G M Walsh

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint Tralokinumab, an anti-IL-13 mAb for the potential treatment of asthma and COPD
    Garry M Walsh
    University of Aberdeen, Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Opin Investig Drugs 11:1305-12. 2010
  2. ncbi request reprint Reslizumab, a humanized anti-IL-5 mAb for the treatment of eosinophil-mediated inflammatory conditions
    Garry M Walsh
    University of Aberdeen, School of Medicine, Institute of Medical Sciences, Aberdeen, UK
    Curr Opin Mol Ther 11:329-36. 2009
  3. doi request reprint Reslizumab for pediatric eosinophilic esophagitis
    Garry M Walsh
    School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Immunotherapy 2:461-5. 2010
  4. pmc Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma
    Garry M Walsh
    Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Biologics 7:7-11. 2013
  5. ncbi request reprint An update on biologic-based therapy in asthma
    Garry M Walsh
    Section of Immunology and Infection, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Immunotherapy 5:1255-64. 2013
  6. ncbi request reprint Therapeutic potential of targeting interleukin 5 in asthma
    Garry M Walsh
    Section of Immunology and Infection, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    BioDrugs 27:559-63. 2013
  7. doi request reprint An update on emerging drugs for asthma
    Garry M Walsh
    Section of Immunology and Infection Division of Applied Medicine, School of Medicine and Dentistry Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Expert Opin Emerg Drugs 17:37-42. 2012
  8. pmc The anti-inflammatory effects of levocetirizine--are they clinically relevant or just an interesting additional effect?
    Garry M Walsh
    School of Medicine, University of Aberdeen, Aberdeen, UK
    Allergy Asthma Clin Immunol 5:14. 2009
  9. ncbi request reprint Levocetirizine: an update
    Garry M Walsh
    Department of Medicine and Therapeutics, School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Curr Med Chem 13:2711-5. 2006
  10. ncbi request reprint Novel therapies for asthma--advances and problems
    Garry M Walsh
    Asthmatic and Allergic Inflammation Group, School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Pharm Des 11:3027-38. 2005

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Tralokinumab, an anti-IL-13 mAb for the potential treatment of asthma and COPD
    Garry M Walsh
    University of Aberdeen, Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Opin Investig Drugs 11:1305-12. 2010
    ..This review summarizes the problems and successes regarding recent developments in mAb-based strategies targeted against IL-13 in asthma and COPD, with an emphasis on tralokinumab...
  2. ncbi request reprint Reslizumab, a humanized anti-IL-5 mAb for the treatment of eosinophil-mediated inflammatory conditions
    Garry M Walsh
    University of Aberdeen, School of Medicine, Institute of Medical Sciences, Aberdeen, UK
    Curr Opin Mol Ther 11:329-36. 2009
    ..However, the rarity of conditions such as HES, EE and EG makes the conduct of such trials difficult...
  3. doi request reprint Reslizumab for pediatric eosinophilic esophagitis
    Garry M Walsh
    School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Immunotherapy 2:461-5. 2010
    ..This article considers the current status of the clinical development of reslizumab for pediatric eosinophilic esophagitis...
  4. pmc Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma
    Garry M Walsh
    Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Biologics 7:7-11. 2013
    ..This review will consider the current status of the clinical development of reslizumab for asthma and in other inflammatory diseases with a marked eosinophilic component...
  5. ncbi request reprint An update on biologic-based therapy in asthma
    Garry M Walsh
    Section of Immunology and Infection, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Immunotherapy 5:1255-64. 2013
    ..This review summarizes recent evidence demonstrating the effectiveness or otherwise of monoclonal antibody-based therapies in patients with asthma. ..
  6. ncbi request reprint Therapeutic potential of targeting interleukin 5 in asthma
    Garry M Walsh
    Section of Immunology and Infection, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    BioDrugs 27:559-63. 2013
    ..This review summarises the current evidence, demonstrating the effectiveness or otherwise of the targeting of IL-5 in patients with asthma. ..
  7. doi request reprint An update on emerging drugs for asthma
    Garry M Walsh
    Section of Immunology and Infection Division of Applied Medicine, School of Medicine and Dentistry Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Expert Opin Emerg Drugs 17:37-42. 2012
    ..However, clinical trials with these biologics in patients with asthma were for the most part disappointing even though they proved to be highly effective in animal models of asthma...
  8. pmc The anti-inflammatory effects of levocetirizine--are they clinically relevant or just an interesting additional effect?
    Garry M Walsh
    School of Medicine, University of Aberdeen, Aberdeen, UK
    Allergy Asthma Clin Immunol 5:14. 2009
    ..This review will consider the potential or otherwise of the reported anti-inflammatory effects of levocetirizine to enhance its effectiveness in the treatment of allergic disease...
  9. ncbi request reprint Levocetirizine: an update
    Garry M Walsh
    Department of Medicine and Therapeutics, School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Curr Med Chem 13:2711-5. 2006
    ....
  10. ncbi request reprint Novel therapies for asthma--advances and problems
    Garry M Walsh
    Asthmatic and Allergic Inflammation Group, School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Pharm Des 11:3027-38. 2005
    ..This paper will provide an overview of both the potential and shortcomings of these diverse approaches to drug development for asthma...
  11. ncbi request reprint New insights into the second generation antihistamines
    G M Walsh
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Scotland
    Drugs 61:207-36. 2001
    ....
  12. ncbi request reprint Statins as emerging treatments for asthma and chronic obstructive pulmonary disease
    Garry M Walsh
    School of Medicine, IMS Building, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Expert Rev Respir Med 2:329-35. 2008
    ..This review will examine the diverse in vitro and in vivo anti-inflammatory properties of statins and consider the available evidence that statins represent novel therapeutic interventions for asthma and COPD...
  13. ncbi request reprint Defective apoptotic cell clearance in asthma and COPD--a new drug target for statins?
    Garry M Walsh
    School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Trends Pharmacol Sci 29:6-11. 2008
    ....
  14. doi request reprint Canakinumab for the treatment of cryopyrin-associated periodic syndromes
    Garry M Walsh
    Division of Applied Medicine, Institute of Medical Science, University of Aberdeen, Foresterhill, Aberdeen, UK
    Drugs Today (Barc) 45:731-5. 2009
    ..This review will assess the utility of canakinumab as a treatment for CAPS...
  15. doi request reprint A review of the role of levocetirizine as an effective therapy for allergic disease
    Garry M Walsh
    University of Aberdeen, School of Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Expert Opin Pharmacother 9:859-67. 2008
    ..Levocetirizine is the R-enantiomer of cetirizine dihydrochloride with pharmacodynamically and pharmacokinetically favourable characteristics...
  16. ncbi request reprint Mepolizumab and eosinophil-mediated disease
    G M Walsh
    Section of Immunology and Infection, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Med Chem 16:4774-8. 2009
    ..This review will consider the current status of the clinical development of mepolizumab for diseases with a significant eosinophilic component to their pathology...
  17. ncbi request reprint Control of eosinophil toxicity in the lung
    G M Walsh
    Allergic and Asthmatic Inflammation Group, School of Medicine, University of Aberdeen, Scotland, UK
    Curr Drug Targets Inflamm Allergy 4:481-6. 2005
    ..This review will discuss both the potential and shortcomings of these diverse approaches to limit eosinophil toxicity in the asthmatic lung...
  18. ncbi request reprint Targeting airway inflammation: novel therapies for the treatment of asthma
    Garry M Walsh
    School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Curr Med Chem 13:3105-11. 2006
    ..This review will discuss the current status, therapeutic potential and potential problems of these novel drug developments in asthma therapy...
  19. ncbi request reprint Antagonism of eosinophil accumulation in asthma
    Garry M Walsh
    School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Scotland, UK
    Recent Pat Inflamm Allergy Drug Discov 4:210-3. 2010
    ..This review will summarise, the problems and successes regarding recent patents and developments in adhesion-based therapeutic strategies aimed at reducing eosinophil-mediated inflammation in the asthmatic lung...
  20. ncbi request reprint A comparative study of different methods for the assessment of apoptosis and necrosis in human eosinophils
    G M Walsh
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Forester Hill, UK
    J Immunol Methods 217:153-63. 1998
    ..In contrast, staurosporine-treated eosinophils exhibited both membrane integrity and rapid apoptosis-associated morphological changes detected by single step Kimura staining which preceded externalisation of PS...
  21. ncbi request reprint Resting and cytokine-stimulated human small airway epithelial cells recognize and engulf apoptotic eosinophils
    G M Walsh
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, UK
    Blood 94:2827-35. 1999
    ..These data demonstrate a novel function for human bronchial epithelial cells that might represent an important mechanism in the resolution of eosinophil-induced asthmatic inflammation...
  22. ncbi request reprint Eosinophil granule proteins and their role in disease
    G M Walsh
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill, UK
    Curr Opin Hematol 8:28-33. 2001
    ..This review will update recent developments in understanding the role that eosinophil granule proteins play in human disease, particularly those of the respiratory tract...
  23. ncbi request reprint Granule protein changes and membrane receptor phenotype in maturing human eosinophils cultured from CD34+ progenitors
    M W Al-Rabia
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Clin Exp Allergy 33:640-8. 2003
    ..Eosinophils are now recognized as major effector cells in allergic and asthmatic disease with a potent armoury of mediators whose release makes a major contribution to the inflammation underlying these conditions...
  24. ncbi request reprint Emerging safety issues regarding long-term usage of H(1)receptor antagonists
    Garry M Walsh
    Department of Medicine and Therapeutics, IMS Building, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Expert Opin Drug Saf 1:225-35. 2002
    ..This review will examine some of the safety issues associated with established and newer second generation drugs particularly in relation to their long-term usage in adults and children...
  25. ncbi request reprint Second-generation antihistamines in asthma therapy: is there a protective effect?
    Garry M Walsh
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, IMS Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Am J Respir Med 1:27-34. 2002
    ..Finally, several well-conducted studies suggest that combination therapy with antihistamines and antileukotrienes may be as effective as corticosteroid use in patients with allergic asthma and seasonal allergic rhinitis...
  26. ncbi request reprint Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells
    L Thomson
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, UK
    Clin Exp Allergy 32:1187-92. 2002
    ....
  27. ncbi request reprint Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines
    L P Erwig
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, United Kingdom
    J Immunol 161:1983-8. 1998
    ..Once activated, BMDMs become unresponsive to alternative activating signals, a finding which has obvious implications for Mphi function in vivo...
  28. ncbi request reprint Phagocytosis of apoptotic eosinophils but not neutrophils by bronchial epithelial cells
    D W Sexton
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Clin Exp Allergy 34:1514-24. 2004
    ..We have previously demonstrated that human bronchial epithelial cells engulf apoptotic eosinophils...
  29. doi request reprint Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions
    A J Robinson
    Section of Immunology and Infection, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Scotland, UK
    Clin Exp Allergy 39:1866-74. 2009
    ..We therefore assessed the ability of five statins to inhibit human eosinophil adhesion to recombinant human inter-cellular adhesion molecule (rhICAM)-1 under physiologically relevant flow conditions...
  30. ncbi request reprint Human alveolar epithelial cells engulf apoptotic eosinophils by means of integrin- and phosphatidylserine receptor-dependent mechanisms: a process upregulated by dexamethasone
    D W Sexton
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    J Allergy Clin Immunol 108:962-9. 2001
    ..CONCLUSIONS: These data further suggest a nonpassive role for airway epithelium in the resolution of eosinophilic inflammation in asthma...
  31. ncbi request reprint Corticosteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma
    G M Walsh
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    J Endocrinol 178:37-43. 2003
    ..These findings point the way to new and more targeted anti-inflammatory therapy for asthma and may provide important clues for the development of alternative therapies for glucocorticoid resistance...
  32. ncbi request reprint A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions
    P Wu
    School of Medicine, University of Aberdeen, Aberdeen, Scotland, UK
    Clin Exp Allergy 35:1073-9. 2005
    ..We previously demonstrated that low concentrations of a new antihistamine levocetirizine inhibited eosinophil transmigration through human microvascular endothelial cells...
  33. ncbi request reprint Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45RO
    M G Blaylock
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Clin Exp Allergy 33:936-41. 2003
    ..Comparisons were made between expression of CD45, CD45RA, CD45RB and CD45RO by eosinophils from asthmatic patients and non-asthmatic atopic and non-atopic, non-asthmatic control subjects...
  34. ncbi request reprint Reduced eosinophil apoptosis in induced sputum correlates with asthma severity
    C J A Duncan
    Allergic and Asthmatic Inflammation Research Group, Dept of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Eur Respir J 22:484-90. 2003
    ....
  35. ncbi request reprint Previous uptake of apoptotic neutrophils or ligation of integrin receptors downmodulates the ability of macrophages to ingest apoptotic neutrophils
    L P Erwig
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, UK
    Blood 93:1406-12. 1999
    ..Therefore, apoptotic PMN regulate their own uptake through an integrin-dependent process, which can be reproduced by ligation of other integrins expressed by macrophages...
  36. ncbi request reprint Emerging drugs for asthma
    Garry M Walsh
    Division of Applied Medicine Institute of Medical Sciences, University of Aberdeen Foresterhill, Aberdeen AB25 2ZD, UK
    Expert Opin Emerg Drugs 13:643-53. 2008
    ..However, this approach requires life-time therapy while a subset of patients remains symptomatic despite optimal treatment creating a clear unmet medical need...
  37. doi request reprint Sputum eosinophil apoptotic rate is positively correlated to exhaled nitric oxide in children
    Jennifer Pontin
    Department of Child Health, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Pediatr Pulmonol 43:1130-4. 2008
    ..Eosinophil apoptotic rate (AR) may be increased by NO but the relationship between eosinophil AR and NO has not been studied in vivo. This study tested the hypothesis that eosinophil AR will be positively related to FE(NO)...
  38. doi request reprint Montelukast inhibition of resting and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under flow conditions appears independent of cysLT(1)R antagonism
    Alexander J Robinson
    School of Medicine, University of Aberdeen, Aberdeen, Scotland, UK
    J Leukoc Biol 83:1522-9. 2008
    ..These findings demonstrate that MLK-mediated inhibition of unstimulated and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under shear-stress conditions appears independent of cysLT(1)R antagonism...
  39. pmc Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies
    Catherine M McDougall
    School of Medicine, University of Aberdeen, Royal Aberdeen Children s Hospital, Aberdeen, UK
    Am J Respir Cell Mol Biol 39:560-8. 2008
    ..Therefore, nasal epithelial cultures constitute an accessible surrogate for studying lower airway inflammation...
  40. ncbi request reprint Membrane receptor-mediated apoptosis and caspase activation in the differentiated EoL-1 eosinophilic cell line
    Mohammed W Al-Rabia
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Leukoc Biol 75:1045-55. 2004
    ....
  41. ncbi request reprint Eosinophil-epithelial cell interactions: an important facet of asthmatic inflammation
    Darren W Sexton
    Clin Exp Allergy 32:811-3. 2002