Thomas von Zglinicki
Affiliation: University of Newcastle
Fielder E, Weigand M, Agneessens J, Griffin B, Parker C, Miwa S, et al
. Sublethal whole-body irradiation causes progressive premature frailty in mice. Mech Ageing Dev. 2019;180:63-69 pubmed publisher
..We conclude that progressive frailty following sub-lethal irradiation comprises a sensitive and easy to use test bed for interventions to stop premature ageing in long-term tumour survivors. ..
Short S, Fielder E, Miwa S, von Zglinicki T. Senolytics and senostatics as adjuvant tumour therapy. EBioMedicine. 2019;41:683-692 pubmed publisher
..This becomes pertinent because treatments that are senostatic in vitro (e.g. dietary restriction mimetics) persistently reduce numbers of senescent cells in vivo, i.e. act as net senolytics in immunocompetent hosts. ..
Mitnitski A, Collerton J, Martin Ruiz C, Jagger C, von Zglinicki T, Rockwood K, et al
. Age-related frailty and its association with biological markers of ageing. BMC Med. 2015;13:161 pubmed publisher
..In the future, blood biomarkers may indicate the nature of the underlying causal deficits leading to age-related frailty, thereby helping to expose targets for early preventative interventions. ..
Miwa S, Treumann A, Bell A, Vistoli G, Nelson G, Hay S, et al
. Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays. Free Radic Biol Med. 2016;90:173-83 pubmed publisher
..Our results call for a serious re-examination of previous data. ..
Korolchuk V, Miwa S, Carroll B, von Zglinicki T. Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?. EBioMedicine. 2017;21:7-13 pubmed publisher
..Abstracts and reports from meetings were excluded. Articles published in English between 1995 and 2017 were included. Articles were selected according to their relevance to the topic as perceived by the authors. ..
Nelson G, Kucheryavenko O, Wordsworth J, von Zglinicki T. The senescent bystander effect is caused by ROS-activated NF-κB signalling. Mech Ageing Dev. 2018;170:30-36 pubmed publisher
..However, their activation in senescence is only partially controlled by NF-κB, and they are thus not strong candidates as intercellular mediators of the bystander effect as mediated by the ROS-NF-κB axis. ..