Suellen M Walker

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Overview of neurodevelopment and pain research, possible treatment targets
    Suellen M Walker
    Portex Unit Pain Research and Department of Anaesthesia and Pain Medicine, UCL Institute of Child Health and Great Ormond St Hospital for Children NHS Foundation Trust, 30 Guilford St, London WC1N 1EH, UK Electronic address
    Best Pract Res Clin Rheumatol 28:213-28. 2014
  2. doi request reprint Biological and neurodevelopmental implications of neonatal pain
    Suellen M Walker
    Portex Unit Pain Research, UCL Institute of Child Health, Great Ormond St Hospital for Children NHS Foundation Trust, 30 Guilford Street, London, UK
    Clin Perinatol 40:471-91. 2013
  3. ncbi request reprint Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data
    Suellen M Walker
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    Anesth Analg 115:638-62. 2012
  4. doi request reprint Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity
    Suellen M Walker
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond St Hospital NHS Trust, 30 Guilford St, London WC1N 1EH, United Kingdom
    Anesth Analg 115:450-60. 2012
  5. ncbi request reprint Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pups
    Suellen M Walker
    University of Sydney Pain Management and Research Centre, Royal North Shore Hospital, St Leonard s, New South Wales, Australia
    Anesthesiology 102:1226-34. 2005
  6. ncbi request reprint Hindpaw incision in early life increases the hyperalgesic response to repeat surgical injury: critical period and dependence on initial afferent activity
    Suellen M Walker
    Portex Unit, Pain Research, UCL Institute of Child Health and Great Ormond St Hospital, 6th Floor Cardiac Wing, London, UK
    Pain 147:99-106. 2009
  7. doi request reprint Infant pain management: a developmental neurobiological approach
    Maria Fitzgerald
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Clin Pract Neurol 5:35-50. 2009
  8. pmc Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity
    Simon Beggs
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond St Hospital NHS Trust, 30 Guilford St, London WC1N 1EH, UK
    Brain 135:404-17. 2012
  9. pmc Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome
    Suellen M Walker
    Department of Anesthesiology, University of California, San Diego, La Jolla, California, USA
    Anesthesiology 113:147-59. 2010
  10. ncbi request reprint Primary and secondary hyperalgesia can be differentiated by postnatal age and ERK activation in the spinal dorsal horn of the rat pup
    Suellen M Walker
    Department of Anaesthesia, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Pain 128:157-68. 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Overview of neurodevelopment and pain research, possible treatment targets
    Suellen M Walker
    Portex Unit Pain Research and Department of Anaesthesia and Pain Medicine, UCL Institute of Child Health and Great Ormond St Hospital for Children NHS Foundation Trust, 30 Guilford St, London WC1N 1EH, UK Electronic address
    Best Pract Res Clin Rheumatol 28:213-28. 2014
    ..An integrated approach to management is required to effectively select and target interventions, reduce pain and disability and improve long-term outcome...
  2. doi request reprint Biological and neurodevelopmental implications of neonatal pain
    Suellen M Walker
    Portex Unit Pain Research, UCL Institute of Child Health, Great Ormond St Hospital for Children NHS Foundation Trust, 30 Guilford Street, London, UK
    Clin Perinatol 40:471-91. 2013
    ..Parallel preclinical studies have elucidated underlying mechanisms and evaluate preventive strategies to inform future clinical trials. ..
  3. ncbi request reprint Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data
    Suellen M Walker
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    Anesth Analg 115:638-62. 2012
    ..Finally, we advocate use of neuraxial drugs with the widest demonstrable safety margin and suggest minimum standards for preclinical evaluation before adoption of new analgesics or preparations into routine clinical practice...
  4. doi request reprint Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity
    Suellen M Walker
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond St Hospital NHS Trust, 30 Guilford St, London WC1N 1EH, United Kingdom
    Anesth Analg 115:450-60. 2012
    ..Neuraxial clonidine is used for perioperative analgesia in children of all ages. Preclinical studies in the postnatal rat allow comparison of the relative toxicity and safety of spinal analgesics throughout postnatal development...
  5. ncbi request reprint Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pups
    Suellen M Walker
    University of Sydney Pain Management and Research Centre, Royal North Shore Hospital, St Leonard s, New South Wales, Australia
    Anesthesiology 102:1226-34. 2005
    ..The aim of this study was to determine the effect of epidural dexmedetomidine on sensory processing, reversal of inflammatory hyperalgesia, and sedation during early development in rats...
  6. ncbi request reprint Hindpaw incision in early life increases the hyperalgesic response to repeat surgical injury: critical period and dependence on initial afferent activity
    Suellen M Walker
    Portex Unit, Pain Research, UCL Institute of Child Health and Great Ormond St Hospital, 6th Floor Cardiac Wing, London, UK
    Pain 147:99-106. 2009
    ..This has potential therapeutic implications for the type and duration of peri-operative analgesia used for neonatal surgery...
  7. doi request reprint Infant pain management: a developmental neurobiological approach
    Maria Fitzgerald
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Clin Pract Neurol 5:35-50. 2009
    ..The evidence that untreated pain in infancy results in long-term adverse consequences is presented, thereby emphasizing the need for a longer term view of infant pain management...
  8. pmc Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity
    Simon Beggs
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond St Hospital NHS Trust, 30 Guilford St, London WC1N 1EH, UK
    Brain 135:404-17. 2012
    ..These data suggest that early life injury may predispose individuals to enhanced sensitivity to painful events...
  9. pmc Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome
    Suellen M Walker
    Department of Anesthesiology, University of California, San Diego, La Jolla, California, USA
    Anesthesiology 113:147-59. 2010
    ..Ketamine-induced spinal cord toxicity has been reported in adult animals but has not been systematically studied in early development...
  10. ncbi request reprint Primary and secondary hyperalgesia can be differentiated by postnatal age and ERK activation in the spinal dorsal horn of the rat pup
    Suellen M Walker
    Department of Anaesthesia, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Pain 128:157-68. 2007
    ....
  11. ncbi request reprint The ontogeny of neuropathic pain: postnatal onset of mechanical allodynia in rat spared nerve injury (SNI) and chronic constriction injury (CCI) models
    Richard F Howard
    Department of Anaesthesia, Level 4, Old Building, Great Ormond Street Hospital for Children NHS Trust and the Institute of Child Health, London WC1N 2JH, UK
    Pain 115:382-9. 2005
    ..The results are consistent with human neonatal responses to nerve injury; further study of underlying mechanisms are likely to yield important information about the pathogenesis and treatment of neuropathic pain...
  12. pmc Neonatal pain
    Suellen M Walker
    Portex Unit Pain Research, Department of Anaesthesia and Pain Medicine, UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Paediatr Anaesth 24:39-48. 2014
    ..Translation into improved clinical care will continue to depend on an integrated approach to implementation that encompasses assessment and titration against individual response, education and training, and audit and feedback. ..
  13. doi request reprint Neuropathic pain in children
    Richard F Howard
    Department of Anaesthesia and Pain Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Arch Dis Child 99:84-9. 2014
    ..Improvements in the understanding and management of NP are likely to come from developmentally appropriate improvements in the clarity and consistency of diagnosis and systematic, well-researched approaches to treatment. ..
  14. doi request reprint Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm
    Suellen M Walker
    Portex Unit, Pain Research and Respiratory Physiology, UCL Institute of Child Health, 6th Floor Cardiac Wing, 30 Guilford St, London WC1N 1EH, UK
    Pain 141:79-87. 2009
    ....
  15. doi request reprint Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children
    Ivan Wong
    Department of Anaesthesia, Great Ormond St Hospital for Children NHS Foundation Trust, London, UK
    Paediatr Anaesth 23:475-95. 2013
    ....
  16. ncbi request reprint Neonatal inflammation and primary afferent terminal plasticity in the rat dorsal horn
    Suellen M Walker
    Department of Anatomy and Developmental Biology, University College London, Malet Place, London WC1E 6BT, UK
    Pain 105:185-95. 2003
    ..This effect is not seen in adult animals, emphasising the plasticity of the nervous system early in development...
  17. ncbi request reprint Acute pain management: current best evidence provides guide for improved practice
    Suellen M Walker
    Pain Med 7:3-5. 2006
  18. ncbi request reprint Combination spinal analgesic chemotherapy: an additional clinical trial of opioid plus local anesthetic
    Leonidas C Goudas
    Anesth Analg 96:1841. 2003