Research Topics
Species | G J VealSummaryAffiliation: University of Newcastle Country: UK Publications
| Collaborators
|
Detail Information
Publications
Adaptive dosing approaches to the individualization of 13-cis-retinoic Acid (isotretinoin) treatment for children with high-risk neuroblastomaGareth J Veal
Authors Affiliations Northern Institute for Cancer Research and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne and Section of Paediatric Oncology, Institute of Cancer Research and Royal Marsden Hospital, Surrey, United Kingdom
Clin Cancer Res 19:469-79. 2013..To investigate the feasibility of adaptive dosing and the impact of pharmacogenetic variation on 13-cis-retinoic acid (13-cisRA) disposition in high-risk patients with neuroblastoma...
Busulfan pharmacokinetics following intravenous and oral dosing regimens in children receiving high-dose myeloablative chemotherapy for high-risk neuroblastoma as part of the HR-NBL-1/SIOPEN trialG J Veal
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom Electronic address
Eur J Cancer 48:3063-72. 2012..The current study reports on the pharmacokinetics of oral versus intravenous (IV) busulfan in high-risk neuroblastoma patients treated on the European HR-NBL-1/SIOPEN study...- Chemotherapy in newborns and preterm babiesGareth J Veal
Newcastle Cancer Centre at the Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne NE2 4H, UK
Semin Fetal Neonatal Med 17:243-8. 2012.... - Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patientsGareth J Veal
Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Cancer Chemother Pharmacol 65:1057-66. 2010..However, there are very limited published data concerning the pharmacokinetics of these agents in infants and very young children, for whom dose reductions are frequently implemented... 
Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography-mass spectrometryGareth J Veal
Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
J Chromatogr B Analyt Technol Biomed Life Sci 795:237-43. 2003..8%, respectively. Accuracy data showed relative errors of 2.0-16.4 and 10.4-15.2% for intra-assay (n=10) and inter-assay (n=7) experiments, respectively. Initial results of actinomycin D pharmacokinetics in paediatric patients are shown...- Chemotherapy individualizationGareth J Veal
Northern Institute for Cancer Research, Cancer Research Unit, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
Invest New Drugs 21:149-56. 2003.... - Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cellsGareth J Veal
Cancer Research Unit, Medical School, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
Biochem Pharmacol 63:207-15. 2002..In summary, these results indicate either an intracellular conversion of 13-cis RA to ATRA or a selective uptake of ATRA and suggest that this may mediate the differential activity of 13-cis RA in neuroblastoma cell subtypes... - Influence of cellular factors and pharmacokinetics on the formation of platinum-DNA adducts in leukocytes of children receiving cisplatin therapyG J Veal
Cancer Research Unit, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
Clin Cancer Res 7:2205-12. 2001..These results imply that analysis of adducts in PBLs after incubation of pretreatment blood samples with cisplatin may be used to predict in vivo adduct levels, leukopenia, and, potentially, response to cisplatin therapy... - Estimation of renal function and its potential impact on carboplatin dosing in children with cancerG Chinnaswamy
Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
Br J Cancer 99:894-9. 2008..A standard methodology for estimating GFR should be followed to achieve uniform dosing in children with cancer... - Adaptive dosing and platinum-DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumoursG J Veal
Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Br J Cancer 96:725-31. 2007..Pharmacodynamic data suggest a strong correlation between carboplatin pharmacokinetics and the drug-target interaction... - Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivoJ L Armstrong
Newcastle University, Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Br J Cancer 96:1675-83. 2007..These data suggest considerable potential for CYP26 inhibitors in the future treatment of neuroblastoma with 13cisRA... - Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma - a study of the United Kingdom Children's Cancer Study GroupG J Veal
Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
Br J Cancer 96:424-31. 2007..d. 4.67+/-3.17 microM) higher than those of 13-cisRA (2.83+/-1.44 microM) in 16 out of 23 patients on day 14 of course 2. Extensive metabolism to 4-oxo-13-cisRA may influence pharmacological activity of 13-cisRA... - Pharmacokinetics of dactinomycin in a pediatric patient population: a United Kingdom Children's Cancer Study Group StudyGareth J Veal
Northern Institute for Cancer Research, University of Newcastle upon Tyne, UK
Clin Cancer Res 11:5893-9. 2005..CONCLUSIONS: Data presented suggest that dosing of dactinomycin based on surface area is not optimal, either in younger patients in whom the risk of toxicity is greater, or in older patients where doses are capped... - A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatinG J Veal
Cancer Research Unit, Medical School, University of Newcastle upon Tyne, UK
Br J Cancer 84:1029-35. 2001..Results from this phase I study indicate that high doses of liposomal cisplatin can safely be given to patients, but further studies are required to address the issue of reformulation of liposomally bound cisplatin... - Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cellsJ L Armstrong
Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
Br J Cancer 92:696-704. 2005..The response of neuroblastoma cells to R116010 was consistent with inhibition of CYP26, indicating that inhibition of RA metabolism may further optimise retinoid treatment in neuroblastoma... - Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumoursJane L Armstrong
Northern Institute for Cancer Research, School of Clinical and Laboratory Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Apoptosis 12:613-22. 2007..These data demonstrate the importance of Noxa induction in determining the apoptotic response to fenretinide and emphasise the role of Noxa in p53-independent apoptosis... - Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cellsJane L Armstrong
Northern Institute for Cancer Research, Newcastle upon Tyne NE2 4HH, United Kingdom
J Biol Chem 285:6091-100. 2010.... - 13-cis retinoic acid and isomerisation in paediatric oncology--is changing shape the key to success?Jane L Armstrong
Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
Biochem Pharmacol 69:1299-306. 2005.... - Estimation of glomerular filtration rate in paediatric cancer patients using 51CR-EDTA population pharmacokineticsM Cole
Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
Br J Cancer 90:60-4. 2004..7 and 20.0%. These simple additive models provide a more rationale approach than the use of complex formulae, involving additional parameters, to predict renal function... - A study to determine the minimum volume of blood necessary to be discarded from a central venous catheter before a valid sample is obtained in children with cancerM Cole
Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
Pediatr Blood Cancer 48:687-95. 2007.... - Retinoid X receptors and retinoid response in neuroblastoma cellsBirju Rana
Department of Endocrinology, Medical Molecular Biology Group, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
J Cell Biochem 86:67-78. 2002..The results of this study suggest that interactions between retinoid receptors and other nuclear proteins may be critical determinants of retinoid responses in neural cells... - Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferasesN A Illingworth
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
Br J Pharmacol 162:989-99. 2011..Here, we assessed the enzymes involved in various 4-HPR metabolic pathways... - Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylationSophie E Rowbotham
Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
Drug Metab Dispos 38:1261-6. 2010..No differences were observed with respect to 13cisRA 4-hydroxylase activity. We conclude that common CYP2C8 polymorphisms are unlikely to explain reported interindividual variation in 13cisRA or paclitaxel pharmacokinetics... - Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomyGareth J Veal
Northern Institute for Cancer Research, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
Cancer Chemother Pharmacol 54:295-300. 2004.... - Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humansSophie E Rowbotham
Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
Drug Metab Dispos 38:1211-7. 2010..Therefore, UGT1A9 is likely to be the most important enzyme in the glucuronidation of both substrates as this enzyme had the lowest K(m) and is expressed in both the intestine and at high levels in the liver... - Biliary excretion of etoposide in children with cancerGareth J Veal
Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, University of Newcastle upon Tyne, UK
Cancer Chemother Pharmacol 58:415-7. 2006..These unusual cases provided an opportunity to investigate the biliary clearance of etoposide by determining etoposide concentrations in bile and plasma samples obtained during chemotherapy... - Potential clinical impact of taking multiple blood samples for research studies in paediatric oncology: how much do we really know?Michael Cole
Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
Pediatr Blood Cancer 46:723-7. 2006..Research involving children with cancer should be limited to those studies addressing key scientific questions and should be designed to limit both the number and volume of blood samples required... - Population pharmacokinetic investigation of actinomycin-D in children and young adultsJohn T Mondick
Division of Clinical Pharmacology and Therapeutics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
J Clin Pharmacol 48:35-42. 2008..Relationships between pharmacokinetics and toxicity will be examined in future prospective studies in which children less than 1 year old will be enrolled... - Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cellsMohamed Sayed Gomaa
Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
Bioorg Med Chem 16:8301-13. 2008..These data suggest that further structure-function studies leading to clinical development are warranted... - Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11Youssef Jounaidi
Division of Cell and Molecular Biology, Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
Mol Cancer Ther 5:541-55. 2006..Thus, P450 gene-directed enzyme prodrug therapy can be greatly improved by using the low Km P450 enzyme 2B11, which catalyzes intratumoral activation of cyclophosphamide and ifosfamide at pharmacologically relevant drug concentrations...