Sarah R Walmsley

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
    Sarah R Walmsley
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Arthritis Res Ther 11:219. 2009
  2. pmc Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
    Sarah R Walmsley
    Academic Unit of Respiratory Medicine, The Medical School, University of Sheffield, Sheffield, United Kingdom
    J Clin Invest 121:1053-63. 2011
  3. pmc A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia
    Helen M Marriott
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Thorax 67:985-92. 2012
  4. pmc Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease
    Steve J Webster
    Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
    J Immunol 185:2968-79. 2010
  5. ncbi request reprint Hypoxia, the HIF pathway and neutrophilic inflammatory responses
    A A Roger Thompson
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Biol Chem 394:471-7. 2013
  6. pmc Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines
    Alexander Basran
    Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Rd, Sheffield, UK
    J Leukoc Biol 93:7-19. 2013
  7. ncbi request reprint The HIF/VHL pathway: from oxygen sensing to innate immunity
    Sarah R Walmsley
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Am J Respir Cell Mol Biol 38:251-5. 2008
  8. pmc Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin
    Lynne R Prince
    Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield, UK
    J Immunol 180:3502-11. 2008
  9. ncbi request reprint Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination
    Le A Luong
    Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, UK
    Circ Res 112:1583-91. 2013
  10. doi request reprint Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model
    Philip M Elks
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
    Blood 118:712-22. 2011

Collaborators

Detail Information

Publications11

  1. pmc Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
    Sarah R Walmsley
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Arthritis Res Ther 11:219. 2009
    ..As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed...
  2. pmc Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
    Sarah R Walmsley
    Academic Unit of Respiratory Medicine, The Medical School, University of Sheffield, Sheffield, United Kingdom
    J Clin Invest 121:1053-63. 2011
    ..These data support what we believe to be a novel function for PHD3 in regulating neutrophil survival in hypoxia and may enable the development of new therapeutics for inflammatory disease...
  3. pmc A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia
    Helen M Marriott
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Thorax 67:985-92. 2012
    ..This study used mice with impaired Fas signalling to examine susceptibility to pneumococcal pneumonia and decoy receptor 3 analogue (DcR3-a) to correct factors associated with increased susceptibility...
  4. pmc Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease
    Steve J Webster
    Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
    J Immunol 185:2968-79. 2010
    ..coli and K. pneumoniae or bacterial stimulation of cell metabolism. In this regard, the fate of monocytes following bacterial challenge more closely resembles neutrophils than macrophages...
  5. ncbi request reprint Hypoxia, the HIF pathway and neutrophilic inflammatory responses
    A A Roger Thompson
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Biol Chem 394:471-7. 2013
    ....
  6. pmc Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines
    Alexander Basran
    Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Rd, Sheffield, UK
    J Leukoc Biol 93:7-19. 2013
    ....
  7. ncbi request reprint The HIF/VHL pathway: from oxygen sensing to innate immunity
    Sarah R Walmsley
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Am J Respir Cell Mol Biol 38:251-5. 2008
    ..Understanding these processes and the role they play in regulating innate immune responses within inflamed sites, both hypoxic and normoxic, may offer new opportunities for therapeutic intervention...
  8. pmc Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin
    Lynne R Prince
    Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield, UK
    J Immunol 180:3502-11. 2008
    ..This may be a pathological pathway of cell death to which neutrophils are particularly susceptible, and could be therapeutically targeted to limit neutrophil death and preserve host responses...
  9. ncbi request reprint Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination
    Le A Luong
    Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, UK
    Circ Res 112:1583-91. 2013
    ..Thus, cellular mechanisms that suppress tumor necrosis factor receptor-associated factor 6 ubiquitination are potential therapeutic targets to reduce inflammation in hypoxic tissues...
  10. doi request reprint Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model
    Philip M Elks
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
    Blood 118:712-22. 2011
    ..Our data demonstrate that Hif-1α regulates neutrophil function in complex ways during inflammation resolution in vivo...
  11. pmc Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis
    Emmet E McGrath
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Thorax 67:796-803. 2012
    ..We therefore explored the capacity of TRAIL to modify chronic inflammatory lung injury and studied TRAIL expression in patients with IPF...