B C Urban

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi A role for CD36 in the regulation of dendritic cell function
    B C Urban
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 98:8750-5. 2001
  2. ncbi Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria
    B C Urban
    Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, and National Blood Service, John Radcliffe Hospital, University of Oxford, United Kingdom
    Blood 98:2859-61. 2001
  3. ncbi Malaria, monocytes, macrophages and myeloid dendritic cells: sticking of infected erythrocytes switches off host cells
    Britta C Urban
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Curr Opin Immunol 14:458-65. 2002
  4. ncbi Early interactions between blood-stage plasmodium parasites and the immune system
    B C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Old Road, Oxford, UK
    Curr Top Microbiol Immunol 297:25-70. 2005
  5. ncbi Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays
    K L Flanagan
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Immunol 167:4729-37. 2001
  6. ncbi PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes
    Paul Horrocks
    Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK
    J Cell Sci 118:2507-18. 2005
  7. ncbi Frequencies of peripheral blood myeloid cells in healthy Kenyan children with alpha+ thalassemia and the sickle cell trait
    Britta C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Oxford, United Kingdom
    Am J Trop Med Hyg 74:578-84. 2006
  8. ncbi Malaria pigment paralyzes dendritic cells
    Britta C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    J Biol 5:4. 2006
  9. ncbi The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria
    Britta C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, United Kingdom
    Infect Immun 74:6700-6. 2006
  10. ncbi Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue
    Damien V Cordery
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    J Infect Dis 195:905-12. 2007

Collaborators

Detail Information

Publications19

  1. ncbi A role for CD36 in the regulation of dendritic cell function
    B C Urban
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 98:8750-5. 2001
    ..These findings may have important consequences for the treatment of malaria and may suggest strategies for modulating pathological immune responses in autoimmune diseases...
  2. ncbi Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria
    B C Urban
    Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, and National Blood Service, John Radcliffe Hospital, University of Oxford, United Kingdom
    Blood 98:2859-61. 2001
    ..The results suggest that a proportion of peripheral blood DCs may be functionally impaired due to the low expression of HLA-DR on their surface...
  3. ncbi Malaria, monocytes, macrophages and myeloid dendritic cells: sticking of infected erythrocytes switches off host cells
    Britta C Urban
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Curr Opin Immunol 14:458-65. 2002
    ....
  4. ncbi Early interactions between blood-stage plasmodium parasites and the immune system
    B C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Old Road, Oxford, UK
    Curr Top Microbiol Immunol 297:25-70. 2005
    ..The implications of these findings for the development of an effective and safe malaria vaccine are also discussed...
  5. ncbi Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays
    K L Flanagan
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Immunol 167:4729-37. 2001
    ..The data suggest that natural immunity to malaria is a complex function of T cell subgroups with different effector functions and has important implications for future studies of natural T cell immunity...
  6. ncbi PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes
    Paul Horrocks
    Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK
    J Cell Sci 118:2507-18. 2005
    ..However, despite this reduction, the gross distribution of PfEMP1 in K(-) IEs appears unaltered. These data impact on our current interpretation of the role of knobs in adhesion and the mechanism of trafficking PfEMP1 to the IE surface...
  7. ncbi Frequencies of peripheral blood myeloid cells in healthy Kenyan children with alpha+ thalassemia and the sickle cell trait
    Britta C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Oxford, United Kingdom
    Am J Trop Med Hyg 74:578-84. 2006
    ....
  8. ncbi Malaria pigment paralyzes dendritic cells
    Britta C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    J Biol 5:4. 2006
    ..A prime suspect, the parasite-produced pigment hemozoin, has now been clearly shown to mediate immunosuppression by inhibiting dendritic cell activity...
  9. ncbi The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria
    Britta C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, United Kingdom
    Infect Immun 74:6700-6. 2006
    ....
  10. ncbi Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue
    Damien V Cordery
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    J Infect Dis 195:905-12. 2007
    ..The identification of a parasite homologue of MIF raised the question of whether it affects monocyte function in a manner similar to its human counterpart...
  11. ncbi Immunological properties of human decidual macrophages--a possible role in intrauterine immunity
    Uma Singh
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Reproduction 129:631-7. 2005
    ....
  12. ncbi Fatal Plasmodium falciparum malaria causes specific patterns of splenic architectural disorganization
    Britta C Urban
    Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Old Road, Oxford, OX3 7LJ, United Kingdom
    Infect Immun 73:1986-94. 2005
    ..Furthermore, we found strong HLA-DR expression on sinusoidal lining cells but downregulation on cordal macrophages. P. falciparum infection results in alterations in splenic leukocytes, many of which are not seen in sepsis...
  13. ncbi Deficiency of a subset of T-cells with immunoregulatory properties in sarcoidosis
    Ling Pei Ho
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 7DS, UK
    Lancet 365:1062-72. 2005
    ..We explored whether abnormalities in these cells are implicated in the pathogenesis of sarcoidosis...
  14. ncbi CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion
    Ling Pei Ho
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 7DS, UK
    J Immunol 172:7350-8. 2004
    ..We suggest that one mechanism by which CD1d-restricted NKT cells can exert a regulatory role is by containing the proliferation of activated T cells, possibly through timely lysis of APCs or activated T cells bearing CD1d...
  15. ncbi Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction
    Mihaela S Kojouharova
    Department of Biochemistry, Sofia University, St Kliment Ohridski, Sofia, Bulgaria
    J Immunol 172:4351-8. 2004
    ....
  16. ncbi Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains
    Uday Kishore
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    J Immunol 171:812-20. 2003
    ..The heterotrimeric organization thus offers functional flexibility and versatility to the whole C1q molecule...
  17. ncbi Inhibition of T cell function during malaria: implications for immunology and vaccinology
    Britta C Urban
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Exp Med 197:137-41. 2003
  18. ncbi Protective roles of pulmonary surfactant proteins, SP-A and SP-D, against lung allergy and infection caused by Aspergillus fumigatus
    Uday Kishor
    Department of Biochemistry, University of Oxford, UK
    Immunobiology 205:610-8. 2002
    ..These results highlight the potential of SP-A, SP-D and their recombinant forms, as novel therapeutics for lung allergy and infection...
  19. ncbi Dendritic cells in Plasmodium infection
    Stephen M Todryk
    Biomolecular and Biomedical Research Centre, School of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Future Microbiol 3:279-86. 2008
    ..Furthermore, immune responses to other infections and vaccines may be impaired. A greater understanding of the effects of the parasite on dendritic cells will contribute to insight and potential defeat of this infectious disease...