A R Venkitaraman

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer
    Thomas Lo
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    DNA Repair (Amst) 2:1015-28. 2003
  2. ncbi request reprint DUBing down a tumour suppressor
    Ashok R Venkitaraman
    Nat Cell Biol 7:332-3. 2005
  3. ncbi request reprint Targeting the molecular defect in BRCA-deficient tumors for cancer therapy
    Ashok R Venkitaraman
    The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Cancer Cell 16:89-90. 2009
  4. pmc Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase
    Eeson Rajendra
    The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleic Acids Res 38:82-96. 2010
  5. pmc A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor
    M Lee
    Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK
    Oncogene 30:3360-9. 2011
  6. pmc Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest
    P Russell
    University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Oncogene 31:2450-60. 2012
  7. pmc A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
    Mahmud K K Shivji
    Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Nucleic Acids Res 34:4000-11. 2006
  8. pmc A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
    Anand D Jeyasekharan
    The Medical Research Council MRC Cancer Unit, University of Cambridge, Hutchison MRC Research Centre, Cambridge, UK
    Nat Struct Mol Biol 20:1191-8. 2013
  9. pmc UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
    Mathew J Garnett
    University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 OXZ, UK
    Nat Cell Biol 11:1363-9. 2009
  10. pmc A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission
    Juan A Bernal
    Medical Research Council Research Centre, Cambridge CB2 0XZ, England, UK
    J Cell Biol 192:969-78. 2011

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer
    Thomas Lo
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    DNA Repair (Amst) 2:1015-28. 2003
    ..The idea of multiple BRC repeats with binding specificity towards RAD51 leads us to suggest a possible model for the participation of BRCA2 in RAD51 nucleoprotein filament formation...
  2. ncbi request reprint DUBing down a tumour suppressor
    Ashok R Venkitaraman
    Nat Cell Biol 7:332-3. 2005
  3. ncbi request reprint Targeting the molecular defect in BRCA-deficient tumors for cancer therapy
    Ashok R Venkitaraman
    The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Cancer Cell 16:89-90. 2009
    ..A recent report in the New England Journal of Medicine on the early clinical evaluation of Olaparib in cancers lacking the BRCA1 or BRCA2 genes exemplifies this promising new trend...
  4. pmc Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase
    Eeson Rajendra
    The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleic Acids Res 38:82-96. 2010
    ..Our findings suggest a model for the modular architecture of BRC repeats that provides fresh insight into the mechanisms regulating homologous DNA recombination...
  5. pmc A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor
    M Lee
    Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK
    Oncogene 30:3360-9. 2011
    ..We propose that divergent tumor-suppressive pathways regulating chromosome segregation as well as chromosome structure may be governed by the conserved BRC motifs in BRCA2...
  6. pmc Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest
    P Russell
    University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Oncogene 31:2450-60. 2012
    ..Collectively, our findings implicate CCNG1 in regulating slippage and the outcome of taxane-induced mitotic arrest, with potential implications for cancer therapy...
  7. pmc A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
    Mahmud K K Shivji
    Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Nucleic Acids Res 34:4000-11. 2006
    ..Thus, the human BRC repeats, embedded within their surronding sequences as an eight-repeat unit, mediate homologous recombination independent of the BRCA2(CTD) through a previously unrecognized role in control of RAD51 activity...
  8. pmc A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
    Anand D Jeyasekharan
    The Medical Research Council MRC Cancer Unit, University of Cambridge, Hutchison MRC Research Centre, Cambridge, UK
    Nat Struct Mol Biol 20:1191-8. 2013
    ..Our findings suggest a mechanism for the regulation of the nucleocytoplasmic distribution of BRCA2 and RAD51 and its impairment by a heterozygous disease-associated mutation. ..
  9. pmc UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
    Mathew J Garnett
    University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 OXZ, UK
    Nat Cell Biol 11:1363-9. 2009
    ..Thus, UBE2S functions with the APC/C in a two-step mechanism to control substrate ubiquitylation that is essential for mitotic exit after prolonged SAC activation, providing a new model for APC/C function in human cells...
  10. pmc A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission
    Juan A Bernal
    Medical Research Council Research Centre, Cambridge CB2 0XZ, England, UK
    J Cell Biol 192:969-78. 2011
    ..Thus, vertebrate Orc6 is necessary during mitosis for the abscission stage of cytokinesis. Our findings exemplify N-end rule degrons as tools to unravel functions of a single protein during different phases of the vertebrate cell cycle...
  11. pmc The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry
    Nabieh Ayoub
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Curr Biol 19:1075-85. 2009
    ..Using "hit-and-run" gene targeting to insert single-codon substitutions into the avian Brca2 locus, we report here a previously unrecognized role for the C-terminal motif...
  12. ncbi request reprint Connecting Fanconi's anaemia to breast cancer predisposition
    Ashok R Venkitaraman
    CR UK Department of Oncology, University of Cambridge, and Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, CB2 2XZ, Cambridge, UK
    Lancet 360:1344-5. 2002
  13. ncbi request reprint Functions of BRCA1 and BRCA2 in the biological response to DNA damage
    A R Venkitaraman
    University of Cambridge, CRC Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    J Cell Sci 114:3591-8. 2001
    ..The new work suggests that, although the phenotypic consequences of their disruption are similar, BRCA1 and BRCA2 play distinct roles in the mechanisms that lead to the repair of DNA double-strand breaks...
  14. ncbi request reprint Tracing the network connecting BRCA and Fanconi anaemia proteins
    Ashok R Venkitaraman
    University of Cambridge, CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 2XZ, UK
    Nat Rev Cancer 4:266-76. 2004
  15. ncbi request reprint Chromosome stability, DNA recombination and the BRCA2 tumour suppressor
    A R Venkitaraman
    University of Cambridge, CRC Department of Oncology, The Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
    Curr Opin Cell Biol 13:338-43. 2001
    ....
  16. ncbi request reprint Cancer susceptibility and the functions of BRCA1 and BRCA2
    Ashok R Venkitaraman
    University of Cambridge, CRC Department of Oncology, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cell 108:171-82. 2002
    ..Here, I examine what is known about the biological functions of the BRCA proteins and ask how their disruption can induce susceptibility to specific types of cancer...
  17. ncbi request reprint Involvement of Brca2 in DNA repair
    K J Patel
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
    Mol Cell 1:347-57. 1998
    ..These findings define a function of Brca2 in DNA repair, whose loss precipitates replicative failure, mutagen sensitivity, and genetic instability reminiscent of Bloom syndrome and Fanconi anemia...
  18. ncbi request reprint A growing network of cancer-susceptibility genes
    Ashok R Venkitaraman
    University of Cambridge, Cancer Research United Kingdom Department of Oncology, Medical Research Council Cancer Cell Unit, Cambridge, United Kingdom
    N Engl J Med 348:1917-9. 2003
  19. ncbi request reprint DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2
    Mahmud K K Shivji
    CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    DNA Repair (Amst) 3:835-43. 2004
    ....
  20. pmc Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
    Mikhail Lomonosov
    University of Cambridge, CR UK Department of Oncology, Hutchison MRC Research Centre, Cambridge CB2 2XZ, UK
    Genes Dev 17:3017-22. 2003
    ....
  21. pmc The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Structure 17:105-16. 2009
    ..The structure provides insight into the molecular basis of Blinkin-specific recognition by BUB1 and, on a broader perspective, of the mechanism that mediates kinetochore localization of BUB1 in checkpoint-activated cells...
  22. ncbi request reprint Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment
    Ashok R Venkitaraman
    Department of Oncology, University of Cambridge, and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Center, Cambridge, UK
    Annu Rev Pathol 4:461-87. 2009
    ..The chromosomal instability model proposed here suggests a conceptual framework for the connections between chromosomal aberrations and cancer...
  23. ncbi request reprint Chromosomal instability in cancer: causality and interdependence
    Ashok R Venkitaraman
    University of Cambridge, Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 0XZ, UK
    Cell Cycle 6:2341-3. 2007
    ....
  24. ncbi request reprint Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
    Luca Pellegrini
    University of Cambridge, Department of Biochemistry, Tennis Court Road, Cambridge CB2 1GA, UK
    Nature 420:287-93. 2002
    ..Cancer-associated mutations that affect the BRC repeat disrupt its predicted interaction with RAD51, yielding structural insight into mechanisms for cancer susceptibility...
  25. ncbi request reprint Preface: chromosomal instability and breast cancer pathogenesis
    Ashok R Venkitaraman
    University of Cambridge, CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    J Mammary Gland Biol Neoplasia 9:217-20. 2004
  26. ncbi request reprint PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein
    Matthew J Daniels
    University of Cambridge, Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 2XZ, UK
    Nat Struct Mol Biol 11:1114-21. 2004
    ..Thus, PML bodies control the distribution, dynamics and function of CHFR. Our findings implicate the interaction between these tumor suppressors in a checkpoint response to microtubule poisons, an important class of anticancer drugs...
  27. ncbi request reprint An increase in DNA double-strand breaks, induced by Ku70 depletion, is associated with human papillomavirus 16 episome loss and de novo viral integration events
    D M Winder
    Medical Research Council Cancer Cell Unit, MRC Hutchison Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    J Pathol 213:27-34. 2007
    ..We found no evidence to support the notion that major chromosomal instability precedes HPV16 integration, although such instability is an important consequence of the integration event...
  28. ncbi request reprint Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
    A E Corcoran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nature 391:904-7. 1998
    ..This mechanism augments the recombinational diversity of the primary antibody repertoire...
  29. ncbi request reprint Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer
    Ferdinandos Skoulidis
    Department of Oncology and The Medical Research Council Cancer Cell Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK
    Cancer Cell 18:499-509. 2010
    ..We suggest a revised model for tumor suppression by BRCA2 with implications for the therapeutic strategy targeting BRCA2 mutant cancer cells...
  30. ncbi request reprint Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression
    MiYoung Lee
    CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Oncogene 23:865-72. 2004
    ..Thus, our findings define a regulatory circuit for BRCA2 phosphorylation by Plk1 that is responsive to DNA damage as well as mitotic progression...
  31. ncbi request reprint Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2
    Matthew J Daniels
    University of Cambridge, Cancer Research UK, Department of Oncology and the Medical Research Council MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Science 306:876-9. 2004
    ..Our findings thus link cytokinetic abnormalities to a hereditary cancer syndrome characterized by chromosomal instability and may help to explain why BRCA2-deficient tumors are frequently aneuploid...
  32. ncbi request reprint Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2
    David S Yu
    CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Mol Cell 12:1029-41. 2003
    ....
  33. ncbi request reprint The B-cell antigen receptor of the five immunoglobulin classes
    A R Venkitaraman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 352:777-81. 1991
    ..But the classes differ both in the glycosylation of their associated alpha chain and in their dependence on alpha/beta for surface transport...
  34. pmc Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor
    Hiroyoshi Hattori
    Department of Oncology and The Medical Research Council Cancer Cell Unit, University of Cambridge, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom
    Mol Cancer Ther 10:670-8. 2011
    ..This concept should be taken into account in the ongoing and future development of targeted cancer therapies...
  35. ncbi request reprint Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome
    Mahesh N Sangrithi
    Cancer Research UK Department of Oncology, University of Cambridge, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cell 121:887-98. 2005
    ..This role connects defective replication initiation to a chromosome-fragility disorder...
  36. ncbi request reprint AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    Shubha Anand
    CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cancer Cell 3:51-62. 2003
    ..Consistent with this conclusion, elevated Aurora-A expression causes resistance to apoptosis induced by Taxol in a human cancer cell line...
  37. ncbi request reprint Modifying chromatin architecture during the response to DNA breakage
    Ashok R Venkitaraman
    University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, UK
    Crit Rev Biochem Mol Biol 45:2-13. 2010
    ..The importance of these fundamental biological processes is underscored by the growing appreciation that they are aberrant in human diseases, and that their modulation could provide new approaches to disease therapy...
  38. pmc The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
    Mahmud K K Shivji
    The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom
    Proc Natl Acad Sci U S A 106:13254-9. 2009
    ..Our work provides fresh insight into the mechanism of HDR in humans, and its regulation by the BRCA2 tumor suppressor...
  39. ncbi request reprint Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response
    Nabieh Ayoub
    The Medical Research Council Cancer Cell Unit, Cambridge, UK
    Cell Cycle 8:1494-500. 2009
    ....
  40. pmc A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene
    Himesh Fernando
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Biochemistry 45:7854-60. 2006
    ..Collectively, the evidence suggests that this quadruplex is a serious target for a detailed functional investigation at the cell-biology level...
  41. ncbi request reprint Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51
    Xinyi Su
    The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Nat Struct Mol Biol 15:1049-58. 2008
    ..We suggest a model for the vertebrate cell cycle in which HDR during the G2 phase is separated from DNA replication in S phase and chromosome segregation in M...
  42. ncbi request reprint HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
    Nabieh Ayoub
    The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Nature 453:682-6. 2008
    ..Our findings reveal an unrecognized signalling cascade that helps to initiate the DNA damage response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code itself...
  43. ncbi request reprint Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations
    Lucy Heady
    Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK
    J Med Chem 49:5141-53. 2006
    ..Our results provide a generally applicable computational method for the analysis of biomolecular structures and reveal hitherto unrecognized features of the interaction between protein kinases and their inhibitors...
  44. ncbi request reprint Medicine: aborting the birth of cancer
    Ashok R Venkitaraman
    Nature 434:829-30. 2005
  45. ncbi request reprint A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair
    Nobuko Matsushita
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701 0192, Japan
    Mol Cell 19:841-7. 2005
    ..These results define functional consequences of FancD2 monoubiquitination and reveal previously hidden functions for the FA protein core complex...
  46. pmc Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2
    David S Shin
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 22:4566-76. 2003
    ..Together, these structural and mutational results support an interface exchange hypothesis for coordinated protein interactions in homologous recombination...