Jill P G Urban

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint 2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc
    H A Horner
    Physiology Laboratory, Oxford University, Parks Road, Oxford OX1 3PT, England, United Kingdom
    Spine (Phila Pa 1976) 26:2543-9. 2001
  2. ncbi request reprint Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype
    Heather A Horner
    Physiology Laboratory, Oxford University, Oxford, and the Centre for Spinal Studies, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Spine (Phila Pa 1976) 27:1018-28. 2002
  3. ncbi request reprint Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells
    Susan R S Bibby
    University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
    Spine (Phila Pa 1976) 30:487-96. 2005
  4. pmc Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure
    Cornelia Neidlinger-Wilke
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081, Ulm, Germany
    Eur Spine J 15:S372-8. 2006
  5. ncbi request reprint Effect of extracellular ph on matrix synthesis by chondrocytes in 3D agarose gel
    Min Hsien Wu
    Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK
    Biotechnol Prog 23:430-4. 2007
  6. ncbi request reprint Nutrition of the intervertebral disc
    Jill P G Urban
    Physiology Laboratory, Oxford University, Oxford, United Kingdom
    Spine (Phila Pa 1976) 29:2700-9. 2004
  7. ncbi request reprint Pathophysiology of the intervertebral disc and the challenges for MRI
    Jill P G Urban
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    J Magn Reson Imaging 25:419-32. 2007
  8. pmc Degeneration of the intervertebral disc
    Jill P G Urban
    University Laboratory of Physiology, Oxford University, Oxford, UK
    Arthritis Res Ther 5:120-30. 2003
  9. ncbi request reprint The role of the physicochemical environment in determining disc cell behaviour
    J P G Urban
    Physiology Laboratory, Oxford University, UK
    Biochem Soc Trans 30:858-64. 2002
  10. doi request reprint Notochordal intervertebral disc cells: sensitivity to nutrient deprivation
    Thorsten Guehring
    University of Oxford, Oxford, UK
    Arthritis Rheum 60:1026-34. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint 2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc
    H A Horner
    Physiology Laboratory, Oxford University, Parks Road, Oxford OX1 3PT, England, United Kingdom
    Spine (Phila Pa 1976) 26:2543-9. 2001
    ..Disc cell viability was analyzed in relation to nutrient supply and cellular demand in vitro in a diffusion chamber...
  2. ncbi request reprint Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype
    Heather A Horner
    Physiology Laboratory, Oxford University, Oxford, and the Centre for Spinal Studies, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Spine (Phila Pa 1976) 27:1018-28. 2002
    ..This study examined how the culture system and region of cellular origin affect disc cell morphology and extracellular matrix production...
  3. ncbi request reprint Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells
    Susan R S Bibby
    University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
    Spine (Phila Pa 1976) 30:487-96. 2005
    ..In vitro measurements of metabolic rates of isolated bovine nucleus pulposus cells at varying levels of oxygen, glucose, and pH...
  4. pmc Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure
    Cornelia Neidlinger-Wilke
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081, Ulm, Germany
    Eur Spine J 15:S372-8. 2006
    ..5 MPa) tends to decrease the matrix protein expression with a tendency to increase some matrix-turnover enzymes. Therefore, hydrostatic pressure may regulate disc matrix turnover in a dose-dependent way...
  5. ncbi request reprint Effect of extracellular ph on matrix synthesis by chondrocytes in 3D agarose gel
    Min Hsien Wu
    Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK
    Biotechnol Prog 23:430-4. 2007
    ..Consequently, the control of extracellular pH condition is crucially important for successful cartilage tissue engineering and for the study of chondrocyte physiology and functions...
  6. ncbi request reprint Nutrition of the intervertebral disc
    Jill P G Urban
    Physiology Laboratory, Oxford University, Oxford, United Kingdom
    Spine (Phila Pa 1976) 29:2700-9. 2004
    ..A review of the literature on disc nutrition...
  7. ncbi request reprint Pathophysiology of the intervertebral disc and the challenges for MRI
    Jill P G Urban
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    J Magn Reson Imaging 25:419-32. 2007
    ....
  8. pmc Degeneration of the intervertebral disc
    Jill P G Urban
    University Laboratory of Physiology, Oxford University, Oxford, UK
    Arthritis Res Ther 5:120-30. 2003
    ..New developments, such as genetic and biological approaches, may allow better diagnosis and treatments in the future...
  9. ncbi request reprint The role of the physicochemical environment in determining disc cell behaviour
    J P G Urban
    Physiology Laboratory, Oxford University, UK
    Biochem Soc Trans 30:858-64. 2002
    ..Here we will briefly review these factors and discuss the influence of changes in the physicochemical environment on cellular activity, in particular on the rate at which disc cells synthesize and degrade matrix macromolecules...
  10. doi request reprint Notochordal intervertebral disc cells: sensitivity to nutrient deprivation
    Thorsten Guehring
    University of Oxford, Oxford, UK
    Arthritis Rheum 60:1026-34. 2009
    ..We undertook this study to test the hypothesis that the consequent nutrient stress could be associated with NC disappearance...
  11. ncbi request reprint Influence of perfusion on metabolism and matrix production by bovine articular chondrocytes in hydrogel scaffolds
    Xia Xu
    Department of Engineering Science, University of Oxford, Parks Rd, Oxford, OX1 3PJ, United Kingdom
    Biotechnol Bioeng 93:1103-11. 2006
    ..It is suggested that the positive effect of perfusion culture only can be achieved by an appropriate choice of other factors such as scaffold materials...
  12. doi request reprint Nutrient gradients in engineered cartilage: metabolic kinetics measurement and mass transfer modeling
    Shengda Zhou
    Department of Engineering Science, Oxford University, Parks Road, Oxford OX1 3PJ, UK
    Biotechnol Bioeng 101:408-21. 2008
    ..This study provides useful guidance for design of engineered cartilage constructs...
  13. pmc Monitoring of metabolite gradients in tissue-engineered constructs
    Olga A Boubriak
    Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK
    J R Soc Interface 3:637-48. 2006
    ..Such information during the growth of tissue-engineered constructs would allow either corrective action or else an early end to an unsuccessful test...
  14. doi request reprint Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites
    Thijs Grunhagen
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    Orthop Clin North Am 42:465-77, vii. 2011
    ..This article reviews pathways of nutrient supply to these cells; examines factors that may interrupt these pathways, and discusses consequences for disk cell survival, disk degeneration, and disk repair...
  15. pmc The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus
    Sajjad Razaq
    University Laboratory of Physiology, University of Oxford, Parks Road, OX1 3PT, Oxford, UK
    Eur Spine J 12:341-9. 2003
    ..The low values of pH seen in some degenerate discs are thus likely to be involved in breakdown of the disc matrix...
  16. doi request reprint Differential gene expression profiling of metalloproteinases and their inhibitors: a comparison between bovine intervertebral disc nucleus pulposus cells and articular chondrocytes
    Ying Cui
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
    Spine (Phila Pa 1976) 35:1101-8. 2010
    ..A comparative in vitro metalloproteinases and their inhibitors gene expression profile...
  17. ncbi request reprint Cell viability and the physical environment in the scoliotic intervertebral disc
    Susan R S Bibby
    Physiology Laboratory, Oxford University, Oxford OX1 3PT, UK
    Stud Health Technol Inform 91:419-21. 2002
  18. ncbi request reprint Functional replacement of oxygen by other oxidants in articular cartilage
    Robert B Lee
    University of Oxford, Oxford, UK
    Arthritis Rheum 46:3190-200. 2002
    ..This study was undertaken to investigate the role of O(2) in articular chondrocyte metabolism...
  19. ncbi request reprint The elastic fiber network of the anulus fibrosus of the normal and scoliotic human intervertebral disc
    Jing Yu
    University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
    Spine (Phila Pa 1976) 30:1815-20. 2005
    ..Immunohistochemical study of elastic fibers in human intervertebral discs (IVD) collected at surgery from patients with scoliosis...
  20. pmc Factors regulating viable cell density in the intervertebral disc: blood supply in relation to disc height
    Olga A Boubriak
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Anat 222:341-8. 2013
    ..Results indicate that changes in blood vessels in the vertebral bodies supplying the disc, as well as changes in endplate architecture appear to influence density of cells in intervertebral discs...
  21. ncbi request reprint Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study
    Shengda Zhou
    Oxford University, Oxford, UK
    Arthritis Rheum 50:3915-24. 2004
    ..We therefore measured rates of cellular consumption of oxygen and used these rates to calculate oxygen tension profiles across articular cartilage...
  22. ncbi request reprint Nutrient supply and intervertebral disc metabolism
    Thijs Grunhagen
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, United Kingdom
    J Bone Joint Surg Am 88:30-5. 2006
    ..Although gradients cannot be measured easily in humans, they can be calculated. Measured concentrations in surgical patients are in agreement with calculated values...
  23. pmc The elastic network of articular cartilage: an immunohistochemical study of elastin fibres and microfibrils
    Jing Yu
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Anat 216:533-41. 2010
    ....
  24. ncbi request reprint Measurement of the chondrocyte membrane permeability to Me2SO, glycerol and 1,2-propanediol
    Xia Xu
    Department of Engineering Science, Oxford University, Parks Road, OX1 3PJ, Oxford, UK
    Med Eng Phys 25:573-9. 2003
    ..The measured parameters can be used to optimise the CPA addition and removal protocols to maximize the cell survival during cryopreservation...
  25. ncbi request reprint Adaptation of articular chondrocytes to changes in osmolality
    Bethan Hopewell
    University Laboratory of Physiology, Parks Road, Oxford, UK
    Biorheology 40:73-7. 2003
    ..These results suggest that osmolality is a powerful regulator of macromolecular synthesis, and that perturbations in the osmotic environment may alter the set point for turnover...
  26. ncbi request reprint Study of on-line monitoring of lactate based on optical fibre sensor and in-channel mixing mechanism
    Min Hsien Wu
    Central Microstructure Facility, Rutherford Appleton Laboratory, Oxford, UK
    Biomed Microdevices 9:167-74. 2007
    ..Due to the miniaturization of sensing system and micro-scale mixing, higher detection sensitivity (0.15 V/mM) can be realized than the mixing in lab-scale equipments (0.08 V/mM)...
  27. pmc Elastic fibre organization in the intervertebral discs of the bovine tail
    Jing Yu
    Laboratory of Physiology, Oxford University, UK
    J Anat 201:465-75. 2002
    ..The varying organization of the elastic fibres in the different regions of the disc is likely to relate to the different regional loading patterns...
  28. pmc The distribution of fibrillin-2 and LTBP-2, and their co-localisation with fibrillin-1 in adult bovine tail disc
    Bing Li
    Department of Orthopedics, Tianjin Hospital, Tianjin Medical University, Tianjin, China
    J Anat 220:164-72. 2012
    ..However, interestingly LTBP-2 but not fibrillin-1 or fibrillin-2 was removed by hyaluronidase but not collagenase pre-digestion. Our results suggest that fibrillin-2 and LTBP-2 could play an important role in disc function...
  29. ncbi request reprint Cell viability in scoliotic discs in relation to disc deformity and nutrient levels
    Susan R S Bibby
    Laboratory of Physiology, University of Oxford, UK
    Spine (Phila Pa 1976) 27:2220-8; discussion 2227-8. 2002
    ..Intervertebral disc tissue was analyzed during or removed at routine surgery for correction of scoliosis. Tissue was analyzed for glucose, lactate, oxygen, glycosaminoglycan, collagen concentrations, and cell viability...
  30. pmc Bovine explant model of degeneration of the intervertebral disc
    Sally Roberts
    Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire SY10 7AG, UK
    BMC Musculoskelet Disord 9:24. 2008
    ..Bovine explant model systems have many advantages but it is not possible to inject any significant volume into an intact disc. Therefore we have attempted to mimic disc degeneration in an explant bovine model via enzymatic digestion...
  31. ncbi request reprint Finite element study of nutrient diffusion in the human intervertebral disc
    Eric Sélard
    Department of Mechanical Engineering, Ecole Polytechnique, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Spine (Phila Pa 1976) 28:1945-53; discussion 1953. 2003
    ..The diffusion of small nutrients in the intervertebral human disc was examined using a finite element model...
  32. ncbi request reprint Development of PDMS microbioreactor with well-defined and homogenous culture environment for chondrocyte 3-D culture
    Min Hsien Wu
    Department of Engineering Science, University of Oxford, UK
    Biomed Microdevices 8:331-40. 2006
    ..As a whole, the proposed culture system is capable of providing a well-defined and homogenous culture environment...
  33. ncbi request reprint A SU-8/PDMS hybrid microfluidic device with integrated optical fibers for online monitoring of lactate
    Min Hsien Wu
    Department of Engineering Science, University of Oxford, UK
    Biomed Microdevices 7:323-9. 2005
    ..The fabrication of device is simple and low cost. The present work has provided some fundamental data for further system optimization to meet specific detection requirements...