David A Walsh

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Performance problems of patients with chronic low-back pain and the measurement of patient-centered outcome
    David Andrew Walsh
    Back Pain Unit, Sears Centre, King s Mill Hospital, Notts, United Kingdom
    Spine (Phila Pa 1976) 29:87-93. 2004
  2. pmc Rasch analysis of the intermittent and constant osteoarthritis pain (ICOAP) scale
    B J Moreton
    Arthritis Research U K Pain Centre, University of Nottingham, UK
    Osteoarthritis Cartilage 20:1109-15. 2012
  3. doi request reprint Pain in rheumatoid arthritis
    David A Walsh
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, NG5 1PB, UK
    Curr Pain Headache Rep 16:509-17. 2012
  4. doi request reprint Lymphatic vessels in osteoarthritic human knees
    D A Walsh
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
    Osteoarthritis Cartilage 20:405-12. 2012
  5. pmc Bisphosphonates for osteoarthritis
    David A Walsh
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Arthritis Res Ther 13:128. 2011
  6. pmc Osteochondral angiogenesis and increased protease inhibitor expression in OA
    R E Fransès
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 18:563-71. 2010
  7. doi request reprint Evaluation of a Photographic Chondropathy Score (PCS) for pathological samples in a study of inflammation in tibiofemoral osteoarthritis
    D A Walsh
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 17:304-12. 2009
  8. ncbi request reprint Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomes
    David A Walsh
    Academic Rheumatology, University of Nottingham, UK
    Curr Opin Rheumatol 16:609-15. 2004
  9. ncbi request reprint Tachykinins and the cardiovascular system
    David A Walsh
    Division of Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB, UK
    Curr Drug Targets 7:1031-42. 2006
  10. ncbi request reprint Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis
    D A Walsh
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 15:743-51. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Performance problems of patients with chronic low-back pain and the measurement of patient-centered outcome
    David Andrew Walsh
    Back Pain Unit, Sears Centre, King s Mill Hospital, Notts, United Kingdom
    Spine (Phila Pa 1976) 29:87-93. 2004
    ....
  2. pmc Rasch analysis of the intermittent and constant osteoarthritis pain (ICOAP) scale
    B J Moreton
    Arthritis Research U K Pain Centre, University of Nottingham, UK
    Osteoarthritis Cartilage 20:1109-15. 2012
    ..The current study examined the fit between data obtained from the ICOAP questionnaire and the Rasch model to determine whether it meets the requirements of interval-level measurement...
  3. doi request reprint Pain in rheumatoid arthritis
    David A Walsh
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, NG5 1PB, UK
    Curr Pain Headache Rep 16:509-17. 2012
    ..Holistic approaches to pain management are indicated, including pharmacologic analgesia where randomized controlled trials (RCTs) offer evidence of efficacy...
  4. doi request reprint Lymphatic vessels in osteoarthritic human knees
    D A Walsh
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
    Osteoarthritis Cartilage 20:405-12. 2012
    ..This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic parameters in osteoarthritis (OA)...
  5. pmc Bisphosphonates for osteoarthritis
    David A Walsh
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Arthritis Res Ther 13:128. 2011
    ....
  6. pmc Osteochondral angiogenesis and increased protease inhibitor expression in OA
    R E Fransès
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 18:563-71. 2010
    ..We hypothesized that dysregulated expression of four key anti-angiogenic protease inhibitors may contribute to increased osteochondral vascularity in osteoarthritis (OA)...
  7. doi request reprint Evaluation of a Photographic Chondropathy Score (PCS) for pathological samples in a study of inflammation in tibiofemoral osteoarthritis
    D A Walsh
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 17:304-12. 2009
    ..We have compared the ability of the different severity measures to distinguish between samples obtained at total knee replacement surgery or postmortem (PM), and to detect associations between structural severity and synovitis...
  8. ncbi request reprint Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomes
    David A Walsh
    Academic Rheumatology, University of Nottingham, UK
    Curr Opin Rheumatol 16:609-15. 2004
    ..This review aims to place recent evidence in the context of previous work emphasizing the dynamic nature of tissues in these conditions...
  9. ncbi request reprint Tachykinins and the cardiovascular system
    David A Walsh
    Division of Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB, UK
    Curr Drug Targets 7:1031-42. 2006
    ..Sophisticated modelling of human disease is required to enable neurokinin receptor antagonists to achieve this therapeutic potential...
  10. ncbi request reprint Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis
    D A Walsh
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 15:743-51. 2007
    ..We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA...
  11. ncbi request reprint Post-mortem collection of human joint tissues for research
    D A Walsh
    Rheumatology, King s Mill Hospital, Sutton in Ashfield, Nottinghamshire, UK
    Rheumatology (Oxford) 42:1556-8. 2003
    ..A feasibility study aiming to obtain post-mortem knee joint tissues from 10 donors for research...
  12. ncbi request reprint Pain beliefs and perceived physical disability of patients with chronic low back pain
    David Andrew Walsh
    Back Pain Unit, King s Mill Centre for Healthcare Services, Mansfield Road, Sutton in Ashfield NG17 4JL, UK
    Pain 97:23-31. 2002
    ..Modification of these beliefs may be associated with improvements in patients' perceptions of the level of their disability...
  13. ncbi request reprint Angiogenesis: a therapeutic target in arthritis
    D A Walsh
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, UK
    Curr Opin Investig Drugs 2:1054-63. 2001
    ....
  14. pmc Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis
    David A Walsh
    Arthritis Research UK Pain Centre, Division of Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, UK
    Rheumatology (Oxford) 49:1852-61. 2010
    ..NGF expression and sensory nerve growth may link osteochondral angiogenesis to pain in arthritis...
  15. pmc Angiogenesis in the pathogenesis of inflammatory joint and lung diseases
    D A Walsh
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Nottingham, UK
    Arthritis Res 3:147-53. 2001
    ..Angiogenesis inhibitors may reduce inflammation and may also help to restore appropriate tissue structure and function...
  16. ncbi request reprint Provisional guidelines for applying the Department of Health (England) 18-week-patient pathway to specialist rheumatology care
    D A Walsh
    Honorary Consultant Rheumatologist, King s Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust, Mansfield Road, Sutton in Ashfield, NG17 4JL, UK
    Rheumatology (Oxford) 46:1200-6. 2007
    ..Department of Health guidance must be interpreted and applied to patients with rheumatological problems...
  17. doi request reprint Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis
    Sadaf Ashraf
    Arthritis Research UK Pain Centre, Department of Academic Rheumatology, University of Nottingham, Nottingham, UK
    Arthritis Rheum 62:1890-8. 2010
    ..To determine whether blood vessel growth at the onset of resolving synovitis leads to its subsequent persistence and whether inhibiting this angiogenesis at the onset of persistent inflammation leads to its subsequent resolution...
  18. doi request reprint Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
    Paul I Mapp
    Arthritis Research UK Pain Centre, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Nat Rev Rheumatol 8:390-8. 2012
    ..Angiogenesis could, therefore, contribute to structural damage and pain in OA and provide potential targets for new treatments...
  19. pmc A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo
    Paul I Mapp
    Arthritis Research UK Pain Centre, University of Nottingham, City Hospital, Nottingham, UK
    Br J Pharmacol 166:1261-71. 2012
    ..We have tested the hypothesis that calcitonin gene-related peptide (CGRP) is a mediator of capsaicin-induced angiogenesis in vivo...
  20. pmc Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis
    Sunita Suri
    Academic Rheumatology, University of Nottingham, City Hospital, Hucknall Road, Nottingham, Notts NG5 1PB, UK
    Ann Rheum Dis 66:1423-8. 2007
    ..Normal adult articular cartilage is thought to be avascular and aneural...
  21. ncbi request reprint Combined effect of bradykinin B2 and neurokinin-1 receptor activation on endothelial cell proliferation in acute synovitis
    Hélène C Seegers
    Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
    FASEB J 18:762-4. 2004
    ..These findings demonstrate that substance P and bradykinin can act on NK1 and B2 receptors, respectively, to promote endothelial cell proliferation in acute synovitis...
  22. pmc Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort
    Daniel F McWilliams
    Division of Academic Rheumatology, Arthritis Research UK Pain Centre, City Hospital, Nottingham, UK
    BMC Musculoskelet Disord 14:153. 2013
    ....
  23. doi request reprint Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis
    Sadaf Ashraf
    Arthritis Research UK Pain Centre, Department of Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
    Arthritis Rheum 63:2700-10. 2011
    ..To determine the contributions of angiogenesis to inflammation, joint damage, and pain behavior in a rat meniscal transection model of osteoarthritis (OA)...
  24. pmc Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study
    Daniel F McWilliams
    Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, UK
    Arthritis Care Res (Hoboken) 64:1505-13. 2012
    ..To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA)...
  25. ncbi request reprint Pathophysiological mechanisms of angiogenesis
    David A Walsh
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Nottingham NG5 1PB, United Kingdom
    Adv Clin Chem 44:187-221. 2007
    ..Therapeutic targeting of angiogenesis will depend both on the generation of acceptable pharmacological agents and on the identification of patients who may and do gain benefit from such treatments...
  26. doi request reprint Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis
    Sadaf Ashraf
    Academic Rheumatology, Arthritis Research UK Pain Centre, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Ann Rheum Dis 70:523-9. 2011
    ..This study describes vascular penetration and nerve growth in human menisci, providing a potential mechanism for the genesis of pain in knee OA...
  27. pmc Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis
    P I Mapp
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 18:593-600. 2010
    ....
  28. ncbi request reprint Vasculature of the normal and arthritic synovial joint
    L Haywood
    Academic Rheumatology, City Hospital, Nottingham, UK
    Histol Histopathol 16:277-84. 2001
    ..Growth of the subchondral vasculature into the articular cartilage may also occur, leading to ossification of the articular cartilage...
  29. ncbi request reprint Osteoarthritis, angiogenesis and inflammation
    C S Bonnet
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Rheumatology (Oxford) 44:7-16. 2005
    ....
  30. ncbi request reprint Angiogenesis in two animal models of osteoarthritis
    P I Mapp
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 16:61-9. 2008
    ..This study aimed to characterise two animal models of knee OA with particular respect to osteochondral and synovial angiogenesis...
  31. doi request reprint Osteochondral alterations in osteoarthritis
    Sunita Suri
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, NG5 1PB, UK
    Bone 51:204-11. 2012
    ..Here we review pathological changes at the osteochondral junction and explore their potential therapeutic implications for OA. This article is part of a Special Issue entitled "Osteoarthritis"...
  32. doi request reprint Beliefs about the causes and consequences of pain in patients with chronic inflammatory or noninflammatory low back pain and in pain-free individuals
    Tim John Sloan
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham, UK
    Spine (Phila Pa 1976) 33:966-72. 2008
    ..Case control study including 2 groups of patients with low back pain (LBP, inflammatory and noninflammatory) and a pain-free community control group...
  33. doi request reprint Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort
    Daniel F McWilliams
    Academic Rheumatology, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Rheumatology (Oxford) 53:473-81. 2014
    ..RA is an important cause of work disability. This study aimed to identify predictive factors for work disability and state benefit claims in a cohort with early RA...
  34. ncbi request reprint Inflammation and angiogenesis in osteoarthritis
    L Haywood
    University of Nottingham City Hospital, Clinical Sciences Building, Hucknall Road, Nottingham NG5 1PB, UK
    Arthritis Rheum 48:2173-7. 2003
    ..To quantify the relationship between inflammation and angiogenesis in synovial tissue from patients with osteoarthritis (OA)...
  35. doi request reprint Hand and Foot Surgery Rates in Rheumatoid Arthritis Have Declined From 1986 to 2011, but Large-Joint Replacement Rates Remain Unchanged: Results From Two UK Inception Cohorts
    Elena Nikiphorou
    St Albans City Hospital, St Albans, UK, and University College London, London, UK
    Arthritis Rheumatol 66:1081-9. 2014
    ..To assess whether there have been any secular changes in orthopedic interventions in patients with rheumatoid arthritis (RA) since 1986, as examined in 2 early rheumatoid arthritis (RA) inception cohorts with up to 25 years of followup...
  36. ncbi request reprint Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation
    Hélène C Seegers
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
    J Pharmacol Exp Ther 306:8-12. 2003
    ..NK1 receptor antagonists could have therapeutic potential in conditions where neurogenic angiogenesis contributes to disease...
  37. ncbi request reprint Localization of 3-nitrotyrosine to rheumatoid and normal synovium
    P I Mapp
    Department of Medical Sciences, University of Bath, Claverton Down, UK
    Arthritis Rheum 44:1534-9. 2001
    ..These findings suggest a physiologic role for ONOO- in normal synovial vascular function...
  38. pmc Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung
    D A Walsh
    Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 113:1407-15. 1994
    ..However, the similar microvascular distributions of NK,binding sites in human and guinea pig lung suggest that the selective tachykinin receptor antagonistsFK888 and FK224 may be useful in the management of airway inflammation in man...
  39. pmc Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritis
    D A Walsh
    Inflammation Group, London Hospital, Whitechapel, United Kingdom
    Ann Rheum Dis 51:313-7. 1992
    ..This provides further evidence that substance P may play a part in the vascular control of human synovium and may influence inflammatory processes in joints...