Jing Wang

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc Function-informed transcriptome analysis of Drosophila renal tubule
    Jing Wang
    Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, UK
    Genome Biol 5:R69. 2004
  2. pmc Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster
    Dean A Baker
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB1 3QA, UK
    BMC Genomics 8:454. 2007
  3. ncbi request reprint Roles of CD4+CD25(high) FOXP3+ Tregs in lymphomas and tumors are complex
    Xiaoyan Ke
    Department of Hematology and Lymphoma Research Center, Peking University Third Hospital, Beijing, 100083, PR China
    Front Biosci 13:3986-4001. 2008
  4. pmc Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia
    Venkateswara R Chintapalli
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    BMC Genomics 14:518. 2013
  5. ncbi request reprint Using FlyAtlas to identify better Drosophila melanogaster models of human disease
    Venkateswara R Chintapalli
    Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK
    Nat Genet 39:715-20. 2007
  6. ncbi request reprint Wangia profunda gen. nov., sp. nov., a novel marine bacterium of the family Flavobacteriaceae isolated from southern Okinawa Trough deep-sea sediment
    Qi Long Qin
    The State Key Lab of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Jinan, China
    FEMS Microbiol Lett 271:53-8. 2007
  7. ncbi request reprint Microarrays: retracing steps
    Kevin R Coombes
    Nat Med 13:1276-7; author reply 1277-8. 2007
  8. ncbi request reprint Globally predicting protein functions based on co-expressed protein-protein interaction networks and ontology taxonomy similarities
    Mingzhu Zhu
    Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China
    Gene 391:113-9. 2007
  9. ncbi request reprint The formation of improved tetraploid population of red crucian carp x common carp hybrids by androgenesis
    Wei Duan
    Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, 410081, China
    Sci China C Life Sci 50:753-61. 2007
  10. ncbi request reprint Transcriptional profile induced by furazolidone treatment of Shigella flexneri
    Hua Fu
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100176, China
    Appl Microbiol Biotechnol 77:657-67. 2007

Collaborators

Detail Information

Publications56

  1. pmc Function-informed transcriptome analysis of Drosophila renal tubule
    Jing Wang
    Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, UK
    Genome Biol 5:R69. 2004
    ..We applied such an analysis to Drosophila melanogaster Malpighian (renal) tubule, a defined differentiated tissue...
  2. pmc Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster
    Dean A Baker
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB1 3QA, UK
    BMC Genomics 8:454. 2007
    ..Here, our goal was to identify genes that display transcriptional variation between laboratory strains of Drosophila melanogaster, and to explore evidence of gender-biased interactions underlying that variability...
  3. ncbi request reprint Roles of CD4+CD25(high) FOXP3+ Tregs in lymphomas and tumors are complex
    Xiaoyan Ke
    Department of Hematology and Lymphoma Research Center, Peking University Third Hospital, Beijing, 100083, PR China
    Front Biosci 13:3986-4001. 2008
    ..Further characterization of Tregs in lymphomas and other tumors will provide insight on the differential regulation of Tregs' function and survival, and define the potentials of Tregs-based immunotherapeutics...
  4. pmc Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia
    Venkateswara R Chintapalli
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    BMC Genomics 14:518. 2013
    ....
  5. ncbi request reprint Using FlyAtlas to identify better Drosophila melanogaster models of human disease
    Venkateswara R Chintapalli
    Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK
    Nat Genet 39:715-20. 2007
    ....
  6. ncbi request reprint Wangia profunda gen. nov., sp. nov., a novel marine bacterium of the family Flavobacteriaceae isolated from southern Okinawa Trough deep-sea sediment
    Qi Long Qin
    The State Key Lab of Microbial Technology, Marine Biotechnology Research Center, Shandong University, Jinan, China
    FEMS Microbiol Lett 271:53-8. 2007
    ..nov., sp. nov. The type strain is SM-A87(T) (CCTCC AB 206139(T)=DSM 18752)...
  7. ncbi request reprint Microarrays: retracing steps
    Kevin R Coombes
    Nat Med 13:1276-7; author reply 1277-8. 2007
  8. ncbi request reprint Globally predicting protein functions based on co-expressed protein-protein interaction networks and ontology taxonomy similarities
    Mingzhu Zhu
    Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China
    Gene 391:113-9. 2007
    ....
  9. ncbi request reprint The formation of improved tetraploid population of red crucian carp x common carp hybrids by androgenesis
    Wei Duan
    Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, 410081, China
    Sci China C Life Sci 50:753-61. 2007
    ..These results indicated that androgenesis could produce bisexual fertile tetraploids and improve the shape of allotetraploid hybrids as well, which will be of great significance in both the cell genetics research and fish breeding...
  10. ncbi request reprint Transcriptional profile induced by furazolidone treatment of Shigella flexneri
    Hua Fu
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100176, China
    Appl Microbiol Biotechnol 77:657-67. 2007
    ..flexneri should be considered...
  11. ncbi request reprint Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors
    Jue Liu
    Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No 9 Shuguang Garden Central Road, Haidian District, Beijing 100097, PR China
    Virus Genes 35:719-27. 2007
    ..Taken together, our data suggest that proteasome inhibitor reduces IBDV replication through inhibition of viral RNA transcription and protein synthesis, and thus preventing IBDV-induced apoptosis...
  12. ncbi request reprint Biogenesis of the T1-S1 linker of voltage-gated K+ channels
    Liwei Tu
    Department of Physiology, University of Pennsylvania, Philadelpha, Pennsylvania 19104 6085, USA
    Biochemistry 46:8075-84. 2007
    ..Both alpha5 and S1 manifest compact structures (helical) inside the ribosomal exit tunnel, whereas the T1-S1 linker does not. Moreover, the location of the peptide in the tunnel influences compaction...
  13. ncbi request reprint The spectrum of SCN1A-related infantile epileptic encephalopathies
    Louise A Harkin
    Department of Genetic Medicine, Women s and Children s Hospital, North Adelaide, South Australia
    Brain 130:843-52. 2007
    ..Knowledge of an expanded spectrum of epileptic encephalopathies associated with SCN1A mutations allows earlier diagnostic confirmation for children with these devastating disorders...
  14. ncbi request reprint RefSeq refinements of UniGene-based gene matching improve the correlation of expression measurements between two microarray platforms
    Yuan Ji
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Appl Bioinformatics 5:89-98. 2006
    ..It is a sensible approach for matching probes across platforms. We conclude that UniGene alone is insufficient to match genes across platforms. Refined matching based on RefSeq significantly improves the quality of matches...
  15. ncbi request reprint Macrophage contribution to the response of the rat organ of Corti to amikacin
    Sabine Ladrech
    INSERM, U 583, Laboratoire de Physiopathologie et thérapie des déficits sensoriels et moteurs, Montpellier, France
    J Neurosci Res 85:1970-9. 2007
    ..Consequently, early treatments with anti-inflammatory factors might promote supporting cell survival, thus improving the efficacy of more specific strategies aimed to regenerate hair cells from nonsensory cells...
  16. ncbi request reprint Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney
    Ruimin Gu
    Dept of Pharmacology, Harbin Medical University, Harbin 150086, China
    Am J Physiol Renal Physiol 293:F299-305. 2007
    ..We conclude that adenosine activates the 50 pS K channel in the basolateral membrane of the TAL and the stimulatory effect is mainly mediated by a PKA-dependent pathway via the A2 adenosine receptor in the TAL...
  17. ncbi request reprint Gaining confidence in biological interpretation of the microarray data: the functional consistence of the significant GO categories
    Da Yang
    Department of Bioinformatics, Bio pharmaceutical Key Laboratory of Heilongjiang Province Incubator of State Key Laboratory, Harbin Medical University, Harbin 150086, China
    Bioinformatics 24:265-71. 2008
    ....
  18. ncbi request reprint Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae
    Xiao hong Feng
    Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China
    Acta Histochem 110:151-4. 2008
    ..The expression of GLP-1 suggests that it may play an important role in the taste stimulation of nutrients and gut hormone secretion...
  19. doi request reprint The mitochondrial 13513G>A mutation is associated with Leigh disease phenotypes independent of complex I deficiency in muscle
    Ariel Brautbar
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, TX 77030, USA
    Mol Genet Metab 94:485-90. 2008
    ....
  20. doi request reprint Identifying cancer genes from cancer mutation profiles by cancer functions
    Yanhui Li
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, China
    Sci China C Life Sci 51:569-74. 2008
    ..Finally, with precision 0.42, we suggest a list of 46 kinase genes as candidate cancer genes which are annotated to cancer functions and carry at least 3 non-silent mutations...
  21. pmc SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2
    Ming Li
    Department of Microbiology, Third Military Medical University, Chongqing, China
    PLoS ONE 3:e2080. 2008
    ..However, the molecular pathogenesis of this new emerging pathogen is still poorly understood...
  22. pmc Evaluation of biological pathways involved in chemotherapy response in breast cancer
    Attila Tordai
    Department of Breast Medical Oncology, The University of Texas M, d, Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    Breast Cancer Res 10:R37. 2008
    ..Our goal was to examine the association between biological pathways and response to chemotherapy in estrogen receptor-positive (ER+) and ER-negative (ER-) breast tumors separately...
  23. pmc How many human genes can be defined as housekeeping with current expression data?
    Jiang Zhu
    Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
    BMC Genomics 9:172. 2008
    ..Although many studies have aimed at large-scale and thorough categorization of human HK genes, a meaningful consensus has yet to be reached...
  24. pmc Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells
    Shujie Zhao
    Department of Medicine, Division of Medical Oncology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 283:11293-301. 2008
    ..These studies indicate that loss of Smad4 contributes to aberrant RON expression and that cross-talk of Smad4-independent TGF-beta signaling and the RON pathway promotes an invasive phenotype...
  25. pmc Modeling transcriptome based on transcript-sampling data
    Jiang Zhu
    Chinese Academy of Sciences CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 3:e1659. 2008
    ..for different cell types (transcriptome diversity) and the distribution of their copy numbers (transcriptome dynamics)? What is the probability that a transcript with a given expression level to be detected at a certain sampling depth?..
  26. pmc CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer
    Francisco J Esteva
    Department of Breast Medical Oncology, Unit 1354, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Breast Cancer Res 9:R87. 2007
    ..We performed gene expression analysis to identify molecular predictors of resistance to preoperative concomitant trastuzumab and paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide (T/FEC)...
  27. pmc Modulation of bacterial Type III secretion system by a spermidine transporter dependent signaling pathway
    Lian Zhou
    Institute of Molecular and Cell Biology, Singapore, Singapore
    PLoS ONE 2:e1291. 2007
    ..Many gram-negative bacterial pathogens employ Type III secretion systems (T3SS) to inject effector proteins into host cells in infectious processes...
  28. ncbi request reprint Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats
    Zhen Zhi Tang
    Department of Physiology, National University of Singapore, Singapore 117597
    Biochim Biophys Acta 1783:118-30. 2008
    ..2 transcripts identified in SHR hearts provide a different and new perspective in understanding the possible role of molecular remodeling of Cav1.2 channels in cardiac hypertrophy as a consequence of hypertension...
  29. ncbi request reprint Gene expression profiling of the pH response in Shigella flexneri 2a
    Fan Cheng
    Department of Microbiology, Medical College of Xi an Jiaotong University, Xi an, China
    FEMS Microbiol Lett 270:12-20. 2007
    ..These results also illustrate that many unknown genes are significantly regulated under acid or basic conditions, providing researchers with important information to characterize their function...
  30. pmc GO-2D: identifying 2-dimensional cellular-localized functional modules in Gene Ontology
    Jing Zhu
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, China
    BMC Genomics 8:30. 2007
    ..Based on Gene Ontology, a large number of automatic tools have been developed for the functional analysis and biological interpretation of the high-throughput microarray data...
  31. ncbi request reprint Genome organization of the SARS-CoV
    Jing Xu
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China
    Genomics Proteomics Bioinformatics 1:226-35. 2003
    ..The analysis of TRS supports the minus strand extending transcription mechanism of coronavirus. The SNP analysis of different isolates reveals that mutations of the sequences do not affect the prediction results of ORFs...
  32. ncbi request reprint A draft sequence for the genome of the domesticated silkworm (Bombyx mori)
    Qingyou Xia
    Southwest Agricultural University, Chongqing Beibei, 400716, China
    Science 306:1937-40. 2004
    ..Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities and differences in gene content...
  33. ncbi request reprint [TASK-1, an acid-sensitive K+ channel may modulate respiration and its clinical significance]
    Jing Wang
    Zhonghua Jie He He Hu Xi Za Zhi 27:624-6. 2004
  34. ncbi request reprint Overexpression of the Arabidopsis 14-3-3 protein GF14 lambda in cotton leads to a "stay-green" phenotype and improves stress tolerance under moderate drought conditions
    Juqiang Yan
    Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
    Plant Cell Physiol 45:1007-14. 2004
    ..Whatever the mechanisms, the traits observed in the GF14 lambda-expressing cotton plants are beneficial to crops under certain water-deficit conditions...
  35. ncbi request reprint Control of phyllotaxy by the cytokinin-inducible response regulator homologue ABPHYL1
    Anna Giulini
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 430:1031-4. 2004
    ..We propose that ABPH1 controls phyllotactic patterning by negatively regulating the cytokinin-induced expansion of the shoot meristem, thereby limiting the space available for primordium initiation at the apex...
  36. ncbi request reprint Members of a new group of chitinase-like genes are expressed preferentially in cotton cells with secondary walls
    Deshui Zhang
    Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
    Plant Mol Biol 54:353-72. 2004
    ..However, the mechanism by which they act is more likely to involve binding of chitin oligosaccharides than catalysis...
  37. pmc A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon
    David M Barrett
    Massey Cancer Center, Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298 0037, USA
    Mol Cell Biol 24:6194-204. 2004
    ..We propose that the GATA-1 transcription factor represents a cell type-restricted mediator of IFN-gamma induction of the HLA-E gene...
  38. pmc Fitness of anopheline mosquitoes expressing transgenes that inhibit Plasmodium development
    Luciano A Moreira
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Genetics 166:1337-41. 2004
    ..These results have important implications for implementation of malaria control via genetic modification of mosquitoes...
  39. ncbi request reprint Hemopoietic cells with features of the mast cell and basophil lineages and their potential role in allergy
    Jing Wang
    Department of Medicine, University of New South Wales, Department of Immunology, Allergy and Infectious Disease, St George Hospital, Kogarah, New South Wales, 2217, Australia
    Curr Drug Targets Inflamm Allergy 2:293-302. 2003
    ....
  40. ncbi request reprint Degeneration of sensory outer hair cells following pharmacological blockade of cochlear KCNQ channels in the adult guinea pig
    Régis Nouvian
    INSERM UMR 583 et Universités de Montpellier I et II, Physiopathologie et Therapie des deficits sensoriels et moteurs, 71 rue de Navacelles, 34090 Montpellier, France
    Eur J Neurosci 17:2553-62. 2003
    ..Our study shows that OHC KCNQ4 dysfunction could contribute to the early (40dB) hearing loss, but not for the profound deafness observed at the final stage of this disease...
  41. ncbi request reprint Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion
    Patrick E MacDonald
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:44938-45. 2002
    ..1 is an important component of beta-cell stimulus-secretion coupling, and a compound that enhances, but does not initiate, beta-cell electrical activity by acting on Kv2.1 would be a useful antidiabetic agent...
  42. ncbi request reprint Biodistribution of carbon single-wall carbon nanotubes in mice
    Haifang Wang
    Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    J Nanosci Nanotechnol 4:1019-24. 2004
    ..This study, for the first time, affords a quantitative analysis of carbon nanotubes accumulated in animal tissues...
  43. ncbi request reprint Applications of beta-mixture models in bioinformatics
    Yuan Ji
    Department of Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Bioinformatics 21:2118-22. 2005
    ..To determine the number of components in the mixture model, we suggest an alternative criterion, ICL-BIC, which is shown to perform better in selecting the correct mixture model...
  44. ncbi request reprint Inhibition effect of Chinese herbal medicine on transcription of hepatitis C virus structural gene in vitro
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing 210009, Jiangsu Province, China
    World J Gastroenterol 11:3619-22. 2005
    ..To investigate the inhibitory effect of Chinese herbal medicine on the transcription of hepatitis C virus (HCV) structural gene in Hela D cells...
  45. ncbi request reprint Enrichment analysis in high-throughput genomics - accounting for dependency in the NULL
    David L Gold
    Department of Statistics, Texas A and M University, 3134 TAMU, College Statio, TX 77843 3143, USA
    Brief Bioinform 8:71-7. 2007
    ..In applications with publicly available data sets, our test results are similar to the conventional approach which assumes independence. We argue that the independence assumption is not detrimental...
  46. ncbi request reprint Signature combinatorial splicing profiles of rat cardiac- and smooth-muscle Cav1.2 channels with distinct biophysical properties
    Zhen Zhi Tang
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Blk MD9, 2 Medical Drive, Singapore 117597, Singapore
    Cell Calcium 41:417-28. 2007
    ..The unique sequences in these tissue-specific splice variants may provide the potential targets for drug design and screening...
  47. ncbi request reprint Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma
    Michael E Kupferman
    Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030, USA
    Oral Oncol 43:440-54. 2007
    ..Therapies targeting these potential mediators of anoikis resistance may prove to be beneficial in the treatment of metastatic squamous cell carcinoma...
  48. ncbi request reprint The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1
    Jing Wang
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 281:33842-8. 2006
    ..Thus, our results suggest that Rev-erb alpha is a major determinant of the circadian PAI-1 expression and a potential modulator of the morning susceptibility to myocardial infarction...
  49. ncbi request reprint Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, and Department of Obstetrics and Gynecology, Affiliated Zhongda Hospital, Nanjing 210009, China
    Cell Mol Immunol 3:227-33. 2006
    ....
  50. ncbi request reprint PQN and DQN: algorithms for expression microarrays
    Wei Min Liu
    Roche Molecular Systems, Inc, 4300 Hacienda Drive, Pleasanton, CA 94588, USA
    J Theor Biol 243:273-8. 2006
    ..We found the computation for AUC of ROC at affycomp.biostat.jhsph.edu can be improved...
  51. ncbi request reprint Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo
    Xiujie Wang
    Division of Experimental Oncology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China
    Toxicol Appl Pharmacol 215:168-78. 2006
    ....
  52. pmc Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors
    Li Chen
    Section of Adult Cardiothoracic Service, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    J Biol Chem 281:10849-55. 2006
    ....
  53. ncbi request reprint OPA1 R445H mutation in optic atrophy associated with sensorineural deafness
    Patrizia Amati-Bonneau
    INSERM U694, Laboratoire de Biochimie et Biologie Moleculaire, Centre Hospitalier Universitaire, F 49033 Angers, France
    Ann Neurol 58:958-63. 2005
    ..In addition, OPA1 was found to be widely expressed in the sensory and neural cochlear cells of the guinea pig. Thus, optic atrophy and deafness may be related to energy defects due to a fragmented mitochondrial network...
  54. pmc Comparison of the predictive accuracy of DNA array-based multigene classifiers across cDNA arrays and Affymetrix GeneChips
    James Stec
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    J Mol Diagn 7:357-67. 2005
    ..We conclude that multigene predictors optimized for one platform lose accuracy when applied to data from another platform due to missing genes and sequence differences in probes that result in differing measurements for the same gene...
  55. pmc Biological validation of differentially expressed genes in chronic lymphocytic leukemia identified by applying multiple statistical methods to oligonucleotide microarrays
    Lynne V Abruzzo
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Mol Diagn 7:337-45. 2005
    ..A comprehensive list of all differentially expressed genes can only be obtained by combining the results of multiple statistical tests...
  56. ncbi request reprint Downregulation of otospiralin, a novel inner ear protein, causes hair cell degeneration and deafness
    Benjamin Delprat
    Institut National de la Santé et de la Recherche Médicale U 254, Laboratoire de Neurobiologie de l audition, 34090 Montpellier, France
    J Neurosci 22:1718-25. 2002
    ..Cochlear examination by transmission electron microscopy revealed hair cell loss and degeneration of the organ of Corti. This demonstrates that otospiralin is essential for the survival of the neurosensory epithelium...