Research Topics
| David A WalshSummaryAffiliation: University of Nottingham Country: UK Publications
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Detail Information
Publications
Performance problems of patients with chronic low-back pain and the measurement of patient-centered outcomeDavid Andrew Walsh
Back Pain Unit, Sears Centre, King s Mill Hospital, Notts, United Kingdom
Spine (Phila Pa 1976) 29:87-93. 2004....
Pain in rheumatoid arthritisDavid A Walsh
Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, NG5 1PB, UK
Curr Pain Headache Rep 16:509-17. 2012..Holistic approaches to pain management are indicated, including pharmacologic analgesia where randomized controlled trials (RCTs) offer evidence of efficacy...- Lymphatic vessels in osteoarthritic human kneesD A Walsh
Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
Osteoarthritis Cartilage 20:405-12. 2012..This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic parameters in osteoarthritis (OA)... 
Bisphosphonates for osteoarthritisDavid A Walsh
Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Arthritis Res Ther 13:128. 2011....- Osteochondral angiogenesis and increased protease inhibitor expression in OAR E Fransès
Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Osteoarthritis Cartilage 18:563-71. 2010..We hypothesized that dysregulated expression of four key anti-angiogenic protease inhibitors may contribute to increased osteochondral vascularity in osteoarthritis (OA)... - Tachykinins and the cardiovascular systemDavid A Walsh
Division of Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB, UK
Curr Drug Targets 7:1031-42. 2006..Sophisticated modelling of human disease is required to enable neurokinin receptor antagonists to achieve this therapeutic potential... - Angiogenesis in the synovium and at the osteochondral junction in osteoarthritisD A Walsh
Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Osteoarthritis Cartilage 15:743-51. 2007..We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA... - Provisional guidelines for applying the Department of Health (England) 18-week-patient pathway to specialist rheumatology careD A Walsh
Honorary Consultant Rheumatologist, King s Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust, Mansfield Road, Sutton in Ashfield, NG17 4JL, UK
Rheumatology (Oxford) 46:1200-6. 2007..Department of Health guidance must be interpreted and applied to patients with rheumatological problems... - Evaluation of a Photographic Chondropathy Score (PCS) for pathological samples in a study of inflammation in tibiofemoral osteoarthritisD A Walsh
Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Osteoarthritis Cartilage 17:304-12. 2009..We have compared the ability of the different severity measures to distinguish between samples obtained at total knee replacement surgery or postmortem (PM), and to detect associations between structural severity and synovitis... - Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritisDavid A Walsh
Arthritis Research UK Pain Centre, Division of Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, UK
Rheumatology (Oxford) 49:1852-61. 2010..NGF expression and sensory nerve growth may link osteochondral angiogenesis to pain in arthritis... - Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomesDavid A Walsh
Academic Rheumatology, University of Nottingham, UK
Curr Opin Rheumatol 16:609-15. 2004..This review aims to place recent evidence in the context of previous work emphasizing the dynamic nature of tissues in these conditions... - Pain beliefs and perceived physical disability of patients with chronic low back painDavid Andrew Walsh
Back Pain Unit, King s Mill Centre for Healthcare Services, Mansfield Road, Sutton in Ashfield NG17 4JL, UK
Pain 97:23-31. 2002..Modification of these beliefs may be associated with improvements in patients' perceptions of the level of their disability... - Angiogenesis in the pathogenesis of inflammatory joint and lung diseasesD A Walsh
Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Nottingham, UK
Arthritis Res 3:147-53. 2001..Angiogenesis inhibitors may reduce inflammation and may also help to restore appropriate tissue structure and function... - Angiogenesis: a therapeutic target in arthritisD A Walsh
Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, UK
Curr Opin Investig Drugs 2:1054-63. 2001.... - Post-mortem collection of human joint tissues for researchD A Walsh
Rheumatology, King s Mill Hospital, Sutton in Ashfield, Nottinghamshire, UK
Rheumatology (Oxford) 42:1556-8. 2003..A feasibility study aiming to obtain post-mortem knee joint tissues from 10 donors for research... - Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitisSadaf Ashraf
Arthritis Research UK Pain Centre, Department of Academic Rheumatology, University of Nottingham, Nottingham, UK
Arthritis Rheum 62:1890-8. 2010..To determine whether blood vessel growth at the onset of resolving synovitis leads to its subsequent persistence and whether inhibiting this angiogenesis at the onset of persistent inflammation leads to its subsequent resolution... - A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivoPaul I Mapp
Arthritis Research UK Pain Centre, University of Nottingham, City Hospital, Nottingham, UK
Br J Pharmacol 166:1261-71. 2012..We have tested the hypothesis that calcitonin gene-related peptide (CGRP) is a mediator of capsaicin-induced angiogenesis in vivo... - Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritisSunita Suri
Academic Rheumatology, University of Nottingham, City Hospital, Hucknall Road, Nottingham, Notts NG5 1PB, UK
Ann Rheum Dis 66:1423-8. 2007..Normal adult articular cartilage is thought to be avascular and aneural... - Combined effect of bradykinin B2 and neurokinin-1 receptor activation on endothelial cell proliferation in acute synovitisHélène C Seegers
Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
FASEB J 18:762-4. 2004..These findings demonstrate that substance P and bradykinin can act on NK1 and B2 receptors, respectively, to promote endothelial cell proliferation in acute synovitis... - Mechanisms and targets of angiogenesis and nerve growth in osteoarthritisPaul I Mapp
Arthritis Research UK Pain Centre, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Nat Rev Rheumatol 8:390-8. 2012..Angiogenesis could, therefore, contribute to structural damage and pain in OA and provide potential targets for new treatments... - Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritisSadaf Ashraf
Arthritis Research UK Pain Centre, Department of Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
Arthritis Rheum 63:2700-10. 2011..To determine the contributions of angiogenesis to inflammation, joint damage, and pain behavior in a rat meniscal transection model of osteoarthritis (OA)... - Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort studyDaniel F McWilliams
Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, UK
Arthritis Care Res (Hoboken) 64:1505-13. 2012..To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA)... - Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritisSadaf Ashraf
Academic Rheumatology, Arthritis Research UK Pain Centre, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Ann Rheum Dis 70:523-9. 2011..This study describes vascular penetration and nerve growth in human menisci, providing a potential mechanism for the genesis of pain in knee OA... - Vasculature of the normal and arthritic synovial jointL Haywood
Academic Rheumatology, City Hospital, Nottingham, UK
Histol Histopathol 16:277-84. 2001..Growth of the subchondral vasculature into the articular cartilage may also occur, leading to ossification of the articular cartilage... - Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritisP I Mapp
Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
Osteoarthritis Cartilage 18:593-600. 2010.... - Osteoarthritis, angiogenesis and inflammationC S Bonnet
Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Rheumatology (Oxford) 44:7-16. 2005.... - Angiogenesis in two animal models of osteoarthritisP I Mapp
Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
Osteoarthritis Cartilage 16:61-9. 2008..This study aimed to characterise two animal models of knee OA with particular respect to osteochondral and synovial angiogenesis... - Osteochondral alterations in osteoarthritisSunita Suri
Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, NG5 1PB, UK
Bone 51:204-11. 2012..Here we review pathological changes at the osteochondral junction and explore their potential therapeutic implications for OA. This article is part of a Special Issue entitled "Osteoarthritis"... - Beliefs about the causes and consequences of pain in patients with chronic inflammatory or noninflammatory low back pain and in pain-free individualsTim John Sloan
Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham, UK
Spine (Phila Pa 1976) 33:966-72. 2008..Case control study including 2 groups of patients with low back pain (LBP, inflammatory and noninflammatory) and a pain-free community control group... - Pathophysiological mechanisms of angiogenesisDavid A Walsh
Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Nottingham NG5 1PB, United Kingdom
Adv Clin Chem 44:187-221. 2007..Therapeutic targeting of angiogenesis will depend both on the generation of acceptable pharmacological agents and on the identification of patients who may and do gain benefit from such treatments... - Inflammation and angiogenesis in osteoarthritisL Haywood
University of Nottingham/City Hospital, Clinical Sciences Building, Hucknall Road, Nottingham NG5 1PB, UK
Arthritis Rheum 48:2173-7. 2003..CONCLUSION: Inflammation and angiogenesis in the synovium are associated with OA. The angiogenic growth factor VEGF generated by the inflamed synovium may promote angiogenesis, thereby contributing to inflammation in OA... - Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammationHélène C Seegers
Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
J Pharmacol Exp Ther 306:8-12. 2003..NK1 receptor antagonists could have therapeutic potential in conditions where neurogenic angiogenesis contributes to disease... - Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lungD A Walsh
Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
Br J Pharmacol 113:1407-15. 1994..However, the similar microvascular distributions of NK,binding sites in human and guinea pig lung suggest that the selective tachykinin receptor antagonistsFK888 and FK224 may be useful in the management of airway inflammation in man... - Localization of 3-nitrotyrosine to rheumatoid and normal synoviumP I Mapp
Department of Medical Sciences, University of Bath, Claverton Down, UK
Arthritis Rheum 44:1534-9. 2001..These findings suggest a physiologic role for ONOO- in normal synovial vascular function... - Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritisD A Walsh
Inflammation Group, London Hospital, Whitechapel, United Kingdom
Ann Rheum Dis 51:313-7. 1992..This provides further evidence that substance P may play a part in the vascular control of human synovium and may influence inflammatory processes in joints...