Chris Ward

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease
    Sukhwinder S Sohal
    NHMRC National Centre for Research Excellence in Chronic Respiratory Disease, Menzies Research Institute, 17 Liverpool Street, Hobart, 7000, Australia
    Respir Res 12:130. 2011
  2. pmc Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts
    C Ward
    Applied Immunobiology and Transplantation Research Group, Freeman Hospital and University of Newcastle upon Tyne, Newcastle upon Tyne NE7 7DN, UK
    Thorax 60:872-4. 2005
  3. pmc Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients
    C Ward
    ImmunoBiology and Transplantation Group, University of Newcastle upon Tyne and The Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK
    Thorax 58:444-6. 2003
  4. ncbi request reprint Airway wall remodelling: the influence of corticosteroids
    Chris Ward
    ImmunoBiology and Transplantation Group, Sir William Leech Centre, The Freeman Hospital and University of Newcastle upon Tyne, UK
    Curr Opin Allergy Clin Immunol 5:43-8. 2005
  5. pmc Bronchial epithelial cells cultured from clinically stable lung allograft patients promote the development of macrophages from monocytes rather than dendritic cells
    C Ward
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Thorax 64:430-5. 2009
  6. ncbi request reprint Hypothesis: epithelial-to-mesenchymal transition is a common cause of chronic allograft failure
    C Ward
    Applied Immunobiology and Transplantation Research Group, Faculty of Medical Sciences, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Transplant Proc 37:977-80. 2005
  7. ncbi request reprint A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients
    Chris Ward
    Applied Immunobiology and Transplantation Research Group, Freeman Hospital and University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Heart Lung Transplant 24:533-7. 2005
  8. doi request reprint Azithromycin attenuates effects of lipopolysaccharide on lung allograft bronchial epithelial cells
    Desmond M Murphy
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Heart Lung Transplant 27:1210-6. 2008
  9. doi request reprint Aspiration and allograft injury secondary to gastroesophageal reflux occur in the immediate post-lung transplantation period (prospective clinical trial)
    S Michael Griffin
    Northern Oesophago Gastric Unit, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, United Kingdom
    Ann Surg 258:705-11; discussion 711-2. 2013
  10. ncbi request reprint Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection
    Rachel Stovold
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Am J Respir Crit Care Med 175:1298-303. 2007

Collaborators

Detail Information

Publications32

  1. pmc Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease
    Sukhwinder S Sohal
    NHMRC National Centre for Research Excellence in Chronic Respiratory Disease, Menzies Research Institute, 17 Liverpool Street, Hobart, 7000, Australia
    Respir Res 12:130. 2011
    ..Such changes are likely hallmarks of epithelial mesenchymal transition (EMT). We aimed to confirm the epithelial origin of these Rbm cells, and to exclude potential confounding by infiltrating inflammatory cells...
  2. pmc Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts
    C Ward
    Applied Immunobiology and Transplantation Research Group, Freeman Hospital and University of Newcastle upon Tyne, Newcastle upon Tyne NE7 7DN, UK
    Thorax 60:872-4. 2005
    ..We have tested the hypothesis that pepsin, as a marker of aspiration, is detectable in bronchoalveolar lavage (BAL) fluid of allograft recipients who had not reported symptoms of GOR...
  3. pmc Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients
    C Ward
    ImmunoBiology and Transplantation Group, University of Newcastle upon Tyne and The Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK
    Thorax 58:444-6. 2003
    ..It was hypothesised that AHLs may be detected even in clinically stable lung transplant recipients free of clinical infection or rejection...
  4. ncbi request reprint Airway wall remodelling: the influence of corticosteroids
    Chris Ward
    ImmunoBiology and Transplantation Group, Sir William Leech Centre, The Freeman Hospital and University of Newcastle upon Tyne, UK
    Curr Opin Allergy Clin Immunol 5:43-8. 2005
    ..Having described these basic changes, we have then given an update on recent studies investigating the effects of corticosteroid medication on the different manifestations of remodelled airways...
  5. pmc Bronchial epithelial cells cultured from clinically stable lung allograft patients promote the development of macrophages from monocytes rather than dendritic cells
    C Ward
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Thorax 64:430-5. 2009
    ..This study focused on the ex vivo influence of primary bronchial epithelial cells derived from lung allografts on DC differentiation...
  6. ncbi request reprint Hypothesis: epithelial-to-mesenchymal transition is a common cause of chronic allograft failure
    C Ward
    Applied Immunobiology and Transplantation Research Group, Faculty of Medical Sciences, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Transplant Proc 37:977-80. 2005
    ..Research in this area may provide insights into chronic rejection of kidney, liver, and lung allografts that impact on future therapeutic strategies...
  7. ncbi request reprint A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients
    Chris Ward
    Applied Immunobiology and Transplantation Research Group, Freeman Hospital and University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Heart Lung Transplant 24:533-7. 2005
    ..We tested the hypothesis that small airway reticular basement membrane thickening exists even in clinically stable lung transplant recipients with some evidence of inflammation but who are BOS-free...
  8. doi request reprint Azithromycin attenuates effects of lipopolysaccharide on lung allograft bronchial epithelial cells
    Desmond M Murphy
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Heart Lung Transplant 27:1210-6. 2008
    ....
  9. doi request reprint Aspiration and allograft injury secondary to gastroesophageal reflux occur in the immediate post-lung transplantation period (prospective clinical trial)
    S Michael Griffin
    Northern Oesophago Gastric Unit, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, United Kingdom
    Ann Surg 258:705-11; discussion 711-2. 2013
    ..To provide novel pilot data to quantify reflux, aspiration, and allograft injury immediately post-lung transplantation...
  10. ncbi request reprint Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection
    Rachel Stovold
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Am J Respir Crit Care Med 175:1298-303. 2007
    ..Persistent acute rejection and gastric aspiration have been implicated as risk factors but there is little or no evidence to date that they are associated...
  11. doi request reprint Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients
    Desmond M Murphy
    Applied Immunobiology and Transplantation Group, Institute of Molecular Medicine, Faculty of Medical Sciences, University of Newcastle upon Tyne, The William Leech Centre for Lung Research, The Freeman Hospital, High Heaton, Newcastle upon Tyne, UK
    Am J Physiol Lung Cell Mol Physiol 294:L592-9. 2008
    ....
  12. ncbi request reprint Reticular basement membrane thickening in airways of lung transplant recipients is not affected by inhaled corticosteroids
    C Ward
    Applied Immunobiology and Transplantation Group, Freeman Hospital and University of Newcastle upon Tyne, Newcastle upon Tyne NE7 7DN, UK
    Clin Exp Allergy 34:1905-9. 2004
    ..The present study extends this, testing the hypothesis that inhaled corticosteroid (ICS) therapy will lead to a decrease in Rbm thickness in lung transplant recipients...
  13. pmc Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients
    C Ward
    Applied Immunobiology and Transplantation Research Group, Faculty of Medical Sciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Thorax 60:865-71. 2005
    ..It is hypothesised that EMT occurs in lung allografts and plays a potential role in airway remodelling...
  14. ncbi request reprint Primary airway epithelial cell culture from lung transplant recipients
    I A Forrest
    Applied Immunobiology and Transplantation Research Group, University of Newcastle upon Tyne, UK
    Eur Respir J 26:1080-5. 2005
    ..This technique facilitates future mechanistic studies of airway epithelial responses in the pathogenesis of obliterative bronchiolitis...
  15. doi request reprint Targeting allograft injury and inflammation in the management of post-lung transplant bronchiolitis obliterans syndrome
    A G N Robertson
    Northern Oesophago Gastric Unit, Royal Victoria Infirmary, Newcastle University, Newcastle, UK
    Am J Transplant 9:1272-8. 2009
    ..The need for further evidence, including randomized-controlled trials, to evaluate the role of medical and surgical therapies is emphasized by the current literature...
  16. doi request reprint Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?
    Shruti Parikh
    Institute for Cell and Molecular Biosciences, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne, UK
    J Heart Lung Transplant 32:418-23. 2013
    ..2 μmol/liter, and the levels used to inform clinical decisions. This study assessed the sensitivity of detection by 2 enzymatic assay kits compared with tandem mass spectrometry...
  17. doi request reprint Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation
    L A Borthwick
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Thorax 64:770-7. 2009
    ..The potential for airway epithelium from lung transplant recipients to undergo epithelial to mesenchymal cell transition (EMT) was assessed in culture and in vivo in lung allograft tissue...
  18. doi request reprint Airway epithelial cell senescence in the lung allograft
    S M Parker
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Newcastle University, UK
    Am J Transplant 8:1544-9. 2008
    ..A prospective longitudinal study is required to better address any potential causal association between airway epithelial senescence in stable allograft recipients and the subsequent development of BOS...
  19. doi request reprint Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome
    R L Anderson
    Cardiopulmonary Transplant Unit, Freeman Hospital, Institute of Cellular Medicine Newcastle University, Newcastle upon Tyne, UK
    Eur Respir J 32:670-7. 2008
    ..Together with reduced airway secretory leukoprotease inhibitor this may favour nonalloimmune airway injury with reduced antiprotease defence and increased neutrophil degranulation...
  20. doi request reprint Inflammation and epithelial to mesenchymal transition in lung transplant recipients: role in dysregulated epithelial wound repair
    L A Borthwick
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    Am J Transplant 10:498-509. 2010
    ..Crosstalk between macrophage-derived acute inflammation in the airway and elevated TGF-beta1 may favor dysregulated airway epithelial repair and fibrosis in the lung allograft via EMT...
  21. ncbi request reprint Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome
    Bryan Yates
    The William Leech Centre for Lung Research, The Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK
    Am J Respir Crit Care Med 172:772-5. 2005
    ..A recent pilot study noted clinical benefit of macrolide therapy in the management of six lung transplant recipients with bronchiolitis obliterans syndrome (BOS), a condition previously regarded as irreversible...
  22. ncbi request reprint Inter-relationships between airway inflammation, reticular basement membrane thickening and bronchial hyper-reactivity to methacholine in asthma; a systematic bronchoalveolar lavage and airway biopsy analysis
    C Ward
    Applied Immunobiology and Transplantation Research Group, The Freeman Hospital and University of Newcastle upon Tyne, UK
    Clin Exp Allergy 35:1565-71. 2005
    ..d.), in a group of relatively mild but symptomatic, steroid naïve asthma patients...
  23. ncbi request reprint Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma
    Bryce N Feltis
    Caridio Respiratory Research Group, University of Tasmania, Hobart, Australia
    Am J Respir Crit Care Med 173:1201-7. 2006
    ..Although various growth factors have been implicated in modulating vascularity, the important contributors in vivo are still being elucidated. The most likely candidate is vascular endothelial growth factor (VEGF)...
  24. ncbi request reprint Exhaled nitric oxide continues to reflect airway hyperresponsiveness and disease activity in inhaled corticosteroid-treated adult asthmatic patients
    David W Reid
    Department of Respiratory Medicine and Monash University Medical School, Alfred Hospital, Melbourne, Victoria, Australia
    Respirology 8:479-86. 2003
    ..However, whether eNO levels reflect disease activity in symptomatic asthmatics receiving moderate doses of inhaled corticosteroid (ICS) is more uncertain...
  25. pmc Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts
    Desmond M Murphy
    Thorax 62:834. 2007
  26. ncbi request reprint The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients
    Des M Murphy
    The Applied Immunobiology and Transplantation Research Group Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom
    J Heart Lung Transplant 25:1436-40. 2006
    ..We used an ex vivo primary bronchial epithelial cell culture (PBEC) model to investigate this hypothesis. Increasing evidence suggests the epithelium is central in stimulating both inflammatory and proliferative responses in the airway...
  27. ncbi request reprint BAL eotaxin and IL-5 in asthma, and the effects of inhaled corticosteroid and beta2 agonist
    Bryce N Feltis
    Respiratory Research Group, Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    Respirology 9:507-13. 2004
    ..It is hypothesised that changes in airway eosinophils would be related to eosinophil cytokines...
  28. ncbi request reprint Longitudinal comparisons of lymphocytes and subtypes between airway wall and bronchoalveolar lavage after human lung transplantation
    Ling Zheng
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Prahran, Victoria, Australia
    Transplantation 80:185-92. 2005
    ..T lymphocytes are crucial in lung allorejection. The contribution of lymphocyte subtypes to the pathogenesis of chronic rejection (bronchiolitis obliterans syndrome [BOS]) remains unclear...
  29. doi request reprint Angiogenesis: a potentially critical part of remodelling in chronic airway diseases?
    Eugene Haydn Walters
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, Australia
    Pharmacol Ther 118:128-37. 2008
    ..In terms of therapy, evidence for anti-angiogenic effectiveness is strongest for Inhaled Corticosteroid (ICS) and Long Acting Beta-Agonists (LABA) in asthma...
  30. ncbi request reprint HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage
    Christina Karamboulas
    Department of Biochemistry, Medical Sciences Building, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    J Cell Sci 119:4305-14. 2006
    ..Our results suggest that HDAC activity regulates the specification of mesoderm cells into cardiomyoblasts by inhibiting the expression of GATA4 and Nkx2-5 in a stem cell model system...
  31. doi request reprint Vascular remodelling in asthma
    Eugene Haydn Walters
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, Australia
    Curr Opin Allergy Clin Immunol 8:39-43. 2008
    ..We review the recent literature, focusing on 2006 and 2007, to produce an update on the patho-biology of angiogenesis and vascular endothelial growth factor in the asthmatic airway...
  32. ncbi request reprint Addition of inhaled corticosteroids to systemic immunosuppression after lung transplantation: a double-blind, placebo-controlled trial
    Helen Whitford
    Department of Respiratory Medicine, The Alfred Hospital, Commercial Road, Prahran, Victoria, Australia 3181
    Transplantation 73:1793-9. 2002
    ..g., asthma and chronic obstructive pulmonary disease. BOS is the major cause of morbidity and mortality after lung transplantation...