Research Topics
| Christine VogelSummaryAffiliation: University of Cambridge Country: UK Publications
| Collaborators |
Detail Information
Publications
The relationship between domain duplication and recombinationChristine Vogel
MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 2QH, UK
J Mol Biol 346:355-65. 2005..Some of the pair-wise domain combinations that are highly duplicated also recur frequently with other partner domains, and thus represent evolutionary units larger than single protein domains, which we term "supra-domains"...- The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexityChristine Vogel
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
Development 130:6317-28. 2003..These results suggest that the expansion of this protein superfamily is one of the factors that have contributed to the formation of the more complex physiological features that are found in Drosophila... - Structure, function and evolution of multidomain proteinsChristine Vogel
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Curr Opin Struct Biol 14:208-16. 2004..Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations... - Supra-domains: evolutionary units larger than single protein domainsChristine Vogel
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
J Mol Biol 336:809-23. 2004..Since this is the case for only a quarter of the supra-domains, we provide a list of the most important unknown supra-domains as potential targets for structural genomics projects... 
The SUPERFAMILY database in 2007: families and functionsDerek Wilson
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nucleic Acids Res 35:D308-13. 2007..The SUPERFAMILY database can be used for general protein evolution and superfamily-specific studies, genomic annotation, and structural genomics target suggestion and assessment...- Evolution of the protein repertoireCyrus Chothia
Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Science 300:1701-3. 2003..Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes... 
SUPERFAMILY--sophisticated comparative genomics, data mining, visualization and phylogenyDerek Wilson
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, Department of Computer Science, University of Bristol, The Merchant Venturers Building, Bristol BS8 1UB, UK
Nucleic Acids Res 37:D380-6. 2009..The database, models and associated scripts are available for download from the ftp site...- The SUPERFAMILY database in 2004: additions and improvementsMartin Madera
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nucleic Acids Res 32:D235-9. 2004..In addition, the webserver provides the following standard services: sequence search; keyword search for genomes, superfamilies and sequence identifiers; and multiple alignment of genomic, PDB and custom sequences... - Protein family expansions and biological complexityChristine Vogel
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
PLoS Comput Biol 2:e48. 2006..Our work identifies important protein families and provides one explanation of the discrepancy between the total number of genes and the apparent physiological complexity of eukaryotic organisms... - Duplication, divergence and formation of novel protein topologiesChristine Vogel
Institute for Cellular and Molecular Biology, University of Texas at Austin, TX, USA
Bioessays 28:973-8. 2006..In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence... - The (in)dependence of alternative splicing and gene duplicationDavid Talavera
Molecular Modeling and Bioinformatics Unit, Parc Cientific de Barcelona, Barcelona, Spain
PLoS Comput Biol 3:e33. 2007..We discuss possible explanations that relate to the order of appearance of AS and GD in a gene family, and to the selection pressure imposed by the environment...