Jørgen Vestbo

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi request reprint COPD: definition and phenotypes
    Jørgen Vestbo
    Department of Respiratory Medicine J, Odense University Hospital, Clinical Institute, University of Southern Denmark, Odense, Denmark Respiratory Research Group, Manchester Academic Sciences Centre, University Hospital South Manchester NHS Foundation Trust, Southmoor Road, M23 9LT Manchester, UK Electronic address
    Clin Chest Med 35:1-6. 2014
  2. pmc Factors associated with change in exacerbation frequency in COPD
    Gavin C Donaldson
    Centre for Respiratory Medicine, UCL Medical School, Royal Free Campus, Rowland Hill Street Hampstead, London NW3 2PF, UK
    Respir Res 14:79. 2013
  3. doi request reprint Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    Jørgen Vestbo
    Manchester Academic Sciences Health Centre, Respiratory Research Group, University of Manchester, University Hospital South Manchester, Southmoor Road, Manchester M23 9LT, UK
    Am J Respir Crit Care Med 187:347-65. 2013
  4. pmc Health status in the TORCH study of COPD: treatment efficacy and other determinants of change
    Paul W Jones
    Department of Cardiac and Vascular Sciences, St George s Hospital, University of London, London, UK
    Respir Res 12:71. 2011
  5. pmc Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
    Respir Res 11:122. 2010
  6. doi request reprint Onset of effect of aclidinium, a novel, long-acting muscarinic antagonist, in patients with COPD
    Jørgen Vestbo
    Manchester Academic Health Sciences Centre, UK
    COPD 7:331-6. 2010
  7. doi request reprint Adherence to inhaled therapy, mortality and hospital admission in COPD
    J Vestbo
    Respiratory Medicine Research Group, University of Manchester, Manchester, UK
    Thorax 64:939-43. 2009
  8. doi request reprint A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD
    J Vestbo
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Eur Respir J 33:1039-44. 2009
  9. pmc Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease
    J Vestbo
    North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Thorax 60:301-4. 2005
  10. ncbi request reprint Clinical assessment, staging, and epidemiology of chronic obstructive pulmonary disease exacerbations
    Jørgen Vestbo
    North West Lung Centre, South Manchester University Hospital Trust, Wythenshawe Hospital, UK
    Proc Am Thorac Soc 3:252-6. 2006

Collaborators

Detail Information

Publications33

  1. doi request reprint COPD: definition and phenotypes
    Jørgen Vestbo
    Department of Respiratory Medicine J, Odense University Hospital, Clinical Institute, University of Southern Denmark, Odense, Denmark Respiratory Research Group, Manchester Academic Sciences Centre, University Hospital South Manchester NHS Foundation Trust, Southmoor Road, M23 9LT Manchester, UK Electronic address
    Clin Chest Med 35:1-6. 2014
    ..COPD is increasingly divided in subgroups or phenotypes based on specific features and association with prognosis or response to therapy, the most notable being the feature of frequent exacerbations. ..
  2. pmc Factors associated with change in exacerbation frequency in COPD
    Gavin C Donaldson
    Centre for Respiratory Medicine, UCL Medical School, Royal Free Campus, Rowland Hill Street Hampstead, London NW3 2PF, UK
    Respir Res 14:79. 2013
    ..Although most patients do not change category from year to year, some will, and the factors associated with this behaviour have not been examined...
  3. doi request reprint Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    Jørgen Vestbo
    Manchester Academic Sciences Health Centre, Respiratory Research Group, University of Manchester, University Hospital South Manchester, Southmoor Road, Manchester M23 9LT, UK
    Am J Respir Crit Care Med 187:347-65. 2013
    ..The GOLD initiative will continue to bring COPD to the attention of all relevant shareholders and will hopefully inspire future national and local guidelines on the management of COPD...
  4. pmc Health status in the TORCH study of COPD: treatment efficacy and other determinants of change
    Paul W Jones
    Department of Cardiac and Vascular Sciences, St George s Hospital, University of London, London, UK
    Respir Res 12:71. 2011
    ..Little is known about factors that determine health status decline in clinical trials of COPD...
  5. pmc Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
    Respir Res 11:122. 2010
    ..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)...
  6. doi request reprint Onset of effect of aclidinium, a novel, long-acting muscarinic antagonist, in patients with COPD
    Jørgen Vestbo
    Manchester Academic Health Sciences Centre, UK
    COPD 7:331-6. 2010
    ..In conclusion, aclidinium provided effective bronchodilation, similar to that seen with tiotropium, with significant improvements compared with placebo observed from 10 minutes post-dose...
  7. doi request reprint Adherence to inhaled therapy, mortality and hospital admission in COPD
    J Vestbo
    Respiratory Medicine Research Group, University of Manchester, Manchester, UK
    Thorax 64:939-43. 2009
    ..Little is known about adherence to inhaled medication in chronic obstructive pulmonary disease (COPD) and the impact on mortality and morbidity...
  8. doi request reprint A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD
    J Vestbo
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Eur Respir J 33:1039-44. 2009
    ..The findings of the present study question the role of inhaled phosphodiesterase type-4 inhibitors in chronic obstructive pulmonary disease...
  9. pmc Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease
    J Vestbo
    North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Thorax 60:301-4. 2005
    ..Combined treatment with inhaled corticosteroids and long acting beta2 agonists is approved for the treatment of chronic obstructive pulmonary disease (COPD), but little is known about the onset of effect of the combination...
  10. ncbi request reprint Clinical assessment, staging, and epidemiology of chronic obstructive pulmonary disease exacerbations
    Jørgen Vestbo
    North West Lung Centre, South Manchester University Hospital Trust, Wythenshawe Hospital, UK
    Proc Am Thorac Soc 3:252-6. 2006
    ..However, no formal and validated staging system exists today. Given the frequency and impact of COPD exacerbations, there seems to be a need for systematic research in this area...
  11. doi request reprint Predictors of objective cough frequency in chronic obstructive pulmonary disease
    Helen Sumner
    Respiratory Research Group, Faculty of Medicine and Human Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    Am J Respir Crit Care Med 187:943-9. 2013
    ..Cough is one of the principal symptoms of chronic obstructive pulmonary disease (COPD) but the potential drivers of cough are likely to be multifactorial and poorly understood...
  12. doi request reprint Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes
    Umme Kolsum
    North West Lung Research Centre, University of Manchester, South Manchester University Hospitals Trust, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Respir Med 103:136-43. 2009
    ..We set out to investigate which IOS measurements are related to airflow obstruction, airway conductance and lung volumes in chronic obstructive pulmonary disease (COPD)...
  13. pmc The repeatability of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein in COPD patients over one year
    Umme Kolsum
    North West Lung Research Centre, University of Manchester, South Manchester University Hospitals Trust, Wythenshawe, Manchester, UK
    Int J Chron Obstruct Pulmon Dis 4:149-56. 2009
    ..We assessed the long term repeatability of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) over one year and examined the relationships between these systemic markers in COPD...
  14. pmc Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD
    Khaled Al-shair
    University of Manchester, Manchester Academic Health Sciences Centre, University Hospital of South Manchester Foundation Trust, Wythenshawe, Manchester, UK
    Respir Res 12:3. 2011
    ....
  15. pmc Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale
    Khaled Al-shair
    University of Manchester, Medicines Evaluation Unit, NIHR Translational Research Facility, Manchester Academic Health Sciences Centre, University Hospital of South Manchester Foundation Trust, Wythenshawe, Manchester, UK
    Health Qual Life Outcomes 10:100. 2012
    ..The availability of a short, simple, reliable and valid scale would improve assessment of the characteristics and influence of fatigue in COPD...
  16. doi request reprint The 2011 revision of the global strategy for the diagnosis, management and prevention of COPD (GOLD)--why and what?
    Jørgen Vestbo
    Department of Respiratory Medicine J, Odense University Hospital, Odense, Denmark
    Clin Respir J 6:208-14. 2012
    ....
  17. ncbi request reprint [Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease]
    Jørgen Vestbo
    Wythenshawe Hospital, North West Lung Centre, Manchester, UK
    Ugeskr Laeger 166:271-4. 2004
  18. ncbi request reprint The TORCH (towards a revolution in COPD health) survival study protocol
    J Vestbo
    North West Lung Research Centre, Wythenshawe Hospital, Manchester, UK
    Eur Respir J 24:206-10. 2004
    ..The first patient was recruited in September 2000 and results should be available in 2006. This paper describes the "TOwards a Revolution in COPD Health" study and explains the rationale behind it...
  19. pmc COPD phenotype description using principal components analysis
    Kay Roy
    University of Manchester, North West Lung Research Centre, University Hospital of South Manchester Foundation Trust, Manchester, UK
    Respir Res 10:41. 2009
    ..This study set out to explore the heterogeneity of COPD using biomarkers of airway and systemic inflammation and pulmonary function by principal components analysis (PCA)...
  20. pmc MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease
    Sara Kirkham
    1Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 178:1033-9. 2008
    ..Therefore, we hypothesized that the polymeric mucin composition or properties may be different in the sputum from individuals with COPD and smokers without airflow obstruction...
  21. doi request reprint A trial of beclomethasone/formoterol in COPD using EXACT-PRO to measure exacerbations
    Dave Singh
    University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
    Eur Respir J 41:12-7. 2013
    ..FORWARD is therefore expected to provide information on the ability of EXACT to detect and measure exacerbations in a large clinical trial setting. The study design of FORWARD is described in this article...
  22. doi request reprint Tiotropium for treatment of stable COPD: a meta-analysis of clinically relevant outcomes
    Abebaw Mengistu Yohannes
    Department of Health Professions, Manchester Metropolitan University, Manchester, United Kingdom, UK
    Respir Care 56:477-87. 2011
    ....
  23. doi request reprint Development, dimensions, reliability and validity of the novel Manchester COPD fatigue scale
    K Al-shair
    Respiratory Research Group, The University of Manchester, South Manchester University Hospitals NHS Foundation Trust, Manchester, UK
    Thorax 64:950-5. 2009
    ..Fatigue is a prominent symptom in chronic obstructive pulmonary disease (COPD) and it has distinctive features; however, there is a need for a robust scale to measure fatigue in COPD...
  24. doi request reprint Increased T-regulatory cells within lymphocyte follicles in moderate COPD
    J Plumb
    University of Manchester, Education and Research Centre, South Manchester University Hospitals Trust, Manchester, UK
    Eur Respir J 34:89-94. 2009
    ..Lymphoid follicles in COPD patients have increased T-regulatory cells. Therefore, T-regulatory activity may be altered within COPD lymphoid follicles...
  25. pmc Measuring bronchodilation in COPD clinical trials
    Z L Borrill
    Medicines Evaluation Unit, North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Br J Clin Pharmacol 59:379-84. 2005
    ....
  26. pmc Long-term survival for COPD patients receiving noninvasive ventilation for acute respiratory failure
    Ingrid L Titlestad
    Department of Respiratory Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    Int J Chron Obstruct Pulmon Dis 8:215-9. 2013
    ..We present long-term all-cause mortality data from patients receiving NIV for the first time...
  27. doi request reprint Extrafine Beclomethasone/formoterol compared to Fluticasone/salmeterol Combination Therapy in COPD
    Dave Singh
    University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester Foundation Trust, Manchester, UK
    BMC Pulm Med 14:43. 2014
    ..The study evaluated the efficacy of beclomethasone dipropionate/formoterol fumarate (BDP/FF) extrafine combination versus fluticasone propionate/salmeterol (FP/S) combination in COPD patients...
  28. ncbi request reprint Outpatient management of chronic obstructive pulmonary disease
    Jørgen Vestbo
    North West Lung Centre, Wythenshawe Hospital, Manchester
    Clin Med 4:220-4. 2004
  29. doi request reprint Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD
    Khaled Al-shair
    Medicines Evaluation Unit, North West Lung Research Centre, Langley Building, Southmoor Road, The University of Manchester, South Manchester University Hospitals Trust, Wythenshawe, Manchester M23 9QZ, UK
    Respir Med 103:1572-9. 2009
    ..We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle wasting in clinically stable COPD patients...
  30. pmc CD8 chemokine receptors in chronic obstructive pulmonary disease
    L J C Smyth
    North West Lung Centre, School of Translational Medicine, University of Manchester, Southmoor Road, Manchester, UK
    Clin Exp Immunol 154:56-63. 2008
    ..CD8CCR3 and CCR5 expression appear to be regulated by cigarette smoke exposure. We show that COPD lung tissue released more CCL5, suggesting a role for CCL5-CCR3 signalling in pulmonary CD8 recruitment in COPD...
  31. ncbi request reprint Use of different exhaled nitric oxide multiple flow rate models in COPD
    K Roy
    Medicines Evaluation Unit, North West Lung Centre, Wythenshawe Hospital, Manchester, M23 9QZ, UK
    Eur Respir J 29:651-9. 2007
    ..Nonlinear modelling has the least error, suggesting it is the best method. The number of flow rates should be standardised...
  32. ncbi request reprint Chronic mucus hypersecretion, exacerbations and natural history of COPD
    J Vestbo
    North West Lung Centre, Manchester, UK
    Exp Lung Res 31:63-5. 2005
  33. ncbi request reprint Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease
    Z Borrill
    Medicines Evaluation Unit, Wythenshawe Hospital, North West Lung Centre, Manchester M23 9LT, UK
    Eur Respir J 25:269-74. 2005
    ..Reasons for these fluctuations in exhaled breath condensate pH are unclear and require further investigation...