Andy Wardlaw

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Efficacy and safety of mometasone furoate dry powder inhaler vs fluticasone propionate metered-dose inhaler in asthma subjects previously using fluticasone propionate
    Andy Wardlaw
    Institute for Lung Health, Glenfield Hospital NHS Trust, Leicester, England
    Ann Allergy Asthma Immunol 93:49-55. 2004
  2. pmc IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, UK
    BMC Pulm Med 9:34. 2009
  3. ncbi request reprint New insights into the relationship between airway inflammation and asthma
    A J Wardlaw
    Department of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School, Glenfield Hospital, Groby Road, Leicester LE3 9QP, U K
    Clin Sci (Lond) 103:201-11. 2002
  4. ncbi request reprint Multi-dimensional phenotyping: towards a new taxonomy for airway disease
    A J Wardlaw
    Department of Respiratory Medicine, Department of Infection Immunity and Inflammation and Institute for Lung Health, Leicester, UK
    Clin Exp Allergy 35:1254-62. 2005
  5. pmc CRTH2 expression on T cells in asthma
    K Mutalithas
    Institute for Lung Health, Department of Infection Immunity and Inflammation, University Hospitals of Leicester, Leicester, UK
    Clin Exp Immunol 161:34-40. 2010
  6. ncbi request reprint Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease
    A J Morgan
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, Leicester University, Glenfield Hospital, Leicester, UK
    Clin Exp Allergy 35:1572-80. 2005
  7. ncbi request reprint New insights into the role of the mast cell in asthma
    C E Brightling
    University of Leicester and Warwick Medical School, Leicester, UK
    Clin Exp Allergy 33:550-6. 2003
  8. pmc Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Thorax 58:1066-70. 2003
  9. ncbi request reprint Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma
    C E Brightling
    Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 33:1711-6. 2003
  10. doi request reprint The A to E of airway disease
    I D Pavord
    Department of Respiratory Medicine, Institute for Lung Health, University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 40:62-7. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Efficacy and safety of mometasone furoate dry powder inhaler vs fluticasone propionate metered-dose inhaler in asthma subjects previously using fluticasone propionate
    Andy Wardlaw
    Institute for Lung Health, Glenfield Hospital NHS Trust, Leicester, England
    Ann Allergy Asthma Immunol 93:49-55. 2004
    ..To compare the efficacy and safety of mometasone furoate dry powder inhaler (DPI) administered once daily in the evening with fluticasone propionate metered-dose inhaler (MDI) administered twice daily...
  2. pmc IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, UK
    BMC Pulm Med 9:34. 2009
    ..In asthma interleukin (IL)-13 is increased in the airway compared with non-asthmatic eosinophilic bronchitis. Whether this differential expression is specific to the airway or is more generalised is uncertain...
  3. ncbi request reprint New insights into the relationship between airway inflammation and asthma
    A J Wardlaw
    Department of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School, Glenfield Hospital, Groby Road, Leicester LE3 9QP, U K
    Clin Sci (Lond) 103:201-11. 2002
    ....
  4. ncbi request reprint Multi-dimensional phenotyping: towards a new taxonomy for airway disease
    A J Wardlaw
    Department of Respiratory Medicine, Department of Infection Immunity and Inflammation and Institute for Lung Health, Leicester, UK
    Clin Exp Allergy 35:1254-62. 2005
    ....
  5. pmc CRTH2 expression on T cells in asthma
    K Mutalithas
    Institute for Lung Health, Department of Infection Immunity and Inflammation, University Hospitals of Leicester, Leicester, UK
    Clin Exp Immunol 161:34-40. 2010
    ..However, given their small numbers they are unlikely to have a significant involvement in the pathogenesis of asthma. CRTH2 antagonism may not diminish T cell accumulation in the asthmatic lung...
  6. ncbi request reprint Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease
    A J Morgan
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, Leicester University, Glenfield Hospital, Leicester, UK
    Clin Exp Allergy 35:1572-80. 2005
    ..Chemokine receptors (CR) play an important role in T cell migration, but their contribution to lung trafficking is unclear...
  7. ncbi request reprint New insights into the role of the mast cell in asthma
    C E Brightling
    University of Leicester and Warwick Medical School, Leicester, UK
    Clin Exp Allergy 33:550-6. 2003
  8. pmc Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Thorax 58:1066-70. 2003
    ..An immunopathological study was undertaken to test the hypothesis that idiopathic chronic cough is associated with lymphocytic airway inflammation...
  9. ncbi request reprint Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma
    C E Brightling
    Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 33:1711-6. 2003
    ..In asthma, Th2 cytokines have been implicated as playing a critical role in the development of airway inflammation and hyper-responsiveness. Whether inflammatory cells within the airway smooth muscle release these cytokines is unknown...
  10. doi request reprint The A to E of airway disease
    I D Pavord
    Department of Respiratory Medicine, Institute for Lung Health, University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 40:62-7. 2010
    ..We speculate that the use of this system to characterize airway disease will improve outcomes by promoting better targeting of new and existing treatments...
  11. ncbi request reprint The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
    M A Berry
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:1175-9. 2005
    ..Nitric oxide (NO) has potential advantages as a tool to monitor airway inflammation although little is known about the relationship between NO and eosinophilic airway inflammation and the factors which influence it...
  12. ncbi request reprint Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
    R Siva
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, LE3 9PQ, UK
    Eur Respir J 29:906-13. 2007
    ..A management strategy that aims to minimise eosinophilic airway inflammation, as well as symptoms, is associated with a reduction in severe exacerbations of chronic obstructive pulmonary disease...
  13. ncbi request reprint Observational study of the natural history of eosinophilic bronchitis
    M A Berry
    Institute of Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:598-601. 2005
    ..Eosinophilic bronchitis is an important cause of chronic cough. Treatment with inhaled corticosteroids is associated with a short-term improvement in cough and reduced sputum eosinophil count but the long-term outcome is uncertain...
  14. ncbi request reprint Induced sputum eicosanoid concentrations in asthma
    I D Pavord
    Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 160:1905-9. 1999
    ..The inverse relationship between eosinophilic airway inflammation and sputum PGE(2) concentration would be consistent, with the latter having an anti-inflammatory role...
  15. pmc Expression of CCR8 is increased in asthma
    K Mutalithas
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 40:1175-85. 2010
    ..Chemokines and their receptors could play key roles in the recruitment of T cells to the asthmatic lung. CCR8 is preferentially expressed on T-helper type 2 cells, and is thought to play a role in the pathogenesis of human asthma...
  16. ncbi request reprint Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow
    G Woltmann
    Division of Respiratory Medicine, University of Leicester School of Medicine, Glenfield Hospital, Leicester, UK
    Blood 95:3146-52. 2000
    ..This mechanism is likely to be a key event leading to the selective accumulation of eosinophils in allergic inflammation...
  17. pmc A case of cough, lymphocytic bronchoalveolitis and coeliac disease with improvement following a gluten free diet
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, University Hospitals of Leicester, Leicester LE3 9QP, UK
    Thorax 57:91-2. 2002
    ..All features improved markedly on a gluten free diet, suggesting a causal relationship between coeliac disease, cough, and lymphocytic bronchoalveolitis...
  18. ncbi request reprint Multiple inflammatory hits and the pathogenesis of severe airway disease
    I D Pavord
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, LE3 9QP, UK
    Eur Respir J 27:884-8. 2006
    ....
  19. ncbi request reprint Attenuation of human lung mast cell degranulation by bronchial epithelium
    W Yang
    Department of Infection, Immunity, and Inflammation, University of Leicester Medical School, Leicester, UK
    Allergy 61:569-75. 2006
    ..We investigated the consequences of this adhesive interaction on HLMC activation in response to Fc epsilon RI cross-linking...
  20. ncbi request reprint Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Lancet 356:1480-5. 2000
    ..Whether these patients have different airway pathology from other COPD patients is unclear. We tested the hypothesis that response to prednisolone is related to the presence of eosinophilic airway inflammation...
  21. ncbi request reprint Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils
    G Dewson
    Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, United Kingdom
    Blood 98:2239-47. 2001
    ..IL-5 inhibits spontaneous eosinophil apoptosis at a site upstream of Bax translocation...
  22. ncbi request reprint Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Respir Med 95:999-1002. 2001
    ..96. In conclusion, sputum induction is safe and the cell and fluid phase mediators repeatable in the investigation of airway inflammation in patients with COPD. VAS symptom scores and the CRQ are reproducible outcome measures in COPD...
  23. pmc Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Thorax 57:875-9. 2002
    ....
  24. pmc A novel method for isolation of human lung T cells from lung resection tissue reveals increased expression of GAPDH and CXCR6
    C E Day
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, Leicester, United Kingdom
    J Immunol Methods 342:91-7. 2009
    ..This technique highly enriches lung T cells to allow detailed investigation of the biology of these cells...
  25. pmc IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma
    Abbie Fairs
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, UK
    Am J Respir Crit Care Med 182:1362-8. 2010
    ..The importance of Aspergillus fumigatus sensitization and colonization of the airways in patients with asthma is unclear. Objectives: To define the relationship between the clinical and laboratory features of A. fumigatus-associated asthma...
  26. pmc Chemokines and their receptors as potential targets for the treatment of asthma
    C Palmqvist
    Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Br J Pharmacol 151:725-36. 2007
    ..Specific blockade of the responses elicited by chemokines and chemokine receptors responsible for the pathological migration of airway cells could therefore be of great therapeutic interest for the treatment of asthma...
  27. ncbi request reprint Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway
    R A Thomas
    Institute for Lung Health, University of Leicester, UK
    Respir Med 100:1588-97. 2006
    ..We have used a model of cell deformation to measure the effect of stretch on inflammatory cytokine release by the BEAS 2B cell line, and to examine the method of mechanotransduction in these cells...
  28. pmc Management of asthma in adults: current therapy and future directions
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Postgrad Med J 79:259-67. 2003
    ....
  29. pmc Characterisation of adhesion receptors mediating lymphocyte adhesion to bronchial endothelium provides evidence for a distinct lung homing pathway
    M P Ainslie
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School, Glenfield Hospital, Leicester, UK
    Thorax 57:1054-9. 2002
    ..Using a modified version of the Stamper-Woodruff assay we have investigated the receptors mediating adhesion of peripheral blood lymphocytes to airway endothelium...
  30. ncbi request reprint Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma
    M Berry
    Dept of Respiratory Medicine and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur Respir J 25:986-91. 2005
    ..In conclusion, these findings support the hypothesis that alveolar nitric oxide is a measure of distal airway inflammation and suggest that distal lung inflammation is present in refractory asthma...