E Warbrick

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain
    E Warbrick
    CRC Laboratories, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, UK
    Nucleic Acids Res 26:3925-32. 1998
  2. ncbi request reprint Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair
    E Warbrick
    Department Anatomy and Physiology, University of Dundee, UK
    Oncogene 14:2313-21. 1997
  3. ncbi request reprint A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
    E Warbrick
    Department of Anatomy and Physiology, University of Dundee, Scotland, UK
    Curr Biol 5:275-82. 1995
  4. pmc A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design
    E Warbrick
    Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, UK
    Oncogene 25:2850-9. 2006
  5. ncbi request reprint The puzzle of PCNA's many partners
    E Warbrick
    Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Bioessays 22:997-1006. 2000
  6. ncbi request reprint A Drosophila melanogaster homolog of the TIS11 family of immediate early genes that can rescue a cdr1 cdc25 mutant strain of fission yeast
    E Warbrick
    Department of Anatomy and Physiology, University of Dundee, UK
    Gene 151:243-6. 1994
  7. pmc Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif
    N Reynolds
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR
    EMBO J 19:1108-18. 2000
  8. pmc Post-replicative base excision repair in replication foci
    M Otterlei
    Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, N 7005 Trondheim, Norway
    EMBO J 18:3834-44. 1999
  9. ncbi request reprint Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein
    H Mattock
    Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:234-41. 2001
  10. ncbi request reprint A Drosophila gene encoding a DEAD box RNA helicase can suppress loss of wee1/mik1 function in Schizosaccharomyces pombe
    E Warbrick
    Department of Anatomy and Physiology, University of Dundee, Scotland
    Mol Gen Genet 245:654-7. 1994

Collaborators

Detail Information

Publications18

  1. pmc PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain
    E Warbrick
    CRC Laboratories, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, UK
    Nucleic Acids Res 26:3925-32. 1998
    ..Finally, we have investigated the use of this conserved PCNA-binding domain as a predictor of PCNA-binding capacity...
  2. ncbi request reprint Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair
    E Warbrick
    Department Anatomy and Physiology, University of Dundee, UK
    Oncogene 14:2313-21. 1997
    ..Competition between homologous regions of Fen1 and p21Cip1 for binding to the same site on PCNA may provide a mechanism to co-ordinate the functions of PCNA in DNA replication and repair...
  3. ncbi request reprint A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
    E Warbrick
    Department of Anatomy and Physiology, University of Dundee, Scotland, UK
    Curr Biol 5:275-82. 1995
    ..We have investigated the interaction between p21WAF1 and PCNA using a genetic two-hybrid screen and with arrays of synthetic peptides derived from the p21WAF1 protein sequence...
  4. pmc A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design
    E Warbrick
    Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, UK
    Oncogene 25:2850-9. 2006
    ..These results validate the use of functional screening in yeast to identify peptide aptamers that are functional in mammalian cells; such aptamers provide excellent leads for small molecule antiproliferative therapies...
  5. ncbi request reprint The puzzle of PCNA's many partners
    E Warbrick
    Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Bioessays 22:997-1006. 2000
    ..The analysis of how such functional motifs have been recruited to proteins in present day organisms helps us to understand how these complex systems arose from ancestral organisms...
  6. ncbi request reprint A Drosophila melanogaster homolog of the TIS11 family of immediate early genes that can rescue a cdr1 cdc25 mutant strain of fission yeast
    E Warbrick
    Department of Anatomy and Physiology, University of Dundee, UK
    Gene 151:243-6. 1994
    ....
  7. pmc Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif
    N Reynolds
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR
    EMBO J 19:1108-18. 2000
    ..Finally, we show that Cdc27 performs at least two distinct essential functions, one of which is independent of Pcn1 binding...
  8. pmc Post-replicative base excision repair in replication foci
    M Otterlei
    Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, N 7005 Trondheim, Norway
    EMBO J 18:3834-44. 1999
    ..These results demonstrate rapid post-replicative removal of incorporated uracil by UNG2 and indicate the formation of a BER complex that contains UNG2, RPA and PCNA close to the replication fork...
  9. ncbi request reprint Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein
    H Mattock
    Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:234-41. 2001
    ..The capacity of this peptide sequence to suppress cell proliferation in vivo is of interest as the basis for the design of potential antiproliferative therapeutic agents...
  10. ncbi request reprint A Drosophila gene encoding a DEAD box RNA helicase can suppress loss of wee1/mik1 function in Schizosaccharomyces pombe
    E Warbrick
    Department of Anatomy and Physiology, University of Dundee, Scotland
    Mol Gen Genet 245:654-7. 1994
    ..It is possible that the RNA helicase described here may regulate entry into mitosis by down regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis...
  11. ncbi request reprint Characterisation of the interaction between PCNA and Gadd45
    P A Hall
    Department of Pathology, University of Dundee, Scotland
    Oncogene 10:2427-33. 1995
    ..These data provide support for the notion that PCNA-Gadd45 interactions co-ordinate cell cycle and DNA repair...
  12. ncbi request reprint Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1
    J M Kearsey
    Department of Pathology, University of Dundee, Scotland
    Oncogene 11:1675-83. 1995
    ..It is postulated that the interactions of Gadd45 with both p21Cip1 and PCNA are important for the modulation of cell cycles, and for the inhibition of DNA replication...
  13. ncbi request reprint A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: affinity, stoichiometry, and thermodynamics
    D I Zheleva
    Dundee Technopole, Cyclacel Ltd, Dundee, UK
    Biochemistry 39:7388-97. 2000
    ..Such peptides could prove useful in assessing p21-mimetic strategies for cancer treatment...
  14. ncbi request reprint Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts
    H Mattock
    Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:242-51. 2001
    ..However, systems for analyzing the far more complex mechanisms required for the replication of nuclear double-stranded DNA have proved so far to be refractory to specific PCNA depletion...
  15. pmc The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity
    I Samejima
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Biol Cell 9:2325-35. 1998
    ..We discuss the cell cycle phenotype of the win1-1 cdc25-22 wee1-50 mutant and its suppression by wis genes...
  16. ncbi request reprint The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast
    S Stettler
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    J Cell Sci 109:1927-35. 1996
    ....
  17. pmc The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe
    E Warbrick
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    EMBO J 10:4291-9. 1991
    ..wis1- cells undergo a rapid reduction of viability upon entry into stationary phase, suggesting a role for wis1+ in the integration of nutritional sensing with the control over entry into mitosis...
  18. ncbi request reprint Five novel elements involved in the regulation of mitosis in fission yeast
    E Warbrick
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Mol Gen Genet 232:440-6. 1992
    ....