Alexei Verkhratsky

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Physiology of spontaneous [Ca(2+)]i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus
    Stepan Kortus
    Department of Molecular Neurophysiology, Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University in Prague, Salmovska 1, 12000 Prague, Czech Republic
    Cell Calcium 59:280-8. 2016
  2. doi request reprint Neuroglia: Functional Paralysis and Reactivity in Alzheimer's Disease and Other Neurodegenerative Pathologies
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Adv Neurobiol 15:427-449. 2017
  3. ncbi request reprint Astroglia, Glutamatergic Transmission and Psychiatric Diseases
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Adv Neurobiol 13:307-326. 2016
  4. ncbi request reprint Glial Asthenia and Functional Paralysis: A New Perspective on Neurodegeneration and Alzheimer's Disease
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny Novgorod, Russia
    Neuroscientist 21:552-568. 2015
  5. doi request reprint Astroglial calcium signalling in Alzheimer's disease
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny Novgorod, 603022, Russia University of Ljubljana, Institute of Pathophysiology, Laboratory of Neuroendocrinology and Molecular Cell Physiology, Zaloska cesta 4, SI 1000, Ljubljana, Slovenia Celica, Biomedical, Technology Park 24, 1000 Ljubljana, Slovenia Electronic address
    Biochem Biophys Res Commun . 2016
  6. pmc Neurological diseases as primary gliopathies: a reassessment of neurocentrism
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    ASN Neuro 4:. 2012
  7. pmc Translational potential of astrocytes in brain disorders
    Alexei Verkhratsky
    Faculty of Life Science, The University of Manchester, Manchester, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain University of Nizhny Novgorod, Nizhny Novgorod, Russia Electronic address
    Prog Neurobiol 144:188-205. 2016
  8. pmc The homeostatic astroglia emerges from evolutionary specialization of neural cells
    Alexei Verkhratsky
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny, Novgorod 603022, Russia
    Philos Trans R Soc Lond B Biol Sci 371:. 2016
  9. ncbi request reprint Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease
    Dmitry Lim
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Curr Alzheimer Res 13:359-69. 2016
  10. pmc Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain Electronic address
    Neurobiol Dis 85:254-61. 2016

Detail Information

Publications75

  1. pmc Physiology of spontaneous [Ca(2+)]i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus
    Stepan Kortus
    Department of Molecular Neurophysiology, Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University in Prague, Salmovska 1, 12000 Prague, Czech Republic
    Cell Calcium 59:280-8. 2016
    ..Together, these results unveil for the first time that both AVP and OT neurones maintain, via Ca(2+) signals, their remarkable intrinsic in vivo physiological properties in an isolated condition. ..
  2. doi request reprint Neuroglia: Functional Paralysis and Reactivity in Alzheimer's Disease and Other Neurodegenerative Pathologies
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Adv Neurobiol 15:427-449. 2017
    ..Neuroglia may represent a novel target for therapeutic intervention, be that prevention, slowing progression of or possibly curing neurodegenerative diseases...
  3. ncbi request reprint Astroglia, Glutamatergic Transmission and Psychiatric Diseases
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Adv Neurobiol 13:307-326. 2016
    ....
  4. ncbi request reprint Glial Asthenia and Functional Paralysis: A New Perspective on Neurodegeneration and Alzheimer's Disease
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny Novgorod, Russia
    Neuroscientist 21:552-568. 2015
    ..Here, we overview the experimental data indicating glial paralysis in neurodegeneration and argue that loss of glial function is fundamental for defining the progression of neurodegenerative diseases...
  5. doi request reprint Astroglial calcium signalling in Alzheimer's disease
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny Novgorod, 603022, Russia University of Ljubljana, Institute of Pathophysiology, Laboratory of Neuroendocrinology and Molecular Cell Physiology, Zaloska cesta 4, SI 1000, Ljubljana, Slovenia Celica, Biomedical, Technology Park 24, 1000 Ljubljana, Slovenia Electronic address
    Biochem Biophys Res Commun . 2016
    ..In AD astroglial Ca2+ signalling undergoes substantial reorganisation due to an abnormal regulation of expression of Ca2+ handling molecular cascades...
  6. pmc Neurological diseases as primary gliopathies: a reassessment of neurocentrism
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    ASN Neuro 4:. 2012
    ..The majority of therapeutic drugs currently in clinical use target neuronal receptors, channels or transporters. Future therapeutic efforts may benefit by a stronger focus on the supportive homoeostatic functions of astrocytes...
  7. pmc Translational potential of astrocytes in brain disorders
    Alexei Verkhratsky
    Faculty of Life Science, The University of Manchester, Manchester, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain University of Nizhny Novgorod, Nizhny Novgorod, Russia Electronic address
    Prog Neurobiol 144:188-205. 2016
    ..We point out that such as a task will require a holistic and multi-disciplinary approach that will take in consideration the concerted operation of all the cell types in the brain. ..
  8. pmc The homeostatic astroglia emerges from evolutionary specialization of neural cells
    Alexei Verkhratsky
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny, Novgorod 603022, Russia
    Philos Trans R Soc Lond B Biol Sci 371:. 2016
    ..This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'. ..
  9. ncbi request reprint Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease
    Dmitry Lim
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Curr Alzheimer Res 13:359-69. 2016
    ..This remodelling modifies astroglial Ca(2+) signalling and may be linked to cellular mechanisms of AD pathogenesis. ..
  10. pmc Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain Electronic address
    Neurobiol Dis 85:254-61. 2016
    ..Furthermore, astroglia also play a role in major neuropsychiatric disorders, ranging from schizophrenia to depression, as well as in addictive disorders. ..
  11. pmc Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK Achucarro Center for Neuroscience, IKERBASQUE Basque Foundation for Science, Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny Novgorod, Russia Laboratory of Neuroendocrinology Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology University of Ljubljana, Ljubljana, Slovenia Celica BIOMEDICAL, Ljubljana, Slovenia
    EMBO J 35:239-57. 2016
    ..We focus on the biogenesis and trafficking of secretory organelles and on the regulation of the exocytotic secretory system in the context of healthy and diseased astrocytes. ..
  12. doi request reprint Astroglia dynamics in ageing and Alzheimer's disease
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia Electronic address
    Curr Opin Pharmacol 26:74-9. 2016
    ..While at present this bodacious goal represents a wishful thinking, further understanding of astroglial role in ageing and neurodegeneration could bring us closer to laying the foundations for such cell-specific therapeutic approaches. ..
  13. doi request reprint Why are astrocytes important?
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Neurochem Res 40:389-401. 2015
    ..Astroglial cells further contribute to neuropathologies through mounting complex defensive programme generally known as reactive astrogliosis. ..
  14. doi request reprint Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia Kazan Federal University, Kazan 420111, Russia Electronic address
    Cell Calcium 56:362-71. 2014
    ..Molecular cascades responsible for Ca(2+) homeostasis and signalling, therefore, can be regarded as potential therapeutic targets...
  15. doi request reprint Glutamate and ATP: The Crossroads of Signaling and Metabolism in the Brain
    Alexei Verkhratsky
    Faculty of Life Sciences, School of Biological Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Adv Neurobiol 11:1-12. 2014
    ..This chapter is meant to introduce the chapters that follow in this book dedicated to the in-depth overview of the role of glutamate and ATP in the brain metabolism and signaling in health and disease. ..
  16. pmc Astroglial cradle in the life of the synapse
    Alexei Verkhratsky
    Faculty of Life Sciences, University of Manchester, Manchester, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia
    Philos Trans R Soc Lond B Biol Sci 369:20130595. 2014
    ....
  17. pmc Calcium signalling and calcium channels: evolution and general principles
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU, 48940 Leioa, Spain Electronic address
    Eur J Pharmacol 739:1-3. 2014
    ....
  18. doi request reprint Astrogliopathology: a central element of neuropsychiatric diseases?
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
    Neuroscientist 20:576-88. 2014
    ....
  19. doi request reprint Neuroglia in ageing and disease
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Cell Tissue Res 357:493-503. 2014
    ..Not only glial cells exhibit changes associated with the pathology of the brain but they also change with brain aging. ..
  20. doi request reprint History of electrophysiology and the patch clamp
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Methods Mol Biol 1183:1-19. 2014
    ..This chapter is meant to be a perspective to the following sections in this volume dedicated to patch-clamp methods and protocols. ..
  21. pmc TRP channels coordinate ion signalling in astroglia
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Rev Physiol Biochem Pharmacol 166:1-22. 2014
    ..The TRPC channels mediate large Na(+) fluxes that are associated with the endoplasmic reticulum Ca(2+) signalling machinery and hence coordinate Na(+) and Ca(2+) signalling in astroglia. ..
  22. pmc Astrocytes and glutamate homoeostasis in Alzheimer's disease: a decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex
    Magdalena Kulijewicz-Nawrot
    Institute of Experimental Medicine, ASCR, Videnska 1083, 142 20 Prague, Czech Republic
    ASN Neuro 5:273-82. 2013
    ....
  23. pmc Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions
    A A Grolla
    Dipartimento di Scienze del Farmaco, Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara 28100, Italy
    Cell Death Dis 4:e623. 2013
    ..The different sensitivities of the Ca(2+) signalling toolkit of EC versus hippocampal astrocytes to Aβ may account for the lack of astrogliosis in the EC, which in turn can explain the higher vulnerability of this region to AD...
  24. pmc Store-operated calcium entry in neuroglia
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Neurosci Bull 30:125-33. 2014
    ..In physiological conditions the SOCE pathway is instrumental for the sustained phase of the Ca(2+) signal observed following stimulation of metabotropic receptors on glial cells. ..
  25. pmc P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes
    Ulyana Lalo
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:5473-80. 2008
    ....
  26. ncbi request reprint Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    Neuron 50:711-22. 2006
    ..These results reveal an unexpected energy-sensing pathway in neurons that regulate states of consciousness and energy balance...
  27. ncbi request reprint Ivermectin potentiates ATP-induced ion currents in cortical neurones: evidence for functional expression of P2X4 receptors?
    Ulyana Lalo
    Faculty of Medicine, Imperial College, London W12 0 NN, UK
    Neurosci Lett 421:158-62. 2007
    ..These results indicate functional expression of P2X4 receptors in cortical neurones and their involvement in purinergic synaptic transmission in cortex...
  28. doi request reprint Complex and region-specific changes in astroglial markers in the aging brain
    Jose J Rodriguez
    IKERBASQUE, Basque Foundation for Science, Bilbao, Spain Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain Electronic address
    Neurobiol Aging 35:15-23. 2014
    ..Based on the morphological analysis of 3 astroglial markers, we conclude that astrocytes undergo a complex age-dependent remodeling in a brain region-specific manner. ..
  29. doi request reprint Ca(2+) -dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease
    Elena Alberdi
    Departamento de Neurociencias, Achucarro Basque Center for Neuroscience, Universidad del Pais Vasco UPV EHU, 48940, Leioa, Spain
    Aging Cell 12:292-302. 2013
    ..Together, these results provide evidence that amyloid β oligomers disrupt ER Ca(2+) homeostasis, which induces ER stress that leads to astrogliosis; this mechanism may be relevant to AD pathophysiology...
  30. ncbi request reprint Spontaneous autocrine release of protons activates ASIC-mediated currents in HEK293 cells
    Ulyana Lalo
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Cell Physiol 212:473-80. 2007
    ..We concluded that spontaneous currents represent activation of acid-sensitive ion channels (ASICs) by autocrine vesicular release of protons from HEK cells...
  31. doi request reprint Calcium signalling in astroglia
    Alexei Verkhratsky
    The University of Manchester, Manchester, UK
    Mol Cell Endocrinol 353:45-56. 2012
    ..One of the prominent consequences of astroglial Ca(2+) excitability is gliotransmission, a release of transmitters from astroglia which can lead to signalling to adjacent neurones...
  32. pmc Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment
    Matjaz Stenovec
    Celica Biomedical, Ljubljana, Slovenia
    Glia 64:317-29. 2016
    ..001) in 3xTg-AD astrocytes. Expression of PS1M146V in astrocytes impairs vesicle dynamics and reduces evoked secretion of the signaling molecule ANP; both may contribute to the development of AD...
  33. pmc Quantal release of ATP in mouse cortex
    Yuriy Pankratov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Gen Physiol 129:257-65. 2007
    ..Furthermore, the packets of ATP appear to be released from vesicle in a subset of glutamate-containing terminals...
  34. ncbi request reprint NMDA Receptors in glia
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT UK
    Neuroscientist 13:28-37. 2007
    ..The discovery of glial NMDA receptors further indicates the complex nature of intercellular signaling mechanisms in the brain, which involve all types of neural cells, connected through diverse types of chemical and electrical synapses...
  35. pmc Astrocytes in Alzheimer's disease
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester M139PT, United Kingdom
    Neurotherapeutics 7:399-412. 2010
    ..At the later stages, astrocytes become activated and contribute to the neuroinflammatory component of neurodegeneration...
  36. doi request reprint Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer's disease is not affected by pathological progression
    Chia Yu Yeh
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Biogerontology 14:777-87. 2013
    ..Our data also indicate distinct functional populations of astrocytes, which may undergo specific remodelling during AD progression. ..
  37. pmc Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors
    Oksana Forostyak
    Department of Molecular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Stem Cells Dev 22:1506-21. 2013
    ..These results emphasize the notion that with time in culture, these cells attain a transient period of operative Ca(2+) signaling that is predictive of their ability to act as stem elements...
  38. pmc Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease
    Magdalena Kulijewicz-Nawrot
    Institute of Experimental Medicine, ASCR, Videnska, Prague, Czech Republic
    J Anat 221:252-62. 2012
    ..Thus, our results indicate that the progressive reduction in astrocytic branching and domain in the mPFC can account for the integrative dysfunction leading to the cognitive deficits and memory disturbances observed in AD...
  39. ncbi request reprint Purinergic transmission in the central nervous system
    R Alan North
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pflugers Arch 452:479-85. 2006
    ..In addition, ATP can be released from astroglial cells, thereby acting as a mediator of glial-glial and glial-neuronal signaling...
  40. doi request reprint A lentivirally delivered photoactivatable GFP to assess continuity in the endoplasmic reticulum of neurones and glia
    Vicky C Jones
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pflugers Arch 458:809-18. 2009
    ....
  41. pmc Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
    Chia Yu Yeh
    The University of Manchester, Manchester, U K
    ASN Neuro 3:271-9. 2011
    ..Thus we can consider that targeting astroglial atrophy may represent a therapeutic strategy which might slow down the progression of AD...
  42. doi request reprint Sodium fluxes and astroglial function
    Alexei Verkhratsky
    The University of Manchester, Oxford Road, Manchester, UK
    Adv Exp Med Biol 961:295-305. 2013
    ..Concerted action of these molecules in controlling cytosolic Na(+) may complement Ca(2+) signalling to provide basis for complex bidirectional astrocyte-neurone communication at the tripartite synapse...
  43. doi request reprint Hypermetabolism in a triple-transgenic mouse model of Alzheimer's disease
    Elysse M Knight
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    Neurobiol Aging 33:187-93. 2012
    ..These data demonstrate for the first time the existence of a hypermetabolic state in an experimental model of AD, but whether this can explain the weight loss observed in AD patients remains to be determined...
  44. doi request reprint Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model
    Jose J Rodriguez
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Neuroreport 20:907-12. 2009
    ..These results indicate that 3 x Tg-AD mice have impaired SVZ cell proliferation, which exacerbates with age...
  45. doi request reprint Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
    Markel Olabarria
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    Glia 58:831-8. 2010
    ....
  46. pmc Neurogenesis in Alzheimer's disease
    Jose J Rodriguez
    IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
    J Anat 219:78-89. 2011
    ....
  47. doi request reprint Neurotransmitters and integration in neuronal-astroglial networks
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Neurochem Res 37:2326-38. 2012
    ..Further detailed understanding of chemical transmission will aid our comprehension of the brain (dys)function in heath and disease...
  48. doi request reprint Where the thoughts dwell: the physiology of neuronal-glial "diffuse neural net"
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Brain Res Rev 66:133-51. 2011
    ..At the same time potential power of analogue processing offered by internally connected glial networks may represent the alternative mechanism involved in cognition...
  49. doi request reprint Pannexin 1 forms an anion-selective channel
    Weihong Ma
    Faculty of Life Sciences, The University of Manchester, Smith Building, Oxford Road, Manchester, UK
    Pflugers Arch 463:585-92. 2012
    ..Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance...
  50. pmc Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease
    Jose J Rodriguez
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    PLoS ONE 3:e2935. 2008
    ..Thus it is conceivable to speculate that a recovery in neurogenesis rates in AD could help to rescue cognitive impairment...
  51. ncbi request reprint Glial calcium signaling in physiology and pathophysiology
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Acta Pharmacol Sin 27:773-80. 2006
    ..In pathological conditions, calcium signals regulate glial response to injury, which might have both protective and detrimental effects on the nervous tissue...
  52. doi request reprint Neuroglial roots of neurodegenerative diseases?
    Jose Julio Rodriguez
    IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain
    Mol Neurobiol 43:87-96. 2011
    ..Atrophic changes in astroglia may contribute to the initial cognitive deficits due to reduced glial synaptic coverage and decreased neuroprotection...
  53. ncbi request reprint NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes
    Ulyana Lalo
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 26:2673-83. 2006
    ..We conclude that cortical astrocytes express functional NMDA receptors that are devoid of Mg2+ block, and these receptors are involved in neuronal-glial signal transmission...
  54. doi request reprint High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease
    Harun N Noristani
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Aging Cell 11:810-22. 2012
    ....
  55. doi request reprint Physiology of neuronal-glial networking
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Neurochem Int 57:332-43. 2010
    ..In addition neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system, being thus intimately involved in pathogenesis of neurological diseases...
  56. pmc Glutamate-mediated neuronal-glial transmission
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Anat 210:651-60. 2007
    ..e. the ionotropic and metabotropic glutamate receptors as well as the glutamate transporters. We also discuss a transgenic mouse model that permits detailed and specific investigations of the role of glial glutamate receptors...
  57. pmc Glucose-sensing neurons of the hypothalamus
    Denis Burdakov
    The University of Manchester Faculty of Life Sciences 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 360:2227-35. 2005
    ..These results stress the fundamental importance of hypothalamic glucose-sensing neurons in orchestrating sleep-wake cycles, energy expenditure and feeding behaviour...
  58. doi request reprint The serotonergic system in ageing and Alzheimer's disease
    Jose Julio Rodriguez
    IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain
    Prog Neurobiol 99:15-41. 2012
    ....
  59. ncbi request reprint Patching the glia reveals the functional organisation of the brain
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pflugers Arch 453:411-20. 2006
    ..The data accumulated during last 15 years prompt rethinking of the neuronal doctrine towards more inclusive concept, which regards both neurones and glia as equally responsible for information processing in the brain...
  60. ncbi request reprint Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system
    R Maynard Case
    Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK
    Cell Calcium 42:345-50. 2007
    ....
  61. ncbi request reprint Biophysical re-equilibration of Ca2+ fluxes as a simple biologically plausible explanation for complex intracellular Ca2+ release patterns
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    FEBS Lett 580:463-8. 2006
    ....
  62. ncbi request reprint Differential calcium signalling in neuronal-glial networks
    Alexei Verkhratsky
    Institute of Experimental Medicine, ASCR, Videnska 1083, 142 20 Prague 4, Czech Republic
    Front Biosci (Landmark Ed) 14:2004-16. 2009
    ..Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system...
  63. ncbi request reprint Intraluminal calcium as a primary regulator of endoplasmic reticulum function
    Denis Burdakov
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Cell Calcium 38:303-10. 2005
    ..Direct monitoring of [Ca2+](ER) under conditions where the cytosolic [Ca2+] is known may also help to capture elusive biophysical information about the ER, such as the potential difference across the ER membrane...
  64. pmc PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain and Department of Neurosciences, University of the Basque Country UPV EHU and CIBERNED, Leioa, Spain
    Opera Med Physiol 1:13-22. 2016
    ..Astroglia may represent a novel target for therapeutic strategies aimed at preventing and possibly curing neurodegenerative diseases...
  65. doi request reprint Mitochondrial malfunction and Ca2+ dyshomeostasis drive neuronal pathology in diabetes
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Cell Calcium 44:112-22. 2008
    ..The role of hyperglycaemia in diabetes is also discussed and we propose that high glucose concentration may impact at other sites to contribute to the heterogeneous aetiology of nerve damage in diabetes...
  66. pmc Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling
    Vincent Compan
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and
    J Immunol 194:1261-73. 2015
    ..This study reveals that the ASC speck can present different oligomerization assemblies and represents an essential step in the activation of functional NLRP3 inflammasomes. ..
  67. pmc Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?
    Markel Olabarria
    Institute of Experimental Medicine, ASCR, Videnska 1083, 142 20 Prague 4, Czech Republic
    Mol Neurodegener 6:55. 2011
    ....
  68. pmc LV-pIN-KDEL: a novel lentiviral vector demonstrates the morphology, dynamics and continuity of the endoplasmic reticulum in live neurones
    Vicky C Jones
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9NT, UK
    BMC Neurosci 9:10. 2008
    ....
  69. pmc Recent advances in (patho)physiology of astroglia
    Alexei Verkhratsky
    The University of Manchester, UK
    Acta Pharmacol Sin 31:1044-54. 2010
    ..Thus, these star-shaped cells by their roles in (patho)physiology of the brain seem to live up to the expectation one can have from their given name - astrocyte...
  70. ncbi request reprint From Galvani to patch clamp: the development of electrophysiology
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Pflugers Arch 453:233-47. 2006
    ....
  71. ncbi request reprint Vesicular release of ATP at central synapses
    Yuri Pankratov
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pflugers Arch 452:589-97. 2006
    ....
  72. doi request reprint Segregation of calcium signalling mechanisms in magnocellular neurones and terminals
    Govindan Dayanithi
    Department of Molecular Signalling, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Cell Calcium 51:293-9. 2012
    ....
  73. doi request reprint Purinoceptors on neuroglia
    Alexei Verkhratsky
    School of Biological Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Mol Neurobiol 39:190-208. 2009
    ..In this essay, we provide an in depth overview of purinoceptor distribution in two types of CNS glia--in astrocytes and oligodendrocytes--and discuss their physiological and pathophysiological roles...
  74. doi request reprint Pathologic potential of astrocytic vesicle traffic: new targets to treat neurologic diseases?
    Nina Vardjan
    Celica Biomedical, Ljubljana, Slovenia
    Cell Transplant 24:599-612. 2015
    ....
  75. doi request reprint Biology of purinergic signalling: its ancient evolutionary roots, its omnipresence and its multiple functional significance
    Alexei Verkhratsky
    School of Biological Sciences, The University of Manchester, Manchester, UK Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain University of Nizhny Novgorod, Nizhny Novgorod, Russia
    Bioessays 36:697-705. 2014
    ..The purinergic signalling system is expressed in virtually all types of tissues and cells, where it mediates numerous physiological reactions and contributes to pathological responses in a variety of diseases. ..