Affiliation: University of Oxford
Vincent A, Irani S, Lang B. The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins. Curr Opin Neurol. 2010;23:144-50 pubmed publisher
..In autoimmune diseases such as systemic lupus erythematosus or coeliac disease, antibodies to specific membrane targets may also prove to be important in the future. ..
Vincent A. Antibody-mediated disorders of neuromuscular transmission. Suppl Clin Neurophysiol. 2004;57:147-58 pubmed
Vincent A, Bowen J, Newsom Davis J, McConville J. Seronegative generalised myasthenia gravis: clinical features, antibodies, and their targets. Lancet Neurol. 2003;2:99-106 pubmed
..Moreover, muscle wasting may be present, which prevents complete response to these therapies. ..
Vincent A, McConville J, Farrugia M, Bowen J, Plested P, Tang T, et al
. Antibodies in myasthenia gravis and related disorders. Ann N Y Acad Sci. 2003;998:324-35 pubmed
..These antibodies are not found in AChR antibody-positive MG and are predominantly IgG4. MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively. ..
Vincent A, Irani S. Caspr2 antibodies in patients with thymomas. J Thorac Oncol. 2010;5:S277-80 pubmed publisher
..These antibodies are common in the subgroup of patients with thymic malignancies. ..
Vincent A. Autoimmune channelopathies: well-established and emerging immunotherapy-responsive diseases of the peripheral and central nervous systems. J Clin Immunol. 2010;30 Suppl 1:S97-102 pubmed publisher
..The paradigms gained from the study of the peripheral conditions has led to a better appreciation of the role of antibodies in neurological disorders and a growing recognition of their role in central nervous system (CNS) diseases. ..
Vincent A, Lily O, Palace J. Pathogenic autoantibodies to neuronal proteins in neurological disorders. J Neuroimmunol. 1999;100:169-80 pubmed
Vincent A, Buckley C, Schott J, Baker I, Dewar B, Detert N, et al
. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain. 2004;127:701-12 pubmed
..Establishing the frequency of this new syndrome, the full range of clinical presentations and means of early recognition, and optimal immunotherapy, should now be the aim...
Vincent A, Leite M. Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis. Curr Opin Neurol. 2005;18:519-25 pubmed
..Here we review recent clinical and experimental studies on MuSK antibody associated myasthenia gravis, and summarize the results of newer treatments for myasthenia gravis...