Anton van Dellen

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease
    Anton van Dellen
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    Clin Exp Pharmacol Physiol 32:1007-19. 2005
  2. ncbi Genetic and environmental factors in the pathogenesis of Huntington's disease
    Anton van Dellen
    University Laboratory of Physiology, University of Oxford, Parks Road, OX1 3PT, Oxford, UK
    Neurogenetics 5:9-17. 2004
  3. ncbi Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease
    Anton van Dellen
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
    BMC Neurosci 9:34. 2008
  4. ncbi Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Eur J Neurosci 19:2799-807. 2004
  5. ncbi Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice
    Nektarios K Mazarakis
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 25:3059-66. 2005
  6. ncbi Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine
    Helen E Grote
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Eur J Neurosci 22:2081-8. 2005
  7. ncbi Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 24:2270-6. 2004
  8. ncbi Impaired learning-dependent cortical plasticity in Huntington's disease transgenic mice
    Anita Cybulska-Klosowicz
    Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, 02 093, Warsaw, Poland
    Neurobiol Dis 17:427-34. 2004
  9. ncbi Decreased hippocampal cell proliferation in R6/1 Huntington's mice
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Neuroreport 15:811-3. 2004
  10. ncbi Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Neurosci 23:1829-38. 2006

Detail Information

Publications12

  1. ncbi Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease
    Anton van Dellen
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    Clin Exp Pharmacol Physiol 32:1007-19. 2005
    ..The effects of specific environmental manipulations are discussed in the context of gene-environment interactions and experience-dependent plasticity in the healthy and diseased brain, particularly the cerebral cortex...
  2. ncbi Genetic and environmental factors in the pathogenesis of Huntington's disease
    Anton van Dellen
    University Laboratory of Physiology, University of Oxford, Parks Road, OX1 3PT, Oxford, UK
    Neurogenetics 5:9-17. 2004
    ..This review focuses on genetic mediators, environmental modulators, and associated gene-environment interactions in the pathogenesis of Huntington's disease...
  3. ncbi Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease
    Anton van Dellen
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
    BMC Neurosci 9:34. 2008
    ..Furthermore, wheel running initiated in adulthood ameliorates the rear-paw clasping motor sign, but not an accelerating rotarod deficit...
  4. ncbi Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Eur J Neurosci 19:2799-807. 2004
    ..Furthermore, we demonstrate that Huntington's disease pathology interferes with the normal plastic response of dendritic spines to environmental enrichment...
  5. ncbi Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice
    Nektarios K Mazarakis
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 25:3059-66. 2005
    ....
  6. ncbi Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine
    Helen E Grote
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Eur J Neurosci 22:2081-8. 2005
    ..Furthermore, fluoxetine was found to rescue deficits of neurogenesis and volume loss in the dentate gyrus of HD mice...
  7. ncbi Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 24:2270-6. 2004
    ..These results suggest that environmental enrichment benefits animals at early stages of the disease by rescuing protein deficits, possibly through rescuing transcription or protein transport problems...
  8. ncbi Impaired learning-dependent cortical plasticity in Huntington's disease transgenic mice
    Anita Cybulska-Klosowicz
    Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, 02 093, Warsaw, Poland
    Neurobiol Dis 17:427-34. 2004
    ..The results suggest that presymptomatic R6/1 HD transgenic mice show deficits in plasticity of primary somatosensory cortex...
  9. ncbi Decreased hippocampal cell proliferation in R6/1 Huntington's mice
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Neuroreport 15:811-3. 2004
    ..Such a decrease in cell proliferation may be relevant to some of the deficits seen in these mice, although further work is needed to prove this...
  10. ncbi Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Neurosci 23:1829-38. 2006
    ....
  11. ncbi Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, CB2 2PY, UK
    Brain Res 1151:219-26. 2007
    ..These results suggest that olfactory impairments observed in HD patients may be the result of reduced plasticity in the primary olfactory cortex...
  12. ncbi Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
    Emma Hockly
    Division of Medical and Molecular Genetics, GKT School of Medicine, King s College London, UK
    Ann Neurol 51:235-42. 2002
    ..Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease...