Henning Walczak


Affiliation: University College London
Country: UK


  1. Peltzer N, Walczak H. Cell Death and Inflammation - A Vital but Dangerous Liaison. Trends Immunol. 2019;40:387-402 pubmed publisher
    ..Together, this review examines the complex interplay between RIPK1, RIPK3, and LUBAC that is important in regulating cell death and inflammatory signaling. ..
  2. Peltzer N, Walczak H. Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy. Dev Cell. 2019;48:127-128 pubmed publisher
    ..2019) report that TAK1 loss from endothelial cells in adult mice results in intestinal and hepatic vascular destruction due to TNF-induced death of endothelial cells. Additionally, endothelial TAK1 deletion reduces tumor burden. ..
  3. Spit M, Rieser E, Walczak H. Linear ubiquitination at a glance. J Cell Sci. 2019;132: pubmed publisher
    ..Furthermore, we highlight the roles of deubiquitinases (DUBs) that cleave M1 linkages and add an additional layer in the control of LUBAC-mediated immune signalling. ..
  4. Lafont E, Dráber P, Rieser E, Reichert M, Kupka S, De Miguel D, et al. TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation. Nat Cell Biol. 2018;20:1389-1399 pubmed publisher
  5. Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, et al. LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L. Nat Commun. 2018;9:3910 pubmed publisher
  6. Reichert M, Bhamra A, Kupka S, Walczak H. Characterization of the TNFR1-SC Using "Modified Tandem Affinity Purification" in Conjunction with Liquid Chromatography-Mass Spectrometry (LC-MS). Methods Mol Biol. 2018;1857:161-169 pubmed publisher
    ..This methodology allows for a highly sensitive analysis and characterization of complex components, including posttranslational modifications and for the identification of novel complex components. ..
  7. Peltzer N, Darding M, Montinaro A, Dráber P, Draberova H, Kupka S, et al. LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature. 2018;557:112-117 pubmed publisher
    ..Furthermore, they reveal that when LUBAC and caspase-8 are absent, RIPK3 prevents RIPK1 from inducing embryonic lethality by causing defects in fetal haematopoiesis. ..
  8. Montinaro A, Walczak H. Sterile Inflammation Fuels Gastric Cancer. Immunity. 2018;48:481-483 pubmed publisher
    ..In this issue of Immunity, O'Reilly et al. (2018) unveil a link between loss of NF-κB1, aberrant STAT1 signaling, sterile inflammation, and the increased expression of immune checkpoint molecules as cancer drivers. ..
  9. Dondelinger Y, Darding M, Bertrand M, Walczak H. Poly-ubiquitination in TNFR1-mediated necroptosis. Cell Mol Life Sci. 2016;73:2165-76 pubmed publisher

More Information


  1. Zinngrebe J, Rieser E, Taraborrelli L, Peltzer N, Hartwig T, Ren H, et al. --LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation. J Exp Med. 2016;213:2671-2689 pubmed
    ..Thus, LUBAC components control TLR3-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation. ..
  2. Peltzer N, Rieser E, Taraborrelli L, Dráber P, Darding M, Pernaute B, et al. HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death. Cell Rep. 2014;9:153-65 pubmed publisher
    ..Hence, LUBAC and its linear-ubiquitin-forming activity are required for maintaining vascular integrity during embryogenesis by preventing TNFR1-mediated endothelial cell death. ..
  3. Zinngrebe J, Walczak H. TLRs Go Linear - On the Ubiquitin Edge. Trends Mol Med. 2017;23:296-309 pubmed publisher
    ..We propose that defective linear ubiquitination contributes to TLR-mediated disease pathogenesis and that perturbed TLR signaling contributes to the phenotype observed in inherited LUBAC deficiency in humans and mice. ..
  4. Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
    ..Hence, LUBAC controls the TRAIL signalling outcome from complex I and II, two platforms which both trigger cell death and gene activation. ..
  5. Hartwig T, Montinaro A, von Karstedt S, Sevko A, Surinova S, Chakravarthy A, et al. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell. 2017;65:730-742.e5 pubmed publisher
  6. Kupka S, De Miguel D, Dráber P, Martino L, Surinova S, Rittinger K, et al. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep. 2016;16:2271-80 pubmed publisher
    ..In summary, we describe SPATA2 as a previously unrecognized factor in LUBAC-dependent signaling pathways that serves as an adaptor between HOIP and CYLD, thereby enabling recruitment of CYLD to signaling complexes. ..
  7. Peltzer N, Darding M, Walczak H. Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling. Trends Cell Biol. 2016;26:445-61 pubmed publisher
    ..Finally, we discuss recent advances in the knowledge on three ubiquitin E3 ligases that exert regulatory functions on RIPK1 signaling: cIAP1, cIAP2, and LUBAC. ..
  8. Lafont E, Hartwig T, Walczak H. Paving TRAIL's Path with Ubiquitin. Trends Biochem Sci. 2018;43:44-60 pubmed publisher
  9. Dráber P, Kupka S, Reichert M, Draberova H, Lafont E, De Miguel D, et al. LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Cell Rep. 2015;13:2258-72 pubmed publisher
    ..Hence, the interplay between LUBAC, M1-ubiquitin, CYLD, and A20 is central for physiological signaling through innate immune receptors. ..
  10. von Karstedt S, Conti A, Nobis M, Montinaro A, Hartwig T, Lemke J, et al. Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis. Cancer Cell. 2015;27:561-73 pubmed publisher
    ..Consistent with this, high TRAIL-R2 expression correlates with invasion of human PDAC into lymph vessels and with shortened metastasis-free survival of KRAS-mutated colorectal cancer patients. ..