- Determination of haplotypes at structurally complex regions using emulsion haplotype fusion PCRJess Tyson
School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
BMC Genomics 13:693. 2012..This is turn means downstream determination of the true sequence haplotype in these regions poses a particular challenge. For structurally complex regions, a more focussed approach to assembling haplotypes may be required...
- Quadruplex MAPH: improvement of throughput in high-resolution copy number screeningJess Tyson
Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
BMC Genomics 10:453. 2009..Copy number variation (CNV) in the human genome is recognised as a widespread and important source of human genetic variation. Now the challenge is to screen for these CNVs at high resolution in a reliable, accurate and cost-effective way...
- Screening for common copy-number variants in cancer genesJess Tyson
Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
Cancer Genet Cytogenet 203:316-23. 2010..However, this study has demonstrated a very low incidence of deletion and duplication variants within intronic and flanking regions of these nine genes, in both control individuals and colorectal cancer patients...