J M Wardlaw

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
  2. pmc Influence of thickening of the inner skull table on intracranial volume measurement in older people
    N A Royle
    Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK
    Magn Reson Imaging 31:918-22. 2013
  3. pmc Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects
    Benjamin S Aribisala
    Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Scottish Imaging Network, A Platform for Scientific Excellence SINAPSE, Edinburgh, UK Department of Computer Science, Lagos State University, Lagos, Nigeria
    Cortex 53:34-44. 2014
  4. pmc Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke
    Bartosz Karaszewski
    Brain Research Imaging Centre, Division of Neuroimaging Sciences, SINAPSE Collaboration, University of Edinburgh, Edinburgh, UK
    J Cereb Blood Flow Metab 33:1083-9. 2013
  5. pmc Brain white matter damage in aging and cognitive ability in youth and older age
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Neurobiol Aging 34:2740-7. 2013
  6. pmc How much do focal infarcts distort white matter lesions and global cerebral atrophy measures?
    Xin Wang
    School of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
    Cerebrovasc Dis 34:336-42. 2012
  7. pmc Incidental findings on brain MR imaging in older community-dwelling subjects are common but serious medical consequences are rare: a cohort study
    Elaine M Sandeman
    Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e71467. 2013
  8. pmc Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities
    Benjamin S Aribisala
    Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Bramwell Dott Bldg, Crewe Rd, Edinburgh EH4 2XU, United Kingdom
    Hypertension 63:1011-8. 2014
  9. pmc Clinical relevance and practical implications of trials of perfusion and angiographic imaging in patients with acute ischaemic stroke: a multicentre cohort imaging study
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 84:1001-7. 2013
  10. pmc A test-retest fMRI dataset for motor, language and spatial attention functions
    Krzysztof J Gorgolewski
    Institute for Adaptive and Neural Computation, University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB, UK
    Gigascience 2:6. 2013

Collaborators

Detail Information

Publications168 found, 100 shown here

  1. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
    ..IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit...
  2. pmc Influence of thickening of the inner skull table on intracranial volume measurement in older people
    N A Royle
    Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK
    Magn Reson Imaging 31:918-22. 2013
    ..The potential influence that inner table skull thickening may have on ICV measurement in old age has yet to be investigated...
  3. pmc Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects
    Benjamin S Aribisala
    Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Scottish Imaging Network, A Platform for Scientific Excellence SINAPSE, Edinburgh, UK Department of Computer Science, Lagos State University, Lagos, Nigeria
    Cortex 53:34-44. 2014
    ....
  4. pmc Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke
    Bartosz Karaszewski
    Brain Research Imaging Centre, Division of Neuroimaging Sciences, SINAPSE Collaboration, University of Edinburgh, Edinburgh, UK
    J Cereb Blood Flow Metab 33:1083-9. 2013
    ....
  5. pmc Brain white matter damage in aging and cognitive ability in youth and older age
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Neurobiol Aging 34:2740-7. 2013
    ..Early-life IQ also influenced WMH in later life. Determining how lower IQ in youth leads to increasing brain damage with aging is important for future successful cognitive aging. ..
  6. pmc How much do focal infarcts distort white matter lesions and global cerebral atrophy measures?
    Xin Wang
    School of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
    Cerebrovasc Dis 34:336-42. 2012
    ..We evaluated the effect that acute or old stroke lesions at baseline, and new stroke lesions occurring during follow-up, could have on measurement of WML volume, cerebral atrophy and their longitudinal progression...
  7. pmc Incidental findings on brain MR imaging in older community-dwelling subjects are common but serious medical consequences are rare: a cohort study
    Elaine M Sandeman
    Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e71467. 2013
    ..We determined the prevalence and medical consequences of incidental findings found in community-dwelling older subjects on brain magnetic resonance imaging...
  8. pmc Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities
    Benjamin S Aribisala
    Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Bramwell Dott Bldg, Crewe Rd, Edinburgh EH4 2XU, United Kingdom
    Hypertension 63:1011-8. 2014
    ..Reducing vascular stiffness may reduce WMH progression and should be tested in randomized trials, in addition to testing antihypertensive therapy. ..
  9. pmc Clinical relevance and practical implications of trials of perfusion and angiographic imaging in patients with acute ischaemic stroke: a multicentre cohort imaging study
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 84:1001-7. 2013
    ..In randomised trials testing treatments for acute ischaemic stroke, imaging markers of tissue reperfusion and arterial recanalisation may provide early response indicators...
  10. pmc A test-retest fMRI dataset for motor, language and spatial attention functions
    Krzysztof J Gorgolewski
    Institute for Adaptive and Neural Computation, University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB, UK
    Gigascience 2:6. 2013
    ..In addition to the fMRI sessions, high-angular resolution diffusion tensor MRI (DTI), and high-resolution 3D T1-weighted volume scans were acquired...
  11. pmc Neck muscle cross-sectional area, brain volume and cognition in healthy older men: a cohort study
    Alixe H M Kilgour
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 13:20. 2013
    ..However, studies investigating these relationships at older ages are lacking and rarely include a measure of muscle size. Here we test whether neck muscle size is positively associated with cognition and brain structure in older men...
  12. pmc Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
    Joanna M Wardlaw
    Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK
    Lancet Neurol 12:822-38. 2013
    ..This Position Paper summarises the main outcomes of this international effort to provide the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE). ..
  13. doi request reprint Thrombolysis (different doses, routes of administration and agents) for acute ischaemic stroke
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Cochrane Database Syst Rev 5:CD000514. 2013
    ..While most available information comes from RCTs of intravenous rt-PA at 0.9 mg/kg, it is possible that other doses, drugs and other routes of administration might increase benefit and reduce the hazard...
  14. pmc Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
    Joanna M Wardlaw
    Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet Neurol 12:483-97. 2013
    ..We discuss potential mechanisms, detectable with neuroimaging, that might better fit the available evidence and provide testable hypotheses for future study...
  15. pmc Temporal profile of body temperature in acute ischemic stroke: relation to stroke severity and outcome
    Bartosz Karaszewski
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    BMC Neurol 12:123. 2012
    ..Pyrexia after stroke (temperature ≥37.5°C) is associated with poor prognosis, but information on timing of body temperature changes and relationship to stroke severity and subtypes varies...
  16. pmc Acute symptomatic hypoglycaemia mimicking ischaemic stroke on imaging: a systemic review
    Ai Wain Yong
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    BMC Neurol 12:139. 2012
    ..We systematically reviewed the literature to identify how often hypoglycaemia may mimic ischaemic stroke on imaging, common patterns and relationships with hypoglycaemia severity, duration, clinical outcome and add two new cases...
  17. pmc Blood-brain barrier permeability and long-term clinical and imaging outcomes in cerebral small vessel disease
    Joanna M Wardlaw
    Brain Research Imaging Center, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    Stroke 44:525-7. 2013
    ..Increased blood-brain barrier (BBB) permeability occurs in cerebral small vessel disease. It is not known if BBB changes predate progression of small vessel disease...
  18. doi request reprint A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research
    Joanna M Wardlaw
    Scottish Imaging Network, A Platform for Scientific Excellence collaboration, Edinburgh, UK
    Eur Radiol 22:2295-303. 2012
    ..MRI at 3 T is said to be more accurate than 1.5 T MR, but costs and other practical differences mean that it is unclear which to use...
  19. pmc Do acute phase markers explain body temperature and brain temperature after ischemic stroke?
    William N Whiteley
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Neurology 79:152-8. 2012
    ..Both brain and body temperature rise after stroke but the cause of each is uncertain. We investigated the relationship between circulating markers of inflammation with brain and body temperature after stroke...
  20. pmc Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Lancet 379:2364-72. 2012
    ..The IST-3 trial adds substantial new data. We therefore assessed all the evidence from randomised trials for rt-PA in acute ischaemic stroke in an updated systematic review and meta-analysis...
  21. doi request reprint Neuroimaging in acute ischaemic stroke: insights into unanswered questions of pathophysiology
    J M Wardlaw
    SINAPSE Collaboration, SFC Brain Imaging Research Centre, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2EX, UK
    J Intern Med 267:172-90. 2010
    ..This review will explore the information now emerging from imaging studies in large artery ischaemic stroke to summarize knowledge to date and indicate unresolved issues for the future...
  22. ncbi request reprint Systematic review of perfusion imaging with computed tomography and magnetic resonance in acute ischemic stroke: heterogeneity of acquisition and postprocessing parameters: a translational medicine research collaboration multicentre acute stroke imaging s
    Krishna A Dani
    Institute of Neuroscience and Psychology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Stroke 43:563-6. 2012
    ....
  23. pmc Little association between intracranial arterial stenosis and lacunar stroke
    Joanna M Wardlaw
    Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration, SFC Brain Imaging Research Centre, University of Edinburgh, Edinburgh, UK
    Cerebrovasc Dis 31:12-8. 2011
    ..MCA atheromatous stenosis is unlikely to be a common cause of lacunar stroke in white populations. Falling velocities with increasing white matter lesion scores may reflect progressive brain tissue loss leaving less tissue to supply...
  24. pmc "Can it read my mind?" - What do the public and experts think of the current (mis)uses of neuroimaging?
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e25829. 2011
    ..The present study also emphasizes the need for better frameworks for scientific engagement with media and public education...
  25. ncbi request reprint Factors influencing the detection of early CT signs of cerebral ischemia: an internet-based, international multiobserver study
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Stroke 38:1250-6. 2007
    ..Early CT signs of cerebral ischemia are subtle. Little is known of which factors influence the detection of infarct signs. We compared neuroradiologists' scan readings with those of other specialists involved in the care of stroke patients...
  26. doi request reprint Blood-brain barrier and cerebral small vessel disease
    J M Wardlaw
    SINAPSE Collaboration, SFC Brain Imaging Research Centre, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH4 2EX, UK
    J Neurol Sci 299:66-71. 2010
    ..This mechanism may also play a role in other common disorders of ageing such as Alzheimer's disease...
  27. ncbi request reprint The familial risk of subarachnoid haemorrhage
    Graham M Teasdale
    Division of Clinical Neurosciences, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK E mail
    Brain 128:1677-85. 2005
    ..e. index case plus one extra have been affected...
  28. ncbi request reprint The NeuroGrid stroke exemplar clinical trial protocol
    J M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Int J Stroke 2:63-9. 2007
    ..However, multicentre trials use many different scanners in different hospitals and present complex problems for image data collection, interpretation and analysis and long-term secure archiving...
  29. ncbi request reprint Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH4 2EX, UK
    Stroke 37:2633-6. 2006
    ..An association between microbleeds and clinically defined lacunar stroke might suggest a common causal microangiopathy...
  30. ncbi request reprint Increased oxygen extraction demonstrated on gradient echo (T2*) imaging in a patient with acute ischaemic stroke
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Cerebrovasc Dis 22:456-8. 2006
  31. pmc A large web-based observer reliability study of early ischaemic signs on computed tomography. The Acute Cerebral CT Evaluation of Stroke Study (ACCESS)
    Joanna M Wardlaw
    SINAPSE Collaboration, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e15757. 2010
    ..Scoring methods that code for the extent of brain ischaemia may improve stroke diagnosis and quantification of the impact of ischaemia...
  32. ncbi request reprint Lacunar stroke is associated with diffuse blood-brain barrier dysfunction
    Joanna M Wardlaw
    University of Edinburgh, United Kingdom
    Ann Neurol 65:194-202. 2009
    ..We tested for subtle generalized BBB leakiness in patients with lacunar stroke and control patients with cortical ischemic stroke...
  33. ncbi request reprint Carotid artery imaging for secondary stroke prevention: both imaging modality and rapid access to imaging are important
    Joanna M Wardlaw
    University of Edinburgh, Edinburgh, UK
    Stroke 40:3511-7. 2009
    ..We evaluated the influence of carotid imaging methods on secondary stroke prevention...
  34. doi request reprint MR diffusion and perfusion parameters: relationship to metabolites in acute ischaemic stroke
    Vera Cvoro
    SFC Brain Imaging Research Centre, SINAPSE Collaboration, Division of Clinical Neuroscience, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 81:185-91. 2010
    ..The authors compared N-acetyl aspartate (NAA, found in intact neurons) and lactate (anaerobic metabolism) with diffusion/perfusion parameters...
  35. ncbi request reprint Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis
    J M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Lancet 367:1503-12. 2006
    ..We systematically reviewed the accuracy of non-invasive imaging compared with intra-arterial angiography for diagnosing carotid stenosis in patients with carotid territory ischaemic symptoms...
  36. pmc Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke
    F N Doubal
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Neurology 74:1102-7. 2010
    ..Altered retinal vessel fractal dimensions may act as a surrogate marker for diseased cerebral vessels. We used a cross-sectional study to investigate fractal properties of retinal vessels in lacunar stroke...
  37. ncbi request reprint Effects of dexamethasone on cerebral perfusion and water diffusion in patients with high-grade glioma
    M E Bastin
    Department of Medical and Radiological Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    AJNR Am J Neuroradiol 27:402-8. 2006
    ....
  38. ncbi request reprint Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: relation between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland
    Stroke 29:1618-24. 1998
    ....
  39. ncbi request reprint Brain choline concentration. Early quantitative marker of ischemia and infarct expansion?
    B Karaszewski
    SFC Brain Imaging Research Centre, SINAPSE Collaboration, Division of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK
    Neurology 75:850-6. 2010
    ....
  40. ncbi request reprint Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study
    S Muñoz Maniega
    University of Edinburgh, Division of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Neurology 71:1993-9. 2008
    ..We assessed the temporal pattern of neuronal loss and ischemia after ischemic stroke using magnetic resonance spectroscopic imaging (MRSI) and diffusion-weighted imaging (DWI)...
  41. doi request reprint Brain white matter tract integrity as a neural foundation for general intelligence
    L Penke
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 17:1026-30. 2012
    ....
  42. ncbi request reprint Accurate, practical and cost-effective assessment of carotid stenosis in the UK
    J M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, UK
    Health Technol Assess 10:iii-iv, ix-x, 1-182. 2006
    ....
  43. ncbi request reprint MR diffusion-weighted imaging and outcome prediction after ischemic stroke
    P J Hand
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Neurology 66:1159-63. 2006
    ..MR diffusion-weighted imaging (DWI) shows acute ischemic lesions early after stroke so it might improve outcome prediction and reduce sample sizes in stroke treatment trials. Previous studies of DWI and outcome produced conflicting results...
  44. ncbi request reprint A practical assessment of magnetic resonance diffusion-perfusion mismatch in acute stroke: observer variation and outcome
    I Kane
    Division of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol 256:1832-8. 2009
    ..Mismatch alone does not distinguish patients with good and poor prognosis; both can do well or poorly. Other factors, e.g. reperfusion, may influence outcome more strongly, even in patients without mismatch...
  45. ncbi request reprint Is visible infarction on computed tomography associated with an adverse prognosis in acute ischemic stroke?
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital NHS Trust, Edinburgh, Scotland, UK
    Stroke 29:1315-9. 1998
    ..We examined whether visible infarction was associated with a poor outcome after stroke using univariate and multivariate analyses, including easily identifiable clinical baseline variables, and adjusting for time from stroke onset to CT...
  46. ncbi request reprint Counting cavitating lacunes underestimates the burden of lacunar infarction
    Gillian M Potter
    Division of Clinical Neurosciences and SINAPSE Collaboration, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Stroke 41:267-72. 2010
    ..The proportion of symptomatic lacunar infarcts that progress to lacunes is unknown. Noncavitating lacunar infarcts may continue to resemble white matter lesions...
  47. ncbi request reprint Do acute diffusion- and perfusion-weighted MRI lesions identify final infarct volume in ischemic stroke?
    C S Rivers
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, EH4 2XU, UK
    Stroke 37:98-104. 2006
    ..quot; It is unclear which "semiquantitative" perfusion parameter most closely identifies final infarct volume...
  48. ncbi request reprint Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysis
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Stroke 34:1437-42. 2003
    ..Recombinant tissue plasminogen activator (rtPA; Actilyse) is not as widely used in clinical practice as it could be. Have new data since 1995 strengthened the evidence sufficiently to justify more widespread use of rtPA?..
  49. ncbi request reprint Diffusion anisotropy measurements in ischaemic stroke of the human brain
    P A Armitage
    Department of Medical Physics, University of Edinburgh, Western General Hospital, UK
    MAGMA 6:28-36. 1998
    ..27 (p = 0.003) and 0.87 +/- 0.05 (p = 0.005) respectively. The effects of gradient interactions, image registration, noise contamination and rotational variance and their implications for the results obtained in this study are discussed...
  50. doi request reprint Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, UK
    Psychol Med 43:1197-206. 2013
    ..We tested whether depressive symptoms were related to reduced white-matter tract fractional anisotropy (FA), a measure of integrity, and then examined whether high neuroticism or low extraversion mediated this relationship...
  51. pmc Outcome, observer reliability, and patient preferences if CTA, MRA, or Doppler ultrasound were used, individually or together, instead of digital subtraction angiography before carotid endarterectomy
    S G Patel
    Department of Neuroradiology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 73:21-8. 2002
    ....
  52. ncbi request reprint Does feeding alter arterial oxygen saturation in patients with acute stroke?
    A M Rowat
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, UK
    Stroke 31:2134-40. 2000
    ..We measured arterial oxygen saturation (SaO(2)) during eating in acute stroke patients to establish the frequency of any meal-related hypoxemia, which could further damage already vulnerable brain tissue...
  53. ncbi request reprint Traumatic brain injury and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be "ischaemic". A primary study and review of the literature
    C S A Macmillan
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Acta Neurochir (Wien) 144:853-62; discussion 862. 2002
    ..Proton metabolite concentrations were measured in normal and abnormal areas of brain on T2 MR imaging, in regions considered particularly vulnerable to ischaemic injury...
  54. ncbi request reprint improving interrater agreement about brain microbleeds: development of the Brain Observer MicroBleed Scale (BOMBS)
    Charlotte Cordonnier
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    Stroke 40:94-9. 2009
    ..If the diagnostic and prognostic significance of brain microbleeds (BMBs) are to be investigated and used for these purposes in clinical practice, observer variation in BMB assessment must be minimized...
  55. ncbi request reprint Cognitive correlates of cerebral white matter lesions and water diffusion tensor parameters in community-dwelling older people
    S D Shenkin
    Department of Geriatric Medicine, University of Edinburgh, UK
    Cerebrovasc Dis 20:310-8. 2005
    ..Here the relationships between WML load, DT-MRI parameters and cognition in a large cohort of elderly subjects with a very narrow age range were investigated...
  56. pmc Should computed tomography appearance of lacunar stroke influence patient management?
    G E Mead
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 67:682-4. 1999
    ..Brain imaging should modify the clinical classification and influence patient investigation...
  57. ncbi request reprint What is the best imaging strategy for acute stroke?
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital University of Edinburgh, Edinburgh, UK
    Health Technol Assess 8:iii, ix-x, 1-180. 2004
    ....
  58. ncbi request reprint Relationship between pattern of intracranial artery abnormalities on transcranial doppler and Oxfordshire Community Stroke Project clinical classification of ischemic stroke
    G E Mead
    Neurosciences Trials Unit, Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Stroke 31:714-9. 2000
    ..We investigated whether the pattern of intracranial vascular abnormalities is related to the clinical syndrome...
  59. pmc The impact of delays in computed tomography of the brain on the accuracy of diagnosis and subsequent management in patients with minor stroke
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:77-81. 2003
    ..To determine the proportion of haemorrhagic strokes misdiagnosed as infarcts on computed tomography (CT) in patients with mild stroke, and the implications for health care...
  60. ncbi request reprint Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, UK
    Lancet 350:607-14. 1997
    ..To make sense of these results, we have done a systematic review of all available randomised trials of thrombolysis in acute ischaemic stroke...
  61. pmc Can stroke physicians and neuroradiologists identify signs of early cerebral infarction on CT?
    J M Wardlaw
    Department of Clinical Neuroscience, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 67:651-3. 1999
    ..Part of the problem may be in understanding the definitions of the extent of infarction. These difficulties should be considered in the design of acute stroke treatment trials and in the introduction of any new acute stroke treatments...
  62. ncbi request reprint The detection and management of unruptured intracranial aneurysms
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Brain 123:205-21. 2000
    ..Ideally, screening in such subgroups should be tested in a randomized trial. The avoidance of risk factors for aneurysms such as smoking, hypertension and hypercholesterolaemia should be part of the management of at-risk subjects...
  63. ncbi request reprint Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Stroke 34:806-12. 2003
    ..The pathogenesis of and relationship between small deep (lacunar) infarcts, cerebral white matter disease (leukoaraiosis or white matter hyperintensities), and progressive cognitive impairment or dementia are much debated...
  64. pmc Effects of dexamethasone on peritumoural oedematous brain: a DT-MRI study
    S Sinha
    Neurosciences, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 75:1632-5. 2004
    ..Diffusion tensor magnetic resonance imaging (DT-MRI) was used to measure the water diffusion parameters of oedematous and normal brain in a group of patients with intracranial tumours before and after steroid treatment...
  65. pmc Visible infarction on computed tomography is an independent predictor of poor functional outcome after stroke, and not of haemorrhagic transformation
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:452-8. 2003
    ....
  66. pmc No evidence that severity of stroke in internal carotid occlusion is related to collateral arteries
    G E Mead
    Division of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 77:729-33. 2006
    ....
  67. ncbi request reprint 1H spectroscopic imaging of acute head injury--evidence of diffuse axonal injury
    J M Wild
    Department of Medical Physics, University of Edinburgh, Western General Hospital, Scotland, UK
    MAGMA 8:109-15. 1999
    ..This suggests that SI (of NAA in particular) will be useful for the diagnosis of diffuse axonal injury...
  68. pmc How does the degree of carotid stenosis affect the accuracy and interobserver variability of magnetic resonance angiography?
    J M Wardlaw
    Department of Clinical Neurosciences, Bramwell Dott Building, Western General Hospital NHS Trust, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 71:155-60. 2001
    ....
  69. ncbi request reprint Variability in Doppler ultrasound influences referral of patients for carotid surgery
    G E Mead
    Department of Geriatric Medicine, 21 Chalmers Street, EH3 9EW, Edinburgh, UK
    Eur J Ultrasound 12:137-43. 2000
    ..Colour Doppler ultrasound is operator dependent, but it is unclear how much clinical impact this might have on patient referral for carotid endarterectomy. Our aim was to quantify the interobserver variability of Doppler ultrasound...
  70. ncbi request reprint Severe ipsilateral carotid stenosis and middle cerebral artery disease in lacunar ischaemic stroke: innocent bystanders?
    G E Mead
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    J Neurol 249:266-71. 2002
    ..Therefore, our aim was to compare the severity of ipsilateral with contralateral ICA and MCA disease in patients with lacunar ischaemic stroke...
  71. ncbi request reprint Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke
    Vera Cvoro
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Stroke 40:767-72. 2009
    ..We used spectroscopic imaging to measure N-acetyl aspartate (NAA, a marker of normal neurons) and lactate (a marker of ischemia) to compare with diffusion and perfusion values in the diffusion lesion in acute ischemic stroke...
  72. ncbi request reprint Development and initial testing of normal reference MR images for the brain at ages 65-70 and 75-80 years
    C Farrell
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Eur Radiol 19:177-83. 2009
    ..They could also be useful for research into ageing and related conditions. Larger numbers of examinations from more diverse populations and at different ages are required to increase the versatility of these templates...
  73. ncbi request reprint Is diffusion imaging appearance an independent predictor of outcome after ischemic stroke?
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Neurology 59:1381-7. 2002
    ..MR diffusion-weighted imaging (DWI) in ischemic stroke can be quantified by calculating the apparent diffusion coefficient (ADC) or measuring lesion volume...
  74. ncbi request reprint The influence of randomized trials on the use of anticoagulants for atrial fibrillation
    G E Mead
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Age Ageing 28:441-6. 1999
    ..We therefore investigated their use in patients known to be in AF before a stroke, transient ischaemic attack (either cerebral or ocular) or retinal artery occlusion to assess the influence of trials on clinical practice...
  75. ncbi request reprint Choice of spectroscopic lineshape model affects metabolite peak areas and area ratios
    I Marshall
    Department of Medical Physics, University of Edinburgh, Edinburgh, Scotland
    Magn Reson Med 44:646-9. 2000
    ..An explanation of this previously unreported effect is given. This finding clearly has serious implications for the methodology and reporting of spectroscopic studies...
  76. ncbi request reprint The influence of food ingestion on blood pressure in stroke patients
    A M Rowat
    Department of Clinical Neurosciences, Universtiy of Edinburgh, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 12:152-8. 2001
    ....
  77. ncbi request reprint Plasma cortisol levels, brain volumes and cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Psychoneuroendocrinology 30:505-15. 2005
    ..This study examined the hypotheses that higher plasma cortisol levels and altered sensitivity to glucocorticoids are associated with worse cognition and more brain atrophy in elderly men...
  78. ncbi request reprint A grid overlay framework for analysis of medical images and its application to the measurement of stroke lesions
    Paul A Armitage
    Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK
    Eur Radiol 22:625-32. 2012
    ..To create and evaluate an interactive software tool for measuring imaging data in situations where hand-drawn region-of-interest measurements are unfeasible, for example, when the structure of interest is patchy with ill-defined boundaries...
  79. ncbi request reprint Fogging on T2-weighted MR after acute ischaemic stroke: how often might this occur and what are the implications?
    P O'BRIEN
    Department of Clinical Neurosciences, Western General Hospital, Crewe Rd, EH4 2XU, Edinburgh, UK
    Neuroradiology 46:635-41. 2004
    ..This may lead to an underestimation of true final infarct extent. This suggests that true infarct extent on T2-weighted MR can probably only be assessed on scans obtained beyond 7 weeks after stroke...
  80. pmc Magnetic resonance brain imaging in patients with acute stroke: feasibility and patient related difficulties
    P J Hand
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 76:1525-7. 2005
    ..To assess organisational and patient specific limitations and safety of magnetic resonance imaging (MRI) as the first line investigation for hospital admitted stroke patients...
  81. ncbi request reprint In which patients is diffusion-weighted magnetic resonance imaging most useful in routine stroke care?
    S L Keir
    Division of Clinical Neurosciences, Western General Hospital NHS Trust, Edinburgh, United Kingdom
    J Neuroimaging 14:118-22. 2004
    ....
  82. ncbi request reprint Patient positioning influences oxygen saturation in the acute phase of stroke
    A M Rowat
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 12:66-72. 2001
    ..These results may have implications for current practice and for future patient positioning strategies to improve outcome after stroke...
  83. ncbi request reprint Trials of thrombolysis in acute ischemic stroke: does the choice of primary outcome measure really matter?
    J M Wardlaw
    Department of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK
    Stroke 31:1133-5. 2000
    ....
  84. ncbi request reprint White matter integrity and cognition in childhood and old age
    I J Deary
    Department of Psychology, School of Philosophy, Psychology, and Language Sciences, University of Edinburgh, UK
    Neurology 66:505-12. 2006
    ..To test the hypothesis that white matter integrity, as measured by diffusion tensor and magnetization transfer MRI is significantly associated with cognitive ability measured in youth and old age...
  85. pmc Differences in retinal vessels support a distinct vasculopathy causing lacunar stroke
    F N Doubal
    Western General Hospital, Edinburgh, UK
    Neurology 72:1773-8. 2009
    ..We compared retinal microvessel appearance as a surrogate for cerebral small vessels in patients with lacunar and large artery cortical ischemic stroke...
  86. ncbi request reprint Imaging appearance of the symptomatic perforating artery in patients with lacunar infarction: occlusion or other vascular pathology?
    J M Wardlaw
    Department of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, United Kingdom
    Ann Neurol 50:208-15. 2001
    ..We describe the patients' clinical and imaging features, and discuss alternative explanations for the imaging appearance and the implications for gaining insights into the cause of lacunar infarction...
  87. ncbi request reprint Apparent diffusion coefficient (ADC) measurements may be more reliable and reproducible than lesion volume on diffusion-weighted images from patients with acute ischaemic stroke-implications for study design
    Arnab K Rana
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospitals NHS Trust, Scotland, Edinburgh EH4 2XU, UK
    Magn Reson Imaging 21:617-24. 2003
    ..This effect is greatest in large lesions...
  88. ncbi request reprint Childhood and current cognitive function in healthy 80-year-olds: a DT-MRI study
    Susan D Shenkin
    Department of Psychology, University of Edingburgh, Western General Hospital, UK
    Neuroreport 14:345-9. 2003
    ..These novel results suggest, that MR imaging studies of white matter structure and its relationship to mental ability in ageing should control for early life cognition...
  89. pmc Are multiple acute small subcortical infarctions caused by embolic mechanisms?
    D Chowdhury
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 75:1416-20. 2004
    ..To seek evidence of potential embolic sources or other stroke mechanisms in patients who, on chance observation, had several apparently recent small subcortical infarcts on diffusion weighted magnetic resonance imaging (DWI)...
  90. ncbi request reprint Episodic and semantic memory tasks activate different brain regions in Alzheimer disease
    J M Starr
    Geriatric Medicine Unit, University of Edinburgh, UK
    Neurology 65:266-9. 2005
    ..To compare brain activity identified by fMRI in subjects with Alzheimer disease (AD) and older healthy controls (HCs) performing an episodic/working memory (EWM) and semantic memory (SM) task...
  91. doi request reprint Retinal microvascular abnormalities and stroke: a systematic review
    F N Doubal
    Division of Clinical Neurosciences, University of Edinburgh, Bramwell Dott Building, Western General Hospital, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 80:158-65. 2009
    ....
  92. ncbi request reprint Systematic review of diffusion and perfusion imaging in acute ischemic stroke
    S L Keir
    Department of Clinical Neurosciences, Western General Hospital NHS Trust, Edinburgh, UK
    Stroke 31:2723-31. 2000
    ..We sought to determine whether the data published so far are enough to establish the roles of these techniques in everyday clinical practice...
  93. doi request reprint When are summary ROC curves appropriate for diagnostic meta-analyses?
    F M Chappell
    School of Nursing Midwifery and Social Care, Napier University, Edinburgh, UK
    Stat Med 28:2653-68. 2009
    ..A set of R functions, freely available to perform these analyses, can be downloaded from (www.diagmeta.info)...
  94. ncbi request reprint Fractal analysis of the retinal vascular network in fundus images
    T J Macgillivray
    Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK
    Conf Proc IEEE Eng Med Biol Soc 2007:6456-9. 2007
    ..However, statistical analysis showed that to detect a significant difference at the level seen in the data would require a larger sample size of 88 per group...
  95. ncbi request reprint Is routine transcranial Doppler ultrasound monitoring useful in the management of subarachnoid hemorrhage?
    J M Wardlaw
    Department of Neuroradiology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom
    J Neurosurg 88:272-6. 1998
    ....
  96. pmc Diffuse brain oedema in idiopathic intracranial hypertension: a quantitative magnetic resonance imaging study
    M E Bastin
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 74:1693-6. 2003
    ..To investigate the hypothesis that idiopathic intracranial hypertension is associated with diffuse brain oedema, using quantitative magnetic resonance imaging...
  97. ncbi request reprint Power transcranial Doppler ultrasound in the detection of intracranial aneurysms
    P M White
    Department of Neuroradiology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Stroke 32:1291-7. 2001
    ..We sought to perform a large, prospective, multicenter, blinded study comparing power transcranial color duplex sonography (power TCDS) with intra-arterial digital subtraction angiography (IADSA) in the detection of intracranial aneurysms...
  98. ncbi request reprint Interobserver variability of magnetic resonance angiography in the diagnosis of carotid stenosis--effect of observer experience
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospitals NHS Trust, UK
    Neuroradiology 44:126-32. 2002
    ..Observer reliability of MRA processed images is not good, even in experienced hands. Using the source images and views of the circle of Willis might improve the accuracy, but a further study is required to assess this...
  99. ncbi request reprint Intracranial capacity and brain volumes are associated with cognition in healthy elderly men
    A M J Maclullich
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK
    Neurology 59:169-74. 2002
    ..Brain size and intracranial capacity are correlated with cognitive performance in young healthy adults, but data are lacking on these relationships in older healthy adults...
  100. pmc Which CT features help predict outcome after head injury?
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 72:188-92; discussion 151. 2002
    ..The aim of this study was to evaluate which features on the admission CT scan might add significantly to other baseline clinical information for predicting survival in patients with head injury...