Research Topics
| N S WardSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Motor system activation after subcortical stroke depends on corticospinal system integrityNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
Brain 129:809-19. 2006..Secondary motor regions are less efficient at generating motor output so this reorganization can only be considered partially successful in reducing motor impairment after stroke...- Compensatory mechanisms in the aging motor systemNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
Ageing Res Rev 5:239-54. 2006..The evidence that these changes are compensatory in nature is less clear. Incorporation of behavioural and anatomical data will be required in order to fully interpret the functional imaging results... - Neural plasticity and recovery of functionNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Prog Brain Res 150:527-35. 2005.... - The relationship between brain activity and peak grip force is modulated by corticospinal system integrity after subcortical strokeNick S Ward
Wellcome Department of Imaging Neuroscience, and Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
Eur J Neurosci 25:1865-73. 2007..These findings suggest that the premotor cortices might play a new and functionally relevant role in controlling force production in patients with more severe corticospinal system disruption... - Future perspectives in functional neuroimaging in stroke recoveryN S Ward
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London, UK
Eura Medicophys 43:285-94. 2007.... 
Mechanisms underlying recovery of motor function after strokeN S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
Postgrad Med J 81:510-4. 2005....- Age-dependent changes in the neural correlates of force modulation: an fMRI studyNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neurobiol Aging 29:1434-46. 2008..These results indicate that a reduced ability to modulate activity in appropriate motor networks when required may contribute to age-related decline in motor performance... - Functional reorganization of the cerebral motor system after strokeNick S Ward
Institute of Neurology, University College London, London WC1N 3BG, UK
Curr Opin Neurol 17:725-30. 2004..This understanding may in turn lead to the development of techniques that will drive cerebral reorganization in a way that promotes functional improvement... - Longitudinal changes in cerebral response to proprioceptive input in individual patients after stroke: an FMRI studyNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
Neurorehabil Neural Repair 20:398-405. 2006..The authors set out to demonstrate the feasibility of using fMRI to investigate mechanisms of recovery in individual patients presenting with severe motor impairment... - Age-related changes in the neural correlates of motor performanceN S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, UK
Brain 126:873-88. 2003..These results support the notion that an adaptable and plastic motor network is able to respond to age-related degenerative changes in order to maintain performance levels... - Neural correlates of outcome after stroke: a cross-sectional fMRI studyN S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
Brain 126:1430-48. 2003..These results further our understanding of the recovery process by demonstrating for the first time a clear relationship between task-related activation of the motor system and outcome after stroke... - Neural correlates of motor recovery after stroke: a longitudinal fMRI studyN S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
Brain 126:2476-96. 2003..These results further our understanding of the recovery process by demonstrating for the first time a clear temporal relationship between recovery and task-related activation of the motor system after stroke... - The influence of time after stroke on brain activations during a motor taskNick S Ward
Wellcome Department of Imaging Neuroscience, University College London, London, United Kingdom
Ann Neurol 55:829-34. 2004..Thus, in those patients with the most to gain from rehabilitation, different therapeutic approaches may be required at different stages after stroke... 
Neural correlates of age-related changes in cortical neurophysiologyP Talelli
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College, London, UK
Neuroimage 40:1772-81. 2008....- Non-invasive mapping of corticofugal fibres from multiple motor areas--relevance to stroke recoveryJennifer M Newton
Wellcome Department of Imaging Neuroscience, University College London London, UK
Brain 129:1844-58. 2006..These results confirm that selective disruption of motor corticofugal fibres influences functional reorganization and outcome in individual patients... - How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?Nicolas Lang
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom
Eur J Neurosci 22:495-504. 2005..The extensive spatial and temporal effects of tDCS need to be taken into account when tDCS is used to modify brain function... - Nonlinear coupling in the human motor systemChun Chuan Chen
Wellcome Trust Centre for Neuroimaging, University College London, London, UK ucl ac uk
J Neurosci 30:8393-9. 2010..Our results provide empirical evidence for nonlinear coupling among distributed neuronal sources in the motor system and that these play an important role in modulating spectral responses under normal conditions... - The effect of age on task-related modulation of interhemispheric balanceP Talelli
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Sq, Box 146, London WC1N 3BG, UK
Exp Brain Res 186:59-66. 2008..The mechanism underlying changes in IHI with advancing age and the association with changes in corticospinal excitability need further investigation... - How broad is the phenotype of Hallervorden-Spatz disease?S J Hickman
Department of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Acta Neurol Scand 103:201-3. 2001..The increased availability of MRI has allowed more cases of HSD to be diagnosed in life but as our case illustrates classification of the disease may need to be further examined... - The functional anatomy of cerebral reorganisation after focal brain injuryNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, 12 Queen Square, London WC1N 3BG, UK
J Physiol Paris 99:425-36. 2006.... - Stages of motor output reorganization after hemispheric stroke suggested by longitudinal studies of cortical physiologyOrlando B C Swayne
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College, 8 11 Queen Square, London, UK
Cereb Cortex 18:1909-22. 2008.... - Dorsal premotor cortex exerts state-dependent causal influences on activity in contralateral primary motor and dorsal premotor cortexSven Bestmann
Wellcome Trust Centre for Neuroimaging at UCL, Institute of Neurology, University College London, London, UK
Cereb Cortex 18:1281-91. 2008..We conclude that left PMd can exert state-dependent interhemispheric influences on contralateral cortical motor areas relevant for a current motor task... - Plasticity and the functional reorganization of the human brainNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
Int J Psychophysiol 58:158-61. 2005.... - The neural substrates of motor recovery after focal damage to the central nervous systemNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, England
Arch Phys Med Rehabil 87:S30-5. 2006..To discuss how reorganization of the surviving central nervous system tissue might subserve the improvements in function that are commonly seen over weeks, months, and sometimes years after stroke... - The role of contralesional dorsal premotor cortex after stroke as studied with concurrent TMS-fMRISven Bestmann
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
J Neurosci 30:11926-37. 2010..cPMd TMS was not found to influence activity in other brain regions in either hemisphere. This state-dependent influence on ipsilesional sensorimotor regions may provide a mechanism by which cPMd supports recovered function after stroke... - Mechanisms underlying recovery of motor function after strokeNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, England
Arch Neurol 61:1844-8. 2004.... - Towards a new mapping of brain cortex functionNick S Ward
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
Cerebrovasc Dis 17:35-8. 2004..The dynamic plasticity of functional brain maps provides an exciting opportunity to study these processes... - Low-frequency transcranial magnetic stimulation over left dorsal premotor cortex improves the dynamic control of visuospatially cued actionsNick S Ward
Sobell Department of Motor Neuroscience, University College London, Institute of Neurology, London, United Kingdom
J Neurosci 30:9216-23. 2010.... - Recovery of function and plasticity in human brainR S J Frackowiak
Department of Imaging Neuroscience, Institute of Neurology, University College London
Bull Mem Acad R Med Belg 159:145-55. 2004 - Isolated familial hypomagnesaemia with novel neurological features: causal link or chance concurrence?A J Larner
St Mary s Hospital, Praed Street, London, UK
Eur J Neurol 8:495-9. 2001..The pathogenesis of this unusual neurological and ophthalmological syndrome therefore remains uncertain... - A positron emission tomographic study in spontaneous migraineShazia K Afridi
Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, England
Arch Neurol 62:1270-5. 2005..CONCLUSIONS: Our findings provide clear evidence of dorsal pontine activation in migraine and reinforce the view that migraine is a subcortical disorder modulating afferent neural traffic...