Nigel Unwin

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    FEBS Lett 555:91-5. 2003
  2. ncbi request reprint Refined structure of the nicotinic acetylcholine receptor at 4A resolution
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Mol Biol 346:967-89. 2005
  3. pmc Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranes
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
    Q Rev Biophys 46:283-322. 2013
  4. pmc Tackling Africa's chronic disease burden: from the local to the global
    Ama de-Graft Aikins
    Department of Social and Developmental Psychology, Faculty of Politics, Psychology, Sociology and International Studies, University of Cambridge, Cambridge, UK
    Global Health 6:5. 2010
  5. pmc Gating movement of acetylcholine receptor caught by plunge-freezing
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    J Mol Biol 422:617-34. 2012
  6. ncbi request reprint Structure of the acetylcholine-gated channel
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Novartis Found Symp 245:5-15; discussion 15-21, 165-8. 2002
  7. ncbi request reprint Structure and gating mechanism of the acetylcholine receptor pore
    Atsuo Miyazawa
    RIKEN Harima Institute, 1 1 1 Kouto, Mikazuki cho, Sayo, Hyogo 679 5148, Japan
    Nature 423:949-55. 2003

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    FEBS Lett 555:91-5. 2003
    ..The movements are small and involve energetically favourable displacements parallel to the membrane plane...
  2. ncbi request reprint Refined structure of the nicotinic acetylcholine receptor at 4A resolution
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Mol Biol 346:967-89. 2005
    ..Access to the pore on the intracellular side is further influenced by narrow lateral windows, which would be expected to screen out electrostatically ions of the wrong charge and size...
  3. pmc Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranes
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
    Q Rev Biophys 46:283-322. 2013
    ..These results together with the findings of biochemical, biophysical and other structural studies allow an integrated description of the receptor and of its mode of action at the synapse. ..
  4. pmc Tackling Africa's chronic disease burden: from the local to the global
    Ama de-Graft Aikins
    Department of Social and Developmental Psychology, Faculty of Politics, Psychology, Sociology and International Studies, University of Cambridge, Cambridge, UK
    Global Health 6:5. 2010
    ....
  5. pmc Gating movement of acetylcholine receptor caught by plunge-freezing
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    J Mol Biol 422:617-34. 2012
    ..This coupled allosteric transition shifts the structure from a tense (closed) state toward a more relaxed (open) state...
  6. ncbi request reprint Structure of the acetylcholine-gated channel
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Novartis Found Symp 245:5-15; discussion 15-21, 165-8. 2002
    ..Recent results, at nearly 4A resolution, have defined more precisely the structure of the pore and the design of the vestibular entrances...
  7. ncbi request reprint Structure and gating mechanism of the acetylcholine receptor pore
    Atsuo Miyazawa
    RIKEN Harima Institute, 1 1 1 Kouto, Mikazuki cho, Sayo, Hyogo 679 5148, Japan
    Nature 423:949-55. 2003
    ..These rotations are communicated through the inner helices, and open the pore by breaking the girdle apart...