Elizabeth A Veal

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi Translating a low-sugar diet into a longer life by maintaining thioredoxin peroxidase activity of a peroxiredoxin
    Elizabeth A Veal
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Mol Cell 43:699-701. 2011
  2. ncbi A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase
    Elizabeth A Veal
    Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Mol Cell 15:129-39. 2004
  3. ncbi Hydrogen peroxide sensing and signaling
    Elizabeth A Veal
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, Tyne and Wear, UK
    Mol Cell 26:1-14. 2007
  4. ncbi Hydrogen peroxide as a signaling molecule
    Elizabeth Veal
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    Antioxid Redox Signal 15:147-51. 2011
  5. ncbi Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide
    Stephanie M Bozonet
    Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, UK
    J Biol Chem 280:23319-27. 2005
  6. ncbi Hydrogen peroxide-sensitive cysteines in the Sty1 MAPK regulate the transcriptional response to oxidative stress
    Alison M Day
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 285:7505-16. 2010
  7. ncbi Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival
    Alison M Day
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, Tyne and Wear, UK
    Mol Cell 45:398-408. 2012
  8. ncbi Functions of typical 2-Cys peroxiredoxins in yeast
    Brian A Morgan
    Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Subcell Biochem 44:253-65. 2007
  9. ncbi Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor
    Elizabeth A Veal
    School of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 278:30896-904. 2003
  10. ncbi A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance
    Monika Oláhová
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 105:19839-44. 2008

Collaborators

  • Stephanie M Bozonet
  • Janet Quinn
  • Alison M Day
  • Brian A Morgan
  • Sarah R Taylor
  • Monika Oláhová
  • Jonathon D Brown
  • Jonathan D Rand
  • T Keith Blackwell
  • Kunihiro Matsumoto
  • Siavash Khazaipoul
  • Jinling Wang

Detail Information

Publications11

  1. ncbi Translating a low-sugar diet into a longer life by maintaining thioredoxin peroxidase activity of a peroxiredoxin
    Elizabeth A Veal
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Mol Cell 43:699-701. 2011
    ....
  2. ncbi A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase
    Elizabeth A Veal
    Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Mol Cell 15:129-39. 2004
    ..Thus we provide new insight into the response of SAPKs to diverse stimuli by revealing a mechanism for SAPK activation specifically by oxidative stress...
  3. ncbi Hydrogen peroxide sensing and signaling
    Elizabeth A Veal
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, Tyne and Wear, UK
    Mol Cell 26:1-14. 2007
    ....
  4. ncbi Hydrogen peroxide as a signaling molecule
    Elizabeth Veal
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    Antioxid Redox Signal 15:147-51. 2011
    ..We also discuss how the localization and levels of hydrogen peroxide, antioxidants, and the cellular metal composition together influence the nature of the response...
  5. ncbi Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide
    Stephanie M Bozonet
    Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, UK
    J Biol Chem 280:23319-27. 2005
    ..Furthermore, they reveal that a single eukaryotic 2-Cys Prx regulates peroxide signaling by multiple independent mechanisms...
  6. ncbi Hydrogen peroxide-sensitive cysteines in the Sty1 MAPK regulate the transcriptional response to oxidative stress
    Alison M Day
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 285:7505-16. 2010
    ..Intriguingly, the conservation of these cysteine residues in other MAPK raises the possibility that similar mechanisms may ensure appropriate responses to hydrogen peroxide in other eukaryotes...
  7. ncbi Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival
    Alison M Day
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, Tyne and Wear, UK
    Mol Cell 45:398-408. 2012
    ..We conclude that the inactivation of the thioredoxin peroxidase activity of Prx is important to maintain thioredoxin activity and cell viability under oxidative stress conditions...
  8. ncbi Functions of typical 2-Cys peroxiredoxins in yeast
    Brian A Morgan
    Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Subcell Biochem 44:253-65. 2007
    ....
  9. ncbi Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor
    Elizabeth A Veal
    School of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 278:30896-904. 2003
    ..Consequently, Ybp1 represents a novel class of stress regulator of Yap1. These data have important implications for the regulation of protein oxidation and stress responses in eukaryotes...
  10. ncbi A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance
    Monika Oláhová
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 105:19839-44. 2008
    ..Together the data reveal that in metazoans Prx act through multiple biochemical activities, and have tissue-specific functions in stress resistance and longevity...
  11. ncbi Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe
    Elizabeth A Veal
    School of Biochemistry and Genetics, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:35523-31. 2002
    ..Collectively, our data suggest that GSTs have separate and overlapping roles in oxidative stress and drug responses in fission yeast...