Research Topics
Genomes and Genes | A R VenkitaramanSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancerThomas Lo
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
DNA Repair (Amst) 2:1015-28. 2003..The idea of multiple BRC repeats with binding specificity towards RAD51 leads us to suggest a possible model for the participation of BRCA2 in RAD51 nucleoprotein filament formation...- DUBing down a tumour suppressorAshok R Venkitaraman
Nat Cell Biol 7:332-3. 2005 
Targeting the molecular defect in BRCA-deficient tumors for cancer therapyAshok R Venkitaraman
The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
Cancer Cell 16:89-90. 2009..A recent report in the New England Journal of Medicine on the early clinical evaluation of Olaparib in cancers lacking the BRCA1 or BRCA2 genes exemplifies this promising new trend...
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entryNabieh Ayoub
Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
Curr Biol 19:1075-85. 2009..Using "hit-and-run" gene targeting to insert single-codon substitutions into the avian Brca2 locus, we report here a previously unrecognized role for the C-terminal motif...- Tracing the network connecting BRCA and Fanconi anaemia proteinsAshok R Venkitaraman
University of Cambridge, CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 2XZ, UK
Nat Rev Cancer 4:266-76. 2004 - Connecting Fanconi's anaemia to breast cancer predispositionAshok R Venkitaraman
CR UK Department of Oncology, University of Cambridge, and Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, CB2 2XZ, Cambridge, UK
Lancet 360:1344-5. 2002 - Functions of BRCA1 and BRCA2 in the biological response to DNA damageA R Venkitaraman
University of Cambridge, CRC Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
J Cell Sci 114:3591-8. 2001..The new work suggests that, although the phenotypic consequences of their disruption are similar, BRCA1 and BRCA2 play distinct roles in the mechanisms that lead to the repair of DNA double-strand breaks... - Chromosome stability, DNA recombination and the BRCA2 tumour suppressorA R Venkitaraman
University of Cambridge, CRC Department of Oncology, The Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
Curr Opin Cell Biol 13:338-43. 2001.... - Cancer susceptibility and the functions of BRCA1 and BRCA2Ashok R Venkitaraman
University of Cambridge, CRC Department of Oncology, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
Cell 108:171-82. 2002..Here, I examine what is known about the biological functions of the BRCA proteins and ask how their disruption can induce susceptibility to specific types of cancer... - Involvement of Brca2 in DNA repairK J Patel
Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
Mol Cell 1:347-57. 1998..These findings define a function of Brca2 in DNA repair, whose loss precipitates replicative failure, mutagen sensitivity, and genetic instability reminiscent of Bloom syndrome and Fanconi anemia... - A growing network of cancer-susceptibility genesAshok R Venkitaraman
University of Cambridge, Cancer Research United Kingdom Department of Oncology, Medical Research Council Cancer Cell Unit, Cambridge, United Kingdom
N Engl J Med 348:1917-9. 2003 - DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2Mahmud K K Shivji
CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
DNA Repair (Amst) 3:835-43. 2004.... - Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility proteinMikhail Lomonosov
University of Cambridge, CR UK Department of Oncology, Hutchison MRC Research Centre, Cambridge CB2 2XZ, UK
Genes Dev 17:3017-22. 2003.... - A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressorM Lee
Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK
Oncogene 30:3360-9. 2011..We propose that divergent tumor-suppressive pathways regulating chromosome segregation as well as chromosome structure may be governed by the conserved BRC motifs in BRCA2... - PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint proteinMatthew J Daniels
University of Cambridge, Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 2XZ, UK
Nat Struct Mol Biol 11:1114-21. 2004..Thus, PML bodies control the distribution, dynamics and function of CHFR. Our findings implicate the interaction between these tumor suppressors in a checkpoint response to microtubule poisons, an important class of anticancer drugs... - The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochoresVictor M Bolanos-Garcia
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
Structure 17:105-16. 2009..The structure provides insight into the molecular basis of Blinkin-specific recognition by BUB1 and, on a broader perspective, of the mechanism that mediates kinetochore localization of BUB1 in checkpoint-activated cells... - Linking the cellular functions of BRCA genes to cancer pathogenesis and treatmentAshok R Venkitaraman
Department of Oncology, University of Cambridge, and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Center, Cambridge, UK
Annu Rev Pathol 4:461-87. 2009..The chromosomal instability model proposed here suggests a conceptual framework for the connections between chromosomal aberrations and cancer... - Insights into DNA recombination from the structure of a RAD51-BRCA2 complexLuca Pellegrini
University of Cambridge, Department of Biochemistry, Tennis Court Road, Cambridge CB2 1GA, UK
Nature 420:287-93. 2002..Cancer-associated mutations that affect the BRC repeat disrupt its predicted interaction with RAD51, yielding structural insight into mechanisms for cancer susceptibility... - Chromosomal instability in cancer: causality and interdependenceAshok R Venkitaraman
University of Cambridge, Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 0XZ, UK
Cell Cycle 6:2341-3. 2007.... - Preface: chromosomal instability and breast cancer pathogenesisAshok R Venkitaraman
University of Cambridge, CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison/ MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
J Mammary Gland Biol Neoplasia 9:217-20. 2004 - Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptorA E Corcoran
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
Nature 391:904-7. 1998..This mechanism augments the recombinational diversity of the primary antibody repertoire... - Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progressionMiYoung Lee
CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Oncogene 23:865-72. 2004..Thus, our findings define a regulatory circuit for BRCA2 phosphorylation by Plk1 that is responsive to DNA damage as well as mitotic progression... - Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancerFerdinandos Skoulidis
Department of Oncology and The Medical Research Council Cancer Cell Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK
Cancer Cell 18:499-509. 2010..We suggest a revised model for tumor suppression by BRCA2 with implications for the therapeutic strategy targeting BRCA2 mutant cancer cells... - An increase in DNA double-strand breaks, induced by Ku70 depletion, is associated with human papillomavirus 16 episome loss and de novo viral integration eventsD M Winder
Medical Research Council Cancer Cell Unit, MRC Hutchison Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
J Pathol 213:27-34. 2007..We found no evidence to support the notion that major chromosomal instability precedes HPV16 integration, although such instability is an important consequence of the integration event... - Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2Matthew J Daniels
University of Cambridge, Cancer Research UK, Department of Oncology and the Medical Research Council MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
Science 306:876-9. 2004..Our findings thus link cytokinetic abnormalities to a hereditary cancer syndrome characterized by chromosomal instability and may help to explain why BRCA2-deficient tumors are frequently aneuploid... - Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrestP Russell
University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
Oncogene 31:2450-60. 2012..Collectively, our findings implicate CCNG1 in regulating slippage and the outcome of taxane-induced mitotic arrest, with potential implications for cancer therapy... - Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2David S Yu
CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
Mol Cell 12:1029-41. 2003.... - The B-cell antigen receptor of the five immunoglobulin classesA R Venkitaraman
MRC Laboratory of Molecular Biology, Cambridge, UK
Nature 352:777-81. 1991..But the classes differ both in the glycosylation of their associated alpha chain and in their dependence on alpha/beta for surface transport... - Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressorHiroyoshi Hattori
Department of Oncology and The Medical Research Council Cancer Cell Unit, University of Cambridge, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom
Mol Cancer Ther 10:670-8. 2011..This concept should be taken into account in the ongoing and future development of targeted cancer therapies... - AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to TaxolShubha Anand
CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom
Cancer Cell 3:51-62. 2003..Consistent with this conclusion, elevated Aurora-A expression causes resistance to apoptosis induced by Taxol in a human cancer cell line... - Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinaseEeson Rajendra
The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
Nucleic Acids Res 38:82-96. 2010..Our findings suggest a model for the modular architecture of BRC repeats that provides fresh insight into the mechanisms regulating homologous DNA recombination... 
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchangeMahmud K K Shivji
Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Nucleic Acids Res 34:4000-11. 2006..Thus, the human BRC repeats, embedded within their surronding sequences as an eight-repeat unit, mediate homologous recombination independent of the BRCA2(CTD) through a previously unrecognized role in control of RAD51 activity...- The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchangeMahmud K K Shivji
The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom
Proc Natl Acad Sci U S A 106:13254-9. 2009..Our work provides fresh insight into the mechanism of HDR in humans, and its regulation by the BRCA2 tumor suppressor... - Modifying chromatin architecture during the response to DNA breakageAshok R Venkitaraman
University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, UK
Crit Rev Biochem Mol Biol 45:2-13. 2010..The importance of these fundamental biological processes is underscored by the growing appreciation that they are aberrant in human diseases, and that their modulation could provide new approaches to disease therapy... - Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage responseNabieh Ayoub
The Medical Research Council Cancer Cell Unit, Cambridge, UK
Cell Cycle 8:1494-500. 2009.... - Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndromeMahesh N Sangrithi
Cancer Research UK Department of Oncology, University of Cambridge, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
Cell 121:887-98. 2005..This role connects defective replication initiation to a chromosome-fragility disorder... - Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51Xinyi Su
The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
Nat Struct Mol Biol 15:1049-58. 2008..We suggest a model for the vertebrate cell cycle in which HDR during the G2 phase is separated from DNA replication in S phase and chromosome segregation in M... - HP1-beta mobilization promotes chromatin changes that initiate the DNA damage responseNabieh Ayoub
The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
Nature 453:682-6. 2008..Our findings reveal an unrecognized signalling cascade that helps to initiate the DNA damage response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code itself... - A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogeneHimesh Fernando
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
Biochemistry 45:7854-60. 2006..Collectively, the evidence suggests that this quadruplex is a serious target for a detailed functional investigation at the cell-biology level... - Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulationsLucy Heady
Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK
J Med Chem 49:5141-53. 2006..Our results provide a generally applicable computational method for the analysis of biomolecular structures and reveal hitherto unrecognized features of the interaction between protein kinases and their inhibitors... - Medicine: aborting the birth of cancerAshok R Venkitaraman
Nature 434:829-30. 2005 - A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repairNobuko Matsushita
Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701 0192, Japan
Mol Cell 19:841-7. 2005..These results define functional consequences of FancD2 monoubiquitination and reveal previously hidden functions for the FA protein core complex... - Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2David S Shin
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
EMBO J 22:4566-76. 2003..Together, these structural and mutational results support an interface exchange hypothesis for coordinated protein interactions in homologous recombination...