Research Topics
| William ValdarSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
No effect of preterm birth on the risk of multiple sclerosis: a population based studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
BMC Neurol 8:30. 2008..Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS...- Genetic and environmental effects on complex traits in miceWilliam Valdar
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Genetics 174:959-84. 2006..Our results indicate that assays of gene function using mouse models should take into account interactions between gene and environment... - Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of miceWilliam Valdar
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
Genetics 172:1783-97. 2006..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species... - Mapping in structured populations by resample model averagingWilliam Valdar
Wellcome Trust Centre for Human Genetics, Roosevelt Dr, Oxford OX3 7BN, United Kingdom
Genetics 182:1263-77. 2009..The generality of our approach means it can potentially be applied to any population of unknown structure... - High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissuesGuo Jen Huang
Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
Genome Res 19:1133-40. 2009..Approximately one third of cis-acting eQTLs and one half of trans-acting eQTLs are tissue specific. We have created an important systems biology resource for the genetic analysis of complex traits in a key model organism... 
Genome-wide genetic association of complex traits in heterogeneous stock miceWilliam Valdar
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 38:879-87. 2006..Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits...- A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in miceLeah C Solberg
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford Roosevelt Drive, Oxford, OX3 7BN, UK
Mamm Genome 17:129-46. 2006.... - Strategies for mapping and cloning quantitative trait genes in rodentsJonathan Flint
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Nat Rev Genet 6:271-86. 2005..We review the potential of these strategies to identify genes that underlie QTLs in rodents... - A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stockMartina Johannesson
Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
Genome Res 19:150-8. 2009.... - Management, presentation and interpretation of genome scans using GSCANDBMartin Taylor
Wellcome Trust Centre for Human Genetics, Oxford, UK
Bioinformatics 23:1545-9. 2007..In order to achieve a successful outcome, it may be necessary to analyse the data in different ways and compare the results with genome annotations and other genome scans... - Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisitedDavid A Keays
Psychiatric Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom
Mamm Genome 18:123-4. 2007..In particular, we focus on the difference between unconditional and conditional probabilities. We also introduce a website to assist investigators in the application of these equations ( http://www.well.ox.ac.uk/enuMutRat )... - Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humansDavid A Keays
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
Cell 128:45-57. 2007..We identified two patients with de novo mutations in TUBA3, the human homolog of Tuba1. This study demonstrates the utility of ENU mutagenesis in the mouse as a means to discover the basis of human neurodevelopmental disorders... - The Collaborative Cross, a community resource for the genetic analysis of complex traitsGary A Churchill
The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
Nat Genet 36:1133-7. 2004..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease... - Fearfulness in a large N/Nih genetically heterogeneous rat stock: differential profiles of timidity and defensive flight in males and femalesRegina Lopez-Aumatell
Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Institute of Neurosciences, School of Medicine, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
Behav Brain Res 188:41-55. 2008..The results of this first extensive behavioral evaluation of N/Nih-HS rats are discussed in terms of their potential usefulness for present and future neurobehavioral and genetic studies of fearfulness/anxiety...