Szomolay B, van den Berg H. Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model. Integr Biol (Camb). 2014;6:1183-95 pubmed publisher
..Moreover, we propose that in vivo, the T-cell gauges ligand quality by monitoring changes in TCR triggering rate concomitant with shifts in this balance, for instance as the immunological synapse matures. ..
van den Berg H, Kiselev Y, Orlov M. Homeostatic regulation in physiological systems: A versatile Ansatz. Math Biosci. 2015;268:92-101 pubmed publisher
..We discuss the method in relation to optimal control theory as well as more conventional modelling approaches. ..
Nev O, Nev O, van den Berg H. Optimal management of nutrient reserves in microorganisms under time-varying environmental conditions. J Theor Biol. 2017;429:124-141 pubmed publisher