Frank J Ward
Affiliation: University of Aberdeen
Ward F, Dahal L, Wijesekera S, Abdul Jawad S, Kaewarpai T, Xu H, et al
. The soluble isoform of CTLA-4 as a regulator of T-cell responses. Eur J Immunol. 2013;43:1274-85 pubmed publisher
..These results suggest that the immune system exploits the different CTLA-4 isoforms for either intrinsic or extrinsic regulation of T-cell activity. ..
Ward F, Hall A, Cairns L, Leggat A, Urbaniak S, Vickers M, et al
. Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia. Blood. 2008;111:680-7 pubmed
Dahal L, Basu N, Youssef H, Khanolkar R, Barker R, Erwig L, et al
. Immunoregulatory soluble CTLA-4 modifies effector T-cell responses in systemic lupus erythematosus. Arthritis Res Ther. 2016;18:180 pubmed publisher
..The results show that lupus autoantigen-derived peptides display varied immunogenicity in lupus versus healthy volunteer donors, while sCTLA-4 acts to regulate the T-cell activity independently of response profile. ..