Genomes and Genes
Affiliation: University of Newcastle
- Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional studyLouise Hayes
Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
BMC Public Health 10:723. 2010..The aim of this study was to determine to what extent differences in metabolic health in very obese women are explained by differences in body fat distribution, insulin resistance and level of physical activity...
- The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK CaucasiansRachel M Freathy
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
BMC Med Genet 7:51. 2006..We performed a large case-control and family-based study to test the hypothesis that KL-VS is associated with type 2 diabetes in a UK Caucasian population...
- Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjectsM Walker
Diabetes Research Group, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Diabetologia 48:2470-6. 2005..The aim of this prospective study was to investigate predictors of deteriorating glucose tolerance in subjects of British extraction...
- Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk allelesL Pascoe
The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Diabetologia 51:1989-92. 2008..The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals...
- Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK populationS Patel
School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
Diabetologia 49:1209-13. 2006..The aim of our study was to determine whether common variants in ALMS1 contribute to susceptibility to type 2 diabetes in the UK population...
- Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controlsP F Chinnery
Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK
J Med Genet 44:e80. 2007..By studying 897 UK cases of type 2 diabetes and 1010 population-matched controls, it is shown that European mtDNA haplogroups are unlikely to play a major role in the risk of developing the disorder...
- Age-related decline in mitochondrial DNA copy number in isolated human pancreatic isletsL M Cree
Mitochondrial Research Group, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Diabetologia 51:1440-3. 2008..We investigated whether mtDNA copy number decreases with age in human pancreatic beta cells, which might in turn contribute to the age-related decline in insulin secretory capacity...
- Calpain inhibition and insulin action in cultured human muscle cellsL J Logie
School of Clinical Medical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Mol Genet Metab 85:54-60. 2005....
- Increased maternal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) associated with older age at diagnosis of Type 1 diabetes in offspringN J Leech
Department of Medicine, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle University, Newcastle upon Tyne, UK
Diabet Med 27:1450-3. 2010..Inherited differences in insulin action might also influence the evolution of Type 1 diabetes.Our aim was to determine whether parental BMI and insulin resistance influences age of onset of Type 1 diabetes in their offspring...
- Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetesP F Chinnery
Mitochondrial Research Group, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Lancet 366:1650-1. 2005..16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes...
- Rosiglitazone improves insulin sensitivity, glucose tolerance and ambulatory blood pressure in subjects with impaired glucose toleranceS M A Bennett
Department of Diabetes and Metabolism, Diabetes Resource Centre, University of Newcastle, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear NE29 8NH, Newcastle upon Tyne, UK
Diabet Med 21:415-22. 2004..To determine the effects of rosiglitazone on insulin sensitivity, glucose tolerance and ambulatory blood pressure when administered to subjects with persistent impaired glucose tolerance (IGT)...
- Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetesG W Mills
School of Clinical Medical Sciences, 4th Floor William Leech Block, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Diabetologia 47:732-8. 2004..The higher heritability estimate for pancreatic beta cell function suggests that this resource may be most effective when investigating genetic susceptibility to beta cell dysfunction...
- Prevalence and progression of diabetes in mitochondrial diseaseR G Whittaker
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Diabetologia 50:2085-9. 2007..3243A>G mutation...
- Elevated plasma non-esterified fatty acid levels and insulin secretion in non-diabetic relatives of type 2 diabetic patientsT J Butler
Department of Medicine, University of Newcastle, Newcastle upon Tyne, UK
Clin Endocrinol (Oxf) 55:349-55. 2001....
- Non-diabetic relatives of Type 2 diabetic families: dietary intake contributes to the increased risk of diabetesA J Adamson
Human Nutrition Research Centre and School of Clinical Medical Sciences, University of Newcastle, Newcastle, UK
Diabet Med 18:984-90. 2001..This is assumed to reflect a shared genetic predisposition. The aim of this study was to test the hypothesis that lifestyle factors, specifically dietary factors, are also important to the increased risk in non-diabetic relatives...
- Nonrandom tissue distribution of mutant mtDNAP F Chinnery
Department of Neurology, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
Am J Med Genet 85:498-501. 1999..The probability of observing any strict hierarchy in family is 4.82 x 10(-5). These results indicate that the distribution of the A3243G mutation is not solely determined by random processes...
- Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch dietM E Daly
Human Nutrition Research Centre, the Department of Biological and Nutritional Sciences, University of Newcastle upon Tyne, United Kingdom
Am J Clin Nutr 67:1186-96. 1998..001). Plasma fatty acid concentrations showed a late postprandial rise with the sucrose-rich diet relative to the starch-rich diet, which was mirrored with a fractionally later peak in triacylglycerol concentrations...
- Attention and fluctuating attention in patients with dementia with Lewy bodies and Alzheimer diseaseC Ballard
Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle, England NE4 6BE
Arch Neurol 58:977-82. 2001....
- Common variation in the adiponectin gene has an effect on systolic blood pressureP J Avery
School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, UK
J Hum Hypertens 25:719-24. 2011..Genotype at the C-11377G (rs266729) polymorphism has independent effects both on waist-hip ratio and SBP. This may help in understanding the complex role that the adiponectin gene has in atherosclerosis...
- Mitochondrial diabetesM Walker
Diabetes Research Group, School of Clinical Medical Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Diabet Med 22:18-20. 2005
- Genetics of type 2 diabetes and insulin resistance: knowledge from human studiesE A McIntyre
School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
Clin Endocrinol (Oxf) 57:303-11. 2002....
- The characterisation and impact of 'fluctuating' cognition in dementia with Lewy bodies and Alzheimer's diseaseC Ballard
Institute of Health for the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
Int J Geriatr Psychiatry 16:494-8. 2001..CONCLUSIONS: Although attention is the cognitive domain which fluctuates most markedly, other cognitive domains are also affected. FC also has a significant independent impact on activities of daily living...
- An association analysis of the HLA gene region in latent autoimmune diabetes in adultsM Desai
Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford, OX3 7LJ, UK
Diabetologia 50:68-73. 2007..Our aim was to define patterns of HLA-encoded susceptibility/protection in a large, well characterised LADA cohort, and to establish association with disease and age at diagnosis...
- Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian originP G Cassell
Department of Diabetes and Metabolic Medicine, St Bartholomews and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
Diabetologia 43:1558-64. 2000..Our aim was to study the pathophysiological role of this variant in diabetes-related and obesity-related traits using two distinct ethnic populations...
- An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemiaS M Poucher
Cardiovascular and Gastrointestinal Discovery Department, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, UK
Br J Pharmacol 152:1239-47. 2007..Studies in cultured hepatocytes demonstrate glycogen synthase (GS) activation with glycogen phosphorylase (GP) inhibitors. The current study investigated whether these phenomena occurred in vivo using a novel GP inhibitor...
- Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern EuropeansS Wiltshire
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Ann Hum Genet 70:726-37. 2006....
- Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United KingdomJ C Evans
Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter, EX2 5AX, United Kingdom
Am J Hum Genet 69:544-52. 2001..In conclusion, we were not able to replicate the association of the specific calpain-10 alleles identified by Horikawa et al. but suggest that other alleles at this locus may increase type 2 diabetes risk in the U.K. population...
- Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndromeJ A L Minton
Medical and Molecular Genetics, Institute for Biomedical Research, The Medical School, Edgbaston, Birmingham B15 2TT, United Kingdom
J Clin Endocrinol Metab 91:3110-6. 2006..The abdominal obesity, insulin resistance, diabetes, hypertriglyceridemia, and hypertension suggest that AS could represent a monogenic model for the metabolic syndrome...
- Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetesE Zeggini
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Site, Old Road, Headington, Oxford OX3 7LJ, UK
Diabetologia 48:2013-7. 2005..The present study aimed to obtain a robust assessment of the role of variation in the tightly linked TNF/LTA region in diabetes susceptibility by genotyping TNF and LTA variants in large case-control resources...
- A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1qS Wiltshire
Imperial College Genetics and Genomics Research Institute and Division of Medicine, Imperial College, London, United Kingdom
Am J Hum Genet 69:553-69. 2001..These data should accelerate positional cloning efforts in these regions of interest...
- Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutationR Murphy
Institute of Biomedical Sciences, Peninsula Medical School, Exeter, UK
Diabet Med 25:383-99. 2008....
- Soluble adhesion molecules and prediction of coronary heart disease: a prospective study and meta-analysisI Malik
BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, W12 0NN, London, UK
Lancet 358:971-6. 2001..61) and 1.13 (0.78-1.62); and P-selectin: 1.23 (0.96-1.56) and 1.20 (0.81-1.76). INTERPRETATION: The measurement of these adhesion molecules is unlikely to add much predictive information to that provided by more established risk factors...
- The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectivesS A Hills
EGIR-RISC Coordinating Office, Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100, Pisa, Italy
Diabetologia 47:566-70. 2004..CONCLUSIONS: This study will evaluate the importance of insulin resistance in the development of CVD and diabetes, and has implications for the development of prevention and treatment strategies...
- Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samplesE Zeggini
Oxford Centre for Diabetes, Endocrinology and Metabolism, Headington, Oxford, UK
Diabet Med 22:1696-700. 2005..The present study makes use of large, well-characterized case-control resources to enhance understanding of this susceptibility effect by examining related traits, such as body mass index (BMI), waist-hip ratio and age at diagnosis...
- Cultured muscle cells from insulin-resistant type 2 diabetes patients have impaired insulin, but normal 5-amino-4-imidazolecarboxamide riboside-stimulated, glucose uptakeE A McIntyre
School of Clinical Medical Sciences, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
J Clin Endocrinol Metab 89:3440-8. 2004..This supports an intrinsic abnormality of the diabetic muscle cells that is most likely to have a genetic basis...
- Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetesK R Owen
Diabetologia 47:957-8. 2004
- Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolismC F Liew
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
Diabetologia 47:2168-75. 2004..Given this strong positional and biological candidacy, the present study sought to establish whether sequence variation in SCD influences susceptibility to type 2 diabetes and related traits...
- Paternal age and birth defects: how strong is the association?Q Yang
OMNI Research Group, Ottawa Hospital Research Institute, Ottawa, Canada
Hum Reprod 22:696-701. 2007..Although the association between maternal age and the risks of birth defects has been well studied, the evidence from population data linking paternal age with birth defects was limited and inconsistent...
- Effects of intensive glucose lowering in type 2 diabetesHertzel C Gerstein
N Engl J Med 358:2545-59. 2008..These findings identify a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00000620.)..
- Hyperglucagonaemia is not a primary metabolic defect in non-diabetic first-degree relatives from Type 2 diabetic familiesM K Jayapaul
Diabet Med 24:1050-1. 2007
- Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisationJ Danesh
Eur J Epidemiol 23:531-40. 2008..This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis...
- The impact of follicular lymphoma on health-related quality of lifeR Pettengell
Haematology and Oncology, St George s Hospital, London, UK
Ann Oncol 19:570-6. 2008..The purpose of this study was to determine whether there was a relationship between disease activity and health functioning, as measured by a range of patient-reported outcome (PRO) measures in patients with follicular lymphoma (FL)...
- Q-TWiST analysis of lapatinib combined with capecitabine for the treatment of metastatic breast cancerB Sherrill
RTI Health Solutions, Research Triangle Park, NC 27709, USA
Br J Cancer 99:711-5. 2008..Combination therapy of lapatinib with capecitabine resulted in greater quality-adjusted survival than capecitabine monotherapy in trastuzumab-refractory MBC patients...
- GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetesH A J Castleden
Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, UK
Diabet Med 23:834-8. 2006..This suggests that, in this subgroup of patients, autoimmune pancreatic beta-cell destruction occurs on a background of Type 2 diabetes genetic susceptibility...
- Reduced beta cell function in offspring of mothers with young-onset type 2 diabetesR Singh
Institute of Biomedical Sciences, Peninsula Medical School, Barrack Road, Exeter EX2 5AX, UK
Diabetologia 49:1876-80. 2006..This is consistent with exposure to mild maternal hyperglycaemia programming beta cell function...
- Fibrin D-dimer and coronary heart disease: prospective study and meta-analysisJ Danesh
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Medicine, University of Oxford, Oxford
Circulation 103:2323-7. 2001..CONCLUSION:Although there may be an association between circulating D-dimer values and CHD, further studies are needed to determine the extent to which this is causal...
- Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosisW Lowes
Department of Medicine, Human Diabetes and Metabolism Research Centre, The University of Newcastle upon Tyne, UK
Biochim Biophys Acta 1379:134-42. 1998..Furthermore glucokinase is dramatically suppressed in liver disease, which although partly compensated for by the increase in hexokinase I (and II), accounts in part for the well-known glucose intolerance of liver cirrhosis...
- The effect of variable heart rate decelerations on intraventricular hemorrhage and other perinatal outcomes in preterm infantsP Holmes
Division of Maternal-Fetal Medicine, Ottawa Hospital, Ontario, Canada
J Matern Fetal Med 10:264-8. 2001..Further study is required to determine whether these infants would benefit from early Cesarean section...
- Low prevalence of lipid lowering drug use in older men with established coronary heart diseaseP H Whincup
Department of Public Health Sciences, St George s Hospital Medical School, London SW17 ORE, UK
Heart 88:25-9. 2002..To determine the prevalence and correlates of lipid lowering drug use among older British men with established coronary heart disease (CHD)...
- Biochemical measures in a population-based study: effect of fasting duration and time of dayJ R Emberson
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF, UK
Ann Clin Biochem 39:493-501. 2002..Few studies have examined the extent to which the use of a defined protocol for fasting in epidemiological studies abolishes the influence of fasting duration and time of day on biochemical measurements...
- von Willebrand factor and coronary heart disease: prospective study and meta-analysisP H Whincup
Department of Public Health Sciences, St George's Hospital Medical School, London, UK
Eur Heart J 23:1764-70. 2002..CONCLUSION: Though circulating von Willebrand factor concentrations may be associated with incident coronary heart disease, further studies are needed to determine the extent to which this is causal...
- Non-attendance at re-examination 20 years after screening in the British Regional Heart StudyM C Thomas
Department of Primary College Medical School, Rowland Hill Street, London NW3 2PF
J Public Health Med 24:285-91. 2002....
- Heteroplasmic ratio of the A3243G mitochondrial DNA mutation in single pancreatic beta cellsS Lynn
Department of Medicine, The Medical School, University of Newcastle upon Tyne, Framlington Place, NE2 4HH Newcastle upon Tyne, United Kingdom
Diabetologia 46:296-9. 2003....
- North-south gradients in Britain for stroke and CHD: are they explained by the same factors?R W Morris
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF UK
Stroke 34:2604-9. 2003..The geographic variation in CHD and stroke within Great Britain is well known. We aimed to quantify these variations and to determine the contribution of established risk factors...
- Birthweight of offspring and paternal insulin resistance and paternal diabetes in late adulthood: cross sectional surveyS G Wannamethee
Department of Primary Care and Population Science, Royal Free and University College Medical School, Rowland Hill St, NW3 2PF London, UK
Diabetologia 47:12-8. 2004..To confirm this we examined the association between offspring birthweight and paternal insulin resistance and diabetes in late adulthood...
- Overweight and obesity and the burden of disease and disability in elderly menS Goya Wannamethee
Department of Primary Care and Population Science, Royal Free and University College Medical School, London, UK
Int J Obes Relat Metab Disord 28:1374-82. 2004..To examine the prevalence of disease burden and disability associated with overweight and obesity in men aged 60-79 y and to assess whether the current WHO weight guidelines are appropriate in the elderly...
- Inequalities in coronary revascularisation during the 1990s: evidence from the British regional heart studyR W Morris
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF, UK
Heart 91:635-40. 2005..To investigate the influence of age and social circumstances on probability of revascularisation among British men...
- Neonatal mortality and morbidity in vertex-vertex second twins according to mode of delivery and birth weightQ Yang
OMNI Research Group, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, and Ottawa Health Research Institute, Ottawa, Canada
J Perinatol 26:3-10. 2006..To assess the risk of neonatal mortality and morbidity in vertex-vertex second twins according to mode of delivery and birth weight...
- Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysisG D O Lowe
University Department of Medicine, Royal Infirmary, Glasgow, UK
Eur Heart J 25:252-9. 2004..To determine whether circulating tissue plasminogen activator (t-PA) antigen concentrations are prospectively related to risk of coronary heart disease (CHD) in the general population...
- Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trialsI Chau
Department of Medicine, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, and University College London Hospitals, UK
Br J Cancer 94:1107-15. 2006..However, it did not produce survival advantage over PVI 5-FU. Lack of toxicity for gastrazole may allow its combination with cytotoxic drugs...
- Lichen myxoedematosus with associated cardiac abnormalitiesR Morris-Jones
Department of Dermatology, St Mary's Hospital, London W2 1NY
Br J Dermatol 144:594-6. 2001..To our knowledge, this is the first report to link lichen myxoedematosus with a valvular mucinous mass. This case also demonstrates the slow clinical progression of the disease over 20 years...