Research Topics
Genomes and Genes | Neil A TurnerSummaryAffiliation: University of Leeds Country: UK Publications
| Collaborators
|
Detail Information
Publications
Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinedionesNeil A Turner
Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
Cardiovasc Res 76:81-90. 2007..The present study examined the mechanisms by which TNFalpha stimulates expression of pro-inflammatory cytokines in cultured human cardiac fibroblasts and determined the effects of statin or TZD treatment...- Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migrationKaren E Porter
Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, University of Leeds, United Kingdom
J Vasc Surg 36:150-7. 2002..To clarify its mode of action, we studied in parallel the effects of a specific MMP inhibitor, marimastat... 
Function and fate of myofibroblasts after myocardial infarctionNeil A Turner
Division of Cardiovascular and Diabetes Research, and Multidisciplinary Cardiovascular Research Centre, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
Fibrogenesis Tissue Repair 6:5. 2013....- Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinaseNeil A Turner
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
Matrix Biol 29:613-20. 2010..In summary, IL-1α induces a distinct pattern of ECM protein and protease expression in human CMF, in part regulated by distinct p38 MAPK subtypes, affirming the key role of IL-1α and CMF in post-infarction cardiac remodeling... 
Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblastsNeil A Turner
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
Am J Physiol Heart Circ Physiol 297:H1117-27. 2009..In conclusion, IL-1alpha stimulates human CMF to express IL-1beta, TNF-alpha, and IL-6 via specific signaling pathways, responses that are unaffected by IL-10 exposure...- Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulationNeil A Turner
Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
Int J Biochem Cell Biol 43:1450-8. 2011.... - Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathwaysNeil A Turner
Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
Future Cardiol 7:673-91. 2011..Understanding the role of SAPK signaling at the cellular level holds potential for developing novel therapies to ameliorate cardiac dysfunction in man... - Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblastsNeil A Turner
Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
IUBMB Life 64:143-50. 2012..This review summarizes current knowledge on the identity and regulation of MMPs expressed by CF and discusses future directions for reducing adverse myocardial remodeling by modulating the expression and/or activity of CF-derived MMPs... - Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblastsNeil A Turner
Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
IUBMB Life 64:spcone. 2012..2012 IUBMB IUBMB Life, 2012... - Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanismsNeil A Turner
Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
J Mol Cell Cardiol 43:168-76. 2007.... - Peroxisome proliferator-activated receptor gamma-independent effects of thiazolidinediones on human cardiac myofibroblast functionRomana S Mughal
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
Clin Exp Pharmacol Physiol 36:478-86. 2009..Although TZDs do not inhibit CMF invasion, their antiproliferative activity may contribute to the ability of this class of drugs to modulate adverse myocardial remodelling... - Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoAKaren E Porter
Institute for Cardiovascular Research, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
Cardiovasc Res 61:745-55. 2004..Although statins are known to reduce myocyte hypertrophy, their effect on cardiac fibroblast proliferation is unknown. The purpose of this study was to investigate the effects of simvastatin on human atrial myofibroblast proliferation... - Endothelin-1 is an essential co-factor for beta2-adrenergic receptor-induced proliferation of human cardiac fibroblastsNeil A Turner
Institute for Cardiovascular Research, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
FEBS Lett 576:156-60. 2004..Furthermore, despite activation of the MAP kinase pathway, ET-1 treatment did not stimulate CF proliferation. Therefore, the role of ET-1 in this process is that of an essential co-factor acting independently of beta2-AR stimulation... - Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasionNeil A Turner
Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
J Cardiovasc Pharmacol 50:458-61. 2007..Our data provide strong evidence that individual statins possess differential pleiotropic effects on SV-SMC function. This may be of clinical relevance in the selection of individual statins for the treatment of CABG patients... - Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patientsHaifa A Madi
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
Am J Physiol Cell Physiol 297:C1307-17. 2009..In conclusion, SV-SMC from T2DM patients differ from nondiabetic SV-SMC in that they exhibit a rhomboid phenotype and are more migratory, but less proliferative, in response to serum... - MMP-3 (5A/6A) polymorphism does not influence human smooth muscle cell invasionAzhar Maqbool
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
J Surg Res 175:343-9. 2012..The aim of this study was to determine whether the MMP-3 5A/6A polymorphism directly influences endogenous MMP-3 expression levels and, consequently, cell invasion, in SV-derived SMC cultured from patients with different genotypes... - The -1562C/T MMP-9 promoter polymorphism does not predict MMP-9 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patientsAzhar Maqbool
Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
Atherosclerosis 207:458-65. 2009..Our data challenge the functional nature of the -1562C/T polymorphism and its capacity to modulate MMP-9 expression levels and SV-SMC invasion, and hence susceptibility to vascular pathologies in vivo... - Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levelsNeil A Turner
Institute for Cardiovascular Research, University of Leeds, Leeds, UK
FASEB J 19:804-6. 2005.... - Chronic hypoxia inhibits MMP-2 activation and cellular invasion in human cardiac myofibroblastsKirsten Riches
Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds LS2 9JT, UK
J Mol Cell Cardiol 47:391-9. 2009..Regulation of these MMPs remains an attractive target for therapeutic intervention... - Smooth muscle cells cultured from human saphenous vein exhibit increased proliferation, invasion, and mitogen-activated protein kinase activation in vitro compared with paired internal mammary artery cellsNeil A Turner
Institute for Cardiovascular Research, School of Medicine, University of Leeds, Leeds, United Kingdom
J Vasc Surg 45:1022-8. 2007..In this study we used paired cultures of SV-SMCs and IMA-SMCs from the same patients and compared their rates of proliferation, invasion, migration, and MMP-2 and MMP-9 secretion... - Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatinKaren E Porter
Institute for Cardiovascular Research, Academic Unit for Cardiovascular Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
Cardiovasc Res 64:507-15. 2004..Inhibition of cytokine-induced cardiac myofibroblast activation by statins provides a rationale for their use in patients with cardiac pathologies characterized by adverse myocardial remodeling... - Cardiac fibroblasts: at the heart of myocardial remodelingKaren E Porter
Multidisciplinary Cardiovascular Research Centre MCRC, Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS29JT, UK
Pharmacol Ther 123:255-78. 2009..We also review the evidence suggesting that certain cardiovascular drugs can reduce myocardial remodeling specifically via modulatory effects on cardiac fibroblasts... - Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunctionJustin F X Ainscough
BHF Heart Research Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
Cardiovasc Res 81:592-600. 2009..This study aimed to clarify the role of local RAS activity, specifically in the adult heart, in modulating cardiac hypertrophy and pathological remodelling... - Chronic beta2-adrenergic receptor stimulation increases proliferation of human cardiac fibroblasts via an autocrine mechanismNeil A Turner
Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, Worsley Building, University of Leeds, UK
Cardiovasc Res 57:784-92. 2003..The aim of this study was to determine whether chronic beta-adrenergic receptor (beta-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the mechanism(s) involved... - p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblastsJohn K Sinfield
Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
Biochem Biophys Res Commun 430:419-24. 2013..In conclusion, human CF express the α, γ and δ subtypes of p38 MAPK, and the α subtype is important for IL-1α-induced IL-6 and MMP-3 expression in this cell type... - Divergent effects of 17-β-estradiol on human vascular smooth muscle and endothelial cell function diminishes TNF-α-induced neointima formationRungrat Nintasen
Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
Biochem Biophys Res Commun 420:828-33. 2012..E2 exerted distinct cell-type and function-specific modulation, the mechanisms underlying which are worthy of further detailed study... - Statins and myocardial remodelling: cell and molecular pathwaysKaren E Porter
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Clarendon Way, Leeds, UK
Expert Rev Mol Med 13:e22. 2011..The prospects for future therapies and ongoing clinical trials are also summarised... - Selective gene silencing of either MMP-2 or MMP-9 inhibits invasion of human saphenous vein smooth muscle cellsNeil A Turner
Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
Atherosclerosis 193:36-43. 2007..Specific manipulation of either MMP-2 or MMP-9 may therefore provide a valuable strategy for prevention of SV graft stenosis in man... - Changes in glutamate transporter expression in mouse forebrain areas following focal ischemiaPirusha Ketheeswaranathan
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, LS2 9JT, UK
Brain Res 1418:93-103. 2011..Down regulation of GLT-1 in these brain areas may impair normal clearance of synaptically-released glutamate and contribute to neural damage following focal ischemic insult...