William Valdar

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc No effect of preterm birth on the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Neurol 8:30. 2008
  2. pmc Genetic and environmental effects on complex traits in mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genetics 174:959-84. 2006
  3. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
  4. pmc Mapping in structured populations by resample model averaging
    William Valdar
    Wellcome Trust Centre for Human Genetics, Roosevelt Dr, Oxford OX3 7BN, United Kingdom
    Genetics 182:1263-77. 2009
  5. pmc High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues
    Guo Jen Huang
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:1133-40. 2009
  6. ncbi request reprint Genome-wide genetic association of complex traits in heterogeneous stock mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 38:879-87. 2006
  7. ncbi request reprint Strategies for mapping and cloning quantitative trait genes in rodents
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Nat Rev Genet 6:271-86. 2005
  8. ncbi request reprint A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice
    Leah C Solberg
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford Roosevelt Drive, Oxford, OX3 7BN, UK
    Mamm Genome 17:129-46. 2006
  9. pmc A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock
    Martina Johannesson
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:150-8. 2009
  10. ncbi request reprint Management, presentation and interpretation of genome scans using GSCANDB
    Martin Taylor
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Bioinformatics 23:1545-9. 2007

Detail Information

Publications14

  1. pmc No effect of preterm birth on the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Neurol 8:30. 2008
    ..Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS...
  2. pmc Genetic and environmental effects on complex traits in mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genetics 174:959-84. 2006
    ..Our results indicate that assays of gene function using mouse models should take into account interactions between gene and environment...
  3. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
    ..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
  4. pmc Mapping in structured populations by resample model averaging
    William Valdar
    Wellcome Trust Centre for Human Genetics, Roosevelt Dr, Oxford OX3 7BN, United Kingdom
    Genetics 182:1263-77. 2009
    ..The generality of our approach means it can potentially be applied to any population of unknown structure...
  5. pmc High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues
    Guo Jen Huang
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:1133-40. 2009
    ..Approximately one third of cis-acting eQTLs and one half of trans-acting eQTLs are tissue specific. We have created an important systems biology resource for the genetic analysis of complex traits in a key model organism...
  6. ncbi request reprint Genome-wide genetic association of complex traits in heterogeneous stock mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 38:879-87. 2006
    ..Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits...
  7. ncbi request reprint Strategies for mapping and cloning quantitative trait genes in rodents
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Nat Rev Genet 6:271-86. 2005
    ..We review the potential of these strategies to identify genes that underlie QTLs in rodents...
  8. ncbi request reprint A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice
    Leah C Solberg
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford Roosevelt Drive, Oxford, OX3 7BN, UK
    Mamm Genome 17:129-46. 2006
    ....
  9. pmc A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock
    Martina Johannesson
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:150-8. 2009
    ....
  10. ncbi request reprint Management, presentation and interpretation of genome scans using GSCANDB
    Martin Taylor
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Bioinformatics 23:1545-9. 2007
    ..In order to achieve a successful outcome, it may be necessary to analyse the data in different ways and compare the results with genome annotations and other genome scans...
  11. ncbi request reprint Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited
    David A Keays
    Psychiatric Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom
    Mamm Genome 18:123-4. 2007
    ..In particular, we focus on the difference between unconditional and conditional probabilities. We also introduce a website to assist investigators in the application of these equations ( http://www.well.ox.ac.uk/enuMutRat )...
  12. pmc Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans
    David A Keays
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Cell 128:45-57. 2007
    ..We identified two patients with de novo mutations in TUBA3, the human homolog of Tuba1. This study demonstrates the utility of ENU mutagenesis in the mouse as a means to discover the basis of human neurodevelopmental disorders...
  13. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  14. ncbi request reprint Fearfulness in a large N/Nih genetically heterogeneous rat stock: differential profiles of timidity and defensive flight in males and females
    Regina Lopez-Aumatell
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Institute of Neurosciences, School of Medicine, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Behav Brain Res 188:41-55. 2008
    ..The results of this first extensive behavioral evaluation of N/Nih-HS rats are discussed in terms of their potential usefulness for present and future neurobehavioral and genetic studies of fearfulness/anxiety...