William P Unsworth

Summary

Affiliation: University of York
Country: UK

Publications

  1. ncbi request reprint 'Upenamide: trials and tribulations
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Biomol Chem 11:7250-61. 2013
  2. doi request reprint Total synthesis of spirobacillene A
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3306-9. 2013
  3. doi request reprint An expedient protecting-group-free total synthesis of (±)-dievodiamine
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3302-5. 2013
  4. doi request reprint Direct imine acylation: synthesis of the proposed structures of 'upenamide
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:262-5. 2013
  5. doi request reprint Direct imine acylation: rapid access to diverse heterocyclic scaffolds
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:258-61. 2013
  6. doi request reprint Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone
    William P Unsworth
    Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
    Chem Commun (Camb) 47:7659-61. 2011
  7. ncbi request reprint A one-pot C-H insertion/olefination sequence for the formation of α-alkylidene-γ-butyrolactones
    Matthew G Lloyd
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, U K
    Org Lett 16:2772-5. 2014
  8. doi request reprint The Cope rearrangement of gem-dimethyl substituted divinylcyclopropanes
    Jonathan D Osler
    Department of Chemistry, University of York, York, YO10 5DD, UK
    Org Biomol Chem 11:7587-94. 2013

Collaborators

Detail Information

Publications8

  1. ncbi request reprint 'Upenamide: trials and tribulations
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Biomol Chem 11:7250-61. 2013
    ..The evolution of the synthetic route and the development of associated methodologies are described. ..
  2. doi request reprint Total synthesis of spirobacillene A
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3306-9. 2013
    ..A Lewis acid mediated spirocyclization of an anisole derivative onto a tethered ynone was used as a key step, drawing inspiration from a potential biosynthesis of the natural product. ..
  3. doi request reprint An expedient protecting-group-free total synthesis of (±)-dievodiamine
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3302-5. 2013
    ..Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis. ..
  4. doi request reprint Direct imine acylation: synthesis of the proposed structures of 'upenamide
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:262-5. 2013
    ..The key step utilizes direct imine acylation (DIA) with a protected β-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction...
  5. doi request reprint Direct imine acylation: rapid access to diverse heterocyclic scaffolds
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:258-61. 2013
    ..Preliminary mechanistic studies, using ReactIR, are also reported...
  6. doi request reprint Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone
    William P Unsworth
    Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
    Chem Commun (Camb) 47:7659-61. 2011
    ..Analogous cyclisations show that the stereochemical outcome is dictated by the stereochemistry of the diol substrate...
  7. ncbi request reprint A one-pot C-H insertion/olefination sequence for the formation of α-alkylidene-γ-butyrolactones
    Matthew G Lloyd
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, U K
    Org Lett 16:2772-5. 2014
    ..The utility of the process is demonstrated by the synthesis of a known Staphylococcus aureus (MRSA) virulence inhibitor. ..
  8. doi request reprint The Cope rearrangement of gem-dimethyl substituted divinylcyclopropanes
    Jonathan D Osler
    Department of Chemistry, University of York, York, YO10 5DD, UK
    Org Biomol Chem 11:7587-94. 2013
    ....