicts diabetes...
  14. ncbi request reprint Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
    P W Franks
    Department of Public Health an Primary Care, University of Cambridge, UK
    Metabolism 53:11-6. 2004
    ..In contrast, in Ala allele carriers, PAL modifies the association between P:S ratio and fasting insulin level in a multiplicative manner...
  15. ncbi request reprint Fat consumption and HbA(1c) levels: the EPIC-Norfolk study
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Diabetes Care 24:1911-6. 2001
    ..They provide further support to efforts promoting modifications in the intake of dietary fat...
  16. ncbi request reprint Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer--Norfolk (EPIC-Norfolk) study: a population-based study
    L A Sargeant
    Department of Community Medicine, University of Cambridge, Institute of Public Health, UK
    Diabetes Care 23:726-32. 2000
    ..To examine the cross-sectional association between plasma vitamin C, self-reported diabetes, and HbA1c...
  17. ncbi request reprint Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study
    L A Sargeant
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Cambridge, UK
    Eur J Clin Nutr 55:342-8. 2001
    ....
  18. ncbi request reprint Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study
    R W Jakes
    Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Cambridge, UK
    Eur J Clin Nutr 57:1089-96. 2003
    ..This study describes the associations between sedentary behaviour (television viewing) and participation in vigorous recreational activity with obesity and with biomarkers of cardiovascular disease (CVD) risk profile...
  19. ncbi request reprint Cigarette smoking and glycaemia: the EPIC-Norfolk Study. European Prospective Investigation into Cancer
    L A Sargeant
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 30:547-54. 2001
    ..CONCLUSIONS: These results add support to the hypothesis that smoking has long-term effects on glucose homeostasis, an association that cannot be explained by confounding by dietary factors as measured in this study...
  20. ncbi request reprint The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK
    Atherosclerosis 127:35-42. 1996
    ....
  21. ncbi request reprint Cross-sectional but not longitudinal associations between non-esterified fatty acid levels and glucose intolerance and other features of the metabolic syndrome
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Diabet Med 16:1007-15. 1999
    ..However, the direction of causality in these studies is uncertain. The aim of this study was to examine whether NEFA levels predicted the development of glucose intolerance in a prospective population-based cohort study...
  22. ncbi request reprint A common apolipoprotein B signal peptide polymorphism modifies the relation between plasma non-esterified fatty acids and triglyceride concentration in men
    D J Halsall
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, CB2 2QR, Cambridge, UK
    Atherosclerosis 152:9-17. 2000
    ....
  23. ncbi request reprint Family history of diabetes identifies a group at increased risk for the metabolic consequences of obesity and physical inactivity in EPIC-Norfolk: a population-based study. The European Prospective Investigation into Cancer
    L A Sargeant
    Department of Community Medicine, University of Cambridge, Institute of Public Health, UK
    Int J Obes Relat Metab Disord 24:1333-9. 2000
    ..To investigate the interaction of a family history of diabetes with obesity and physical inactivity on diabetes prevalence in middle-aged and elderly men and women...
  24. ncbi request reprint Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity
    P W Franks
    Medical Research Council Epidemiology Unit, Cambridge, UK
    J Appl Physiol 102:1921-6. 2007
    ..Hyperleptinemia predicts a relative decline in PAEE and worsening insulin resistance, possibly via shared molecular pathways...
  25. pmc Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trial
    R K Simmons
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 51:787-94. 2008
    ....
  26. doi request reprint Relationship between plasma fibrinogen and fiber intake in the EPIC-Norfolk cohort
    R N Freitas
    DENCS, School of Nutrition and NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil
    Eur J Clin Nutr 66:443-51. 2012
    ..Fiber-rich diets have been proposed to lower circulating levels of inflammatory makers. Our objective was to investigate cross-sectional relationships between fiber intake and plasma fibrinogen...
  27. doi request reprint Factor VII, blood lipids and fat intake: gene-nutrient interaction and risk of coronary heart disease with the factor VII R353Q polymorphism
    R Bowman
    MRC Dunn Human Nutrition Unit, Cambridge, UK
    Eur J Clin Nutr 63:771-7. 2009
    ..The relation between dietary fat, blood lipids, plasma factor VII coagulant activity (FVIIc) and risk of coronary heart disease (CHD) according to the R353Q polymorphism in the factor VII gene was assessed...
  28. ncbi request reprint Do simple questions about diet and physical activity help to identify those at risk of Type 2 diabetes?
    R K Simmons
    MRC Epidemiology Unit, Cambridge, UK
    Diabet Med 24:830-5. 2007
    ..We determined whether simple measures of physical activity and diet predicted incident diabetes and enhanced prediction by known risk factors including age, body mass index and family history...
  29. doi request reprint Fibre intake in relation to serum total cholesterol levels and CHD risk: a comparison of dietary assessment methods
    H A Ward
    MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Institute of Public Health, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 66:296-304. 2012
    ..The objective of this study was to compare FFQ and 7-day diet diary (7DD) measurements of fibre intake with the incidence of coronary heart disease (CHD)...
  30. doi request reprint Self-reported and measured anthropometric data and risk of colorectal cancer in the EPIC-Norfolk study
    J Y Park
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    Int J Obes (Lond) 36:107-18. 2012
    ..Epidemiological studies have shown inconsistent results for the association between body size and colorectal cancer (CRC) risk. Inconsistencies may be because of the reliance on self-reported measures of body size...
  31. ncbi request reprint Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study
    N G Forouhi
    MRC Epidemiology Unit, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge, CB1 9NL, UK
    Diabetologia 50:949-56. 2007
    ..The aim of this study was to examine the association between baseline body iron stores and new-onset diabetes...
  32. ncbi request reprint How much might achievement of diabetes prevention behaviour goals reduce the incidence of diabetes if implemented at the population level?
    R K Simmons
    MRC Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Diabetologia 49:905-11. 2006
    ..We quantified the association between the achievement of behavioural goals for the prevention of diabetes and the incidence of diabetes in a population-based cohort study...
  33. doi request reprint Psychological distress, major depressive disorder, and risk of stroke
    P G Surtees
    Strangeways Research Laboratory, University of Cambridge, Department of Public Health and Primary Care, Cambridge, CB1 8RN, UK
    Neurology 70:788-94. 2008
    ..We investigated this association based upon a large population-based prospective cohort study...
  34. doi request reprint Effect of screening for Type 2 diabetes on population-level self-rated health outcomes and measures of cardiovascular risk: 13-year follow-up of the Ely cohort
    M Rahman
    General Practice and Primary Care Research Unit, University of Cambridge, Cambridge, UK
    Diabet Med 29:886-92. 2012
    ..We compared clinical measures, prescribed medication, cardiovascular morbidity and self-rated health in individuals without diabetes in a screened vs. an unscreened population...
  35. pmc Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:2345-9. 2009
    ..We sought to assess the usefulness of the LAR as a measure of insulin resistance in non-diabetic white adults...
  36. pmc Dietary antioxidants and asthma in adults
    B D Patel
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, UK
    Thorax 61:388-93. 2006
    ..Several antioxidant nutrients have been reported to be inversely associated with asthma. A study was undertaken to assess the independent associations of these nutrients with asthma in adults...
  37. ncbi request reprint Hormone replacement therapy and glucose tolerance in EPIC-Norfolk: a population-based study
    L A Sargeant
    Department of Community Medicine, University of Cambridge, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Diabetes Metab Res Rev 16:20-5. 2000
    ..The objective was to examine the relationship of glycated haemoglobin (HbA(1C)) concentration with HRT use in non-diabetic postmenopausal women...
  38. pmc The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals
    E H Young
    MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Int J Obes (Lond) 31:1437-41. 2007
    ..Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger studies are needed, however, to confirm this relation...
  39. ncbi request reprint Is the association between dietary fat intake and insulin resistance modified by physical activity?
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Metabolism 50:1186-92. 2001
    ..The findings provide further support for efforts to promote increases in overall physical activity and modifications in the pattern of dietary fat intake in the whole population...
  40. pmc Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
    A H Harding
    MRC Epidemiology Unit, Cambridge, UK
    Diabetologia 49:2642-8. 2006
    ..The present study aimed to replicate our previously reported association in a larger case-control study and to examine an additional five SREBF1c SNPs for their association with diabetes risk and plasma glucose concentrations...
  41. pmc Who attends a UK diabetes screening programme? Findings from the ADDITION-Cambridge study
    L A Sargeant
    MRC Epidemiology Unit, Cambridge, UK
    Diabet Med 27:995-1003. 2010
    ..We examined attendance and practice- and individual-level factors influencing uptake at each stage of a diabetes screening programme in general practice...
  42. pmc The association of intensity and overall level of physical activity energy expenditure with a marker of insulin resistance
    F K Assah
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 51:1399-407. 2008
    ..We examined the association of overall level and intensity of physical activity with fasting insulin level, a marker of insulin resistance...
  43. ncbi request reprint The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity
    A Meirhaeghe
    Department of Medicine, University of Cambridge, Cambridge CB2 2SR, United Kingdom
    J Clin Endocrinol Metab 86:5881-7. 2001
    ..05). These data suggest the existence in this population of a gene-physical activity interaction on NEFA levels...
  44. ncbi request reprint Physical health-related quality of life predicts stroke in the EPIC-Norfolk
    P K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Neurology 69:2243-8. 2007
    ..To examine the relationship between Short Form (SF)-36 physical functional health-related quality of life and incident stroke...
  45. doi request reprint The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals
    N Kurokawa
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 32:1240-9. 2008
    ..The association between the Trp64Arg variant in the ADRB3 and body mass index (BMI) has been widely examined, but previous studies have been small and results have been inconsistent...
  46. ncbi request reprint Does physical activity equally predict gain in fat mass among obese and nonobese young adults?
    U Ekelund
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Int J Obes (Lond) 31:65-71. 2007
    ..Differences in energy metabolism and physical activity (PA) may contribute to the long-term regulation of body weight (BW)...
  47. ncbi request reprint Studies of the SIM1 gene in relation to human obesity and obesity-related traits
    C C C Hung
    University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 31:429-34. 2007
    ..SIM1-deficient mice have a hypocellular PVN and are severely obese with increased food intake...
  48. doi request reprint Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis
    C C Lee
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:1040-7. 2009
    ..We examined the association between serum C-reactive protein (CRP) and incident diabetes in a prospective study, and added these data to a literature-based meta-analysis to explore potential sources of heterogeneity between studies...
  49. ncbi request reprint Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000
    N G Forouhi
    Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratories, Cambridge, UK
    Diabet Med 24:200-7. 2007
    ..To determine the incidence of Type 2 diabetes and to examine the effect of different cut-points for impaired fasting glucose (IFG) on diabetes incidence...
  50. ncbi request reprint Habitual fish consumption and glycated haemoglobin: the EPIC-Norfolk study
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 58:277-84. 2004
    ..To investigate the association between habitual fish consumption and a continuous measure of glycaemia...
  51. ncbi request reprint Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study
    M F Yuyun
    Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK
    J Intern Med 255:247-56. 2004
    ..To examine the relationship between microalbuminuria and incident stroke in the general population...
  52. ncbi request reprint Respiratory function and self-reported functional health: EPIC-Norfolk population study
    P K Myint
    Room 311, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Eur Respir J 26:494-502. 2005
    ..00; 95% CI 0.82-1.22). In conclusion, forced expiratory volume in one second independently predicts self perceived physical well being in a general population across the whole normal distribution of respiratory function...
  53. doi request reprint Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study
    A Moayyeri
    Department of Public Health and Primary Care, University of Cambridge MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    J Intern Med 271:472-80. 2012
    ..The aim of this study was to examine the association between percentage body fat (%BF) and prospective risk of fracture...
  54. doi request reprint Altered respiratory function is associated with increased metabolic risk, independently of adiposity, fitness and physical activity
    R M Steele
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabet Med 26:362-9. 2009
    ....
  55. doi request reprint Effects of body size and sociodemographic characteristics on differences between self-reported and measured anthropometric data in middle-aged men and women: the EPIC-Norfolk study
    J Y Park
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 65:357-67. 2011
    ..To investigate the effects of body size and sociodemographic characteristics on differences between self-reported (SR) and measured anthropometric data in men and women...
  56. doi request reprint A cross-sectional analysis of physical activity and obesity indicators in European participants of the EPIC-PANACEA study
    H Besson
    Medical Research Council, Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Int J Obes (Lond) 33:497-506. 2009
    ....
  57. pmc Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis
    A J Cooper
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Eur J Clin Nutr 66:1082-92. 2012
    ..84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect...
  58. doi request reprint Estimating the potential population impact of stepwise screening strategies for identifying and treating individuals at high risk of Type 2 diabetes: a modelling study
    P Chamnan
    MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Diabet Med 29:893-904. 2012
    ..5%). We estimated the potential population impact of different stepwise screening strategies to identify individuals at high risk who might be offered preventive interventions...
  59. doi request reprint Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies
    N G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 55:2173-82. 2012
    ..We conducted a systematic review and meta-analysis that included new data from previously unpublished studies...
  60. ncbi request reprint Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians
    B G Challis
    University Departments of Medicine and Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes Relat Metab Disord 28:442-6. 2004
    ..To investigate whether genetic variation at the loci encoding the corticotropin-releasing factor receptors-1 and -2 (CRF-R1 and CRF-R2) contributes to human obesity...
  61. doi request reprint Association between serotonin 5-HT-2C receptor gene (HTR2C) polymorphisms and obesity- and mental health-related phenotypes in a large population-based cohort
    K S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Int J Obes (Lond) 34:1028-33. 2010
    ..We aimed to analyse whether variation in the HTR2C is associated with obesity- and mental health-related phenotypes in a large population-based cohort...
  62. doi request reprint How much might cardiovascular disease risk be reduced by intensive therapy in people with screen-detected diabetes?
    J B Echouffo-Tcheugui
    MRC Epidemiology Unit and General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Diabet Med 25:1433-9. 2008
    ..To assess the cardiovascular disease (CVD) risk of people with screen-detected Type 2 diabetes and to estimate the risk reduction achievable through early intensive pharmacological intervention...
  63. ncbi request reprint Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population
    D J Halsall
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes Relat Metab Disord 25:472-7. 2001
    ..To investigate whether genetic variation at the UCP3 locus contributes to human obesity...
  64. ncbi request reprint Diabetes risk score: towards earlier detection of type 2 diabetes in general practice
    S J Griffin
    General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Diabetes Metab Res Rev 16:164-71. 2000
    ..We aimed to develop and evaluate a score based on routinely collected information to identify people at risk of having undetected diabetes...
  65. ncbi request reprint Increased PAI activity and PAI-1 antigen occurring with an oral fat load: associations with PAI-1 genotype and plasma active TGF-beta levels
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Atherosclerosis 140:45-53. 1998
    ..In conclusion, increased PAI and decreased TGF-beta activity occur during a fat tolerance test and this effect may be modulated by a common insertion/deletion polymorphism in the PAI-1 promoter...
  66. pmc Does early intensive multifactorial treatment reduce total cardiovascular burden in individuals with screen-detected diabetes? Findings from the ADDITION-Europe cluster-randomized trial
    R K Simmons
    MRC Epidemiology Unit, Cambridge, UK
    Diabet Med 29:e409-16. 2012
    ....
  67. doi request reprint The association between prior infection with five serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the EPIC-Norfolk study
    E Gkrania-Klotsas
    Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 55:967-70. 2012
    ....
  68. doi request reprint No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach
    R Pfister
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Diabetologia 54:2561-9. 2011
    ..Using a Mendelian randomisation approach, we investigated whether there is evidence for a causal role of serum uric acid for development of type 2 diabetes...
  69. ncbi request reprint Estimating energy expenditure by heart-rate monitoring without individual calibration
    K L Rennie
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, Cambridge, CB2 2SR, UK
    Med Sci Sports Exerc 33:939-45. 2001
    ..This simplification of the heart rate monitoring method could extend its use in ranking individuals in epidemiological studies...
  70. pmc Childhood smoking is an independent risk factor for obstructive airways disease in women
    B D Patel
    Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Thorax 59:682-6. 2004
    ..To assess whether starting to smoke in childhood increases the risk of obstructive airways disease (OAD) in adult life...
  71. ncbi request reprint How should peripheral neuropathy be assessed in people with diabetes in primary care? A population-based comparison of four measures
    M Rahman
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Diabet Med 20:368-74. 2003
    ..To test the accuracy of four measures of peripheral diabetic neuropathy in a primary care population...
  72. ncbi request reprint Elevated plasma adiponectin in humans with genetically defective insulin receptors
    R K Semple
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    J Clin Endocrinol Metab 91:3219-23. 2006
    ..Adiponectin has been suggested to play a role in the etiopathogenesis of at least some forms of insulin resistance, in part based on a strong correlation between plasma levels of adiponectin and measures of insulin sensitivity...
  73. ncbi request reprint Correlated measurement error--implications for nutritional epidemiology
    N E Day
    Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, CB1 8RN, UK
    Int J Epidemiol 33:1373-81. 2004
    ..This paper describes the effect on multivariate regression coefficients of different levels of correlation, both between the variables themselves and between the errors of estimation of these variables...
  74. ncbi request reprint Psychosocial factors and incident asthma hospital admissions in the EPIC-Norfolk cohort study
    N W J Wainwright
    Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK
    Allergy 62:554-60. 2007
    ..General population studies have shown associations between psychosocial factors and prevalent asthma but few have investigated incident asthma outcomes...
  75. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  76. ncbi request reprint Evidence for gene-nutrient interaction at the PPARgamma locus
    J Luan
    Department of Public Health and Primary Care, University of Cambridge, UK
    Diabetes 50:686-9. 2001
    ..This gene-nutrient interaction emphasizes the difficulty of examining the effect of common polymorphisms in the absence of data on nongenetic exposures, and may explain the heterogeneity of findings in previous studies...
  77. ncbi request reprint Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction
    S C McCloskey
    Respiratory Medicine Unit, Department of Medicine, University of Cambridge, The Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    Am J Respir Crit Care Med 164:1419-24. 2001
    ..39 (95% confidence interval, 2.49 to 11.67) when compared with matched control subjects. Taken together these results demonstrate a significant familial risk of airflow obstruction in smoking siblings of patients with severe COPD...
  78. pmc Cardiovascular risk assessment scores for people with diabetes: a systematic review
    P Chamnan
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:2001-14. 2009
    ..However, due to the uncertainty in estimation of true risk, care is needed when using scores to communicate absolute CVD risk to individuals...
  79. ncbi request reprint The performance of a risk score in predicting undiagnosed hyperglycemia
    P J Park
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Diabetes Care 25:984-8. 2002
    ..The objective of this study was to assess the effectiveness of the Cambridge risk score in a large and representative population...
  80. ncbi request reprint The threshold for diagnosing impaired fasting glucose: a position statement by the European Diabetes Epidemiology Group
    N G Forouhi
    MRC Epidemiology Unit, Elsie Widdowson Laboratories, Cambridge, UK
    Diabetologia 49:822-7. 2006
    ..EDEG further recommends that the value of all categorical definitions of non-diabetic hyperglycaemia should be reconsidered...
  81. ncbi request reprint Is there really an epidemic of diabetes?
    N J Wareham
    Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratories, Cambridge CB1 9NL, UK
    Diabetologia 48:1454-5. 2005
  82. ncbi request reprint Cross-sectional association between total level and type of alcohol consumption and glycosylated haemoglobin level: the EPIC-Norfolk Study
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 56:882-90. 2002
    ..To investigate the association between total level and type of alcohol consumed and glycaemia...
  83. ncbi request reprint The role of insulin and proinsulin in the regulation of triglyceride metabolism
    C D Byrne
    University Dept of Clinical Biochemistry, Addenbrookes Hospital, Cambridge
    Exp Clin Endocrinol Diabetes 105:29-35. 1997
    ..We suggest that abnormal NEFA suppression plays an important part in the increase in risk of vascular disease associated with insulin resistance...
  84. pmc Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
    C Langenberg
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Diabetologia 52:1537-42. 2009
    ....
  85. doi request reprint The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 53:624-31. 2010
    ..We sought to determine the effect of an aerobic exercise intervention on clustered metabolic risk and related outcomes in healthy older adults in a single-centre, explanatory randomised controlled trial...
  86. ncbi request reprint Interventions to prevent weight gain: a systematic review of psychological models and behaviour change methods
    W Hardeman
    General Practice and Primary Care Research Unit, Institute of Public Health, University of Cambridge, Cambridge, UK
    Int J Obes Relat Metab Disord 24:131-43. 2000
    ..To identify and review published interventions aimed at the prevention of weight gain...
  87. ncbi request reprint The CART gene and human obesity: mutational analysis and population genetics
    B G Challis
    University Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 49:872-5. 2000
    ....
  88. ncbi request reprint Objectively measured physical activity correlates with indices of insulin resistance in Danish children. The European Youth Heart Study (EYHS)
    S Brage
    Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Main Campus, Odense University, Odense, Denmark
    Int J Obes Relat Metab Disord 28:1503-8. 2004
    ..To explore the association between measures of insulin resistance with objectively assessed physical activity...
  89. ncbi request reprint Reliability and validity of the combined heart rate and movement sensor Actiheart
    S Brage
    MRC Epidemiology Unit, Institute of Public Health, University of Cambridge, CB1 9NL, UK
    Eur J Clin Nutr 59:561-70. 2005
    ..The Actiheart, a combined heart rate (HR) and movement sensor, is designed to assess physical activity in populations...
  90. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  91. ncbi request reprint IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1503-8. 2004
    ..To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women...
  92. ncbi request reprint Population impact of strategies for identifying groups at high risk of type 2 diabetes
    Anne Helen Harding
    MRC Epidemiology Unit, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Prev Med 42:364-8. 2006
    ..To assess the incidence of diabetes among sub-groups of the population defined by the presence of one or more simple risk factors, and to investigate population stratification as a means of identifying groups at high risk of diabetes...
  93. ncbi request reprint Does the association of habitual physical activity with the metabolic syndrome differ by level of cardiorespiratory fitness?
    Paul W Franks
    MRC Epidemiology Unit, Cambridge, UK
    Diabetes Care 27:1187-93. 2004
    ..The purpose of this study was, therefore, to describe the association between physical activity and the metabolic syndrome and to test whether fitness level modifies this relationship...
  94. ncbi request reprint Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study
    Stefan F C Vaessen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 47:2064-70. 2006
    ..The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V...
  95. ncbi request reprint Obesity indices and self-reported functional health in men and women in the EPIC-Norfolk
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    Obesity (Silver Spring) 14:884-93. 2006
    ..To investigate the association between two indices of obesity, BMI and waist-to-hip ratio (WHR), and self-reported physical and mental functional health...
  96. ncbi request reprint Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome
    Sally D Poppitt
    MRC Dunn Clinical Nutrition Centre, Cambridge, United Kingdom
    Am J Clin Nutr 75:11-20. 2002
    ..Overweight individuals with metabolic syndrome are at increased risk of type 2 diabetes and coronary vascular disease. Weight gain and features of the syndrome may be ameliorated by dietary intervention...
  97. ncbi request reprint Genetic variants and common diseases--better late than never
    Stephen O'Rahilly
    N Engl J Med 355:306-8. 2006
  98. ncbi request reprint Combined work and leisure physical activity and risk of stroke in men and women in the European prospective investigation into Cancer-Norfolk Prospective Population Study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Neuroepidemiology 27:122-9. 2006
    ..70, 95% CI: 0.49-0.99, p = 0.024) compared to those who were inactive. This highlights the fact that efforts to increase physical activity in both the work place and in leisure time should be encouraged...
  99. ncbi request reprint Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality?
    Ulf Ekelund
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Clin Nutr 88:612-7. 2008
    ..Whether obesity is a cause or a consequence of a sedentary lifestyle has not yet been fully elucidated, which leaves uncertainty about the direction of causality...
  100. doi request reprint Assessment of physical activity in youth
    Kirsten Corder
    Institute of Metabolic Science, Addenbrooke s Hospital CB2 0QQ Cambridge, UK
    J Appl Physiol 105:977-87. 2008
    ..Although multisensor systems may be more accurate, this must be balanced against feasibility, a balance that shifts with technological and scientific advances and should be considered at the beginning of every new study...
  101. ncbi request reprint Gene-lifestyle interaction on risk of type 2 diabetes
    Paul W Franks
    Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratories, 120 Fulbourn Road, Cambridge, CB1 9NL, UK
    Nutr Metab Cardiovasc Dis 17:104-24. 2007
    ....