Jenny Varley

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Familial breast cancer and the hCHK2 1100delC mutation: assessing cancer risk
    Jenny Varley
    CR UK Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK
    Breast Cancer Res 5:123-5. 2003
  2. pmc Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors
    J M Varley
    Cancer Research Campaign, Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, United Kingdom
    Am J Hum Genet 65:995-1006. 1999
  3. ncbi request reprint Germline TP53 mutations and Li-Fraumeni syndrome
    J M Varley
    Paterson Institute for Cancer Research, Christie NHS Trust, Manchester, UK
    Hum Mutat 21:313-20. 2003
  4. ncbi request reprint Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome
    J M Varley
    CRC Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX, Manchester, UK
    Cancer Genet Cytogenet 129:85-7. 2001
  5. pmc Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts
    E C Burt
    CRC Cancer Genetics Group, Patterson Institute for Cancer Research, Manchester
    Br J Cancer 83:467-72. 2000
  6. ncbi request reprint Characterization of germline TP53 splicing mutations and their genetic and functional analysis
    J M Varley
    CRC Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK
    Oncogene 20:2647-54. 2001
  7. ncbi request reprint Relative frequency and morphology of cancers in carriers of germline TP53 mutations
    J M Birch
    CRC Paediatric and Familial Cancer Research Group and Department of Pathology, Royal Manchester Children s Hospital, Stancliffe, Hospital Road, Manchester M27 4HA, UK
    Oncogene 20:4621-8. 2001
  8. pmc Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families
    J M Boyle
    CRC Department of Cancer Genetics, Christie CRC Research Centre, Manchester, UK
    Br J Cancer 77:2181-92. 1998
  9. ncbi request reprint Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families
    J M Varley
    Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, United Kingdom
    Cancer Res 57:3245-52. 1997
  10. ncbi request reprint Delayed chromosome changes in gamma-irradiated normal and Li-Fraumeni fibroblasts
    J M Boyle
    CRC Cancer Genetics Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 9BX, United Kingdom
    Radiat Res 157:158-65. 2002

Collaborators

Detail Information

Publications29

  1. pmc Familial breast cancer and the hCHK2 1100delC mutation: assessing cancer risk
    Jenny Varley
    CR UK Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK
    Breast Cancer Res 5:123-5. 2003
    ..The present article describes the published studies on hCHK2 1100delC and addresses some of the key questions raised...
  2. pmc Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors
    J M Varley
    Cancer Research Campaign, Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, United Kingdom
    Am J Hum Genet 65:995-1006. 1999
    ..Our findings have considerable implications for the clinical management of children with andrenocortical tumors and their parents, in terms of both genetic testing and the early detection and treatment of tumors...
  3. ncbi request reprint Germline TP53 mutations and Li-Fraumeni syndrome
    J M Varley
    Paterson Institute for Cancer Research, Christie NHS Trust, Manchester, UK
    Hum Mutat 21:313-20. 2003
    ....
  4. ncbi request reprint Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome
    J M Varley
    CRC Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX, Manchester, UK
    Cancer Genet Cytogenet 129:85-7. 2001
    ..We find no evidence for intron 6 sequence variants predisposing to LFS in our cohort of families and, furthermore, we show that some of the conclusions of other groups cannot be supported by data from our analysis...
  5. pmc Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts
    E C Burt
    CRC Cancer Genetics Group, Patterson Institute for Cancer Research, Manchester
    Br J Cancer 83:467-72. 2000
    ..We have also analysed the three groups of strains for microsatellite instability and somatic TP53 mutations, and have found genetic alterations in only one strain...
  6. ncbi request reprint Characterization of germline TP53 splicing mutations and their genetic and functional analysis
    J M Varley
    CRC Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK
    Oncogene 20:2647-54. 2001
    ..Furthermore we have identified the usage of a non-consensus splice donor site in four families with an intron 4 splice donor mutation...
  7. ncbi request reprint Relative frequency and morphology of cancers in carriers of germline TP53 mutations
    J M Birch
    CRC Paediatric and Familial Cancer Research Group and Department of Pathology, Royal Manchester Children s Hospital, Stancliffe, Hospital Road, Manchester M27 4HA, UK
    Oncogene 20:4621-8. 2001
    ..We conclude that germline TP53 mutations do not simply increase general cancer risk. There are tissue-specific effects...
  8. pmc Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families
    J M Boyle
    CRC Department of Cancer Genetics, Christie CRC Research Centre, Manchester, UK
    Br J Cancer 77:2181-92. 1998
    ..Levels of aneuploidy higher than in normal cells were also observed in fibroblasts from families without TP53 mutations, suggesting that chromosome instability is a major factor in determining the cancer proneness of these families...
  9. ncbi request reprint Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families
    J M Varley
    Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, United Kingdom
    Cancer Res 57:3245-52. 1997
    ..This could reflect our analysis of all 11 exons of TP53, including noncoding regions, as well as the use of direct sequencing rather than other less-sensitive mutation detection methods...
  10. ncbi request reprint Delayed chromosome changes in gamma-irradiated normal and Li-Fraumeni fibroblasts
    J M Boyle
    CRC Cancer Genetics Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 9BX, United Kingdom
    Radiat Res 157:158-65. 2002
    ..Our findings raise questions about the validity of quantitative extrapolation of cytogenetic data from Trp53-defective mice to radiogenic cancer risk in humans...
  11. ncbi request reprint A previously undescribed mutation within the tetramerisation domain of TP53 in a family with Li-Fraumeni syndrome
    J M Varley
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK
    Oncogene 12:2437-42. 1996
    ..A cell line has been established from the tumour of the proband and cytogenetic and molecular studies carried out, providing an extensive analysis in this family...
  12. pmc The relationship between radiation-induced G(1)arrest and chromosome aberrations in Li-Fraumeni fibroblasts with or without germline TP53 mutations
    J M Boyle
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, CRC Christie Research Centre, Manchester, UK
    Br J Cancer 85:293-6. 2001
    ..In LF cells with or without TP53 mutations, the reduced capacity to eliminate or repair chromosomal damage of the type induced by ionising radiation, may contribute to cancer predisposition in this syndrome...
  13. pmc A novel TP53 splicing mutation in a Li-Fraumeni syndrome family: a patient with Wilms' tumour is not a mutation carrier
    J M Varley
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK
    Br J Cancer 78:1081-3. 1998
    ..The mutation affects one of the invariant residues at the splice acceptor site, as a result of which two aberrant transcripts are produced. A child with Wilms' tumour aged 3 years in this family was shown not to be a mutation carrier...
  14. pmc Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome
    E C Burt
    CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK
    Br J Cancer 80:9-10. 1999
    ..These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested...
  15. ncbi request reprint Mapping of gene loci in the Q13-Q15 region of chromosome 12
    E L Mitchell
    Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester
    Chromosome Res 3:261-2. 1995
    ..GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2...
  16. pmc Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ
    K E Munn
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK
    Br J Cancer 74:1578-85. 1996
    ..TP53 mutations and AI on 17p have been identified in cases of 'pure' DCIS as well as those with associated invasive carcinoma and, furthermore, have been identified in well-differentiated lesions as well as poorly differentiated ones...
  17. pmc Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
    L A James
    CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK
    Br J Cancer 81:300-4. 1999
    ....
  18. pmc Radiation-induced G1 arrest is not defective in fibroblasts from Li-Fraumeni families without TP53 mutations
    J M Boyle
    CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK
    Br J Cancer 79:1657-64. 1999
    ..Exceptions to the previously reported inverse correlation between G1 arrest and clonogenic radiation resistance were observed, indicating that these phenotypes are not strictly interdependent...
  19. pmc Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry
    K L Marsh
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK
    Br J Cancer 77:1460-8. 1998
    ..Overexpression of cyclin D1 was found in approximately 49% cases, reduced expression of p16 in approximately 46% and reduced expression of pRb in approximately 37%. Allelic imbalance of cyclin D1 was found in approximately 57% cases...
  20. pmc Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast
    K E Munn
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK
    Br J Cancer 73:636-9. 1996
    ..However, two cases showed AI distal to BRCA1, supporting the presence of a second tumour-suppressor gene on 17q...
  21. pmc An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53
    J M Varley
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK
    J Med Genet 32:942-5. 1995
    ..A codon 175 missense mutation was identified in exon 5 in all available affected subjects. Counselling, screening, and issues surrounding presymptomatic testing are discussed...
  22. pmc Identification of recurrent regions of chromosome loss and gain in vestibular schwannomas using comparative genomic hybridisation
    C Warren
    Cancer Research UK Department of Cancer Genetics, The Paterson Institute for Cancer Research, Manchester, UK
    J Med Genet 40:802-6. 2003
    ..The GTPase signalling molecules RhoA and Rac1 regulate merlin function, but to date only mutation in the NF2 gene has been identified as a causal event in schwannoma formation...
  23. pmc Somatic glypican 3 (GPC3) mutations in Wilms' tumour
    G R M White
    Cancer Research UK Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK
    Br J Cancer 86:1920-2. 2002
    ..Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development...
  24. ncbi request reprint Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines
    G R White
    CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, UK
    Biochim Biophys Acta 1491:75-92. 2000
    ..No somatic LPHH1 mutations were detected through sequence analysis of four primary breast tumours that showed loss of the adjacent 1p31.1 marker D1S207...
  25. pmc Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy
    J M Appleby
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
    Br J Cancer 76:1546-9. 1997
    ..These early results suggest that screening for ATM mutations in cancer patients may not be of value in predicting adverse reactions...
  26. pmc Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast
    K L Marsh
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK
    Br J Cancer 77:1439-47. 1998
    ..Surprisingly, considerably higher levels of loss were observed in the tumours with an in situ component. Also, much heterogeneity was observed between different DCIS ducts or invasive tumour and DCIS from the same case...
  27. ncbi request reprint Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene TTC4P to 7p14-->p13 by in situ hybridization
    Y Hey
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK
    Cytogenet Cell Genet 88:272-4. 2000
  28. ncbi request reprint TP53, hChk2, and the Li-Fraumeni syndrome
    Jenny Varley
    CR UK Department of Cancer Genetics, Paterson Institute of Cancer Research, Manchester
    Methods Mol Biol 222:117-29. 2003
    ..It will be fascinating to see what genetic defects are responsible, and whether they involve additional components of DNA damage recognition, repair, or cell cycle checkpoint pathways...
  29. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
    ..To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients...