Karen H Vousden

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint P53 and prognosis: new insights and further complexity
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Cell 120:7-10. 2005
  2. doi request reprint Functions of p53 in metabolism and invasion
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
    Biochem Soc Trans 37:511-7. 2009
  3. ncbi request reprint p53 in health and disease
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Nat Rev Mol Cell Biol 8:275-83. 2007
  4. ncbi request reprint Apoptosis. p53 and PUMA: a deadly duo
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glagsow G61 1BD, UK
    Science 309:1685-6. 2005
  5. doi request reprint Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
  6. ncbi request reprint Live or let die: the cell's response to p53
    Karen H Vousden
    Regulation of Cell Growth Laboratory, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702, USA
    Nat Rev Cancer 2:594-604. 2002
  7. doi request reprint p53 and metabolism
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK
    Nat Rev Cancer 9:691-700. 2009
  8. ncbi request reprint Switching from life to death: the Miz-ing link between Myc and p53
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Galsgow G61 1BD, UK
    Cancer Cell 2:351-2. 2002
  9. doi request reprint Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
    Oliver D K Maddocks
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Nature 493:542-6. 2013
  10. pmc A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo
    Helen S Bell
    Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, United Kingdom
    J Clin Invest 117:1008-18. 2007

Collaborators

Detail Information

Publications65

  1. ncbi request reprint P53 and prognosis: new insights and further complexity
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Cell 120:7-10. 2005
    ..These findings may lead to new diagnostic and therapeutic approaches to treating cancer patients...
  2. doi request reprint Functions of p53 in metabolism and invasion
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
    Biochem Soc Trans 37:511-7. 2009
    ..Such approaches may be useful in the treatment of cancer, but a growing understanding of a role for p53 in other conditions suggests that modulation of p53 may have broader applications...
  3. ncbi request reprint p53 in health and disease
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Nat Rev Mol Cell Biol 8:275-83. 2007
    ..Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life...
  4. ncbi request reprint Apoptosis. p53 and PUMA: a deadly duo
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glagsow G61 1BD, UK
    Science 309:1685-6. 2005
  5. doi request reprint Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
    ..Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53...
  6. ncbi request reprint Live or let die: the cell's response to p53
    Karen H Vousden
    Regulation of Cell Growth Laboratory, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702, USA
    Nat Rev Cancer 2:594-604. 2002
  7. doi request reprint p53 and metabolism
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK
    Nat Rev Cancer 9:691-700. 2009
    ....
  8. ncbi request reprint Switching from life to death: the Miz-ing link between Myc and p53
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Galsgow G61 1BD, UK
    Cancer Cell 2:351-2. 2002
    ....
  9. doi request reprint Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
    Oliver D K Maddocks
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Nature 493:542-6. 2013
    ..The role of p53 in supporting cancer cell proliferation under serine starvation was translated to an in vivo model, indicating that serine depletion has a potential role in the treatment of p53-deficient tumours...
  10. pmc A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo
    Helen S Bell
    Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, United Kingdom
    J Clin Invest 117:1008-18. 2007
    ..This study therefore heralds what we believe to be the first strategy to directly and selectively activate p73 therapeutically and may lead to the development of broadly applicable agents for the treatment of malignant disease...
  11. pmc An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
    Stjepan Uldrijan
    The Beatson Institute for Cancer Research, Glasgow, UK
    EMBO J 26:102-12. 2007
    ..Interestingly, the E3 activity of C-terminal point mutants of MDM2 can also be supported by interaction with wild-type MDMX, suggesting that MDMX can directly contribute to E3 function...
  12. ncbi request reprint C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
    Stephanie Carter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Nat Cell Biol 9:428-35. 2007
    ..Our results suggest that modifications such as sumoylation can regulate the strength of the p53-MDM2 interaction and participate in driving the export of p53...
  13. pmc An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence
    Arnaud M Vigneron
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    EMBO J 31:471-80. 2012
    ....
  14. ncbi request reprint Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
    Yili Yang
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, 1050 Boyles Street, Frederick, MD 21702, USA
    Cancer Cell 7:547-59. 2005
    ..In cells, the compounds allow the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis, although other p53-independent toxicity was also observed...
  15. pmc TIGAR is required for efficient intestinal regeneration and tumorigenesis
    Eric C Cheung
    CR UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK
    Dev Cell 25:463-77. 2013
    ..Our study demonstrates the importance of TIGAR in regulating metabolism for regeneration and cancer development and identifies TIGAR as a potential therapeutic target in diseases such as ulcerative colitis and intestinal cancer...
  16. ncbi request reprint Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
    Yili Yang
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA
    Cancer Res 67:9472-81. 2007
    ..These inhibitors can also be valuable tools for studying ubiquitylation...
  17. ncbi request reprint TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    Karim Bensaad
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Cell 126:107-20. 2006
    ..The decrease of intracellular ROS levels in response to TIGAR may also play a role in the ability of p53 to protect from the accumulation of genomic damage...
  18. ncbi request reprint p53-mediated induction of Noxa and p53AIP1 requires NFkappaB
    Jim O'Prey
    Tumor Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, UK
    Cell Cycle 9:947-52. 2010
    ..In addition, since both Noxa and p53AIP1 have been shown to be important components of p53-mediated cell death responses, these findings may also indicate critical points where NFkappaB plays a pro-apoptotic role downstream of p53...
  19. pmc Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
    Eric C Cheung
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, United Kingdom
    Proc Natl Acad Sci U S A 109:20491-6. 2012
    ....
  20. pmc Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration
    Elena Rainero
    Beatson Institute for Cancer Research, G61 1BD Glasgow, Scotland, UK
    J Cell Biol 196:277-95. 2012
    ....
  21. pmc Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP
    Arnaud M Vigneron
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
    Genes Dev 24:2430-9. 2010
    ..These results reveal a potential oncogenic role for cytoplasmic ASPP1, in contrast to the tumor-suppressive activity described previously for nuclear ASPP1...
  22. pmc p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival
    Daniel R Croft
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell Res 21:666-82. 2011
    ....
  23. pmc Ubiquitination and degradation of mutant p53
    Natalia Lukashchuk
    The Beatson Institute for Cancer Research, Switchback Rd, Glasgow G61 1BD, United Kingdom
    Mol Cell Biol 27:8284-95. 2007
    ..The contribution of Mdm2 to the degradation of mutant p53 may reflect the ability of Mdm2 to deliver the ubiquitinated mutant p53 to the proteasome...
  24. ncbi request reprint Regulation of HDM2 activity by the ribosomal protein L11
    Marion A E Lohrum
    Regulation of Cell Growth Laboratory, NCI FRCDC, Frederick, MD 21702, USA
    Cancer Cell 3:577-87. 2003
    ....
  25. ncbi request reprint HDM2 phosphorylation by MAPKAP kinase 2
    Hans Oliver Weber
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK
    Oncogene 24:1965-72. 2005
    ..Together, our results suggest that MK2 may act to dampen the extent and duration of the p53 response...
  26. doi request reprint p53 mutations in cancer
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Nat Cell Biol 15:2-8. 2013
    ..Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions...
  27. doi request reprint Small molecules that bind the Mdm2 RING stabilize and activate p53
    Patricia Roxburgh
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Carcinogenesis 33:791-8. 2012
    ..Deazaflavin analogs therefore function to activate p53 through a novel mechanism, by inhibiting the E3 ligase activity of MDM2 in a manner that involves binding to the MDM2 RING...
  28. pmc Modulation of intracellular ROS levels by TIGAR controls autophagy
    Karim Bensaad
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
    EMBO J 28:3015-26. 2009
    ....
  29. ncbi request reprint Contribution of membrane localization to the apoptotic activity of PUMA
    Karen S Yee
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK
    Apoptosis 13:87-95. 2008
    ..However, since the loss of the C-terminus does not compromise the ability of PUMA to induce cell death, our results indicate that the key apoptotic function of PUMA is through interaction with anti-apoptotic proteins such as Bcl2...
  30. pmc Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity
    Antonio García Trinidad
    CR UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Mol Cell 50:805-17. 2013
    ..Our data therefore suggest that both growth suppression and cell invasion may be differentially regulated functions of wild-type p53...
  31. pmc Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
    Hao Dou
    The Beatson Institute for Cancer Research, Glasgow, UK
    Nat Struct Mol Biol 19:184-92. 2012
    ..This activation is required for RTK ubiquitination. Our results present a mechanism for regulation of c-Cbl's activity by autoinhibition and phosphorylation-induced activation...
  32. pmc Regulation of p53 stability and function by the deubiquitinating enzyme USP42
    Andreas K Hock
    The Beatson Institute for Cancer Research, Glasgow, UK
    EMBO J 30:4921-30. 2011
    ..These functions of USP42 are likely to contribute to the repair and recovery of cells from mild or transient damage...
  33. ncbi request reprint p53: new roles in metabolism
    Karim Bensaad
    The Beatson Institute for Cancer Research, Glasgow, UK
    Trends Cell Biol 17:286-91. 2007
    ..These activities of p53 appear to be key in tumor suppression, and shed some light on the pathways that underlie the metabolic changes in cancer cells...
  34. doi request reprint Mutant p53 drives invasion by promoting integrin recycling
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Cell 139:1327-41. 2009
    ..These findings open the possibility that blocking alpha5/beta1-integrin and/or the EGF receptor will have therapeutic benefit in mutant p53-expressing cancers...
  35. pmc p53, ROS and senescence in the control of aging
    Arnaud Vigneron
    The Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK
    Aging (Albany NY) 2:471-4. 2010
    ..The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging...
  36. pmc Metabolic regulation by p53 family members
    Celia R Berkers
    The CR UK Beatson Institute, Glasgow G61 1BD, Scotland, UK
    Cell Metab 18:617-33. 2013
    ..A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs. ..
  37. doi request reprint Serine is a natural ligand and allosteric activator of pyruvate kinase M2
    Barbara Chaneton
    Cancer Research UK, The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, Scotland, UK
    Nature 491:458-62. 2012
    ..This reduction in PKM2 activity shifts cells to a fuel-efficient mode in which more pyruvate is diverted to the mitochondria and more glucose-derived carbon is channelled into serine biosynthesis to support cell proliferation...
  38. doi request reprint Modifications of p53: competing for the lysines
    Stephanie Carter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK
    Curr Opin Genet Dev 19:18-24. 2009
    ..This complexity is amplified by the variety of modifications that can target the same lysine residue - often with opposing effects on p53 function...
  39. pmc Induction of p57(KIP2) expression by p73beta
    Eva Balint
    Regulation of Cell Growth Laboratory, Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 99:3529-34. 2002
    ..Our results suggest that p73 may regulate expression of genes through mechanisms that are not shared by p53, potentially explaining the different contributions of p53 and p73 to normal development...
  40. pmc p53 and its mutants in tumor cell migration and invasion
    Patricia A J Muller
    Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 192:209-18. 2011
    ..Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function...
  41. pmc A role for Numb in p53 stabilization
    Stephanie Carter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, UK
    Genome Biol 9:221. 2008
    ..Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53...
  42. ncbi request reprint The secret life of histones
    David A F Gillespie
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, G61 1BD, Glasgow, United Kingdom
    Cell 114:655-6. 2003
    ..2 in DNA damage-induced apoptosis. DNA double strand breaks induce translocation of nuclear H1.2 to the cytoplasm, where it promotes release of cytochrome c from mitochondria by activating the Bcl-2 family protein, Bak...
  43. pmc Metabolic regulation by p53
    Oliver D K Maddocks
    The Beatson Institute for Cancer Research, Glasgow, UK
    J Mol Med (Berl) 89:237-45. 2011
    ..A better understanding of how p53 coordinates metabolic adaptation will facilitate the identification of novel therapeutic targets and will also illuminate the wider role of p53 in human biology...
  44. ncbi request reprint Complicating the complexity of p53
    Karen S Yee
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Carcinogenesis 26:1317-22. 2005
    ..Although complicating our understanding of p53, these new insights may also provide some exciting new targets for the design of therapeutics that can reactivate p53 in cancers...
  45. pmc p53 regulation of metabolic pathways
    Eyal Gottlieb
    The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom
    Cold Spring Harb Perspect Biol 2:a001040. 2010
    ..In the past few years, it became clear that p53, the most studied, if not most important, tumor suppressor protein, can also directly control metabolic traits of cells...
  46. doi request reprint Regulation of the p53 pathway by ubiquitin and related proteins
    Andreas Hock
    The Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
    Int J Biochem Cell Biol 42:1618-21. 2010
    ..Understanding the complexity of this mechanism of p53 regulation will help in the development of therapeutic drugs that function to modulate these events...
  47. ncbi request reprint Activation of the p53 tumor suppressor protein
    Karen H Vousden
    Regulation of Cell Growth Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Biochim Biophys Acta 1602:47-59. 2002
    ....
  48. doi request reprint The role of p53 in glucose metabolism
    Eric C Cheung
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
    Curr Opin Cell Biol 22:186-91. 2010
    ..These new functions of p53 are providing interesting possibilities for the development of novel therapies...
  49. doi request reprint The role of ubiquitin modification in the regulation of p53
    Andreas K Hock
    Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK
    Biochim Biophys Acta 1843:137-49. 2014
    ..This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf. ..
  50. ncbi request reprint Tumor suppression by p53: fall of the triumvirate?
    Andreas K Hock
    The Beatson Institute for Cancer Research, Glasgow, UK
    Cell 149:1183-5. 2012
    ..Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role...
  51. ncbi request reprint Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53
    Kevin M Ryan
    Tumor Cell Death Laboratory, Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow, United Kingdom
    Cancer Res 64:4415-8. 2004
    ..Moreover, this indicates that, although perhaps central to p53 function, loss of the ability to induce programmed cell death does not completely inactivate p53's tumor-suppressive effects...
  52. ncbi request reprint Outcomes of p53 activation--spoilt for choice
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    J Cell Sci 119:5015-20. 2006
    ....
  53. ncbi request reprint p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
    Gerry Melino
    Biochemistry Laboratory, Instituto Dermopatico Dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 279:8076-83. 2004
    ..Our findings demonstrate that p73 elicits apoptosis via the mitochondrial pathway using PUMA and Bax as mediators...
  54. ncbi request reprint Phosphorylation of HDM2 by Akt
    Margaret Ashcroft
    CRC, Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Oncogene 21:1955-62. 2002
    ..Tryptic peptide and mutational analyses revealed evidence for an Akt phosphorylation site in HDM2 additional to the two consensus sites...
  55. pmc The ubiquitin-protein ligase Itch regulates p73 stability
    Mario Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 24:836-48. 2005
    ..In conclusion, we have identified a key mechanism in the control of p73 protein levels both in normal as well as in stress conditions...
  56. pmc Critical role for a central part of Mdm2 in the ubiquitylation of p53
    Erik Meulmeester
    Department of Molecular and Cell Biology and Center for Biomedical Genetics, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
    Mol Cell Biol 23:4929-38. 2003
    ..Strikingly, the function of this domain can be fulfilled in trans, indicating that the RING domain and this internal region perform distinct activities in the ubiquitylation of p53...
  57. pmc INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
    Sharon Brookes
    Molecular Oncology and Human Cytogenetics Laboratories, Cancer Research UK London Research Institute, Lincolns Inn Fields, London WC2A 3PX, UK
    EMBO J 21:2936-45. 2002
    ..We find that in human fibroblasts, ARF is not induced demonstrably by RAS, pointing to significant differences between the proliferative barriers implemented by the CDKN2A locus in different cell types or species...
  58. ncbi request reprint p73: Friend or foe in tumorigenesis
    Gerry Melino
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Rev Cancer 2:605-15. 2002
  59. ncbi request reprint Cancer: pinning a change on p53
    Kevin M Ryan
    Nature 419:795, 797. 2002
  60. ncbi request reprint p73 supports cellular growth through c-Jun-dependent AP-1 transactivation
    Faina Vikhanskaya
    Laboratory of Molecular Carcinogenesis, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
    Nat Cell Biol 9:698-705. 2007
    ..Collectively, our data demonstrates a novel and unexpected role of p73 in augmenting AP-1 transcriptional activity through which it supports cellular growth...
  61. ncbi request reprint Cancer: guarding the guardian?
    Henning F Horn
    Nature 427:110-1. 2004
  62. ncbi request reprint p73-alpha is capable of inducing scotin and ER stress
    Alessandro Terrinoni
    Biochemistry Laboratory, IDI IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Oncogene 23:3721-5. 2004
    ..This molecular mechanism might contribute to the effector events inducing apoptosis downstream of p73...
  63. ncbi request reprint PML regulates p53 stability by sequestering Mdm2 to the nucleolus
    Rosa Bernardi
    Cancer Biology and Genetics Program, Department of Pathology and Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Cell Biol 6:665-72. 2004
    ..These findings demonstrate an unexpected role of PML in the nucleolar network for tumour suppression...
  64. ncbi request reprint Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells
    Jennifer M Wilson
    WestCHEM, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Bioorg Med Chem 15:77-86. 2007
    ..Importantly, we have demonstrated that the nitro group present in all three of the original lead compounds [1-3 (HL198C-E)] is not essential for observation of this biological activity...
  65. ncbi request reprint Savior and slayer: the two faces of p53
    Karim Bensaad
    Nat Med 11:1278-9. 2005