Vincent Vanoosthuyse

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 24:9786-801. 2004
  2. pmc An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe
    Hyun Soo Kim
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
    Nat Struct Mol Biol 16:1286-93. 2009
  3. pmc Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Mol Biol Cell 18:1657-69. 2007
  4. pmc Overcoming inhibition in the spindle checkpoint
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Genes Dev 23:2799-805. 2009
  5. ncbi request reprint Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    Trends Cell Biol 15:231-3. 2005
  6. pmc Bub3p facilitates spindle checkpoint silencing in fission yeast
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, EH9 3JR, United Kingdom
    Mol Biol Cell 20:5096-105. 2009
  7. pmc A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Curr Biol 19:1176-81. 2009
  8. ncbi request reprint The complexity of Bub1 regulation--phosphorylation, phosphorylation, phosphorylation
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Cell Cycle 2:118-9. 2003
  9. ncbi request reprint Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function
    Hyun Soo Kim
    Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10454, USA
    Cell Rep 6:892-905. 2014
  10. ncbi request reprint CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation
    Vincent Vanoosthuyse
    CNRS, UMR5239, LBMC Ecole Normale Supérieure de Lyon Université Lyon 01, Lyon, France Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 10:e1004415. 2014

Collaborators

Detail Information

Publications14

  1. pmc Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 24:9786-801. 2004
    ..Surprisingly, neither this domain nor kinetochore localization is required for other functions of Bub1p in chromosome segregation...
  2. pmc An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe
    Hyun Soo Kim
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
    Nat Struct Mol Biol 16:1286-93. 2009
    ..This and other findings suggest an important role for H2A.Z in the architecture of anaphase chromosomes...
  3. pmc Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Mol Biol Cell 18:1657-69. 2007
    ..Taken together, our results demonstrate that Sgo2 is important for chromosome biorientation and that it controls docking of the Passenger proteins on chromosomes in early mitotic cells...
  4. pmc Overcoming inhibition in the spindle checkpoint
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Genes Dev 23:2799-805. 2009
    ..2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing...
  5. ncbi request reprint Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    Trends Cell Biol 15:231-3. 2005
    ..How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process...
  6. pmc Bub3p facilitates spindle checkpoint silencing in fission yeast
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, EH9 3JR, United Kingdom
    Mol Biol Cell 20:5096-105. 2009
    ....
  7. pmc A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Curr Biol 19:1176-81. 2009
    ..We propose that PP1(Dis2)-mediated dephosphorylation of checkpoint components forms a novel spindle checkpoint silencing mechanism...
  8. ncbi request reprint The complexity of Bub1 regulation--phosphorylation, phosphorylation, phosphorylation
    Vincent Vanoosthuyse
    Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Cell Cycle 2:118-9. 2003
  9. ncbi request reprint Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function
    Hyun Soo Kim
    Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10454, USA
    Cell Rep 6:892-905. 2014
    ..These results are consistent with a model where NCT targets CKII to chromatin in a cell-cycle-directed manner in order to modulate the activity of condensin during chromosome condensation and decondensation...
  10. ncbi request reprint CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation
    Vincent Vanoosthuyse
    CNRS, UMR5239, LBMC Ecole Normale Supérieure de Lyon Université Lyon 01, Lyon, France Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 10:e1004415. 2014
    ..2, are also negative regulators of condensin-mediated chromosome condensation. We conclude that Swd2.2 opposes condensin-mediated chromosome condensation by facilitating the function of the two CPF-associated phosphatases PP1 and Ssu72...
  11. ncbi request reprint Control of Shugoshin function during fission-yeast meiosis
    Sabine Vaur
    Centre National de la Recherche Scientifique, Institut de Biochimie et Génétique Cellulaires, Unité Mixte de Recherche 5095, Bordeaux, F 33077, France
    Curr Biol 15:2263-70. 2005
    ..Sgo1-mediated protection of centromere cohesion might therefore be regulated by the mode of kinetochore attachment...
  12. pmc The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function
    Sheila Kadura
    Verna and Marrs McClean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Biol Cell 16:385-95. 2005
    ..These data indicate that Bub1p-A78V is defective in both nuclear accumulation and kinetochore targeting and that a threshold level of nuclear Bub1p is necessary for the nuclear accumulation of Bub3p and Mad3p...
  13. pmc Interaction of calmodulin, a sorting nexin and kinase-associated protein phosphatase with the Brassica oleracea S locus receptor kinase
    Vincent Vanoosthuyse
    Reproduction et Developpement des Plantes, Unite Mixte de Recherche 5667, Institut National de la Recherche Agronomique, Universite Claude Bernard Lyon, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Plant Physiol 133:919-29. 2003
    ..The sorting nexin also interacted with diverse members of the PRK family, suggesting that all three of the interacting proteins described here may play a general role in signal transduction by this family of proteins...
  14. ncbi request reprint Receptor kinase signalling in plants and animals: distinct molecular systems with mechanistic similarities
    J Mark Cock
    Reproduction et Developpement des Plantes, UMR 5667 CNRS INRA ENSL UCBL, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Curr Opin Cell Biol 14:230-6. 2002
    ..These points of convergence may represent features that are essential for a functional receptor-kinase signalling system...