Matthew Walters

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Cerebrovasc Dis 22:116-22. 2006
  2. ncbi request reprint Effect of perindopril on cerebral and renal perfusion in stroke patients with carotid disease
    M R Walters
    University Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland, UK
    Stroke 32:473-8. 2001
  3. ncbi request reprint Intravenous thrombolysis for acute ischaemic stroke: preliminary experience with recombinant tissue plasminogen activator in the UK
    M R Walters
    Acute Stroke Unit, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow, UK
    Cerebrovasc Dis 20:438-42. 2005
  4. ncbi request reprint The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Cerebrovasc Dis 20:304-9. 2005
  5. ncbi request reprint The prognostic significance of visible infarction on computed tomography following lacunar stroke: results of a long-term follow-up study
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    J Neuroimaging 15:331-5. 2005
  6. ncbi request reprint Hormone replacement therapy: the risks and benefits of treatment
    C Hardie
    Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK
    J R Coll Physicians Edinb 39:324-6. 2009
  7. ncbi request reprint Effect of perindopril on cerebral vasomotor reactivity in patients with lacunar infarction
    Matthew Walters
    Gardiner Institute, Western Infirmary, Division of Cardiovascular and Medical Sciences, University Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland
    Stroke 35:1899-902. 2004
  8. pmc Early clinical experience with the novel NMDA receptor antagonist CNS 5161
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
    Br J Clin Pharmacol 53:305-11. 2002
  9. doi request reprint Comparison of the effects of diuretics on blood pressure and arterial stiffness in patients with stroke
    Manal Alem
    Division of Cardiovascular and Medical Sciences, Acute Stroke Unit, University of Glasgow, United Kingdom
    J Stroke Cerebrovasc Dis 17:373-7. 2008
  10. pmc Trends in incidence and in short term survival following a subarachnoid haemorrhage in Scotland, 1986-2005: a retrospective cohort study
    Karen J Macpherson
    NHS Quality Improvement Scotland, Glasgow, UK
    BMC Neurol 11:38. 2011

Detail Information

Publications42

  1. ncbi request reprint A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Cerebrovasc Dis 22:116-22. 2006
    ..Hyperglycaemia on presentation with acute ischaemic stroke (AIS) is associated with poor outcome, but intervention is unproven. We investigated the safety and tolerability of one method of glycaemic control...
  2. ncbi request reprint Effect of perindopril on cerebral and renal perfusion in stroke patients with carotid disease
    M R Walters
    University Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland, UK
    Stroke 32:473-8. 2001
    ....
  3. ncbi request reprint Intravenous thrombolysis for acute ischaemic stroke: preliminary experience with recombinant tissue plasminogen activator in the UK
    M R Walters
    Acute Stroke Unit, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow, UK
    Cerebrovasc Dis 20:438-42. 2005
    ..To present the preliminary experience of implementing intravenous thrombolytic therapy for acute ischaemic stroke in three UK stroke centres...
  4. ncbi request reprint The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Cerebrovasc Dis 20:304-9. 2005
    ..It has demonstrated neuroprotective efficacy in experimental models of stroke and tolerability in healthy volunteers. We tested the safety and tolerability of ZK 200775 in patients with acute ischaemic stroke...
  5. ncbi request reprint The prognostic significance of visible infarction on computed tomography following lacunar stroke: results of a long-term follow-up study
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    J Neuroimaging 15:331-5. 2005
    ....
  6. ncbi request reprint Hormone replacement therapy: the risks and benefits of treatment
    C Hardie
    Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK
    J R Coll Physicians Edinb 39:324-6. 2009
    ..This article provides a review of the current literature surrounding the risks and benefits of HRT in postmenopausal women, and how the data can be applied safely in everyday clinical practice...
  7. ncbi request reprint Effect of perindopril on cerebral vasomotor reactivity in patients with lacunar infarction
    Matthew Walters
    Gardiner Institute, Western Infirmary, Division of Cardiovascular and Medical Sciences, University Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland
    Stroke 35:1899-902. 2004
    ..We examined the effect of the angiotensin-converting enzyme (ACE) inhibitor perindopril on cerebral vasomotor reactivity to acetazolamide in patients with lacunar cerebral infarction...
  8. pmc Early clinical experience with the novel NMDA receptor antagonist CNS 5161
    M R Walters
    University Department of Medicine and Therapeutics, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
    Br J Clin Pharmacol 53:305-11. 2002
    ..Its objectives were to investigate the haemodynamic effects of the compound, to assess its safety and tolerability in healthy male volunteers, and to provide some preliminary human pharmacokinetic data...
  9. doi request reprint Comparison of the effects of diuretics on blood pressure and arterial stiffness in patients with stroke
    Manal Alem
    Division of Cardiovascular and Medical Sciences, Acute Stroke Unit, University of Glasgow, United Kingdom
    J Stroke Cerebrovasc Dis 17:373-7. 2008
    ..Indapamide (IND) and bendroflumethiazide (BDZ) are both widely used in patients with stroke. We compared their effects on arterial blood pressure (BP) and arterial stiffness in a group of patients with stroke...
  10. pmc Trends in incidence and in short term survival following a subarachnoid haemorrhage in Scotland, 1986-2005: a retrospective cohort study
    Karen J Macpherson
    NHS Quality Improvement Scotland, Glasgow, UK
    BMC Neurol 11:38. 2011
    ..To examine age and sex specific incidence and 30 day case fatality for subarachnoid haemorrhage (SAH) in Scotland over a 20 year period...
  11. doi request reprint Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data
    Peter Langhorne
    Cardiovascular and Medical Sciences Division, University of Glasgow, Glasgow, UK
    J Neurol Neurosurg Psychiatry 81:1301-5. 2010
    ..However, it is unclear what impact this complex intervention actually has in routine practice. A comprehensive national dataset was used to study the impact of stroke unit implementation...
  12. pmc Temporal trends in hospitalisation for stroke recurrence following incident hospitalisation for stroke in Scotland
    James Lewsey
    Public Health and Health Policy, University of Glasgow, Glasgow, UK
    BMC Med 8:23. 2010
    ..The aim of this study was to examine temporal trends in hospitalisation for stroke recurrence following incident hospitalisation for stroke in Scotland during 1986 to 2001...
  13. doi request reprint Blood pressure response to patterns of weather fluctuations and effect on mortality
    Louise Aubinière-Robb
    BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
    Hypertension 62:190-6. 2013
    ..Knowing a patient's blood pressure response to weather can help reduce unnecessary antihypertensive treatment modification, which may in turn increase blood pressure variability and, thus, risk...
  14. doi request reprint Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients
    Jesse Dawson
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, Western Infirmary, University of Glasgow, Glasgow, United Kingdom
    Hypertension 62:105-11. 2013
    ..Serum uric acid level was not associated with longitudinal blood pressure control in adults with treated hypertension but was related to decline in renal function and mortality in women...
  15. doi request reprint Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults
    Laura Paul
    British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
    Hypertension 60:631-8. 2012
    ..Hypertensive patients with hematocrit levels outside of the sex-specific reference ranges identified in this study should be targeted for more aggressive blood pressure and cardiovascular risk reduction treatment...
  16. doi request reprint Socioeconomic status and transient ischaemic attack/stroke: a prospective observational study
    Gillian D Kerr
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK
    Cerebrovasc Dis 31:130-7. 2011
    ..We aimed to determine whether low-SES stroke/transient ischaemic attack (TIA) patients have a greater burden of vascular risk factors/co-morbidity and reduced health care access...
  17. ncbi request reprint Comparison of the effect of diuretics on carotid blood flow in stroke patients
    Paolo Milia
    Acute Stroke Unit, Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    J Cardiovasc Pharmacol 47:446-9. 2006
    ..There are theoretical reasons why these agents may differ with regard to their cardiovascular effects. We compared the effect of these agents on blood pressure and cerebral blood flow in a group of stroke patients...
  18. ncbi request reprint New and emerging treatments for stroke
    Jesse Dawson
    Acute Stroke Unit, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G11 6NT, UK
    Br Med Bull 77:87-102. 2006
    ..This review will discuss the evidence-based management of the acute stroke patient, consider barriers to provision of such care and update the reader on emergent strategies, which may form part of stroke management in the future...
  19. ncbi request reprint Equality of access to "fast-track" stroke services in an older, socio-economically deprived Scottish population
    T J Quinn
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Scott Med J 55:18-21. 2010
    ..Unequal access to specialist stroke services may contribute to the disproportionate stroke burden in certain populations. We evaluated the relationship between access to TIA services, deprivation and age...
  20. ncbi request reprint The effect of HRT on cerebral haemodynamics and cerebral vasomotor reactivity in post-menopausal women
    C A L Bain
    Division of Developmental Medicine, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK
    Hum Reprod 19:2411-4. 2004
    ..Impaired CVR is associated with elevated risk of stroke. We performed a randomized, double-blind placebo-controlled trial to investigate the effect of two HRT preparations upon CVR...
  21. doi request reprint Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
    Kennedy R Lees
    Department of Medicine and Therapeutics, Faculty of Medicine, University of Glasgow, Western Infirmary, Glasgow, UK
    Lancet 375:1695-703. 2010
    ..We re-examined the effect of time to treatment with intravenous rt-PA (alteplase) on therapeutic benefit and clinical risk by adding recent trial data to the analysis...
  22. ncbi request reprint Statin administration prior to ischaemic stroke onset and survival: exploratory evidence from matched treatment-control study
    S Aslanyan
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow, UK
    Eur J Neurol 12:493-8. 2005
    ..09-0.67] and during the follow-up period (hazard ratio 0.57; 95% CI 0.35-0.93). The use of statins prior to stroke onset is associated with improved stroke survival within this cohort study with matched controls...
  23. doi request reprint Functional outcome measures in contemporary stroke trials
    T J Quinn
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Int J Stroke 4:200-5. 2009
    ..Trialists continue to use poorly validated approaches to outcome assessment. Given the potential effects on data quality, explicit description of methodology should be mandatory for all trials and rigour is desirable...
  24. doi request reprint Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register
    K R Lees
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    QJM 101:863-9. 2008
    ..To describe the United Kingdom (UK) experience with thrombolytic therapy with intravenous alteplase (rt-PA) for stroke, as captured by the Implementation of Thrombolysis in Stroke (SITS) project...
  25. doi request reprint A recognition tool for transient ischaemic attack
    J Dawson
    Division of Cardiovascular and Medical Sciences, Western Infirmary Hospital, Dumbarton Road, Glasgow G116NT, UK
    QJM 102:43-9. 2009
    ..Scoring systems exist to assist rapid identification of acute stroke but not for the more challenging diagnosis of transient ischaemic attack (TIA)...
  26. doi request reprint Acute medicine teaching in an undergraduate medical curriculum: a blended learning approach
    I M Shah
    Wolfson Medical School Building, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK
    Emerg Med J 25:354-7. 2008
    ..A study was undertaken to evaluate the teaching and assess the knowledge of acute medicine among final year medical students using an online questionnaire...
  27. ncbi request reprint Effect of gender on stroke management in Glasgow
    Caroline McInnes
    Stobhill Hospital, Glasgow, UK
    Age Ageing 37:220-2. 2008
  28. doi request reprint A link between lunar phase and medically unexplained stroke symptoms: an unearthly influence?
    Faheem Ahmad
    University of Glasgow Medical School, Glasgow, UK
    J Psychosom Res 65:131-3. 2008
    ..We hypothesised that admission with medically unexplained stroke symptoms would be influenced by lunar cycle...
  29. ncbi request reprint Blunted response to systemic nitric oxide synthase inhibition in the cerebral circulation of patients with Type 2 diabetes
    F S Nazir
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Diabet Med 23:398-402. 2006
    ..We sought to investigate the effect of diabetes on basal cerebrovascular endothelial function as assessed by response to the nitric oxide synthase (NOS) inhibitor NG-monomethyl-L-arginine (L-NMMA)...
  30. doi request reprint Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (NICE technology appraisal guidance 90)
    Kirsty Stewart
    College of Medicine, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Heart 97:585-6. 2011
    ..This article considers the update in detail and discusses the implications for clinical practice...
  31. pmc Neckties and cerebrovascular reactivity in young healthy males: a pilot randomised crossover trial
    Mark Rafferty
    Institute of Cardiovascular and Medical Sciences, College of Medical and Life Sciences, University of Glasgow, Glasgow G11 6NT, UK
    Stroke Res Treat 2011:692595. 2010
    ..However, mean BHI is still within a range of considered normal. The situation may differ in patients with vascular risk factors, and confirmatory work is recommended...
  32. doi request reprint What is it with the weather and stroke?
    Kate McArthur
    Acute Stroke Unit, Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, UK
    Expert Rev Neurother 10:243-9. 2010
    ..To date, data are confusing and conflicting and well-conducted prospective studies are required to help clarify these potentially important relationships...
  33. pmc Urinary proteomics to support diagnosis of stroke
    Jesse Dawson
    Institute of Cardiovascular and Medical Sciences, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e35879. 2012
    ..We now plan to refine further and explore the clinical utility of such a test in large prospective clinical trials...
  34. ncbi request reprint Uric acid reduction: a new paradigm in the management of cardiovascular risk?
    Jesse Dawson
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary Hospital, Dumbarton Road, Glasgow, G11 6NT, UK
    Curr Med Chem 14:1879-86. 2007
    ....
  35. doi request reprint Sex differences in incidence, mortality, and survival in individuals with stroke in Scotland, 1986 to 2005
    James D Lewsey
    Public Health and Health Policy, University of Glasgow, Glasgow, UK
    Stroke 40:1038-43. 2009
    ..The aim of this study was to examine the effect of sex across different age groups and over time for stroke incidence, 30-day case-fatality, and mortality...
  36. pmc The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease
    Peter Higgins
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G11 6NT, UK
    Cardiovasc Psychiatry Neurol 2009:282059. 2009
    ..It concludes that large scale trials with clinical endpoints are justified to address this important question and to define whether use of drugs such as allopurinol should be a routine part of preventative strategies...
  37. pmc Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease?
    Jesse Dawson
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary Hospital, Glasgow, UK
    Br J Clin Pharmacol 62:633-44. 2006
    ..If such approaches are shown to be effective in reducing cardiovascular events, they would represent a novel and cost-effective preventative approach...
  38. ncbi request reprint Effect of a gonadotropin releasing hormone analog on cerebral hemodynamics in premenopausal women
    C A L Bain
    Division of Developmental Medicine, University of Glasgow, UK
    Climacteric 8:193-7. 2005
    ..We studied intracranial hemodynamics in a group of premenopausal women before and after induction of a temporary hypoestrogenic state...
  39. ncbi request reprint The continued yin and yang of uric acid
    Jesse Dawson
    Stroke 39:e9; author reply e10. 2008
  40. ncbi request reprint Development and validation of a stroke recognition tool
    Jesse Dawson
    Lancet Neurol 4:691-3. 2005
  41. ncbi request reprint A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer
    Triantafillos Liloglou
    Molecular Oncology Unit, Roy Castle International Centre for Lung Cancer Research, 200 London Road, Liverpool L3 9TA, United Kingdom
    Lung Cancer 37:143-6. 2002
    ..This is the first report on the implication of a polymorphism in the GSTM4 gene in lung cancer risk. Further studies are required to investigate the relation of this polymorphism to cancer risk to substantiate these findings...
  42. ncbi request reprint Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro
    Thomas Zurcher
    Medicine Research Centre, GlaxoSmithKline Stevenage, SG1 2NY, UK
    J Antimicrob Chemother 58:723-32. 2006
    ..However, despite mutations being in conserved residues in the neuraminidase (NA) they do not confer resistance in all NA subtypes...