Angela Vincent

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Myasthenia gravis in a woman with congenital AChR deficiency due to epsilon-subunit mutations
    Rebecca Croxen
    Neurosciences Group, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford, United Kingdom
    Neurology 58:1563-5. 2002
  2. pmc Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
    Sarosh R Irani
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 133:2734-48. 2010
  3. pmc Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition
    Luigi Zuliani
    Department of Neurology, Ospedale Ca Foncello, Treviso, Italy
    J Neurol Neurosurg Psychiatry 83:638-45. 2012
  4. ncbi request reprint Autoantibodies associated with diseases of the CNS: new developments and future challenges
    Angela Vincent
    Neuroimmunology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet Neurol 10:759-72. 2011
  5. ncbi request reprint Potentially pathogenic autoantibodies associated with epilepsy and encephalitis in children and adults
    Angela Vincent
    Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom
    Epilepsia 52:8-11. 2011
  6. pmc John Newsom-Davis: clinician-scientist and so much more
    Angela Vincent
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Brain 134:3755-74. 2011
  7. ncbi request reprint Morvan syndrome: clinical and serological observations in 29 cases
    Sarosh R Irani
    Neurosciences Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Neurol 72:241-55. 2012
  8. ncbi request reprint Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study
    Joanna Kitley
    Nuffield Department of Clinical Neurosciences, Oxford University Hospitals National Health Service Trust, University of Oxford, Oxford, England
    JAMA Neurol 71:276-83. 2014
  9. pmc IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
    Maria Isabel Leite
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Brain 131:1940-52. 2008
  10. ncbi request reprint Dok-7 mutations underlie a neuromuscular junction synaptopathy
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Science 313:1975-8. 2006

Detail Information

Publications95

  1. ncbi request reprint Myasthenia gravis in a woman with congenital AChR deficiency due to epsilon-subunit mutations
    Rebecca Croxen
    Neurosciences Group, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford, United Kingdom
    Neurology 58:1563-5. 2002
    ..The younger sister developed MG at 34 years. This unusual case raises the possibility that genetic defects of the AChR might be a factor in the etiology of autoimmune MG...
  2. pmc Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
    Sarosh R Irani
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 133:2734-48. 2010
    ....
  3. pmc Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition
    Luigi Zuliani
    Department of Neurology, Ospedale Ca Foncello, Treviso, Italy
    J Neurol Neurosurg Psychiatry 83:638-45. 2012
    ..Here, the known conditions associated with neuronal surface antibodies are briefly reviewed, some general aspects of these syndromes are considered and guidelines that could help in the recognition of further disorders are suggested...
  4. ncbi request reprint Autoantibodies associated with diseases of the CNS: new developments and future challenges
    Angela Vincent
    Neuroimmunology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet Neurol 10:759-72. 2011
    ....
  5. ncbi request reprint Potentially pathogenic autoantibodies associated with epilepsy and encephalitis in children and adults
    Angela Vincent
    Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom
    Epilepsia 52:8-11. 2011
    ..The conditions are often refractory to traditional antiepileptic drugs. Detection of these antibodies can help to identify forms of epilepsy that may respond to immunotherapies...
  6. pmc John Newsom-Davis: clinician-scientist and so much more
    Angela Vincent
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Brain 134:3755-74. 2011
    ....
  7. ncbi request reprint Morvan syndrome: clinical and serological observations in 29 cases
    Sarosh R Irani
    Neurosciences Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Neurol 72:241-55. 2012
    ....
  8. ncbi request reprint Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study
    Joanna Kitley
    Nuffield Department of Clinical Neurosciences, Oxford University Hospitals National Health Service Trust, University of Oxford, Oxford, England
    JAMA Neurol 71:276-83. 2014
    ..Here, we showed that patients with NMO/NMOSD with MOG-Abs demonstrate differences when compared with patients with AQP4-Abs...
  9. pmc IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
    Maria Isabel Leite
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Brain 131:1940-52. 2008
    ..These observations throw new light on different forms of MG paving the way for improved diagnosis and management, and the approaches used have applicability to other antibody-mediated conditions...
  10. ncbi request reprint Dok-7 mutations underlie a neuromuscular junction synaptopathy
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Science 313:1975-8. 2006
    ..We showed that recessive inheritance of mutations in Dok-7, which result in a defective structure of the neuromuscular junction, is a cause of CMS with proximal muscle weakness...
  11. ncbi request reprint Non-radioactive serological diagnosis of myasthenia gravis and clinical features of patients from Tianjin, China
    Li Yang
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, UK
    J Neurol Sci 301:71-6. 2011
    ..To establish non-radioactive assays for detection of antibodies (Abs) to the acetylcholine receptor (AChR) and to muscle specific kinase (MuSK). To show that the assays can be used in Tianjin for testing patients with MG...
  12. ncbi request reprint Autoimmune channelopathies: well-established and emerging immunotherapy-responsive diseases of the peripheral and central nervous systems
    Angela Vincent
    Department of Clinical Neurology, Level 6 West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Clin Immunol 30:S97-102. 2010
    ..Over the last decade, antibodies to CNS membrane receptors or ion channels have begun to be identified and these antibodies define antibody-mediated CNS diseases that also respond to immunotherapies...
  13. ncbi request reprint Myasthenia gravis seronegative for acetylcholine receptor antibodies
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom
    Ann N Y Acad Sci 1132:84-92. 2008
    ..Overall, these results suggest that complement-activation may be an important pathogenic mechanism even in patients without conventional AChR antibodies...
  14. ncbi request reprint Diverse molecular mechanisms involved in AChR deficiency due to rapsyn mutations
    Judy Cossins
    Neurosciences Group, Weatherall Institute of Molecular Medicine, Churchill Hospital, Oxford, UK
    Brain 129:2773-83. 2006
    ..The disease severity of patients harbouring the compound allelic mutations was greater than that of patients with homozygous rapsyn mutation N88K, suggesting that the second mutant allele may largely determine severity...
  15. ncbi request reprint Effect of sera from AChR-antibody negative myasthenia gravis patients on AChR and MuSK in cell cultures
    Maria Elena Farrugia
    Neurosciences Group, Weatherall Institute of Molecular Medicine, Department of Clinical Neurology, University of Oxford, UK
    J Neuroimmunol 185:136-44. 2007
    ..Thus, although these results have, disappointingly, demonstrated little effect of MuSK antibodies on AChR expression, they do imply that SNMG antibodies act on AChR-associated pathways...
  16. doi request reprint Presence and pathogenic relevance of antibodies to clustered acetylcholine receptor in ocular and generalized myasthenia gravis
    Saiju Jacob
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Arch Neurol 69:994-1001. 2012
    ....
  17. ncbi request reprint Congenital myasthenic syndromes and the formation of the neuromuscular junction
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Ann N Y Acad Sci 1132:99-103. 2008
    ....
  18. ncbi request reprint MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis
    Maria Elena Farrugia
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Brain 129:1481-92. 2006
    ....
  19. ncbi request reprint Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor
    Hiroyuki Shiono
    Neuroscience Group, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Int Immunol 15:903-13. 2003
    ..With these molecules, it should be easier to identify provoking cell type(s) that may give novel additional clues to autoimmunization against T-cell epitopes from the more complex AChR...
  20. pmc N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes
    Sarosh R Irani
    Department of Clinical Neurology, L6 West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Brain 133:1655-67. 2010
    ..Four patients, who only had temporal lobe epilepsy without oligoclonal bands, may represent restriction to the first stage...
  21. doi request reprint Longitudinally extensive transverse myelitis with and without aquaporin 4 antibodies
    Joanna Kitley
    Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Oxford, England
    JAMA Neurol 70:1375-81. 2013
    ..Aquaporin 4 antibody-negative neuromyelitis optica (NMO) is rare when good assays are used...
  22. ncbi request reprint Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype
    Sarosh R Irani
    1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Brain 136:3151-62. 2013
    ..Immunotherapy is associated with excellent control of the frequently anti-epileptic drug refractory seizures, hastens time to recovery, and may prevent the subsequent development of cognitive impairment observed in this study. ..
  23. ncbi request reprint Autoimmunizing mechanisms in thymoma and thymus
    Nick Willcox
    Neuroscience Group, Weatherall Institute for Molecular Medicine, University of Oxford, England, UK
    Ann N Y Acad Sci 1132:163-73. 2008
    ..Together, moreover, our findings implicate both myoid cells and TEC in autoimmunization, and thus strongly support our hypothesis...
  24. ncbi request reprint Antibodies in myasthenia gravis and related disorders
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:324-35. 2003
    ..These antibodies are not found in AChR antibody-positive MG and are predominantly IgG4. MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively...
  25. pmc Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia
    Esther B E Becker
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:437-40. 2012
    ..Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia...
  26. ncbi request reprint Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis
    Calman A MacLennan
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    J Neuroimmunol 201:28-32. 2008
    ..The greater abundance of mRNA for AChR epsilon-subunit than for other subunits suggests that the AChR epsilon-subunit may play a distinctive role in autosensitization in MG-associated thymomas, particularly those of type A or AB...
  27. doi request reprint Passive and active immunization models of MuSK-Ab positive myasthenia: electrophysiological evidence for pre and postsynaptic defects
    Stuart Viegas
    Weatherall Institute of Molecular Medicine and Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Exp Neurol 234:506-12. 2012
    ..These results raise questions about how MuSK is involved in retrograde signaling, and the combination of post-synaptic defects with lack of presynaptic compensation may begin to explain the more severe disease in MuSK-MG patients...
  28. ncbi request reprint Maternal neuronal antibodies associated with autism and a language disorder
    Paola Dalton
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Ann Neurol 53:533-7. 2003
    ..This evidence supports a role for maternal antibodies in some forms of neurodevelopmental disorder...
  29. pmc Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens
    Yael Hacohen
    Paediatric Neurosciences, Evelina Children s Hospital at Guy s and St Thomas NHS Foundation Trust, King s Health Partners Academic Health Sciences Centre, London SE1 7EH
    J Neurol Neurosurg Psychiatry 84:748-55. 2013
    ..To report the clinical and investigative features of children with a clinical diagnosis of probable autoimmune encephalopathy, both with and without antibodies to central nervous system antigens...
  30. ncbi request reprint Methotrexate is an alternative to azathioprine in neuromyelitis optica spectrum disorders with aquaporin-4 antibodies
    Joanna Kitley
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 84:918-21. 2013
    ..Immunosuppression is the mainstay of treatment but many patients do not tolerate first-line immunosuppressive agents, or experience ongoing relapses...
  31. ncbi request reprint Antibodies identified by cell-based assays in myasthenia gravis and associated diseases
    Angela Vincent
    Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, United Kingdom
    Ann N Y Acad Sci 1274:92-8. 2012
    ..The cell-based method is time consuming but has many advantages and may provide a gold standard for the future in the detection of pathogenic autoantibodies in patients with immune-mediated diseases...
  32. ncbi request reprint The search for new antigenic targets in myasthenia gravis
    Judith Cossins
    Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Ann N Y Acad Sci 1275:123-8. 2012
    ..These assays, combined with use of myotube cultures to explore the effects of the antibodies, enable us to begin to identify new antigenic targets and test antibody pathogenicity in vitro...
  33. doi request reprint Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica
    Sven Jarius
    Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Nat Clin Pract Neurol 4:202-14. 2008
    ..Many aspects of the pathogenesis, however, remain unclear...
  34. doi request reprint Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis
    Sven Jarius
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    J Neurol Sci 298:158-62. 2010
    ....
  35. ncbi request reprint Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis
    Sarosh R Irani
    Department of Clinical Neurology, Oxford University, Oxford, UK
    Ann Neurol 69:892-900. 2011
    ..To describe a distinctive seizure semiology that closely associates with voltage-gated potassium channel (VGKC)-complex/Lgi1 antibodies and commonly precedes the onset of limbic encephalitis (LE)...
  36. ncbi request reprint IgG and complement deposition and neuronal loss in cats and humans with epilepsy and voltage-gated potassium channel complex antibodies
    Andrea Klang
    From the Institute of Pathology and Forensic Veterinary Medicine, Department for Pathobiology AK, PS, Clinic for Internal Medicine and Infectious Diseases AP, Diagnostic Imaging SK, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria Department of Neuroimmunology JB, Center for Brain Research, Medical University of Vienna, Vienna, Austria Austrian Agency for Health and Food Safety ZB, Institute for Veterinary Disease Control, Mödling, Austria Department of Clinical Neurology AV, BL, TM, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, England Hospital Mara CGB, Epilepsy Center Bethel, Bielefeld, Germany Institute of Experimental Medicine PH, Budapest, Hungary
    J Neuropathol Exp Neurol 73:403-13. 2014
    ..These findings provide further evidence that FEPSO is a feline form of VGKC-complex-Ab limbic encephalitis and provide a model for increasing understanding of the human disease. ..
  37. ncbi request reprint Autoimmune disorders of neuronal potassium channels
    John Newsom-Davis
    Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Ann N Y Acad Sci 998:202-10. 2003
    ....
  38. ncbi request reprint Autoimmune channelopathies and related neurological disorders
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Neuron 52:123-38. 2006
    ....
  39. doi request reprint N-methyl-D-aspartate receptor antibody-associated movement disorder without encephalopathy
    Yael Hacohen
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Dev Med Child Neurol 56:190-3. 2014
    ..These patients did not develop the characteristic encephalopathy syndrome seen in NMDAR encephalitis, but all three had other associated subtle cognitive deficits. The patients demonstrated good responses to immunotherapy. ..
  40. ncbi request reprint Fetal arthrogryposis and maternal serum antibodies
    Paola Dalton
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Neuromuscul Disord 16:481-91. 2006
    ..Other maternal antibodies require further study, but these observations add to the emerging literature on maternal antibodies associated with developmental intrauterine disorders...
  41. pmc Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status
    Maria I Leite
    Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Am J Pathol 171:893-905. 2007
    ..Remarkably, the similar changes place many apparent AChR-seronegative patients in the same spectrum as the AChR-seropositive patients...
  42. ncbi request reprint The expanding spectrum of clinically-distinctive, immunotherapy-responsive autoimmune encephalopathies
    Sarosh R Irani
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Arq Neuropsiquiatr 70:300-4. 2012
    ..In the present article, we have summarised recent developments in the clinical and laboratory findings within this rapidly expanding field...
  43. doi request reprint Prognostic factors and disease course in aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder from the United Kingdom and Japan
    Joanna Kitley
    Nuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Brain 135:1834-49. 2012
    ..These factors need to be explored further in future prospective neuromyelitis optica and neuromyelitis optica spectrum disorder studies...
  44. ncbi request reprint Seronegative myasthenia gravis
    Angela Vincent
    Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Semin Neurol 24:125-33. 2004
    ..MuSK antibody-positive patients may also differ in the distribution of their electrophysiological abnormalities and their responses to treatments...
  45. ncbi request reprint The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins
    Angela Vincent
    Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Curr Opin Neurol 23:144-50. 2010
    ..The concept of epilepsy and seizure disorders caused by autoantibodies to specific neuronal membrane proteins has developed significantly during the past few years...
  46. pmc Immunocapture and identification of cell membrane protein antigenic targets of serum autoantibodies
    Edward Littleton
    Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
    Mol Cell Proteomics 8:1688-96. 2009
    ..The approach would also be very suitable for the analysis of human or experimental antitumor responses...
  47. ncbi request reprint Inhibition of acetylcholine receptor function by seronegative myasthenia gravis non-IgG factor correlates with desensitisation
    Ian Spreadbury
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Neuroimmunol 162:149-56. 2005
    ..The results suggest that, rather than acting indirectly as previously proposed, the SNMG factor may bind directly to an allosteric site that induces or enhances AChR desensitisation...
  48. pmc Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss
    Thashi Chang
    Neuroimmunology Group, Weatherall Institute of Molecular Medicine and Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka
    PLoS ONE 8:e72921. 2013
    ....
  49. ncbi request reprint Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis
    Maria Elena Farrugia
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Muscle Nerve 33:568-70. 2006
    ..These findings demonstrate clear differences between the neurophysiology of MuSK-MG and AChR-MG...
  50. ncbi request reprint New autoantibody mediated disorders of the central nervous system
    Bethan Lang
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Curr Opin Neurol 16:351-7. 2003
    ..This review summarizes the recent findings and assesses the evidence that these conditions are caused by the antibodies, using the criteria established for peripheral nervous system autoimmune diseases...
  51. ncbi request reprint Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
    Manuel A Friese
    Medical Research Council Human Immunology Unit and Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nat Med 13:1483-9. 2007
    ..In addition, adoptive transfer of T cells from wild-type mice did not affect the protection mediated by Asic1 disruption. These results suggest that ASIC1 blockers could provide neuroprotection in multiple sclerosis...
  52. ncbi request reprint Lack of association between acetylcholine receptor epsilon polymorphisms and early-onset myasthenia gravis
    Domenico Marco Bonifati
    Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Muscle Nerve 29:436-9. 2004
    ..These data provide no evidence that heteroallelic mutations or polymorphisms in the AChR epsilon subunit are involved in the development of autoimmune early-onset MG but raise issues for future studies...
  53. doi request reprint Paraneoplastic neurologic syndrome in the PNS Euronetwork database: a European study from 20 centers
    Bruno Giometto
    Department of Neurology, Ospedale Ca Foncello, Azienda Unità Locale Socio Sanitaria 9 Treviso, Piazza Ospedale 1, 31100 Treviso, Italy
    Arch Neurol 67:330-5. 2010
    ..Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS...
  54. ncbi request reprint Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy
    Tanja Brenner
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Epilepsia 54:1028-35. 2013
    ..Previous cross-sectional studies have found specific neurologic antibodies in a small proportion of people with established epilepsy, but these investigations have seldom included patients with recent diagnosis...
  55. doi request reprint NMDA receptor antibody encephalitis
    Sarosh R Irani
    Nuffield Department of Clinical Neurosciences, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford OX39DS, UK
    Curr Neurol Neurosci Rep 11:298-304. 2011
    ....
  56. ncbi request reprint Autoimmune disorders of the neuromuscular junction
    Angela Vincent
    Department of Clinical Neurology, Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Neurol India 56:305-13. 2008
    ..The immune mechanisms of acquired NMT relate to loss of voltage-gated potassium channel function. This review will focus on the important recent developments in the immune-mediated disorders of the NMJ...
  57. doi request reprint Caspr2 antibodies in patients with thymomas
    Angela Vincent
    Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom
    J Thorac Oncol 5:S277-80. 2010
    ..These antibodies are common in the subgroup of patients with thymic malignancies...
  58. ncbi request reprint Detection and characterization of MuSK antibodies in seronegative myasthenia gravis
    John McConville
    Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, Oxford, UK
    Ann Neurol 55:580-4. 2004
    ..They bind to the extracellular Ig-like domains of soluble or native MuSK. Surprisingly they are predominantly in the IgG4 subclass. MuSK-antibody associated MG may be different in etiological and pathological mechanisms...
  59. ncbi request reprint Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, University of Oxford, Oxford, UK
    Curr Opin Neurol 18:519-25. 2005
    ..Here we review recent clinical and experimental studies on MuSK antibody associated myasthenia gravis, and summarize the results of newer treatments for myasthenia gravis...
  60. ncbi request reprint Autoimmune disorders of the neuromuscular junction
    Bethan Lang
    Department of Clinical Neurology, University of Oxford, Oxford OX3 9DS, UK
    Curr Opin Pharmacol 9:336-40. 2009
    ..General immunosuppression is still the main treatment, but novel treatments that reduce complement-mediated damage or inhibit the binding of pathogenic antibodies are beginning to look promising...
  61. ncbi request reprint Pathogenic autoantibodies in the lambert-eaton myasthenic syndrome
    Bethan Lang
    Neurosciences Group and Department of Clinical Neurology, Oxford University, Oxford, United Kingdom
    Ann N Y Acad Sci 998:187-95. 2003
    ..These results demonstrate an unexpected plasticity in the expression of VGCCs in mammalian neurons and may represent a mechanism by which the pathogenic effects of LEMS IgG are reduced...
  62. doi request reprint Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels
    Charlotte J Stagg
    Centre for Functional Magnetic Resonance of the Brain FMRIB, University of Oxford, Oxford, United Kingdom
    Epilepsia 51:1898-901. 2010
    ....
  63. ncbi request reprint Antibody-mediated disorders of neuromuscular transmission
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Suppl Clin Neurophysiol 57:147-58. 2004
  64. doi request reprint Prospective study into the incidence of Lambert Eaton myasthenic syndrome in small cell lung cancer
    Miranda Payne
    Department of Medical Oncology, University of Oxford Medical Oncology Unit, Oxford, United Kingdom
    J Thorac Oncol 5:34-8. 2010
    ..VGCC can also be found in patients with SCLC and cerebellar ataxia. This was a prospective study to assess the incidence of clinical and subclinical LEMS or other neurologic disease in patients with SCLC...
  65. doi request reprint Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype
    Joanna Kitley
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Neurology 79:1273-7. 2012
    ..To report an association of myelin-oligodendrocyte glycoprotein (MOG) antibodies with aquaporin-4 (AQP4) antibody-seronegative neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) in adults...
  66. ncbi request reprint Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Brain 127:701-12. 2004
    ..Establishing the frequency of this new syndrome, the full range of clinical presentations and means of early recognition, and optimal immunotherapy, should now be the aim...
  67. ncbi request reprint Diagnostic use of autoantibodies in myasthenia gravis
    M Isabel Leite
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, West Wing OX3 9DS, UK
    Autoimmunity 43:371-9. 2010
    ..The same approaches to antibody detection are now being applied to a wide range of other autoantigens and other autoimmune diseases...
  68. doi request reprint Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort
    Yael Hacohen
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 85:456-61. 2014
    ....
  69. doi request reprint Developments in autoimmune channelopathies
    Angela Vincent
    Neuroimmunology Group, Nuffield Department of Clinical Neurosciences, Level 5 6 John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Autoimmun Rev 12:678-81. 2013
    ..Most importantly, these new antibody-mediated diseases are being identified in patients of all ages, and in the majority of cases, the patients improve substantially with immunotherapies...
  70. ncbi request reprint Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG
    Maria Isabel Leite
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
    Ann Neurol 57:444-8. 2005
    ..However, approximately 75% MuSK- samples showed lymph node-type infiltrates similar to those in AChR+ patients, but with fewer germinal centers. These variations may explain some apparent differences in responses to thymectomy in SNMG...
  71. ncbi request reprint Detection of anti-aquaporin-4 antibodies in neuromyelitis optica: current status of the assays
    P Waters
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Int MS J 15:99-105. 2008
    ..Since the discovery of a specific serum marker for NMO in 2004, and its subsequent identification as an antibody to aquaporin-4 (AQP-4), various methods have been developed to test for the antibodies in patients sera...
  72. ncbi request reprint Interferon Beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titers
    Jacqueline Palace
    DM, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Level 3 West Wing, Oxford OX3 9DU, England
    Arch Neurol 67:1016-7. 2010
    ..To describe a patient with neuromyelitis optica (NMO) whose aquaporin 4 (AQP4) antibody levels increased following treatment with interferon beta...
  73. doi request reprint Systemic and neurologic autoimmune disorders associated with seizures or epilepsy
    Angela Vincent
    Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Epilepsia 52:12-7. 2011
    ....
  74. pmc Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels
    Richard G Webster
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Br J Pharmacol 146:1027-39. 2005
    ..The similarity between beta-pompilidotoxin and oxaliplatin suggests that alteration of voltage-gated Na(+) channel kinetics is likely to underlie the acute neurotoxic actions of oxaliplatin...
  75. ncbi request reprint Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen
    Ian Matthews
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Lab Invest 82:1407-17. 2002
    ....
  76. ncbi request reprint Antibodies to neuronal targets in neurological and psychiatric diseases
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Ann N Y Acad Sci 992:48-55. 2003
    ..This review highlights features of these conditions, preliminary investigations into neurodevelopmental disorders, and areas for further study...
  77. ncbi request reprint The agrin/muscle-specific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction
    Yohan Liyanage
    Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Muscle Nerve 25:4-16. 2002
    ..We then review the development of the NMJ, focusing on the important roles of nerve-derived agrin and MuSK in clustering of AChRs and other essential components of the NMJ...
  78. doi request reprint Human limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission
    Tatjana Lalic
    MRC Anatomical Neuropharmacology Unit, Oxford, UK
    Epilepsia 52:121-31. 2011
    ..We aimed to test the hypothesis that purified immunoglobulin G (IgG) from a VGKC-Ab LE serum would excite hippocampal CA3 pyramidal cells by reducing VGKC function at mossy-fiber (MF)-CA3 pyramidal cell synapses...
  79. ncbi request reprint Immune responses to Campylobacter and serum autoantibodies in patients with complex regional pain syndrome
    Andreas Goebel
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Neuroimmunol 162:184-9. 2005
    ..These results provide preliminary evidence for immune activation early in CRPS and, additionally, that patients with minimal trauma may comprise an autoimmune subgroup...
  80. ncbi request reprint Myasthenia gravis
    Angela Vincent
    Neurosciences Group and Stroke Prevention Group, Department of Clinical Neurology, University of Oxford, UK
    Autoimmunity 37:317-9. 2004
  81. ncbi request reprint Autoimmune channelopathies
    Camilla Buckley
    University of Oxford, UK
    Nat Clin Pract Neurol 1:22-33. 2005
    ....
  82. ncbi request reprint Serum autoantibodies to cell surface determinants in multiple sclerosis: a flow cytometric study
    Oliver Lily
    Neurosciences Group, Weatherall Institute of Molecular Medicine, Department of Clinical Neurology, University of Oxford, UK
    Brain 127:269-79. 2004
    ..Identification of the cell surface determinants to which the antibodies bind may shed light on new targets for therapeutic intervention...
  83. doi request reprint Autoimmune channelopathies: John Newsom-Davis's work and legacy. A summary of the Newsom-Davis Memorial Lecture 2008
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, OX3 9TH
    J Neuroimmunol 201:245-9. 2008
    ..This review will highlight some of his most seminal findings and those that are following on from his work...
  84. ncbi request reprint Unravelling the pathogenesis of myasthenia gravis
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Nat Rev Immunol 2:797-804. 2002
    ....
  85. ncbi request reprint Diseases of the neuromuscular junction
    John McConville
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Curr Opin Pharmacol 2:296-301. 2002
    ..This is proving relevant to seronegative myasthenia gravis, with the discovery of anti-MuSK antibodies, and to a type of congenital myasthenic syndrome, in which acetylcholine receptor deficiency is due to mutations in rapsyn...
  86. ncbi request reprint Structural abnormalities of the AChR caused by mutations underlying congenital myasthenic syndromes
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, The John Radcliffe, Headington, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:114-24. 2003
    ..It was found that mutations within muscle AChRs are the most common cause of CMS. The majority are located within the epsilon-subunit gene and result in AChR deficiency...
  87. ncbi request reprint Maternal antibody-mediated dyslexia? Evidence for a pathogenic serum factor in a mother of two dyslexic children shown by transfer to mice using behavioural studies and magnetic resonance spectroscopy
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DS, Oxford, UK
    J Neuroimmunol 130:243-7. 2002
    ..These preliminary results are consistent with a role for maternal serum factors, probably antibodies, in causing some of the features of dyslexia, and possibly in other neurodevelopmental disorders...
  88. ncbi request reprint Voltage-gated potassium channel antibodies in limbic encephalitis
    Patricia Pozo-Rosich
    Neurosciences Group, Weatherall Insitute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Neurol 54:530-3. 2003
    ..VGKC antibodies do not unambiguously discriminate between idiopathic or paraneoplastic LE but probably indicate a good response to immunotherapy...
  89. ncbi request reprint Autoimmune encephalitis -- new awareness, challenging questions
    Sarosh R Irani
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9TH, United Kingdom
    Discov Med 11:449-58. 2011
    ....
  90. ncbi request reprint Phenotypic variants of autoimmune peripheral nerve hyperexcitability
    Ian K Hart
    Neuroimmunology Group, University Department of Neurological Science, Walton Centre, Liverpool, UK
    Brain 125:1887-95. 2002
    ....
  91. ncbi request reprint A mouse model of AChR deficiency syndrome with a phenotype reflecting the human condition
    Judy Cossins
    Neuroscience Group, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford, UK
    Hum Mol Genet 13:2947-57. 2004
    ....
  92. ncbi request reprint Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons
    Denis Burdakov
    Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
    Eur J Neurosci 20:3281-5. 2004
    ..These results identify an important determinant of the firing dynamics of orexin neurons, and support the idea that the A-current can control neuronal gain...
  93. ncbi request reprint Revised diagnostic criteria for neuromyelitis optica--incorporation of NMO-IgG status
    Sven Jarius
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Clin Pract Neurol 3:E1. 2007
  94. ncbi request reprint Autoantibodies to ion channels at the neuromuscular junction
    Bethan Lang
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Autoimmun Rev 2:94-100. 2003
    ....
  95. ncbi request reprint Seronegative generalised myasthenia gravis: clinical features, antibodies, and their targets
    Angela Vincent
    Department of Clinical Neurology, University of Oxford, UK
    Lancet Neurol 2:99-106. 2003
    ..Moreover, muscle wasting may be present, which prevents complete response to these therapies...