Andrew F Walls

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release
    Shaoheng He
    Immunopharmacology Group, Mailpoint 837, South Block, Southampton General Hospital, Southampton SO16 6YD, UK
    J Pharmacol Exp Ther 309:119-26. 2004
  2. doi request reprint Experimental activation of mast cells and their pharmacological modulation
    Shaoheng He
    Immunopharmacology Group, Southampton General Hospital, Southampton, UK
    Methods Mol Med 138:319-30. 2008
  3. ncbi request reprint The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G
    Shaoheng He
    Immunopharmacology Group, Mailpoint 837, Southampton General Hospital, Southampton SO16 6YD, UK
    Biochem Pharmacol 65:1007-15. 2003
  4. doi request reprint Purification and characterization of mast cell tryptase and chymase from human tissues
    Alan R McEuen
    Immunopharmacology Group, Southampton General Hospital, Southampton, UK
    Methods Mol Med 138:299-317. 2008
  5. ncbi request reprint Inhibition of dipeptidyl peptidase I in the human mast cell line HMC-1: blocked activation of tryptase, but not of the predominant chymotryptic activity
    Parimal D Sheth
    Immunopharmacology Group, Division of Infection, Immunity and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, UK
    Biochem Pharmacol 66:2251-62. 2003
  6. ncbi request reprint The release of basogranulin in response to IgE-dependent and IgE-independent stimuli: validity of basogranulin measurement as an indicator of basophil activation
    Akinori Mochizuki
    Immunopharmacology Group, Southampton General Hospital
    J Allergy Clin Immunol 112:102-8. 2003
  7. ncbi request reprint The heterogeneity of mast cell tryptase from human lung and skin
    Qi Peng
    Immunopharmacology Group and Tissue Remodelling and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Eur J Biochem 270:270-83. 2003
  8. doi request reprint Identification of mast cells and mast cell subpopulations
    Mark Buckley
    Immunopharmacology Group, Southampton General Hospital, Southampton, UK
    Methods Mol Med 138:285-97. 2008
  9. ncbi request reprint Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis
    Patrick Berger
    Laboratoire de Physiologie Cellulaire Respiratoire, INSERM E0356, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    FASEB J 17:2139-41. 2003
  10. ncbi request reprint Selective alterations in mast cell subsets and eosinophil infiltration in two complementary types of intestinal inflammation: ascariasis and Crohn's disease
    Waltraud J Beil
    Institute of Pathology, University of Vienna Medical School, Vienna, Austria
    Pathobiology 70:303-13. 2002

Collaborators

  • Ping Li
  • Akhmed Aslam
  • Dean D Metcalfe
  • P Bradding
  • LAWRENCE BARRY SCHWARTZ
  • P T Kovanen
  • Stephen Holgate
  • G Marone
  • K A Lindstedt
  • R Pabst
  • D Ribatti
  • Alan R McEuen
  • Shaoheng He
  • Mark G Buckley
  • Mark Buckley
  • F Estelle R Simons
  • Kazuki Abe
  • Amato de Paulis
  • Mikko I Mäyränpää
  • Patrick Berger
  • Qi Peng
  • Manabu Nagata
  • Parimal D Sheth
  • Akinori Mochizuki
  • Waltraud J Beil
  • Donald Y M Leung
  • Marianne van Hage
  • Hugh A Sampson
  • Anthony J Frew
  • Jan Lotvall
  • Bruce S Bochner
  • Lanny J Rosenwasser
  • David B K Golden
  • Ulrich Muller
  • Ignacio J Ansotegui
  • Fred D Finkelman
  • Hideo Inoue
  • Amelia Longobardi
  • Francesca Wanda Rossi
  • Pia Ragno
  • Hanna M Heikkilä
  • Nella Prevete
  • Bianca Liccardo
  • Isabella Fiorentino
  • Nunzia Montuori
  • Stefania Staibano
  • Arturo Genovese
  • Toshitsugu Sato
  • Yongsong He
  • Morley D Hollenberg
  • Marianna D A Gaca
  • Noriyuki Sato
  • Roger Marthan
  • Pierre Olivier Girodet
  • Sally A Blewett
  • J Manuel Tunon de Lara
  • Shingo Ichimiya
  • Olga Ousova
  • Diahn Warng Perng
  • R Christopher Benyon
  • Noriharu Shijubo
  • Hugues Begueret
  • John Pedersen
  • Shosaku Abe
  • Paul Leufkens
  • Udo Wefelmeyer
  • Erika Jensen-Jarolim
  • Matthias Schulz
  • Johannes Pammer
  • Georg Kraml

Detail Information

Publications16

  1. ncbi request reprint Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release
    Shaoheng He
    Immunopharmacology Group, Mailpoint 837, South Block, Southampton General Hospital, Southampton SO16 6YD, UK
    J Pharmacol Exp Ther 309:119-26. 2004
    ..The potent actions of tryptase inhibitors as mast cell-stabilizing agents could be of value in the treatment of allergic inflammation of the respiratory tract, possibly by targeting the non-PAR2-mediated actions of tryptase...
  2. doi request reprint Experimental activation of mast cells and their pharmacological modulation
    Shaoheng He
    Immunopharmacology Group, Southampton General Hospital, Southampton, UK
    Methods Mol Med 138:319-30. 2008
    ..The methods described for the experimental activation of mast cells can be readily adapted to studies with cell lines or mast cells obtained through long-term culture...
  3. ncbi request reprint The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G
    Shaoheng He
    Immunopharmacology Group, Mailpoint 837, Southampton General Hospital, Southampton SO16 6YD, UK
    Biochem Pharmacol 65:1007-15. 2003
    ..The ability of lactoferrin to inhibit IgE-dependent activation of human mast cells and modulate protease activity suggests that the release of this neutrophil product may have a role in the downregulation of allergic inflammation...
  4. doi request reprint Purification and characterization of mast cell tryptase and chymase from human tissues
    Alan R McEuen
    Immunopharmacology Group, Southampton General Hospital, Southampton, UK
    Methods Mol Med 138:299-317. 2008
    ..The procedures described here have been developed for the purification of the human proteases and will require some modification if applied to purify mast cell proteases from the tissues of other species...
  5. ncbi request reprint Inhibition of dipeptidyl peptidase I in the human mast cell line HMC-1: blocked activation of tryptase, but not of the predominant chymotryptic activity
    Parimal D Sheth
    Immunopharmacology Group, Division of Infection, Immunity and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, UK
    Biochem Pharmacol 66:2251-62. 2003
    ..As inhibitors of tryptase have proven efficacious in models of allergic disease, these results also indicate that inhibitors of DPPI might provide an additional point of therapeutic control...
  6. ncbi request reprint The release of basogranulin in response to IgE-dependent and IgE-independent stimuli: validity of basogranulin measurement as an indicator of basophil activation
    Akinori Mochizuki
    Immunopharmacology Group, Southampton General Hospital
    J Allergy Clin Immunol 112:102-8. 2003
    ..Basogranulin, the novel basophil granule protein recognized by the monoclonal antibody BB1, can be released by stimulation with anti-IgE antibody or calcium ionophore. However, the kinetics and regulation of its secretion are unknown...
  7. ncbi request reprint The heterogeneity of mast cell tryptase from human lung and skin
    Qi Peng
    Immunopharmacology Group and Tissue Remodelling and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Eur J Biochem 270:270-83. 2003
    ..The heterogeneity demonstrated for tryptase in these studies suggests that there are important differences in tryptase function in different tissues...
  8. doi request reprint Identification of mast cells and mast cell subpopulations
    Mark Buckley
    Immunopharmacology Group, Southampton General Hospital, Southampton, UK
    Methods Mol Med 138:285-97. 2008
    ..There will be a continuing need for validation, for consideration of potential sources of error, and for the development of new and more reliable techniques for mast cell identification...
  9. ncbi request reprint Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis
    Patrick Berger
    Laboratoire de Physiologie Cellulaire Respiratoire, INSERM E0356, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    FASEB J 17:2139-41. 2003
    ..HASMCs may thus be able to stimulate the accumulation of mast cells, and these cells may, in turn, stimulate the secretion of chemotactic factors by HASMCs...
  10. ncbi request reprint Selective alterations in mast cell subsets and eosinophil infiltration in two complementary types of intestinal inflammation: ascariasis and Crohn's disease
    Waltraud J Beil
    Institute of Pathology, University of Vienna Medical School, Vienna, Austria
    Pathobiology 70:303-13. 2002
    ..These two types of intestinal inflammation are complementary with regard to T cell response (TH1 versus TH2), prevalence and environmental factors...
  11. ncbi request reprint The role of the mast cell in the pathophysiology of asthma
    Peter Bradding
    Division of Respiratory Medicine, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Allergy Clin Immunol 117:1277-84. 2006
    ..The development of potent and specific inhibitors of mast cell secretion, which remain active when administered long-term to asthmatic airways, should offer a novel approach to the treatment of asthma...
  12. ncbi request reprint Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion
    Mikko I Mäyränpää
    Wihuri Research Institute, University of Helsinki, Helsinki, Finland
    Coron Artery Dis 17:611-21. 2006
    ..As activated mast cells capable of secreting neutral proteases are present in the intima of eroded coronary plaques, we investigated their potential roles in endothelial erosion...
  13. ncbi request reprint Expression and functions of the vascular endothelial growth factors and their receptors in human basophils
    Amato de Paulis
    Divisione di Immunologia Clinica ed Allergologia e Centro Interdipartimentale di Ricerca di Scienze Immunologiche di Base e Cliniche Università di Napoli Federico II, Naples, Italy
    J Immunol 177:7322-31. 2006
    ..Our data suggest that basophils could play a role in angiogenesis and inflammation through the expression of several forms of VEGF and their receptors...
  14. ncbi request reprint Risk assessment in anaphylaxis: current and future approaches
    F Estelle R Simons
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada, and Department of Respiratory Medicine, Brighton General Hospital, Belfast, UK
    J Allergy Clin Immunol 120:S2-24. 2007
    ....
  15. ncbi request reprint Chymase-positive mast cells in small sized adenocarcinoma of the lung
    Manabu Nagata
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16 Chuo ku, 060 8543 Sapporo, Japan
    Virchows Arch 443:565-73. 2003
    ..Counting chymase-positive (MCTC-type) mast cells in tumor stroma may be a good prognosis predictor for LBACs, especially Noguchi type-C tumors...
  16. ncbi request reprint Up-regulation of protease-activated receptor-2 by bFGF in cultured human synovial fibroblasts
    Kazuki Abe
    Pharmacological Research Department, Minophagen Pharmaceutical Co, 2 2 3, Komatsubara, Zama shi, Kanagawa 228 0002, Japan
    Life Sci 79:898-904. 2006
    ..An important role could be played by bFGF in the regulation of functional PAR-2 expression in cultured RA synovial fibroblasts...