H Waldmann

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology
    Susmit Suvas
    Department of Microbiology, M409, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Virol 79:11935-42. 2005
  2. pmc Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance
    Adrian R Kendal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, England, UK
    J Exp Med 208:2043-53. 2011
  3. pmc Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    BMC Immunol 7:9. 2006
  4. ncbi request reprint Reprogramming the immune system
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford, UK
    Immunol Rev 185:227-35. 2002
  5. doi request reprint Regulatory T cells: context matters
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Immunity 30:613-5. 2009
  6. ncbi request reprint A personal history of the CAMPATH-1H antibody
    Herman Waldmann
    Sir William Dunn School of Pathology, Oxford
    Med Oncol 19:S3-9. 2002
  7. doi request reprint Regulation and privilege in transplantation tolerance
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    J Clin Immunol 28:716-25. 2008
  8. ncbi request reprint Therapeutic approaches for transplantation
    H Waldmann
    Sir William Dunn School of Pathology, South Parks Road, OX13RE, Oxford, UK
    Curr Opin Immunol 13:606-10. 2001
  9. ncbi request reprint Approaching tolerance in transplantation
    H Waldmann
    Sir William Dunn School of Pathology, Oxford, UK
    Int Arch Allergy Immunol 126:11-22. 2001
  10. ncbi request reprint Therapeutic aspects of tolerance
    H Waldmann
    Sir William Dunn School of Pathology, Oxford, UK
    Curr Opin Pharmacol 1:392-7. 2001

Detail Information

Publications106 found, 100 shown here

  1. pmc In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology
    Susmit Suvas
    Department of Microbiology, M409, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Virol 79:11935-42. 2005
    ..Our results are the first observations to determine in vivo kinetics of GITR and GITR-L expression after virus infection, and they emphasize the role of GITR-GITR-L interaction to regulate virus-induced immuno-inflammatory lesions...
  2. pmc Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance
    Adrian R Kendal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, England, UK
    J Exp Med 208:2043-53. 2011
    ..Empowering Foxp3(+) regulatory T cells in vivo offers a tractable route to avoid and correct tissue immunopathology...
  3. pmc Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    BMC Immunol 7:9. 2006
    ..A major challenge in the application of marrow transplantation as a route to immunological tolerance of a transplanted organ is to achieve hematopoietic stem cell (HSC) engraftment with minimal myelosuppressive treatments...
  4. ncbi request reprint Reprogramming the immune system
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford, UK
    Immunol Rev 185:227-35. 2002
    ..This review outlines the efforts of this laboratory over the last 25 years to exploit tolerance so as to reprogram the immune system for therapeutic purposes...
  5. doi request reprint Regulatory T cells: context matters
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Immunity 30:613-5. 2009
    ..Understanding how these cells develop and maintain stable function provides general insights into cellular differentiation in general, as well as new opportunities for therapeutic manipulation...
  6. ncbi request reprint A personal history of the CAMPATH-1H antibody
    Herman Waldmann
    Sir William Dunn School of Pathology, Oxford
    Med Oncol 19:S3-9. 2002
    ..Such studies have taught us a lot about the diseases themselves, as well as offering the prospect of harnessing immunological tolerance processes to facilitate a whole new approach to immunosuppression...
  7. doi request reprint Regulation and privilege in transplantation tolerance
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    J Clin Immunol 28:716-25. 2008
    ..Tolerated grafts can be shown to contain Treg cells, and we have proposed that they function within the graft and draining lymphoid tissue to generate a state of acquired privilege...
  8. ncbi request reprint Therapeutic approaches for transplantation
    H Waldmann
    Sir William Dunn School of Pathology, South Parks Road, OX13RE, Oxford, UK
    Curr Opin Immunol 13:606-10. 2001
    ....
  9. ncbi request reprint Approaching tolerance in transplantation
    H Waldmann
    Sir William Dunn School of Pathology, Oxford, UK
    Int Arch Allergy Immunol 126:11-22. 2001
    ..Perhaps to the patient, the holy grail of tolerance is not as important as the complete assurance that the graft will survive and continue to function in all circumstances...
  10. ncbi request reprint Therapeutic aspects of tolerance
    H Waldmann
    Sir William Dunn School of Pathology, Oxford, UK
    Curr Opin Pharmacol 1:392-7. 2001
    ....
  11. pmc Special regulatory T cell review: The suppression problem!
    Herman Waldmann
    Sir William Dunn School of Pathology, Oxford University, Oxford, UK
    Immunology 123:11-2. 2008
    ..I speak not to disprove what Brutus spoke, But here I am to speak what I do know" Shakespeare. Julius Caesar Act 3, Scene 2...
  12. ncbi request reprint Tolerance can be infectious
    Herman Waldmann
    Sir William Dunn School of Pathology, Oxford OX1 3RE, UK
    Nat Immunol 9:1001-3. 2008
    ..Studies focused on the goal of eliciting transplant tolerance led Herman Waldmann to rejuvenate discarded ideas of 'suppressor T cells'. Such cells are now known to exist...
  13. ncbi request reprint Regulatory T cells and organ transplantation
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
    Semin Immunol 16:119-26. 2004
    ..The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination...
  14. ncbi request reprint Infectious tolerance and the long-term acceptance of transplanted tissue
    Herman Waldmann
    Sir William Dunn School of Pathology, Oxford, UK
    Immunol Rev 212:301-13. 2006
    ..Regulation may operate at many stages of an immune response, even as a censor at the terminal differentiation stages of effector function...
  15. ncbi request reprint Transplantation tolerance-where do we stand?
    H Waldmann
    Sir William Dunn School of Pathology South Parks Road Oxford OX13RE United Kingdom
    Nat Med 5:1245-8. 1999
    ..However, a range of scientific, ethical, logistic and commercial issues have arisen, and must be resolved before tolerance induction for human allograft patients can become a reality...
  16. ncbi request reprint Exploiting tolerance processes in transplantation
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
    Science 305:209-12. 2004
    ..This would allow the minimization of immunosuppressive treatment and offers the prospect of eventually weaning transplant recipients off their drugs...
  17. ncbi request reprint The new immunosuppression
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
    Curr Opin Chem Biol 7:476-80. 2003
    ..Harnessing of tolerance mechanisms may enable more judicious use of conventional immunosuppressive agents even to the point of maintenance monotherapy, so limiting drug side effects and ensuring compliance...
  18. ncbi request reprint Contact between good friends: what limiting dilution analysis taught us
    H Waldmann
    Sir William Dunn School of Pathology, Oxford, UK
    Scand J Immunol 62:30-2. 2005
    ..Remarkably, those claims have not yet been retracted and our original findings that collaborating T cells and B cells must come into contact have never achieved the recognition that they deserved...
  19. pmc CAMPATH: from concept to clinic
    Herman Waldmann
    Sir William Dunn School of Pathology, University of Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 360:1707-11. 2005
    ..This drug has the potential to facilitate recruitment of tolerance processes so enabling drug minimization in transplantation, autoimmune and hypersensitivity diseases...
  20. ncbi request reprint Regulatory T cells in transplantation tolerance
    H Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Curr Top Microbiol Immunol 293:249-64. 2005
    ..Once tolerance is established, the continuous supply of graft antigens should sustain T cell mediated regulation as the dominant mechanism preventing graft rejection...
  21. doi request reprint Tolerance: an overview and perspectives
    Herman Waldmann
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Nat Rev Nephrol 6:569-76. 2010
    ....
  22. ncbi request reprint Regulatory T cells in transplantation
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Semin Immunol 18:111-9. 2006
    ..Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection...
  23. doi request reprint Reprogramming the immune system: co-receptor blockade as a paradigm for harnessing tolerance mechanisms
    Herman Waldmann
    Sir William Dunn School of Pathology, Oxford, UK
    Immunol Rev 223:361-70. 2008
    ..They have also identified an unexpected role for tissues to contribute to their own protection...
  24. ncbi request reprint CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression
    K Honey
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 163:4805-10. 1999
    ..Our results suggest that, although anti-CD40L Abs are attractive clinical immunotherapeutic agents, additional therapies to control aggressive CD8+ T cell responses may be required...
  25. ncbi request reprint Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance
    L Graca
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 165:4783-6. 2000
    ..Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise...
  26. ncbi request reprint Regulatory T cells overexpress a subset of Th2 gene transcripts
    Diana Zelenika
    Therapeutic Immunology Group, Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    J Immunol 168:1069-79. 2002
    ..They seem to represent a subset of transcripts shared with Th2 cells, suggesting that transplantation tolerance and normal immunoregulation may represent a unique form of Th2-like differentiation...
  27. pmc Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance
    H Waldmann
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Philos Trans R Soc Lond B Biol Sci 356:659-63. 2001
    ..Instead simple and low-impact procedures that harness tolerance processes used in conjunction with low doses of immunosuppressive drugs may prove the most reliable and user-friendly of approaches...
  28. ncbi request reprint The role of CD4+ T-cell subsets in determining transplantation rejection or tolerance
    D Zelenika
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:164-79. 2001
    ..g. tryptophan hydroxylase and FcepsilonR1alpha), suggesting that regulatory cell activity and this form of tolerance may be associated with a localised but non-destructive form of Th2-like activation and a recruitment of mast cells...
  29. ncbi request reprint Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection
    G Hale
    Sir William Dunn School of Pathology, University of Oxford, UK
    Blood 92:4581-90. 1998
    ..Using CAMPATH-1G to deplete residual host lymphocytes is a simple and practical method to do this. At least in AML, the beneficial reduction in GVHD can be achieved without an increased risk of relapse...
  30. ncbi request reprint Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen
    Tse Ching Chen
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 172:5900-7. 2004
    ..These results suggest that persistent exposure to Ag in conditions that fail to evoke proinflammatory stimuli leads to the development of T cells that are both anergic and regulatory...
  31. ncbi request reprint Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 168:5558-65. 2002
    ..Further characterization of the differentially expressed genes may lead to the development of diagnostic tests to monitor the tolerant state...
  32. ncbi request reprint Directed differentiation of dendritic cells from mouse embryonic stem cells
    P J Fairchild
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
    Curr Biol 10:1515-8. 2000
    ..This novel source should prove valuable for the generation of primary, untransformed DCs in which candidate genes have been overexpressed or functionally ablated, while providing insights into the earliest stages of DC ontogeny...
  33. ncbi request reprint CAMPATH-1 antibodies in stem-cell transplantation
    G Hale
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Cytotherapy 3:145-64. 2001
    ..Future studies will seek to understand the mechanism of the CYA effect and to improve the quality of immune reconstitution...
  34. ncbi request reprint High level transcription of the complement regulatory protein CD59 requires an enhancer located in intron 1
    M Tone
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 274:710-6. 1999
    ..To investigate the enhancer activity in vivo, a new CD59 minigene was constructed by the addition of the enhancer fragment into CD59 minigene-1. High expressor CD59 transgenic mice were generated using the new minigene...
  35. ncbi request reprint The new immunosuppression: intervention at the dendritic cell-T-cell interface
    A M Paterson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, UK
    Curr Drug Targets Immune Endocr Metabol Disord 5:397-411. 2005
    ..Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function...
  36. ncbi request reprint Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation
    Stephen F Yates
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 179:967-76. 2007
    ..Furthermore, they suggest a role for quiescent endogenous DC in the maintenance of the tolerant state...
  37. ncbi request reprint Dominant transplantation tolerance impairs CD8+ T cell function but not expansion
    Chun Yen Lin
    Sir William Dunn School of Pathology, University of Oxford, UK
    Nat Immunol 3:1208-13. 2002
    ..These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responses...
  38. ncbi request reprint A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts
    Stephen R Daley
    Therapeutic Immunology Group, Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 179:3648-54. 2007
    ..These results show that TGF-beta signaling to T cells is dispensable for mounting destructive responses against skin allografts while appearing to be an essential intermediary in establishing long-term tolerance...
  39. ncbi request reprint Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning?
    G Hale
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Bone Marrow Transplant 30:797-804. 2002
    ....
  40. pmc Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby
    Tse Ching Chen
    University of Oxford, Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Clin Invest 113:1754-62. 2004
    ..Our results demonstrate that incomplete signaling through the TCR may establish a network of T(reg) cells that may be harnessed in the service of transplantation tolerance...
  41. ncbi request reprint Antibody-induced transplantation tolerance: the role of dominant regulation
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunol Res 28:181-91. 2003
    ..Here, we review recent progress on understanding the nature, specificity, and mechanisms of action of T cells mediating dominant tolerance brought about by antibody therapy...
  42. ncbi request reprint Tolerogenicity is not an absolute property of a dendritic cell
    Claire A Farquhar
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 40:1728-37. 2010
    ....
  43. ncbi request reprint Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose
    F Bemelman
    Therapeutic Immunology Group, Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 160:2645-8. 1998
    ..Only this low dose tolerance can be transferred to unmanipulated recipients via CD4+ T cells, can be passed onto naive T cells as if infectious, and can act to suppress rejection of third party Ags when "linked" on F1 grafts...
  44. doi request reprint Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance
    S R Daley
    Therapeutic Immunology Group, Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Am J Transplant 8:2265-71. 2008
    ..These results show that short pulses of anti-CD40L antibody therapy may still be useful in tolerance protocols even when the Fc region is disabled...
  45. ncbi request reprint Posttranscriptional regulation of IL-10 gene expression through sequences in the 3'-untranslated region
    M J Powell
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Immunol 165:292-6. 2000
    ..This suggests that many cells are poised to secrete IL-10 and will do so if they receive appropriate posttranscriptional signals...
  46. ncbi request reprint Structure and chromosomal location of mouse and human CD52 genes
    M Tone
    Sir William Dunn School of Pathology, University of Oxford, UK
    Biochim Biophys Acta 1446:334-40. 1999
    ..Promoter activities and transcription start sites were also analysed. These results suggest that human CD52 and mouse B7-Ag gene expressions are controlled by TATA-less promoters...
  47. ncbi request reprint Infectious tolerance
    S Cobbold
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Curr Opin Immunol 10:518-24. 1998
    ....
  48. pmc Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 101:10122-6. 2004
    ..Such data question whether CD4(+)CD25(+) regulatory T cells alone can account for the antigen specificity of dominant transplantation tolerance...
  49. ncbi request reprint Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells
    D Zelenika
    Therapeutic Immunology Group, Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 161:1868-74. 1998
    ..Surprisingly, the transfer of either Th1 or Th2 CD4+ T cell lines from these mice into T cell-depleted recipients was sufficient to cause a specific rejection of male skin...
  50. ncbi request reprint Extrathymic signals regulate the onset of T cell repertoire selection
    P J Fairchild
    Sir William Dunn School of Pathology, University of Oxford, GB
    Eur J Immunol 30:1948-56. 2000
    ....
  51. ncbi request reprint Dendritic cells and prospects for transplantation tolerance
    P J Fairchild
    Sir William Dunn School of Pathology, University of Oxford, UK
    Curr Opin Immunol 12:528-35. 2000
    ..Nevertheless these advances have posed many new questions, the answers to which may subtly influence our approach to the treatment of rejection while bringing ever closer the prospect of donor-specific transplanation tolerance...
  52. pmc Regulation of CD40 function by its isoforms generated through alternative splicing
    M Tone
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 98:1751-6. 2001
    ..Modulation of isoform expression may provide a mechanism by which cells regulate their susceptibility to CD40L signaling...
  53. ncbi request reprint IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3
    M Tone
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Immunol 165:286-91. 2000
    ..The requirement for Sp1 and Sp3 in transcription of IL-10 was confirmed using Drosophila SL2 cells, which lack endogenous Sp factors. These results suggest that the transcription of IL-10 is positively regulated by both Sp1 and Sp3...
  54. ncbi request reprint Dominant transplantation tolerance. Opinion
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 15:499-506. 2003
    ..The phenotype of these cells, their relationship to CD4+CD25+ T cells, and the mechanism of action are still controversial...
  55. ncbi request reprint Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy
    Kathy O Lui
    Sir William Dunn School of Pathology, South Parks Road, Oxford, UK
    Curr Stem Cell Res Ther 4:70-80. 2009
    ..This overview therefore surveys prospects for developing novel regimes to prolong acceptance of ES cell-derived tissues with minimal use of immunosuppressive drugs...
  56. pmc Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance
    Nathan J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 104:20920-5. 2007
    ....
  57. pmc CD73 and adenosine generation in the creation of regulatory microenvironments
    F S Regateiro
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Clin Exp Immunol 171:1-7. 2013
    ..We review here these recent findings and discuss their implications in disease...
  58. doi request reprint Th17 cells induce a distinct graft rejection response that does not require IL-17A
    E I Agorogiannis
    University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Am J Transplant 12:835-45. 2012
    ..Antibody-mediated neutralization of IL-17A or IFN╬│ did not interfere with Th17-induced pathology, nor did it prevent neutrophil infiltration. In conclusion, tissue damage by Th17 cells does not require IL-17A...
  59. pmc Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine
    J H McIntosh
    Department of Haematology, UCL Cancer Institute, University College London, Oxford, UK
    Gene Ther 19:78-85. 2012
    ..These observations could significantly improve the prospects of using rAAV vectors for chronic disorders by allowing for repeated vector administration and avoiding the development of antibodies to the transgene product...
  60. ncbi request reprint The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci
    K F Nolan
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Genomics 51:161-3. 1998
  61. ncbi request reprint Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance
    Stephen P Cobbold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, Oxfordshire, OX1 3RE, UK
    Transpl Int 16:66-75. 2003
    ..The challenge is now to understand the biological principles that allow such immune re-programming so that they can be safely applied to clinical organ grafting...
  62. ncbi request reprint Embryonic stem cells: protecting pluripotency from alloreactivity
    Paul J Fairchild
    University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 19:596-602. 2007
    ..While the dust begins to settle, it is perhaps pertinent to ask whether the promise of SNT is still worth pursuing or whether alternative strategies for immune evasion might help fill the void...
  63. ncbi request reprint Immune privilege induced by regulatory T cells in transplantation tolerance
    Stephen P Cobbold
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 213:239-55. 2006
    ..The induction of local immune privilege has implications for the design of therapeutic regimens and the monitoring of the tolerant status of patients being weaned off immunosuppression...
  64. ncbi request reprint Cell replacement therapy and the evasion of destructive immunity
    Paul J Fairchild
    University of Oxford, Sir William Dunn School of Pathology, Oxford OX1 3RE, UK
    Stem Cell Rev 1:159-67. 2005
    ....
  65. ncbi request reprint SAGE analysis of cell types involved in tolerance induction
    Kathleen F Nolan
    Sir William Dunn School of Pathology, University of Oxford, UK
    Methods Mol Biol 380:225-51. 2007
    ....
  66. ncbi request reprint The role of Sp1 and NF-kappa B in regulating CD40 gene expression
    Masahide Tone
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 277:8890-7. 2002
    ..Transfectants of p65 were generated using RAW 264 cells, and it was shown that the up-regulation of CD40 mRNA expression was dependent on the presence of the p65 molecule...
  67. ncbi request reprint Reprogramming the immune system using antibodies
    Luis Graca
    Therapeutic Immunology Group, Sir William Dunn School of Pathology, Oxfordshire, Oxford, England
    Methods Mol Biol 333:247-68. 2006
    ..This chapter emphasizes recent evidence that shows that self-tolerance does not rely on several mechanisms running independently, but rather a continuum of synergistic and overlapping mechanisms...
  68. ncbi request reprint Probing dendritic cell function by guiding the differentiation of embryonic stem cells
    Paul J Fairchild
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Methods Enzymol 365:169-86. 2003
  69. ncbi request reprint Stable lines of genetically modified dendritic cells from mouse embryonic stem cells
    Paul J Fairchild
    University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford, United Kingdom
    Transplantation 76:606-8. 2003
    ..The inherent resistance of terminally differentiated DCs to conventional strategies for genetic modification has, however, greatly limited our understanding of the molecular mechanisms underlying their function...
  70. ncbi request reprint IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals
    Kathleen F Nolan
    Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
    J Immunol 172:2201-9. 2004
    ....
  71. ncbi request reprint Serial analysis of gene expression provides new insights into regulatory T cells
    Stephen P Cobbold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Semin Immunol 15:209-14. 2003
    ....
  72. ncbi request reprint Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration
    Geoff Hale
    Therapeutic Antibody Centre, Old Road, Headington, Oxford, OX3 7JT, United Kingdom
    Blood 104:948-55. 2004
    ..Subcutaneous alemtuzumab is more convenient and better tolerated but may be associated with some patients forming anti-alemtuzumab antibodies, particularly those patients who were previously untreated...
  73. ncbi request reprint Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms
    Stephen P Cobbold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunol Rev 196:109-24. 2003
    ..DCs that were treated with the tolerance-enhancing agents IL-10 or vitamin D3 expressed a gene signature reflecting a functional specification in common with the most immature DCs derived from embryonic stem cells...
  74. ncbi request reprint Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
    Stephen P Cobbold
    Sir William Dunn School of Pathology, Oxford, UK
    J Immunol 172:6003-10. 2004
    ..These data suggest that regulatory T cells maintaining transplantation tolerance after CD4 Ab blockade can be induced de novo through a TGF-beta-dependent mechanism, and come to accumulate in tolerated grafts...
  75. pmc Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
    Masahide Tone
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 100:15059-64. 2003
    ..Expression was controlled by the transcription factor NF-1 and potentially by alternative splicing of mRNA destabilization sequences...
  76. ncbi request reprint Embryonic stem cells: a novel source of dendritic cells for clinical applications
    Paul J Fairchild
    The University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Int Immunopharmacol 5:13-21. 2005
    ....
  77. doi request reprint Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link
    Stephen P Cobbold
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 236:203-18. 2010
    ..If correct, this provides a molecular explanation for the in vivo phenomena of linked suppression and infectious tolerance...
  78. doi request reprint MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation
    Duncan Howie
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Immunol 183:4197-204. 2009
    ....
  79. pmc Infectious tolerance via the consumption of essential amino acids and mTOR signaling
    Stephen P Cobbold
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 106:12055-60. 2009
    ..Inhibition of the mTOR pathway by limiting EAAs, or by specific inhibitors, induces the Treg-specific transcription factor forkhead box P3, which depends on both T cell receptor activation and synergy with TGF-beta...
  80. pmc Identification of regulatory T cells in tolerated allografts
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 195:1641-6. 2002
    ..Our results suggest that T cell suppression of graft rejection is an active process that operates beyond secondary lymphoid tissue, and involves the persistent presence of regulatory T cells at the site of the tolerated transplant...
  81. ncbi request reprint Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes
    Y Tone
    Sir William Dunn School of Pathology, University of Oxford, GB
    Eur J Immunol 26:1222-7. 1996
    ..An AGTTTCTACTTT sequence, which acts as an interferon-gamma response element in the promoter of the major histocompatibility complex class I gene, was also found upstream of the p40 gene...
  82. doi request reprint A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development
    Lynn D Poulton
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Int J Dev Biol 54:815-25. 2010
    ..25-10 hpf). We found Stat3 signalling to be altered in the gitrl-morphants, suggesting that one possible role for Gitrl during embryogenesis may be modulation of Jak/Stat signalling...
  83. ncbi request reprint Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells
    Paul J Fairchild
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Methods Mol Biol 380:59-72. 2007
    ..The protocols we outline in this chapter may, therefore, offer new opportunities for dissecting the biology of DC and the molecular basis of their unique properties...
  84. ncbi request reprint Embryonic stem cells and the challenge of transplantation tolerance
    Paul J Fairchild
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Trends Immunol 25:465-70. 2004
    ....
  85. ncbi request reprint Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells
    Luis Graca
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Trends Immunol 26:130-5. 2005
  86. ncbi request reprint Guiding postablative lymphocyte reconstitution as a route toward transplantation tolerance
    G Piotti
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Am J Transplant 14:1678-89. 2014
    ..These findings point to the feasibility of building on lympholytic induction by guiding early lymphocyte reconstitution to favor endogenous regulatory mechanisms. ..
  87. ncbi request reprint Expression of murine IL-12 is regulated by translational control of the p35 subunit
    J M Babik
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Immunol 162:4069-78. 1999
    ..Furthermore, p35 mRNA levels were substantially up-regulated after LPS stimulation in both cell types. Thus, our results show that p35 gene expression is highly regulated by both transcriptional and translational mechanisms...
  88. ncbi request reprint The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model
    Julian A Symons
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, UK
    J Gen Virol 83:2833-44. 2002
    ..However, infection of BALB/c mice by the intranasal route showed that the deletion mutant was attenuated and induced lower weight loss and signs of illness compared to controls...
  89. ncbi request reprint Induction of immunological tolerance/hyporesponsiveness in baboons with a nondepleting CD4 antibody
    Dawn Winsor-Hines
    TolerRx, Inc, Cambridge, MA 02139, USA
    J Immunol 173:4715-23. 2004
    ..These studies demonstrate that anti-CD4 Ab-mediated, Ag-specific tolerance can be achieved in baboons without long term immune suppression...
  90. ncbi request reprint Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    Andrew L Mellor
    Department of Medicine, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912 2600, USA
    Int Immunol 16:1391-401. 2004
    ..These findings suggest that IDO-competent DCs provide a regulatory bridge, mediated by CTLA4-B7 engagement, between certain regulatory T cell subsets and naive responder T cells...
  91. ncbi request reprint Enhanced production of IL-10 by dendritic cells deficient in CIITA
    Christina S K Yee
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 174:1222-9. 2005
    ..In all, these data suggest that CIITA negatively regulates expression of IL-10, and that CIITA may direct DC function in ways that extend beyond control of MHC class II...
  92. ncbi request reprint T- and B-cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T-cell-depleted, reduced-intensity allogeneic stem cell transplantation with an alemtuzumab-containing conditioning regimen followed by escalated donor ly
    Shirley D'Sa
    Department of Haematology, University College London Hospitals NHS Trust, UK
    Br J Haematol 123:309-22. 2003
    ..Over 80% of all patients have relapsed at a median of 283 (range 153-895) d after transplant, suggesting that the initially low rate of GVHD comes at a high price with regard to the desired graft-versus-myeloma effect...
  93. ncbi request reprint Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression
    Fleur Samantha Benghiat
    Institute for Medical Immunology, Universite Libre de Bruxelles, 8, Rue Adrienne Bolland, B 6041 Charleroi Gosselies, Belgium
    Transplantation 79:648-54. 2005
    ....
  94. ncbi request reprint The new immunosuppression: just kill the T cell
    Herman Waldmann
    Nat Med 9:1259-60. 2003
  95. ncbi request reprint Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells
    Sylvaine You
    INSERM U580, Paris, France
    Diabetes 54:1415-22. 2005
    ..We propose that progression to overt disease correlates with the pathogenic T-cell's escape from TGF-beta-dependent T-cell-mediated regulation...
  96. ncbi request reprint Reconstitution of the Epstein-Barr virus-specific cytotoxic T-lymphocyte response following T-cell-depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation
    Suparno Chakrabarti
    Department of Haematology, Birmingham Heartlands Hospital, Birmingham, United Kingdom
    Blood 102:839-42. 2003
    ..The use of alemtuzumab in vivo in the nonmyeloablative conditioning might have resulted in the delay in EBV-specific T-cell recovery and increased virus infections...
  97. ncbi request reprint Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    Jeanette Lundin
    Department of Hematology, Karolinska Hospital, and Huddinge University Hospital, Stockholm, Sweden
    Blood 100:768-73. 2002
    ..Prolonged treatment is important for maximal bone marrow response. Subcutaneous administration induced very few "first-dose" flulike symptoms and may reduce health care costs in comparison with the intravenous infusions...
  98. ncbi request reprint High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution
    Suparno Chakrabarti
    Department of Haematology, Birmingham Heartlands Hospital, University of Birmingham, Birmingham, United Kingdom
    Blood 99:4357-63. 2002
    ..The use of Campath-1H appeared to be associated with a low incidence of GVHD but a high incidence of CMV infections and prolonged immune paresis...
  99. ncbi request reprint Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis
    Amanda L Cox
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Eur J Immunol 35:3332-42. 2005
    ..We speculate that CCL21 and IL-15 responses to lymphopaenia may be suboptimal in multiple sclerosis...
  100. ncbi request reprint Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it
    David C Neujahr
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 176:4632-9. 2006
    ..These data have clinically relevant implications related to the development of novel strategies to overcome resistance to tolerance...
  101. ncbi request reprint T-cell depletion with Campath-1H "in the bag" for matched related allogeneic peripheral blood stem cell transplantation is associated with reduced graft-versus-host disease, rapid immune constitution and improved survival
    Suparno Chakrabarti
    Department of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
    Br J Haematol 121:109-18. 2003
    ....