Gareth J Veal

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Biliary excretion of etoposide in children with cancer
    Gareth J Veal
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, University of Newcastle upon Tyne, UK
    Cancer Chemother Pharmacol 58:415-7. 2006
  2. ncbi request reprint Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy
    Gareth J Veal
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
    Cancer Chemother Pharmacol 54:295-300. 2004
  3. pmc Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma
    Gareth J Veal
    Northern Institute for Cancer Research and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Clin Cancer Res 19:469-79. 2013
  4. doi request reprint Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients
    Gareth J Veal
    Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Cancer Chemother Pharmacol 65:1057-66. 2010
  5. ncbi request reprint Pharmacokinetics of dactinomycin in a pediatric patient population: a United Kingdom Children's Cancer Study Group Study
    Gareth J Veal
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, UK
    Clin Cancer Res 11:5893-9. 2005
  6. doi request reprint The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide
    Jane L Armstrong
    Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Oncol Rep 27:293-8. 2012
  7. ncbi request reprint Retinoid X receptors and retinoid response in neuroblastoma cells
    Birju Rana
    Department of Endocrinology, Medical Molecular Biology Group, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    J Cell Biochem 86:67-78. 2002
  8. doi request reprint Pharmacokinetics of cyclophosphamide and its metabolites in paediatric patients receiving high-dose myeloablative therapy
    Girish Chinnaswamy
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Eur J Cancer 47:1556-63. 2011
  9. doi request reprint Chemotherapy in newborns and preterm babies
    Gareth J Veal
    Newcastle Cancer Centre at the Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne NE2 4H, UK
    Semin Fetal Neonatal Med 17:243-8. 2012
  10. doi request reprint Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans
    Sophie E Rowbotham
    Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Drug Metab Dispos 38:1211-7. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Biliary excretion of etoposide in children with cancer
    Gareth J Veal
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, University of Newcastle upon Tyne, UK
    Cancer Chemother Pharmacol 58:415-7. 2006
    ..These unusual cases provided an opportunity to investigate the biliary clearance of etoposide by determining etoposide concentrations in bile and plasma samples obtained during chemotherapy...
  2. ncbi request reprint Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy
    Gareth J Veal
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
    Cancer Chemother Pharmacol 54:295-300. 2004
    ....
  3. pmc Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma
    Gareth J Veal
    Northern Institute for Cancer Research and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Clin Cancer Res 19:469-79. 2013
    ..To investigate the feasibility of adaptive dosing and the impact of pharmacogenetic variation on 13-cis-retinoic acid (13-cisRA) disposition in high-risk patients with neuroblastoma...
  4. doi request reprint Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients
    Gareth J Veal
    Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Cancer Chemother Pharmacol 65:1057-66. 2010
    ..However, there are very limited published data concerning the pharmacokinetics of these agents in infants and very young children, for whom dose reductions are frequently implemented...
  5. ncbi request reprint Pharmacokinetics of dactinomycin in a pediatric patient population: a United Kingdom Children's Cancer Study Group Study
    Gareth J Veal
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, UK
    Clin Cancer Res 11:5893-9. 2005
    ..Despite concerns over the incidence of toxicity, little is known about the pharmacology of dactinomycin. A study was done to investigate dactinomycin pharmacokinetics in children...
  6. doi request reprint The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide
    Jane L Armstrong
    Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Oncol Rep 27:293-8. 2012
    ..The interaction between RA and fenretinide could have important implications for the scheduling of fenretinide in therapeutic protocols for neuroblastoma...
  7. ncbi request reprint Retinoid X receptors and retinoid response in neuroblastoma cells
    Birju Rana
    Department of Endocrinology, Medical Molecular Biology Group, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    J Cell Biochem 86:67-78. 2002
    ..The results of this study suggest that interactions between retinoid receptors and other nuclear proteins may be critical determinants of retinoid responses in neural cells...
  8. doi request reprint Pharmacokinetics of cyclophosphamide and its metabolites in paediatric patients receiving high-dose myeloablative therapy
    Girish Chinnaswamy
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Eur J Cancer 47:1556-63. 2011
    ..In order to better understand the impact of high-dose on the pharmacokinetics and metabolism of cyclophosphamide, a pharmacological study was performed in children with malignant mesenchymal tumours with metastatic disease...
  9. doi request reprint Chemotherapy in newborns and preterm babies
    Gareth J Veal
    Newcastle Cancer Centre at the Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne NE2 4H, UK
    Semin Fetal Neonatal Med 17:243-8. 2012
    ....
  10. doi request reprint Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans
    Sophie E Rowbotham
    Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Drug Metab Dispos 38:1211-7. 2010
    ..Therefore, UGT1A9 is likely to be the most important enzyme in the glucuronidation of both substrates as this enzyme had the lowest K(m) and is expressed in both the intestine and at high levels in the liver...
  11. doi request reprint Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation
    Sophie E Rowbotham
    Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Drug Metab Dispos 38:1261-6. 2010
    ..No differences were observed with respect to 13cisRA 4-hydroxylase activity. We conclude that common CYP2C8 polymorphisms are unlikely to explain reported interindividual variation in 13cisRA or paclitaxel pharmacokinetics...
  12. ncbi request reprint Potential clinical impact of taking multiple blood samples for research studies in paediatric oncology: how much do we really know?
    Michael Cole
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Pediatr Blood Cancer 46:723-7. 2006
    ..Research involving children with cancer should be limited to those studies addressing key scientific questions and should be designed to limit both the number and volume of blood samples required...
  13. ncbi request reprint 13-cis retinoic acid and isomerisation in paediatric oncology--is changing shape the key to success?
    Jane L Armstrong
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Biochem Pharmacol 69:1299-306. 2005
    ....
  14. pmc Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo
    Christopher R Hill
    Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Biochem Pharmacol 85:29-37. 2013
    ..These data have implications for ongoing clinical pharmacology trials involving children treated with actinomycin D...
  15. ncbi request reprint Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography-mass spectrometry
    Gareth J Veal
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 795:237-43. 2003
    ..8%, respectively. Accuracy data showed relative errors of 2.0-16.4 and 10.4-15.2% for intra-assay (n=10) and inter-assay (n=7) experiments, respectively. Initial results of actinomycin D pharmacokinetics in paediatric patients are shown...
  16. ncbi request reprint Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours
    Jane L Armstrong
    Northern Institute for Cancer Research, School of Clinical and Laboratory Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Apoptosis 12:613-22. 2007
    ..These data demonstrate the importance of Noxa induction in determining the apoptotic response to fenretinide and emphasise the role of Noxa in p53-independent apoptosis...
  17. doi request reprint Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues
    Ian W H Jarvis
    Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, UK
    Biochem Pharmacol 83:69-77. 2012
    ..No correlation was apparent between these two data sets. The present results demonstrate that reliable measurements of adducts in clinical tumours are feasible. Future results should provide insight into drug resistance...
  18. ncbi request reprint Institutional Profile: Pharmacogenomics research at Newcastle University
    Ann K Daly
    Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Pharmacogenomics 13:1333-8. 2012
    ..This article describes the various ongoing research projects and the teams involved together with our teaching activities in the subject...
  19. ncbi request reprint Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells
    Gareth J Veal
    Cancer Research Unit, Medical School, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
    Biochem Pharmacol 63:207-15. 2002
    ..In summary, these results indicate either an intracellular conversion of 13-cis RA to ATRA or a selective uptake of ATRA and suggest that this may mediate the differential activity of 13-cis RA in neuroblastoma cell subtypes...
  20. ncbi request reprint Chemotherapy individualization
    Gareth J Veal
    Northern Institute for Cancer Research, Cancer Research Unit, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Invest New Drugs 21:149-56. 2003
    ....
  21. ncbi request reprint A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia
    Brenda W Cooper
    Department of Medicine, University Hospitals of Cleveland, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Clin Cancer Res 10:6830-9. 2004
    ..A novel regimen designed to maximize antileukemia activity of carboplatin through inhibiting repair of platinum-DNA adducts was conducted in poor prognosis, acute leukemia patients...
  22. ncbi request reprint Population pharmacokinetic investigation of actinomycin-D in children and young adults
    John T Mondick
    Division of Clinical Pharmacology and Therapeutics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Clin Pharmacol 48:35-42. 2008
    ..Relationships between pharmacokinetics and toxicity will be examined in future prospective studies in which children less than 1 year old will be enrolled...