Russell Wallis

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway
    Russell Wallis
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 282:7844-51. 2007
  2. pmc Paths reunited: Initiation of the classical and lectin pathways of complement activation
    Russell Wallis
    Department of Infection, Immunity and Inflammation, University of Leicester, UK
    Immunobiology 215:1-11. 2010
  3. pmc Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway
    Russell Wallis
    Departments of Infection, Immunity and Inflammation and Biochemistry, University of Leicester, Leicester, UK
    Immunobiology 212:289-99. 2007
  4. pmc Engineering novel complement activity into a pulmonary surfactant protein
    Umakhanth Venkatraman Girija
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, UK
    J Biol Chem 285:10546-52. 2010
  5. pmc Analogous interactions in initiating complexes of the classical and lectin pathways of complement
    Anna E Phillips
    Department of Infection, University of Leicester, Leicester, United Kingdom
    J Immunol 182:7708-17. 2009
  6. pmc Carbohydrate recognition and complement activation by rat ficolin-B
    Umakhanth Venkatraman Girija
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Eur J Immunol 41:214-23. 2011
  7. pmc Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation
    Umakhanth Venkatraman Girija
    Departments of Infection, Immunity, and Inflammation and Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 110:13916-20. 2013
  8. doi request reprint Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation
    Alexandre R Gingras
    Department of Biochemistry, University of Leicester, Leicester, LE1 9HN, UK
    Structure 19:1635-43. 2011
  9. pmc The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection
    Youssif M Ali
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    PLoS Pathog 8:e1002793. 2012
  10. ncbi request reprint Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency
    Russell Wallis
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom
    J Immunol 175:6846-51. 2005

Collaborators

  • Daniel A Mitchell
  • Teizo Fujita
  • Alister W Dodds
  • Peter Gal
  • Kazue Takahashi
  • Allan J Beveridge
  • Uffe Holmskov
  • Yuichi Endo
  • Soren Hansen
  • James E Clark
  • Ming Zhang
  • James N Arnold
  • Aras Kadioglu
  • D J Harvey
  • Umakhanth Venkatraman Girija
  • Wilhelm J Schwaeble
  • Alexandre R Gingras
  • Anthony H Keeble
  • Silke Roscher
  • Roshni Panchal
  • Peter C E Moody
  • Youssif M Ali
  • Thomas Dudler
  • Cordula M Stover
  • Nicholas J Lynch
  • Julia Toth
  • Anna E Phillips
  • Kenneth B M Reid
  • Jin Geng
  • Philippe E Van Den Steen
  • Ce Belle Chen
  • Hadar Feinberg
  • Jamie E Marshall
  • Md Arif Sheikh
  • Peter W Andrew
  • Kashif S Haleem
  • Umakhanth V Girija
  • Gregory L Stahl
  • Steven Sacks
  • Youssif Mohammed Ali
  • Minoru Takahashi
  • Brian Parent
  • Karl Lhotta
  • Conrad A Farrar
  • Nilesh J Samani
  • Michael Marber
  • CLARK E TEDFORD
  • Haekyung Lee
  • Daisuke Iwaki
  • Christopher Furze
  • Ralf Schmid
  • Robert B Sim
  • Eleni Pala
  • Christopher M Furze
  • David M Haddleton
  • Giuseppe Mantovani
  • Lei Tao
  • Gaojian Chen
  • Benjamin R G Johnson
  • Julien Nicolas
  • Stephen D Evans
  • Helene Piccard
  • Louise Royle
  • Raymond A Dwek
  • Simon Fry
  • Soren K Moestrup
  • Pierre Fiten
  • Ghislain Opdenakker
  • Christian Jacobsen
  • Mark R Wormald
  • Pauline M Rudd
  • Vibeke Hvidberg
  • Ilse Van Aelst
  • Kurt Drickamer
  • Joost C M Uitdehaag
  • William I Weis
  • Jason M Davies

Detail Information

Publications20

  1. ncbi request reprint Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway
    Russell Wallis
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 282:7844-51. 2007
    ....
  2. pmc Paths reunited: Initiation of the classical and lectin pathways of complement activation
    Russell Wallis
    Department of Infection, Immunity and Inflammation, University of Leicester, UK
    Immunobiology 215:1-11. 2010
    ..Here, we develop and expand these concepts and delineate their implications towards the key aspects of complement activation via the classical and lectin pathways...
  3. pmc Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway
    Russell Wallis
    Departments of Infection, Immunity and Inflammation and Biochemistry, University of Leicester, Leicester, UK
    Immunobiology 212:289-99. 2007
    ..In this review, I will summarise the main findings of these studies and describe current theories to explain how the components combine to initiate the reaction cascade...
  4. pmc Engineering novel complement activity into a pulmonary surfactant protein
    Umakhanth Venkatraman Girija
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, UK
    J Biol Chem 285:10546-52. 2010
    ..Thus, the active rather than the zymogen state is default in lectin.MASP complexes and must be inhibited through additional regions in circulating MBLs until triggered by pathogen recognition...
  5. pmc Analogous interactions in initiating complexes of the classical and lectin pathways of complement
    Anna E Phillips
    Department of Infection, University of Leicester, Leicester, United Kingdom
    J Immunol 182:7708-17. 2009
    ..Importantly, these new data are contrary to existing models of C1 and enable us to propose a new model using mannan-binding lectin-mannan-binding lectin-associated serine protease interactions as a template...
  6. pmc Carbohydrate recognition and complement activation by rat ficolin-B
    Umakhanth Venkatraman Girija
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Eur J Immunol 41:214-23. 2011
    ..Mutagenesis data reveal that lack of activity in mouse ficolin-B is probably caused by a single amino acid change in the putative MASP-binding site that blocks the ficolin-MASP interaction...
  7. pmc Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation
    Umakhanth Venkatraman Girija
    Departments of Infection, Immunity, and Inflammation and Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 110:13916-20. 2013
    ..Together with previously determined structures of C1r fragments, the results reported here provide a structural basis for understanding the early steps of complement activation via the classical pathway. ..
  8. doi request reprint Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation
    Alexandre R Gingras
    Department of Biochemistry, University of Leicester, Leicester, LE1 9HN, UK
    Structure 19:1635-43. 2011
    ..The structural insights reveal a new focus for inhibitors and we have validated this concept by targeting the binding pocket of the MASP...
  9. pmc The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection
    Youssif M Ali
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    PLoS Pathog 8:e1002793. 2012
    ..This study corroborates the essential function of MASP-2 in the lectin pathway and highlights the importance of MBL-independent lectin pathway activation in the host defense against pneumococci...
  10. ncbi request reprint Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency
    Russell Wallis
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom
    J Immunol 175:6846-51. 2005
    ..Analogous molecular defects in human MBL probably combine to create the mutant phenotypes of immunodeficient individuals...
  11. ncbi request reprint Carbohydrate recognition and complement activation by rat ficolin-B
    Umakhanth Venkatraman Girija
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Eur J Immunol 41:214-23. 2011
    ..Mutagenesis data reveal that lack of activity in mouse ficolin-B is probably caused by a single amino acid change in the putative MASP-binding site that blocks the ficolin-MASP interaction...
  12. doi request reprint A molecular dynamics study of C1r and C1s dimers: implications for the structure of the C1 complex
    Allan J Beveridge
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom
    Proteins 80:1987-97. 2012
    ..Furthermore, it identifies a number of putative binding residues that can be tested using site-directed mutagenesis...
  13. pmc Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
    Wilhelm J Schwaeble
    Department of Infection, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 108:7523-8. 2011
    ..The therapeutic effects of MASP-2 inhibition in this experimental model suggest the utility of anti-MASP-2 antibody therapy in reperfusion injury and other lectin pathway-mediated disorders...
  14. ncbi request reprint Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?
    James N Arnold
    Medical Research Council Immunochemistry Unit and Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    J Biol Chem 281:6955-63. 2006
    ..Binding would lead to opsonization or activation of enzyme systems such as complement...
  15. pmc Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins
    Umakhanth Venkatraman Girija
    Department of Biochemistry, Medical Research Council Immunochemistry Unit, University of Oxford, Oxford, United Kingdom
    J Immunol 179:455-62. 2007
    ..Equivalent binding sites and comparable activation kinetics of MASP-2 suggest that complement activation by ficolins and MBLs proceeds by analogous mechanisms...
  16. pmc Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
    Hadar Feinberg
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Drive West, CA 94305 5126, USA
    EMBO J 22:2348-59. 2003
    ..A model of the full six-domain structure and its interaction with MBPs suggests mechanisms by which binding to a target cell transmits conformational changes from MBP to MASP that allow activation of its protease activity...
  17. ncbi request reprint Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases
    Ce Belle Chen
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:26058-65. 2004
    ..MASP-1 cleaves C2 almost as efficiently as MASP-2 does, but it does not cleave C4. Thus MASP-1 probably enhances complement activation triggered by MBP.MASP-2 complexes, but it cannot initiate activation itself...
  18. ncbi request reprint The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors
    Philippe E Van Den Steen
    Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, B 3000, Belgium
    J Biol Chem 281:18626-37. 2006
    ..Therefore, the OG and hemopexin domains down-regulate the bioavailability of active MMP-9 and the interactions with the cargo receptors are proposed to be the original function of hemopexin domains in MMPs...
  19. pmc Site-directed conjugation of "clicked" glycopolymers to form glycoprotein mimics: binding to mammalian lectin and induction of immunological function
    Jin Geng
    Department of Chemistry, University of Warwick, CV4 7AL, Coventry, United Kingdom
    J Am Chem Soc 129:15156-63. 2007
    ....
  20. ncbi request reprint Structural and functional aspects of complement activation by mannose-binding protein
    Russell Wallis
    Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
    Immunobiology 205:433-45. 2002
    ..MBP/MASP complexes share many features with the C1 complex of the classical pathway. The relatively simple MBP/MASP complexes serve as useful models for understanding activation of the classical pathway of the complement cascade...