Bart Vanhaesebroeck

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, University College London Branch, UK
    Nat Cell Biol 1:69-71. 1999
  2. pmc Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K
    Klaus Okkenhaug
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK, CB2 4AT
    Trends Immunol 28:80-7. 2007
  3. ncbi Signalling by PI3K isoforms: insights from gene-targeted mice
    Bart Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Trends Biochem Sci 30:194-204. 2005
  4. pmc Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, UK
    EMBO J 18:1292-302. 1999
  5. ncbi Synthesis and function of 3-phosphorylated inositol lipids
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, Riding House Street, London W1W 7BS
    Annu Rev Biochem 70:535-602. 2001
  6. pmc The PI3K-PDK1 connection: more than just a road to PKB
    B Vanhaesebroeck
    Cell Signalling Group, Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, U K
    Biochem J 346:561-76. 2000
  7. ncbi Signaling by distinct classes of phosphoinositide 3-kinases
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1P 8BT, United Kingdom
    Exp Cell Res 253:239-54. 1999
  8. pmc Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo
    Khaled Ali
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Sir John Vane Research Centre, Charterhouse Square, London, United Kingdom
    J Immunol 180:2538-44. 2008
  9. pmc Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
    Britta J Eickholt
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 2:e869. 2007
  10. ncbi Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
    Lazaros C Foukas
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Nature 441:366-70. 2006

Detail Information

Publications53

  1. ncbi Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, University College London Branch, UK
    Nat Cell Biol 1:69-71. 1999
  2. pmc Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K
    Klaus Okkenhaug
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK, CB2 4AT
    Trends Immunol 28:80-7. 2007
    ..The p110delta isoform of PI3K is the main source of PI3K activity following antigen recognition by B cells, T cells and mast cells. Here, we review the roles of p110delta in regulating antigen-dependent responses in these cell types...
  3. ncbi Signalling by PI3K isoforms: insights from gene-targeted mice
    Bart Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Trends Biochem Sci 30:194-204. 2005
    ..Targeting strategies that take into account the complex interplay between members of the PI3K family will be crucial to gain a full understanding of the physiological roles of the isoforms of PI3K...
  4. pmc Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, UK
    EMBO J 18:1292-302. 1999
    ..In summary, we show that PI3Ks are subject to regulatory phosphorylations in vivo similar to those identified under in vitro conditions, identifying a new level of control of these signalling molecules...
  5. ncbi Synthesis and function of 3-phosphorylated inositol lipids
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, Riding House Street, London W1W 7BS
    Annu Rev Biochem 70:535-602. 2001
    ..This field is now moving toward a genetic dissection of 3-phosphoinositide action in a variety of model organisms. Such approaches will reveal the true role of the 3-phosphoinositides at the organismal level in health and disease...
  6. pmc The PI3K-PDK1 connection: more than just a road to PKB
    B Vanhaesebroeck
    Cell Signalling Group, Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, U K
    Biochem J 346:561-76. 2000
    ....
  7. ncbi Signaling by distinct classes of phosphoinositide 3-kinases
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1P 8BT, United Kingdom
    Exp Cell Res 253:239-54. 1999
    ..Here we review the activation mechanisms of the different types of PI3Ks and their downstream actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation...
  8. pmc Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo
    Khaled Ali
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Sir John Vane Research Centre, Charterhouse Square, London, United Kingdom
    J Immunol 180:2538-44. 2008
    ..These observations identify p110delta as a key therapeutic target among PI3K isoforms for allergy- and mast cell-related diseases...
  9. pmc Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
    Britta J Eickholt
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 2:e869. 2007
    ..Our data identify p110delta as an important signaling component for efficient axonal elongation in the developing and regenerating nervous system...
  10. ncbi Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
    Lazaros C Foukas
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Nature 441:366-70. 2006
    ..These findings demonstrate a critical role for p110alpha in growth factor and metabolic signalling and also suggest an explanation for selective mutation or overexpression of p110alpha in a variety of cancers...
  11. ncbi Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells
    Antonio Bilancio
    Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, United Kingdom
    Blood 107:642-50. 2006
    ....
  12. ncbi Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages
    Yann Leverrier
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London W1W 7BS, United Kingdom
    J Biol Chem 278:38437-42. 2003
    ..Our findings demonstrate that p110beta is the major class I catalytic isoform required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by primary macrophages...
  13. pmc Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
    Lazaros C Foukas
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, UK
    EMBO Mol Med 5:563-71. 2013
    ..This temporal metabolic plasticity upon p110α inactivation indicates that prolonged PI3K inhibition, as intended in human cancer treatment, might not negatively impact on organismal metabolism...
  14. ncbi Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
    Khaled Ali
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Nature 431:1007-11. 2004
    ..Inactivation of p110delta protects mice against anaphylactic allergic responses. These results identify p110delta as a new target for therapeutic intervention in allergy and mast-cell-related pathologies...
  15. pmc The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
    Evangelia A Papakonstanti
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 26:3050-61. 2007
    ..This work identifies the RhoA/ROCK pathway as a major target of p110delta-mediated PI3K signalling, and establishes for the first time that PI3K controls itself, via a feedback loop involving PTEN...
  16. ncbi Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
    Klaus Okkenhaug
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Science 297:1031-4. 2002
    ..They also developed inflammatory bowel disease. These results reveal a selective role for p110delta in immunity...
  17. pmc Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
    Barbara Geering
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom
    Proc Natl Acad Sci U S A 104:7809-14. 2007
    ..These results argue against a role of free p85 in PI3K signaling and provide insights into the nonredundant functions of the different class IA PI3K isoforms...
  18. pmc Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry
    Pedro R Cutillas
    Cell Signaling in Cancer Laboratory, Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom
    Proc Natl Acad Sci U S A 103:8959-64. 2006
    ..Due to its special analytical capabilities and potential for multiplexing, this approach could contribute significantly to cell-signaling studies and to the development and implementation of personalized cancer therapies...
  19. pmc Regulation of p110delta PI 3-kinase gene expression
    Klaartje Kok
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    PLoS ONE 4:e5145. 2009
    ..This also applies to the leukocyte-enriched p110delta catalytic subunit of PI3K, an enzyme that has attracted widespread interest because of its role in immunity and allergy...
  20. ncbi Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line
    Pedro R Cutillas
    Cell Signalling Group, Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS
    Mol Cell Proteomics 4:1038-51. 2005
    ..Our results illustrate the capacity of this conceptually simple LC-MS method for quantification of gel-separated proteins and their phosphorylation sites and for quantitative profiling of biological systems...
  21. doi Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation
    Clotilde Billottet
    Centre for Cell Signalling, Queen Mary University of London, Institute of Cancer, Barts and the London School of Medicine, John Vane Science Centre University College London, London, United Kingdom
    Cancer Res 69:1027-36. 2009
    ..Addition of PI3K inhibitors to induction treatment regimens may provide therapeutic benefit...
  22. doi The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
    Ezra Aksoy
    Centre for Cell Signaling, Barts Institute of Cancer, Queen Mary, University of London, London, UK
    Nat Immunol 13:1045-54. 2012
    ..In line with that altered signaling output, p110δ-deficient mice showed enhanced endotoxin-induced death. Thus, by controlling the 'topology' of TLR4 signaling complexes, p110δ balances overall homeostasis in the TLR4 pathway...
  23. doi The emerging mechanisms of isoform-specific PI3K signalling
    Bart Vanhaesebroeck
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, UK
    Nat Rev Mol Cell Biol 11:329-41. 2010
    ..A better understanding of how the different PI3K isoforms are regulated and control signalling could uncover their roles in pathology and reveal in which disease contexts their blockade could be most beneficial...
  24. pmc Activity of any class IA PI3K isoform can sustain cell proliferation and survival
    Lazaros C Foukas
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 107:11381-6. 2010
    ..Such functional redundancy of class IA PI3K isoforms upon sustained PI3K inhibition has implications for the development and use of PI3K inhibitors in cancer...
  25. doi A new tool to dissect the function of p70 S6 kinase
    Benoit Bilanges
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, UK
    Biochem J 431:e1-3. 2010
    ..S6K1 inhibitors may ultimately be useful in the treatment of diseases such as cancer where S6K1 is overexpressed, but most importantly in metabolic disease such as insulin resistance and obesity...
  26. ncbi Quantitative profile of five murine core proteomes using label-free functional proteomics
    Pedro R Cutillas
    Cell Signalling Group, Ludwig Institute for Cancer Research, London, UK
    Mol Cell Proteomics 6:1560-73. 2007
    ....
  27. ncbi Gene targeting: attention to detail
    Bart Vanhaesebroeck
    Ludwig Institute for Cancer Research, London, United Kingdom
    Cell 118:274-6. 2004
    ..When it comes to silencing genes in mice, not all approaches are equal. An example published in this issue of Cell (Patrucco et al., 2004) suggests that caution should be used when validating potential drug targets by genetic disruption...
  28. ncbi Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta
    Carol Sawyer
    Cell Signalling Group, The Ludwig Institute for Cancer Research, University College and Royal Free Medical School Branch, London, W1W 7BS
    Cancer Res 63:1667-75. 2003
    ..The potential clinical implications of p110delta expression in non-WBC-derived tumors are discussed...
  29. pmc PI3K: from the bench to the clinic and back
    Bart Vanhaesebroeck
    University of London, London, EC1M 6BQ, UK
    Curr Top Microbiol Immunol 347:1-19. 2010
    ..PI3K will most likely be no exception. Below, we describe some of these early "surprises" and how these inform and shape basic science investigations...
  30. doi Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif
    Yen Chung Chen
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, No 155, Li Nong St, Sec 2, Peitou, Taipei 112, Taiwan
    J Mol Med (Berl) 86:401-12. 2008
    ..These results demonstrate that NBS1 can function as an adaptor/activator of p110alpha PI 3-kinase through a novel activation motif, consistent with its possible role in cell transformation and tumorigenesis...
  31. pmc The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
    Hailong Guo
    Laboratory of Molecular Immunology, Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 205:2419-35. 2008
    ..These results reveal a previously unrecognized role of PI3K-p110 delta in NK cell development and effector functions...
  32. ncbi Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition
    Kathrine Abell
    Mammary Apoptosis and Development Group, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK
    Nat Cell Biol 7:392-8. 2005
    ..We propose a novel mechanism in which Stat3 regulates apoptosis by inducing expression of distinct PI(3)K regulatory subunits to downregulate PI(3)K-Akt-mediated survival signalling...
  33. ncbi Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
    Pierre Sujobert
    Service d Hematologie, Hopital Cochin, AP HP, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Blood 106:1063-6. 2005
    ..Moreover, IC87114 inhibited AML cell proliferation without affecting the proliferation of normal hematopoietic progenitor cells. These observations identify p110delta as a potential therapeutic target in AML...
  34. ncbi Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
    Alison M Condliffe
    The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Blood 106:1432-40. 2005
    ..These results start to define which PI3K isoforms are responsible for modulating neutrophil responsiveness to infection and inflammation...
  35. ncbi Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways
    Malcolm Campbell
    Department of Clinical Biochemistry and Metabolic Medicine, Queen s University Belfast, Institute of Clinical Science, Royal Victoria Hospital, Grosvenor Road, Belfast, UK
    Circ Res 95:380-8. 2004
    ..In conclusion, glucose sensitizes VSMC to serum, inducing chemotaxis via pathways involving p110beta-PI3K, Akt, mTOR, and ERK1/2 MAPK. Cross-talk between the PI3K and MAPK pathways is necessary for VSMC chemotaxis under these conditions...
  36. pmc Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    Sohye Kang
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 239, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:1289-94. 2006
    ....
  37. ncbi PI3K in lymphocyte development, differentiation and activation
    Klaus Okkenhaug
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Rev Immunol 3:317-30. 2003
    ..Additional recent work has provided new insights into the molecular interactions that lead to PI3K activation and the signalling pathways that are regulated by PI3K...
  38. pmc Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
    Alexandre Arcaro
    Lung Cancer Biology Group, Division of Medicine, Imperial College Faculty of Medicine, Du Cane Road, London W12 0NN, UK
    EMBO J 21:5097-108. 2002
    ..A dominant-negative PI3KC2beta blocked both PKB activation and SCLC cell growth in response to SCF. Together our data provide novel insights into the specificity and functional significance of PI3K signalling in human cancer...
  39. ncbi The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
    Klaus Okkenhaug
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 177:5122-8. 2006
    ..Thus, p110delta contributes significantly to Th cell expansion and differentiation in vitro and in vivo, also in the context of CD28 costimulation...
  40. ncbi Charging the batteries to heal wounds through PI3K
    Bart Vanhaesebroeck
    Nat Chem Biol 2:453-5. 2006
  41. ncbi Human platelets contain p110delta phosphoinositide 3-kinase
    Jin Zhang
    Kimmel Cancer Center and Cardeza Foundation for Hematological Research, Thomas Jefferson University, JAH 476, 1020 Locust Street, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 296:178-81. 2002
    ..We report that p110delta is present in association with p85alpha and p85beta in platelets, both in cytosolic and cytoskeletal fractions. The latter finding is consistent with the proposed role of p110delta in cytoskeletal function...
  42. pmc The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
    Julie Guillermet-Guibert
    Center for Cell Signaling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 105:8292-7. 2008
    ..p110beta, which shows a much broader tissue distribution than the leukocyte-restricted p110gamma, could thus provide a conduit for GPCR-linked PI3K signaling in the many cell types where p110gamma expression is low or absent...
  43. pmc Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma
    Nandini Krishnamoorthy
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 14:565-73. 2008
    ..Collectively, these results highlight the importance of the c-Kit-PI3 kinase-IL-6 signaling axis in DCs in regulating T cell responses...
  44. doi Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
    Mariona Graupera
    Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nature 453:662-6. 2008
    ..These results provide the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis...
  45. ncbi Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells
    Daniel T Patton
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 177:6598-602. 2006
    ..The identification of p110delta as an intracellular signaling protein that regulates the activity of CD4+CD25+Foxp3+ Tregs may facilitate the further elucidation of the molecular mechanisms responsible for Treg-mediated suppression...
  46. ncbi The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells
    Hiroyuki Kishimoto
    Department of Molecular Biology, Akita University School of Medicine, Hondo 1 1 1, Akita 0108 543, Japan
    Blood 109:3316-24. 2007
    ..Thus, the Pten/PI3K pathway is indispensable for the homeostasis and antitumor surveillance function of Valpha14iNKT cells...
  47. ncbi Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
    Baher F Nashed
    CIHR National Training Program in Allergy and Asthma Research and Department of Immunology, University of Manitoba, Winnipeg, Canada
    Eur J Immunol 37:416-24. 2007
    ..These data demonstrate a novel functional role for p110delta signaling in induction of type 2 responses in vivo and may offer a new therapeutic target for Th2-mediated airway disease...
  48. ncbi Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation
    Monther M Al-Alwan
    Department of Immunology, University of Manitoba, Winnipeg, Canada
    J Immunol 178:2328-35. 2007
    ..Our data demonstrate a role for p110delta signaling in B cell Ag presentation function, implicating 3-phosphoinositides and their targets in the latter stages of this process...
  49. pmc Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets
    Yotis A Senis
    Centre for Cardiovascular Sciences, Division of Medical Sciences, Institute of Biomedical Research, Wolfson Drive, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Platelets 16:191-202. 2005
    ..The more pronounced inhibitory effect of LY294002 and wortmannin indicates that other isoforms of PI 3-kinase play a more significant role in signalling by the two platelet glycoprotein receptors...
  50. ncbi Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation
    Hong Ji
    Merck Serono S A, Geneva Research Center, Geneva, Switzerland
    Blood 110:2940-7. 2007
    ..Thus, the pathology in the p110gammadelta-deficient mice is likely to be secondary to a developmental block in the thymus that leads to lymphopenia-associated inflammatory responses...
  51. ncbi Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases
    Matthew J Thomas
    Novartis Institutes for BioMedical Research, Horsham, UK
    Eur J Immunol 35:1283-91. 2005
    ..These data resolve the complexities of chemokine-induced neutrophilia and PI3K signaling and define the gamma isoform as a promising target for new therapeutics to treat airway inflammatory diseases...
  52. ncbi Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing
    Karin Reif
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 173:2236-40. 2004
    ..These observations establish that p110gamma and p110delta function in lymphocyte chemotaxis, and show differential roles for PI3K family members in B and T cell migration...
  53. ncbi Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells
    Lindsay C Spender
    Department of Virology, Imperial College Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    J Gen Virol 87:2859-67. 2006
    ..p55alpha is thus a functional target of EBNA2 in EREB2.5 cells and the specific regulation of p55alpha by EBV will provide an opportunity to investigate the physiological function of p55alpha in this human cell line...