Research Topics
Genomes and Genes
| Karen H VousdenSummaryAffiliation: University of Glasgow Country: UK Publications
| Collaborators
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Detail Information
Publications
P53 and prognosis: new insights and further complexityKaren H Vousden
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
Cell 120:7-10. 2005..These findings may lead to new diagnostic and therapeutic approaches to treating cancer patients...
Functions of p53 in metabolism and invasionKaren H Vousden
The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
Biochem Soc Trans 37:511-7. 2009..Such approaches may be useful in the treatment of cancer, but a growing understanding of a role for p53 in other conditions suggests that modulation of p53 may have broader applications...- Switching from life to death: the Miz-ing link between Myc and p53Karen H Vousden
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Galsgow G61 1BD, UK
Cancer Cell 2:351-2. 2002.... - p53 in health and diseaseKaren H Vousden
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Nat Rev Mol Cell Biol 8:275-83. 2007..Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life... - Blinded by the Light: The Growing Complexity of p53Karen H Vousden
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
Cell 137:413-31. 2009..Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53... - Live or let die: the cell's response to p53Karen H Vousden
Regulation of Cell Growth Laboratory, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702, USA
Nat Rev Cancer 2:594-604. 2002 - Apoptosis. p53 and PUMA: a deadly duoKaren H Vousden
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glagsow G61 1BD, UK
Science 309:1685-6. 2005 - p53 and metabolismKaren H Vousden
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK
Nat Rev Cancer 9:691-700. 2009.... - Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cellsOliver D K Maddocks
The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Nature 493:542-6. 2013..The role of p53 in supporting cancer cell proliferation under serine starvation was translated to an in vivo model, indicating that serine depletion has a potential role in the treatment of p53-deficient tumours... 
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivoHelen S Bell
Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, United Kingdom
J Clin Invest 117:1008-18. 2007..This study therefore heralds what we believe to be the first strategy to directly and selectively activate p73 therapeutically and may lead to the development of broadly applicable agents for the treatment of malignant disease...- An essential function of the extreme C-terminus of MDM2 can be provided by MDMXStjepan Uldrijan
The Beatson Institute for Cancer Research, Glasgow, UK
EMBO J 26:102-12. 2007..Interestingly, the E3 activity of C-terminal point mutants of MDM2 can also be supported by interaction with wild-type MDMX, suggesting that MDMX can directly contribute to E3 function... - An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescenceArnaud M Vigneron
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
EMBO J 31:471-80. 2012.... - C-terminal modifications regulate MDM2 dissociation and nuclear export of p53Stephanie Carter
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Nat Cell Biol 9:428-35. 2007..Our results suggest that modifications such as sumoylation can regulate the strength of the p53-MDM2 interaction and participate in driving the export of p53... - Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cellsYili Yang
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, 1050 Boyles Street, Frederick, MD 21702, USA
Cancer Cell 7:547-59. 2005..In cells, the compounds allow the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis, although other p53-independent toxicity was also observed... - TIGAR, a p53-inducible regulator of glycolysis and apoptosisKarim Bensaad
The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Cell 126:107-20. 2006..The decrease of intracellular ROS levels in response to TIGAR may also play a role in the ability of p53 to protect from the accumulation of genomic damage... - p53-mediated induction of Noxa and p53AIP1 requires NFkappaBJim O'Prey
Tumor Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, UK
Cell Cycle 9:947-52. 2010..In addition, since both Noxa and p53AIP1 have been shown to be important components of p53-mediated cell death responses, these findings may also indicate critical points where NFkappaB plays a pro-apoptotic role downstream of p53... - Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell deathEric C Cheung
The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, United Kingdom
Proc Natl Acad Sci U S A 109:20491-6. 2012.... - Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migrationElena Rainero
Beatson Institute for Cancer Research, G61 1BD Glasgow, Scotland, UK
J Cell Biol 196:277-95. 2012.... - p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survivalDaniel R Croft
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
Cell Res 21:666-82. 2011.... - Cytoplasmic ASPP1 inhibits apoptosis through the control of YAPArnaud M Vigneron
The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
Genes Dev 24:2430-9. 2010..These results reveal a potential oncogenic role for cytoplasmic ASPP1, in contrast to the tumor-suppressive activity described previously for nuclear ASPP1... - Ubiquitination and degradation of mutant p53Natalia Lukashchuk
The Beatson Institute for Cancer Research, Switchback Rd, Glasgow G61 1BD, United Kingdom
Mol Cell Biol 27:8284-95. 2007..The contribution of Mdm2 to the degradation of mutant p53 may reflect the ability of Mdm2 to deliver the ubiquitinated mutant p53 to the proteasome... - Regulation of HDM2 activity by the ribosomal protein L11Marion A E Lohrum
Regulation of Cell Growth Laboratory, NCI FRCDC, Frederick, MD 21702, USA
Cancer Cell 3:577-87. 2003.... - HDM2 phosphorylation by MAPKAP kinase 2Hans Oliver Weber
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK
Oncogene 24:1965-72. 2005..Together, our results suggest that MK2 may act to dampen the extent and duration of the p53 response... - Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeuticsYili Yang
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA
Cancer Res 67:9472-81. 2007..These inhibitors can also be valuable tools for studying ubiquitylation... - p53 mutations in cancerPatricia A J Muller
The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
Nat Cell Biol 15:2-8. 2013..Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions... - Small molecules that bind the Mdm2 RING stabilize and activate p53Patricia Roxburgh
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Carcinogenesis 33:791-8. 2012..Deazaflavin analogs therefore function to activate p53 through a novel mechanism, by inhibiting the E3 ligase activity of MDM2 in a manner that involves binding to the MDM2 RING... - Contribution of membrane localization to the apoptotic activity of PUMAKaren S Yee
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK
Apoptosis 13:87-95. 2008..However, since the loss of the C-terminus does not compromise the ability of PUMA to induce cell death, our results indicate that the key apoptotic function of PUMA is through interaction with anti-apoptotic proteins such as Bcl2... - Modulation of intracellular ROS levels by TIGAR controls autophagyKarim Bensaad
The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
EMBO J 28:3015-26. 2009.... - Structural basis for autoinhibition and phosphorylation-dependent activation of c-CblHao Dou
The Beatson Institute for Cancer Research, Glasgow, UK
Nat Struct Mol Biol 19:184-92. 2012..This activation is required for RTK ubiquitination. Our results present a mechanism for regulation of c-Cbl's activity by autoinhibition and phosphorylation-induced activation... - Regulation of p53 stability and function by the deubiquitinating enzyme USP42Andreas K Hock
The Beatson Institute for Cancer Research, Glasgow, UK
EMBO J 30:4921-30. 2011..These functions of USP42 are likely to contribute to the repair and recovery of cells from mild or transient damage... - p53, ROS and senescence in the control of agingArnaud Vigneron
The Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK
Aging (Albany NY) 2:471-4. 2010..The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging... - p53: new roles in metabolismKarim Bensaad
The Beatson Institute for Cancer Research, Glasgow, UK
Trends Cell Biol 17:286-91. 2007..These activities of p53 appear to be key in tumor suppression, and shed some light on the pathways that underlie the metabolic changes in cancer cells... - Mutant p53 drives invasion by promoting integrin recyclingPatricia A J Muller
The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Cell 139:1327-41. 2009..These findings open the possibility that blocking alpha5/beta1-integrin and/or the EGF receptor will have therapeutic benefit in mutant p53-expressing cancers... - Serine is a natural ligand and allosteric activator of pyruvate kinase M2Barbara Chaneton
Cancer Research UK, The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, Scotland, UK
Nature 491:458-62. 2012..This reduction in PKM2 activity shifts cells to a fuel-efficient mode in which more pyruvate is diverted to the mitochondria and more glucose-derived carbon is channelled into serine biosynthesis to support cell proliferation... - p53 and its mutants in tumor cell migration and invasionPatricia A J Muller
Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK
J Cell Biol 192:209-18. 2011..Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function... - Induction of p57(KIP2) expression by p73betaEva Balint
Regulation of Cell Growth Laboratory, Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702 1201, USA
Proc Natl Acad Sci U S A 99:3529-34. 2002..Our results suggest that p73 may regulate expression of genes through mechanisms that are not shared by p53, potentially explaining the different contributions of p53 and p73 to normal development... - Modifications of p53: competing for the lysinesStephanie Carter
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK
Curr Opin Genet Dev 19:18-24. 2009..This complexity is amplified by the variety of modifications that can target the same lysine residue - often with opposing effects on p53 function... - The secret life of histonesDavid A F Gillespie
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, G61 1BD, Glasgow, United Kingdom
Cell 114:655-6. 2003..2 in DNA damage-induced apoptosis. DNA double strand breaks induce translocation of nuclear H1.2 to the cytoplasm, where it promotes release of cytochrome c from mitochondria by activating the Bcl-2 family protein, Bak... - A role for Numb in p53 stabilizationStephanie Carter
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, UK
Genome Biol 9:221. 2008..Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53... - Metabolic regulation by p53Oliver D K Maddocks
The Beatson Institute for Cancer Research, Glasgow, UK
J Mol Med (Berl) 89:237-45. 2011..A better understanding of how p53 coordinates metabolic adaptation will facilitate the identification of novel therapeutic targets and will also illuminate the wider role of p53 in human biology... - Activation of the p53 tumor suppressor proteinKaren H Vousden
Regulation of Cell Growth Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Biochim Biophys Acta 1602:47-59. 2002.... - Regulation of the p53 pathway by ubiquitin and related proteinsAndreas Hock
The Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
Int J Biochem Cell Biol 42:1618-21. 2010..Understanding the complexity of this mechanism of p53 regulation will help in the development of therapeutic drugs that function to modulate these events... - p53 regulation of metabolic pathwaysEyal Gottlieb
The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom
Cold Spring Harb Perspect Biol 2:a001040. 2010..In the past few years, it became clear that p53, the most studied, if not most important, tumor suppressor protein, can also directly control metabolic traits of cells... - Complicating the complexity of p53Karen S Yee
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Carcinogenesis 26:1317-22. 2005..Although complicating our understanding of p53, these new insights may also provide some exciting new targets for the design of therapeutics that can reactivate p53 in cancers... - The role of p53 in glucose metabolismEric C Cheung
The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
Curr Opin Cell Biol 22:186-91. 2010..These new functions of p53 are providing interesting possibilities for the development of novel therapies... - Tumor suppression by p53: fall of the triumvirate?Andreas K Hock
The Beatson Institute for Cancer Research, Glasgow, UK
Cell 149:1183-5. 2012..Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role... - Outcomes of p53 activation--spoilt for choiceKaren H Vousden
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
J Cell Sci 119:5015-20. 2006.... - Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53Kevin M Ryan
Tumor Cell Death Laboratory, Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow, United Kingdom
Cancer Res 64:4415-8. 2004..Moreover, this indicates that, although perhaps central to p53 function, loss of the ability to induce programmed cell death does not completely inactivate p53's tumor-suppressive effects... - Critical role for a central part of Mdm2 in the ubiquitylation of p53Erik Meulmeester
Department of Molecular and Cell Biology and Center for Biomedical Genetics, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
Mol Cell Biol 23:4929-38. 2003..Strikingly, the function of this domain can be fulfilled in trans, indicating that the RING domain and this internal region perform distinct activities in the ubiquitylation of p53... - Phosphorylation of HDM2 by AktMargaret Ashcroft
CRC, Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Oncogene 21:1955-62. 2002..Tryptic peptide and mutational analyses revealed evidence for an Akt phosphorylation site in HDM2 additional to the two consensus sites... - p73-alpha is capable of inducing scotin and ER stressAlessandro Terrinoni
Biochemistry Laboratory, IDI-IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome 'Tor Vergata, 00133 Rome, Italy
Oncogene 23:3721-5. 2004..This molecular mechanism might contribute to the effector events inducing apoptosis downstream of p73... - INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescenceSharon Brookes
Molecular Oncology and Human Cytogenetics Laboratories, Cancer Research UK London Research Institute, Lincolns Inn Fields, London WC2A 3PX, UK
EMBO J 21:2936-45. 2002..We find that in human fibroblasts, ARF is not induced demonstrably by RAS, pointing to significant differences between the proliferative barriers implemented by the CDKN2A locus in different cell types or species... - p73: Friend or foe in tumorigenesisGerry Melino
Biochemistry Laboratory, IDI-IRCCS, c/o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
Nat Rev Cancer 2:605-15. 2002 - p73 supports cellular growth through c-Jun-dependent AP-1 transactivationFaina Vikhanskaya
Laboratory of Molecular Carcinogenesis, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
Nat Cell Biol 9:698-705. 2007..Collectively, our data demonstrates a novel and unexpected role of p73 in augmenting AP-1 transcriptional activity through which it supports cellular growth... - p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocationGerry Melino
Biochemistry Laboratory, Instituto Dermopatico Dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
J Biol Chem 279:8076-83. 2004..Our findings demonstrate that p73 elicits apoptosis via the mitochondrial pathway using PUMA and Bax as mediators... - Cancer: pinning a change on p53Kevin M Ryan
Nature 419:795, 797. 2002 - The ubiquitin-protein ligase Itch regulates p73 stabilityMario Rossi
Department of Biology, University of Rome Tor Vergata, Rome, Italy
EMBO J 24:836-48. 2005..In conclusion, we have identified a key mechanism in the control of p73 protein levels both in normal as well as in stress conditions... - PML regulates p53 stability by sequestering Mdm2 to the nucleolusRosa Bernardi
Cancer Biology and Genetics Program, Department of Pathology and Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nat Cell Biol 6:665-72. 2004..These findings demonstrate an unexpected role of PML in the nucleolar network for tumour suppression... - Cancer: guarding the guardian?Henning F Horn
Nature 427:110-1. 2004 - Savior and slayer: the two faces of p53Karim Bensaad
Nat Med 11:1278-9. 2005 - Synthesis of 5-deazaflavin derivatives and their activation of p53 in cellsJennifer M Wilson
WestCHEM, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
Bioorg Med Chem 15:77-86. 2007..Importantly, we have demonstrated that the nitro group present in all three of the original lead compounds [1-3 (HL198C-E)] is not essential for observation of this biological activity...