B R Walker

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint 11 beta-hydroxysteroid dehydrogenase in vascular smooth muscle and heart: implications for cardiovascular responses to glucocorticoids
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, United Kingdom
    Endocrinology 129:3305-12. 1991
  2. ncbi request reprint Activation of the hypothalamic-pituitary-adrenal axis in obesity: cause or consequence?
    B R Walker
    Department of Medical Sciences, Western General Hospital, University of Edinburgh, UK
    Growth Horm IGF Res 11:S91-5. 2001
  3. ncbi request reprint Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats
    Dawn E W Livingstone
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    J Pharmacol Exp Ther 305:167-72. 2003
  4. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Trends Endocrinol Metab 15:418-24. 2004
  5. ncbi request reprint Glucocorticoids and cardiovascular disease
    Brian R Walker
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Eur J Endocrinol 157:545-59. 2007
  6. pmc Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis
    David P Macfarlane
    University BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom
    Am J Physiol Endocrinol Metab 300:E402-9. 2011
  7. pmc Measurement of tamsulosin in human serum by liquid chromatography-tandem mass spectrometry
    Rita Upreti
    Endocrinology, University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 930:121-8. 2013
  8. pmc 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo
    Tijana Mitić
    Endocrinology, University British Heart Foundation Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Biochem Pharmacol 86:146-53. 2013
  9. ncbi request reprint Is "Cushing's disease of the omentum" an affliction of mouse and men?
    B R Walker
    Endocrinology Unit, University of Edinburgh, Western General Hospital, EH4 2XU, Edinburgh, UK
    Diabetologia 47:767-9. 2004
  10. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 in obesity
    Brian R Walker
    University of Edinburgh, Endocrinology Unit, Western General Hospital, Edinburgh, United Kingdom
    Obes Res 12:1-3. 2004

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint 11 beta-hydroxysteroid dehydrogenase in vascular smooth muscle and heart: implications for cardiovascular responses to glucocorticoids
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, United Kingdom
    Endocrinology 129:3305-12. 1991
    ..Thus, 11 beta-OHSD is appropriately sited to modulate access of corticosterone to vascular receptors and could influence vascular resistance, cardiac output and thereby blood pressure...
  2. ncbi request reprint Activation of the hypothalamic-pituitary-adrenal axis in obesity: cause or consequence?
    B R Walker
    Department of Medical Sciences, Western General Hospital, University of Edinburgh, UK
    Growth Horm IGF Res 11:S91-5. 2001
    ..Selective inhibition of 11beta-HSD1 provides a novel therapeutic target for lowering intra-adipose cortisol concentrations and effect, without inducing other adverse effects of cortisol deficiency...
  3. ncbi request reprint Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats
    Dawn E W Livingstone
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    J Pharmacol Exp Ther 305:167-72. 2003
    ..Inhibition of adipose 11beta-HSD1 is probably necessary to gain the maximum benefit of an 11beta-HSD1 inhibitor...
  4. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Trends Endocrinol Metab 15:418-24. 2004
    ..The ongoing development of selective 11beta-HSD1 inhibitors affords the opportunity to explore a new approach to some major common disorders...
  5. ncbi request reprint Glucocorticoids and cardiovascular disease
    Brian R Walker
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Eur J Endocrinol 157:545-59. 2007
    ..The conclusion is that manipulation of glucocorticoid action within metabolic and cardiovascular tissues may provide novel therapeutic avenues to combat cardiovascular disease...
  6. pmc Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis
    David P Macfarlane
    University BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom
    Am J Physiol Endocrinol Metab 300:E402-9. 2011
    ..4 ± 0.4 μmol/day, P < 0.01). These findings suggest that important alterations in hepatic fatty acid metabolism may promote the development of steatohepatitis. Similar mechanisms may predispose to hepatocyte damage in human NASH...
  7. pmc Measurement of tamsulosin in human serum by liquid chromatography-tandem mass spectrometry
    Rita Upreti
    Endocrinology, University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 930:121-8. 2013
    ..The method was successfully applied to samples taken from research volunteers in a clinical study of benign prostatic hyperplasia...
  8. pmc 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo
    Tijana Mitić
    Endocrinology, University British Heart Foundation Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Biochem Pharmacol 86:146-53. 2013
    ..In health, 7-oxysterols are unlikely to regulate glucocorticoid metabolism. However, in hyperlipidaemia, 7-oxysterols may inhibit glucocorticoid metabolism and modulate signaling through corticosteroid receptors...
  9. ncbi request reprint Is "Cushing's disease of the omentum" an affliction of mouse and men?
    B R Walker
    Endocrinology Unit, University of Edinburgh, Western General Hospital, EH4 2XU, Edinburgh, UK
    Diabetologia 47:767-9. 2004
  10. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 in obesity
    Brian R Walker
    University of Edinburgh, Endocrinology Unit, Western General Hospital, Edinburgh, United Kingdom
    Obes Res 12:1-3. 2004
  11. ncbi request reprint Low birth weight predicts higher blood pressure but not dermal capillary density in two populations
    R John Irving
    BHF Senior Research Fellow and Professor of Endocrinology, University of Edinburgh, Endocrinology Unit, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK
    Hypertension 43:610-3. 2004
    ..We have found no evidence in these 2 cohorts that reduced capillary density explains the associations between lower birth weight and higher blood pressure...
  12. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease
    Brian R Walker
    University of Edinburgh, Endocrinology Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Expert Opin Ther Targets 7:771-83. 2003
    ..The clinical development of potent selective 11HSD1 inhibitors is now a high priority...
  13. ncbi request reprint Contrasting effects of intrauterine growth retardation and premature delivery on adult cortisol secretion and metabolism in man
    Brian R Walker
    University of Edinburgh, Department of Medical Sciences, Western General Hospital, UK
    Clin Endocrinol (Oxf) 57:351-5. 2002
    ..Body composition was measured by dual-energy X-ray absorptiometry (DEXA); plasma was obtained at 0900 h after overnight fast; and cortisol metabolites were measured in a 24-h urine sample by gas chromatography/mass spectrometry (GCMS)...
  14. ncbi request reprint Cortisol--cause and cure for metabolic syndrome?
    B R Walker
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Diabet Med 23:1281-8. 2006
    ..Thus, glucocorticoid signalling provides a potentially tractable system to influence both risk factors for, and the outcome of, Type 2 diabetes and cardiovascular disease...
  15. ncbi request reprint Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, UK
    Clin Endocrinol (Oxf) 49:257-63. 1998
    ..In this study, we examined the effects of GH replacement on cortisol metabolism...
  16. ncbi request reprint Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease
    Brian R Walker
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Ann N Y Acad Sci 1083:165-84. 2006
    ....
  17. ncbi request reprint Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, Edinburgh, UK
    J Intern Med 247:198-204. 2000
    ..This study sought to establish whether plasma cortisol is associated with cardiovascular risk factors in women as it is in men, and whether these relationships in either sex are confounded by obesity...
  18. ncbi request reprint Endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome
    B R Walker
    University of Edinburgh, Endocrinology Unit, Western General Hospital, Edinburgh, UK
    Clin Endocrinol (Oxf) 52:77-80. 2000
    ..Endogenous inhibitors of hepatic 11beta-HSD1 can be extracted from urine. We have tested the hypothesis that these are increased in patients with polycystic ovary syndrome...
  19. ncbi request reprint Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning
    Brian R Walker
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Proc Nutr Soc 66:1-8. 2007
    ..The present article focuses on the physiological role of glucocorticoids in regulating energy partitioning, and the evidence that this process is modulated by 11beta-HSD1 in human subjects...
  20. ncbi request reprint Increased glucocorticoid activity in men with cardiovascular risk factors
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, UK
    Hypertension 31:891-5. 1998
    ..It may be mediated by an abnormal glucocorticoid receptor, and it may contribute to the association between hypertension and insulin resistance...
  21. ncbi request reprint Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome
    R H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Minerva Endocrinol 32:141-59. 2007
    ..Trials in humans though will be the ultimate test to determine if inhibition of 11beta-HSD1 offers a new tool in the treatment of metabolic disease...
  22. ncbi request reprint Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids
    Mark E Cleasby
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 144:999-1007. 2003
    ..However, increased GR and attenuated fatty acid uptake specifically in visceral adipose are consistent with insulin resistance in this crucial metabolic depot and could indirectly contribute to increased hepatic glucose output...
  23. ncbi request reprint Activation of the endothelin system in insulin resistance
    R J Irving
    University of Edinburgh, Department of Medical Sciences, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, Scotland, UK
    QJM 94:321-6. 2001
    ..30, p<0.005). Endothelin-1 levels are not related to blood pressure, but are higher in healthy young men with insulin resistance and obesity...
  24. ncbi request reprint Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
    M J Finken
    University of Edinburgh, Department of Medical Sciences, Western General Hospital, United Kingdom
    J Clin Endocrinol Metab 84:3316-21. 1999
    ..A-Ring reductases may have an equally important influence on metabolic clearance of cortisol and intracellular cortisol concentrations...
  25. ncbi request reprint Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity
    Deborah J Wake
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh EH16 4TJ
    Endocrine 29:101-8. 2006
    ..The therapeutic potential of 11HSD1 in human obesity therefore remains highly promising but as yet unproven...
  26. ncbi request reprint Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men
    Deborah J Wake
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, United Kingdom
    J Clin Endocrinol Metab 92:1848-56. 2007
    ....
  27. ncbi request reprint Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
    Robert C Andrews
    University of Edinburgh, Endocrinology Unit, Department of Medical Sciences, Western General Hospital, Edinburgh, United Kingdom EH4 2XU
    J Clin Endocrinol Metab 88:285-91. 2003
    ..However, clinically useful therapeutic effects will probably require selective 11 beta-HSD1 inhibitors that lower intraadipose cortisol levels and enhance peripheral glucose uptake...
  28. ncbi request reprint Microvascular correlates of blood pressure, plasma glucose, and insulin resistance in health
    R J Irving
    Department of Medical Sciences, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK
    Cardiovasc Res 53:271-6. 2002
    ..Altered microvascular structure and function could contribute by increasing peripheral vascular resistance and decreasing tissue delivery of glucose. We addressed this hypothesis in a sample of healthy men...
  29. ncbi request reprint Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure
    P W F Hadoke
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Endocrinol 188:435-42. 2006
    ....
  30. ncbi request reprint Increased vasoconstrictor sensitivity to glucocorticoids in essential hypertension
    B R Walker
    Department of Medicine, Western General Hospital, University of Edinburgh, Scotland, UK
    Hypertension 27:190-6. 1996
    ....
  31. ncbi request reprint Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity
    Deborah J Wake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland EH4 2XU
    J Clin Endocrinol Metab 88:3983-8. 2003
    ..Although this may drive a compensatory increase in leptin synthesis, whether it has an adverse effect on intraadipose cortisol concentrations and GR-dependent gene regulation remains to be established...
  32. ncbi request reprint 11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome
    P M Stewart
    Department of Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Endocrinol Metab 80:3617-20. 1995
    ..The reason for the defective 11 beta HSD activity is unclear, but it may be secondary to substrate saturation, inhibition by other adrenal steroids, or product inhibition...
  33. ncbi request reprint Platelet aggregation in young men with contrasting predisposition to high blood pressure
    M E Dockrell
    University of Edinburgh, Department of Medicine, Western General Hospital, Scotland
    Am J Hypertens 12:115-9. 1999
    ..We conclude that enhanced platelet sensitivity to endothelin-1 appears to be a feature of the familial predisposition to hypertension, rather than a nonspecific consequence of high blood pressure...
  34. pmc Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries
    C A McIntyre
    Department of Medical Sciences, Western General Hospital, University of Edinburgh, Edinburgh
    Br J Pharmacol 133:902-8. 2001
    ....
  35. ncbi request reprint Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
    Thekkepat C Sandeep
    Endocrinology Unit, School of MolecularClinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, U K
    Diabetes 54:872-9. 2005
    ..However, obese men are less susceptible than lean men to the insulin-sensitizing effects of carbenoxolone. To be useful in obese patients, 11HSD1 inhibitors will need to inhibit the enzyme more effectively in adipose tissue...
  36. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids
    Clare Christy
    School of Molecular and Clinical Medicine, Endocrinology Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Hypertension 42:580-7. 2003
    ..Therefore, additional mechanisms, possibly involving indirect effects of enhanced corticosterone action in the kidney and the resultant hypertension, must be involved...
  37. ncbi request reprint The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans
    Ruth Andrew
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Diabetes 54:1364-70. 2005
    ..Thus, in addition to free fatty acids and adipokines, the portal vein delivers cortisol to the liver, and inhibition of 11HSD1 in visceral adipose tissue may indeed be valuable in ameliorating insulin resistance in obesity...
  38. ncbi request reprint Glucocorticoid metabolism and the Metabolic Syndrome: associations in an elderly cohort
    R Andrew
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU
    Exp Clin Endocrinol Diabetes 110:284-90. 2002
    ..We have investigated relationships between glucocorticoid production and features of the Metabolic Syndrome in a cohort of elderly subjects...
  39. ncbi request reprint Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women
    R M Reynolds
    Endocrinology Unit, University of Edinburgh, Queens Medical Research Institute, EH16 4TJ Edinburgh, UK
    Calcif Tissue Int 77:134-8. 2005
    ..These data provide evidence that circulating endogenous glucocorticoids influence the rate of involutional bone loss in healthy individuals...
  40. ncbi request reprint 11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity
    Katherine A Hughes
    Clinical Fellow University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Expert Opin Investig Drugs 17:481-96. 2008
    ..Glucocorticoids such as cortisol are important regulators of fuel metabolism during starvation and stress. Chronic glucocorticoid excess induces obesity with multiple features of the metabolic syndrome...
  41. ncbi request reprint Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats
    Pascal Barat
    Paediatric Endocrinology, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh, United Kingdom
    Endocrinology 148:4836-43. 2007
    ..By contrast, androgens tonically suppress hepatic A-ring reductases in male rats and do not contribute to dysregulation of these enzymes in obesity...
  42. ncbi request reprint Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?
    Mark E Cleasby
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 148:129-38. 2003
    ..However, cause and effect between altered GR expression, hypercorticosteronaemia, and hyperinsulinaemia remains to be established...
  43. ncbi request reprint A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet
    Peter J Raubenheimer
    University of Edinburgh, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Diabetes 55:2015-20. 2006
    ..We conclude that liver fat accumulation per se does not cause insulin resistance during high-fat feeding and that choline deficiency may shunt potentially toxic free fatty acids toward innocuous storage triglyceride in the liver...
  44. ncbi request reprint Obese Zucker rats have reduced mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 1 expression in hippocampus-implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity
    Cecilia Mattsson
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 144:2997-3003. 2003
    ..This may be exacerbated by impaired local regeneration of corticosterone by 11betaHSD1. These abnormalities could contribute to the subtle changes in the HPA axis in rodent and human obesity...
  45. ncbi request reprint Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Recent Prog Horm Res 59:359-93. 2004
    ..Adipose 11beta-HSD1 deficiency contributes to a protective metabolic phenotype, supporting its role as a therapeutic target for the metabolic syndrome...
  46. ncbi request reprint A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid
    S Forbes
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Diabetologia 56:2021-33. 2013
    ....
  47. pmc Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    J Labad
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Diabetologia 53:467-71. 2010
    ..The aim of the study was to identify risk factors for depression and anxiety in a well-characterised cohort of individuals with type 2 diabetes mellitus...
  48. pmc Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice
    Alison D McNeilly
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Hepatol 52:705-11. 2010
    ..We investigated whether this was mediated through bile acids acting to impair steroid clearance by inhibiting glucocorticoid metabolism by 5beta-reductase...
  49. ncbi request reprint Acute in vivo regulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans
    Deborah J Wake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Clin Endocrinol Metab 91:4682-8. 2006
    ....
  50. ncbi request reprint Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome
    David P Macfarlane
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    J Endocrinol 197:189-204. 2008
    ....
  51. ncbi request reprint Pathophysiology of modulation of local glucocorticoid levels by 11beta-hydroxysteroid dehydrogenases
    T C Sandeep
    Endocrinology Unit, Dept of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, UK EH4 2XU
    Trends Endocrinol Metab 12:446-53. 2001
    ..These data provide encouragement that novel therapies will arise from a fuller understanding of the 11beta HSD system...
  52. ncbi request reprint Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity
    Zoi Michailidou
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Obesity (Silver Spring) 15:1155-63. 2007
    ..Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome...
  53. ncbi request reprint Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma
    John Stokes
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, U K
    Invest Ophthalmol Vis Sci 44:5163-7. 2003
    ..This study was an investigation of the central and peripheral sensitivity to glucocorticoids in patients with POAG or ocular hypertension (OHT) and the differential metabolism of glucocorticoids by 11beta-HSDs...
  54. ncbi request reprint Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance
    Robert C Andrews
    University of Edinburgh, Endocrinology Unit, Department of Medical Sciences, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Clin Endocrinol Metab 87:5587-93. 2002
    ..Thus, altered cortisol action occurs not only in obesity and hypertension but also in glucose intolerance, and could therefore contribute to the link between these multiple cardiovascular risk factors...
  55. ncbi request reprint Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity
    Deborah J Wake
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Scotland, UK
    Clin Endocrinol (Oxf) 66:440-6. 2007
    ..We aimed to test associations between body fat or fat distribution and mRNA transcript levels for androgen and oestrogen receptors and for enzymes metabolizing sex steroids in adipose tissue...
  56. pmc Preventing local regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 enhances angiogenesis
    Gary R Small
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK
    Proc Natl Acad Sci U S A 102:12165-70. 2005
    ....
  57. ncbi request reprint Steroid metabolism in metabolic syndrome X
    B R Walker
    The University of Edinburgh, Endocrinology Unit, Department of Medical Sciences, Western General Hospital, Edinburgh, Scotland, EH4 2XU, UK
    Best Pract Res Clin Endocrinol Metab 15:111-22. 2001
    ..Some of these changes in steroid metabolism lend themselves to therapeutic manipulation which may provide novel strategies to reduce cardiovascular risk...
  58. doi request reprint Idiopathic intracranial hypertension: can studies of obesity provide the key to understanding pathogenesis?
    L Y Ooi
    Department of Clinical Neurosciences, Western General Hospital and Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Br J Neurosurg 22:187-94. 2008
    ....
  59. ncbi request reprint Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action
    J R Seckl
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:1371-6. 2001
    ..Inhibition of 11beta-HSD1 represents a potential target for therapy of disorders that might be ameliorated by local reduction of glucocorticoid action, including type 2 diabetes, obesity, and age-related cognitive dysfunction...
  60. ncbi request reprint Elevated plasma cortisol in glucose-intolerant men: differences in responses to glucose and habituation to venepuncture
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, SO16 6YD Southampton, United Kingdom
    J Clin Endocrinol Metab 86:1149-53. 2001
    ..18), who showed a lack of habituation to repeated plasma measurements. These data support the hypothesis that alterations in central regulation of the hypothalamic-pituitary-adrenal axis may be important in glucose intolerance...
  61. ncbi request reprint Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 86:245-50. 2001
    ..This may be an important mechanism underpinning the effects of events in early life on later cardiovascular disease...
  62. ncbi request reprint Acute effects of glucocorticoids on endothelial fibrinolytic and vasodilator function in humans
    Anna R Dover
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK
    J Cardiovasc Pharmacol 50:321-6. 2007
    ..These findings suggest that glucocorticoids do not exert acute effects on endothelial function in vivo in humans...
  63. pmc Increased whole-body and sustained liver cortisol regeneration by 11beta-hydroxysteroid dehydrogenase type 1 in obese men with type 2 diabetes provides a target for enzyme inhibition
    Roland H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    Diabetes 60:720-5. 2011
    ..To examine this, we quantified in vivo whole-body, splanchnic, and hepatic 11β-HSD1 activity in obese type 2 diabetic subjects...
  64. pmc Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles
    Scott P Webster
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Bioorg Med Chem Lett 20:3265-71. 2010
    ..Compounds are selective for 11beta-HSD1 over 11beta-HSD2 and possess good cellular potency in human and murine 11beta-HSD1 assays. A range of in vitro stabilities are observed in human liver microsome assays...
  65. doi request reprint Glucocorticoids turn over slowly in human adipose tissue in vivo
    Katherine A Hughes
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 95:4696-702. 2010
    ..In other organs, transport can be regulated in a steroid- and tissue-specific manner. Moreover, 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) generates additional cortisol within adipose...
  66. doi request reprint Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 151:1581-7. 2010
    ..This may be due to depot-specific-programmed alterations in fat metabolism in adipose tissue...
  67. pmc Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010
    ..We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
  68. pmc Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency
    Dawn E W Livingstone
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 201:211-8. 2009
    ....
  69. ncbi request reprint Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors
    Scott P Webster
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Bioorg Med Chem Lett 17:2838-43. 2007
    ..Selected compounds are selective for 11beta-HSD1 over 11beta-HSD2 and possess excellent cellular potency in human and murine 11beta-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays...
  70. pmc Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice
    Karen Sooy
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Neurosci 30:13867-72. 2010
    ..These data support the use of selective 11β-HSD1 inhibitors in the treatment of age-related cognitive impairments...
  71. doi request reprint Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queen s Medical Research Institute, Edinburgh, UK
    Hypertension 53:932-6. 2009
    ....
  72. pmc Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease
    Patrick W F Hadoke
    Centre for Cardiovascular Sciences, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    Br J Pharmacol 156:689-712. 2009
    ..This will provide greater insights into the potential benefit of selective 11beta-hydroxysteroid dehydrogenase inhibitors in treatment of cardiovascular disease...
  73. pmc Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans
    Roland H Stimson
    Endocrinology Unit, University of Edinburgh, Edinburgh, Scotland, UK
    Diabetes 58:46-53. 2009
    ..Inhibition of 11beta-HSD1 is a promising therapeutic approach in type 2 diabetes. However, release of cortisol by 11beta-HSD1 from adipose tissue and its effect on portal vein cortisol concentrations have not been quantified in vivo...
  74. ncbi request reprint Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men
    Roland H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 92:4480-4. 2007
    ..However, whether longer-term differences in dietary macronutrients affect cortisol metabolism in humans and contribute to the tissue-specific dysregulation of cortisol metabolism in obesity is unknown...
  75. pmc Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 95:1602-8. 2010
    ..People with type 2 diabetes are at increased cardiovascular disease risk and thus are suitable to study associations of plasma cortisol with cardiovascular risk...
  76. ncbi request reprint Can cortisol predict the future in obesity?
    Rebecca M Reynolds
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, Edinburgh, UK
    Clin Endocrinol (Oxf) 67:1-2. 2007
  77. ncbi request reprint Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Diabetes 53:931-8. 2004
    ..These data provide the first in vivo evidence that adipose 11 beta-HSD-1 deficiency beneficially alters adipose tissue distribution and function, complementing the reported effects of hepatic 11 beta-HSD-1 deficiency or inhibition...
  78. ncbi request reprint Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
    ....
  79. ncbi request reprint 11 beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome
    Deborah J Wake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, 2nd Floor Out Patients Building, Edinburgh EH4 2XU, UK
    Mol Cell Endocrinol 215:45-54. 2004
    ..Newer selective 11HSD1 inhibitors are in development, which may achieve reduced cortisol action in adipose tissue and confer therapeutic benefit in obese patients...
  80. ncbi request reprint Human insulin resistance: the role of glucocorticoids
    Rebecca M Reynolds
    University of Edinburgh, Department of Medical Sciences, Western General Hospital, Edinburgh, UK
    Diabetes Obes Metab 5:5-12. 2003
  81. ncbi request reprint Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 146:913-9. 2005
    ..Acute exposure to HF diet alters glucocorticoid metabolism, predicting lower hepatic and adipose intracellular glucocorticoid concentrations, which may be a key mechanism protecting against the metabolic complications of obesity...
  82. ncbi request reprint Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity?
    Rebecca M Reynolds
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 152:249-53. 2005
    ..In animal models females are more sensitive than males to HPA axis programming, but whether gender influences susceptibility in humans is unknown...
  83. pmc Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats
    Roland H Stimson
    Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e8779. 2010
    ....
  84. ncbi request reprint Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization
    Dawn E W Livingstone
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Obes Res 13:1523-6. 2005
    ..Here we characterize hepatic 5alpha- and 5beta-reductase in obese rats and their responses to insulin sensitization...
  85. ncbi request reprint Intravascular glucocorticoid metabolism during inflammation and injury in mice
    Anna R Dover
    Clinical Lecturer, Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, Scotland, UK
    Endocrinology 148:166-72. 2007
    ..We conclude that increased generation of glucocorticoids by 11betaHSD1 in the murine vessel wall is unlikely to contribute to feedback regulation of inflammation...
  86. ncbi request reprint Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, UK
    Neurosci Lett 393:74-7. 2006
    ..91) and rs846910-A/G (p=.90) between the groups. We conclude that these variants in HSD11B1 are not significant contributors to the range of cognitive ageing examined here...
  87. ncbi request reprint Distinguishing the activities of 11beta-hydroxysteroid dehydrogenases in vivo using isotopically labeled cortisol
    Ruth Andrew
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland EH4 2XU, United Kingdom
    J Clin Endocrinol Metab 87:277-85. 2002
    ..This technique offers a significant advance in the methods available to measure turnover in 11betaHSDs and isozymes of 11betaHSDs in vivo in human studies, and this study confirms that carbenoxolone inhibits both isozymes of 11betaHSD...
  88. ncbi request reprint Differences in cortisol concentrations in South Asian and European men living in the United Kingdom
    Rebecca M Reynolds
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Clin Endocrinol (Oxf) 64:530-4. 2006
    ..The aim of the study was to examine ethnic differences in cortisol levels and to compare the relationships between cortisol levels and cardiovascular risk factors in men from different ethnic groups...
  89. pmc 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects
    C Yang
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 164:1661-71. 2011
    ..5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo...
  90. ncbi request reprint Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase
    P W Hadoke
    Endocrinology, Endothelial Cell Biology, and Molecular Physiology groups, University of Edinburgh, Edinburgh, UK
    Circulation 104:2832-7. 2001
    ..Both are present in the vessel wall; here, using mice with selective inactivation of 11betaHSD isozymes, we test the hypothesis that 11betaHSDs influence vascular function...
  91. ncbi request reprint The utility of three different methods for measuring urinary 18-hydroxycortisol in the differential diagnosis of suspected primary hyperaldosteronism
    R M Reynolds
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 152:903-7. 2005
    ..We have evaluated three urine 18-OHF methods using a panel of urine samples from patients with hypertension...
  92. ncbi request reprint Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease
    R M Reynolds
    Centre for Cardiovascular Sciences, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland, UK
    QJM 102:469-75. 2009
    ..This may be due to different sampling conditions, reflecting basal cortisol levels, vs. responsiveness of HPA axis activity, which may have diverse influences on the pathogenesis of atherosclerosis...
  93. doi request reprint Cortisol inactivation by 11beta-hydroxysteroid dehydrogenase-2 may enhance endometrial angiogenesis via reduced thrombospondin-1 in heavy menstruation
    Mick Rae
    Centre for Reproductive Biology, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 94:1443-50. 2009
    ..Because glucocorticoids inhibit angiogenesis in other organs, we hypothesized that endometrium of women with HMB is subject to decreased local glucocorticoid exposure and enhanced angiogenesis, thereby increasing menstrual bleeding...
  94. pmc 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics
    Thekkepat C Sandeep
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 101:6734-9. 2004
    ..11beta-HSD1 inhibition may be a new approach to prevent/ameliorate cognitive decline...
  95. ncbi request reprint Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function
    P W F Hadoke
    Endocrinology Unit, Centre for Cardiovascular Science, Edinburgh University, The Queen s Medical Research Institute, 47, Little France Crescent, Edinburgh EH16 4TJ, Scotland United Kingdom
    Cell Mol Life Sci 63:565-78. 2006
    ..Hence, inhibition of 11HSD isozymes may provide a novel therapeutic target in vascular disease...
  96. ncbi request reprint 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor
    Kerry J McInnes
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 279:22908-12. 2004
    ..Transcription of glucocorticoid-regulated genes in tissues that express 5alpha-reductases will thus be influenced by intracellular levels of both corticosterone and its 5alpha-reduced metabolites...
  97. doi request reprint Low serum cortisol predicts early death after acute myocardial infarction
    Rebecca M Reynolds
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Crit Care Med 38:973-5. 2010
    ..Low serum cortisol concentrations have been associated with adverse prognosis in critical illness of diverse etiology...
  98. ncbi request reprint Relationship Between Final Height and Health Outcomes in Adults With Congenital Adrenal Hyperplasia: United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE)
    T S Han
    Department of Endocrinology T S H, St Peter s National Health Service Foundation Trust, Surrey KT16 0PZ, United Kingdom Department of Endocrinology G S C, University College London Hospitals, London W1T 3AA, United Kingdom Society for Endocrinology D S W, Bristol BS32 4JT, United Kingdom Centre for Endocrinology, Diabetes, and Metabolism N K, W A, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom Centre for Endocrine and Diabetes Sciences D A R, Institute for Molecular and Experimental Medicine, Cardiff University, Cardiff CF10 3US, United Kingdom Endocrinology Unit R H S, B R W, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom and Academic Unit of Diabetes, Endocrinology, and Metabolism R J R, University of Sheffield, Sheffield S10 2HF, United Kingdom
    J Clin Endocrinol Metab 99:E1547-55. 2014
    ..We hypothesized that shorter adults will have more severe underlying disease and worse health outcomes...
  99. doi request reprint Increased prevalence of non-alcoholic fatty liver disease in European women with a history of gestational diabetes
    S Forbes
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Diabetologia 54:641-7. 2011
    ..We studied the prevalence of, and risk factors for, NAFLD in European women with previous gestational diabetes (GDM) at high risk of type 2 diabetes...
  100. ncbi request reprint The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk
    A J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK
    J Endocrinol 180:1-16. 2004
    ..This may represent a mechanism for the non-genetic inheritance of a predisposition to low birth weight and adverse cardiovascular risk across a number of generations...
  101. pmc Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels
    Elise L V Malavasi
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Endocrinology 151:195-202. 2010
    ..However, the rs13306421 A sequence variant originally reported in other ethnic groups may be of low prevalence because it was not detected in a population of 600 European Caucasian women...