Neil A Turner

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration
    Karen E Porter
    Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, University of Leeds, United Kingdom
    J Vasc Surg 36:150-7. 2002
  2. ncbi request reprint Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 76:81-90. 2007
  3. pmc p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts
    John K Sinfield
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Biochem Biophys Res Commun 430:419-24. 2013
  4. doi request reprint Effects of interleukin-1 on cardiac fibroblast function: relevance to post-myocardial infarction remodelling
    Neil A Turner
    Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, UK Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK Electronic address
    Vascul Pharmacol 60:1-7. 2014
  5. pmc Function and fate of myofibroblasts after myocardial infarction
    Neil A Turner
    Division of Cardiovascular and Diabetes Research, and Multidisciplinary Cardiovascular Research Centre, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Fibrogenesis Tissue Repair 6:5. 2013
  6. pmc Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Matrix Biol 29:613-20. 2010
  7. doi request reprint Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Int J Biochem Cell Biol 43:1450-8. 2011
  8. doi request reprint Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H1117-27. 2009
  9. doi request reprint Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    Future Cardiol 7:673-91. 2011
  10. doi request reprint Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    IUBMB Life 64:143-50. 2012

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration
    Karen E Porter
    Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, University of Leeds, United Kingdom
    J Vasc Surg 36:150-7. 2002
    ..To clarify its mode of action, we studied in parallel the effects of a specific MMP inhibitor, marimastat...
  2. ncbi request reprint Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 76:81-90. 2007
    ..The present study examined the mechanisms by which TNFalpha stimulates expression of pro-inflammatory cytokines in cultured human cardiac fibroblasts and determined the effects of statin or TZD treatment...
  3. pmc p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts
    John K Sinfield
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Biochem Biophys Res Commun 430:419-24. 2013
    ..In conclusion, human CF express the α, γ and δ subtypes of p38 MAPK, and the α subtype is important for IL-1α-induced IL-6 and MMP-3 expression in this cell type...
  4. doi request reprint Effects of interleukin-1 on cardiac fibroblast function: relevance to post-myocardial infarction remodelling
    Neil A Turner
    Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, UK Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK Electronic address
    Vascul Pharmacol 60:1-7. 2014
    ..This review summarises these data and sets it in the context of post-MI cardiac remodelling, identifying the fibroblast as a potential therapeutic target for reducing adverse cardiac remodelling and its devastating consequences. ..
  5. pmc Function and fate of myofibroblasts after myocardial infarction
    Neil A Turner
    Division of Cardiovascular and Diabetes Research, and Multidisciplinary Cardiovascular Research Centre, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Fibrogenesis Tissue Repair 6:5. 2013
    ....
  6. pmc Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Matrix Biol 29:613-20. 2010
    ..In summary, IL-1α induces a distinct pattern of ECM protein and protease expression in human CMF, in part regulated by distinct p38 MAPK subtypes, affirming the key role of IL-1α and CMF in post-infarction cardiac remodeling...
  7. doi request reprint Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Int J Biochem Cell Biol 43:1450-8. 2011
    ....
  8. doi request reprint Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H1117-27. 2009
    ..In conclusion, IL-1alpha stimulates human CMF to express IL-1beta, TNF-alpha, and IL-6 via specific signaling pathways, responses that are unaffected by IL-10 exposure...
  9. doi request reprint Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    Future Cardiol 7:673-91. 2011
    ..Understanding the role of SAPK signaling at the cellular level holds potential for developing novel therapies to ameliorate cardiac dysfunction in man...
  10. doi request reprint Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    IUBMB Life 64:143-50. 2012
    ..This review summarizes current knowledge on the identity and regulation of MMPs expressed by CF and discusses future directions for reducing adverse myocardial remodeling by modulating the expression and/or activity of CF-derived MMPs...
  11. ncbi request reprint Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    IUBMB Life 64:spcone. 2012
    ..2012 IUBMB IUBMB Life, 2012...
  12. ncbi request reprint Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    J Mol Cell Cardiol 43:168-76. 2007
    ....
  13. doi request reprint Peroxisome proliferator-activated receptor gamma-independent effects of thiazolidinediones on human cardiac myofibroblast function
    Romana S Mughal
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Clin Exp Pharmacol Physiol 36:478-86. 2009
    ..Although TZDs do not inhibit CMF invasion, their antiproliferative activity may contribute to the ability of this class of drugs to modulate adverse myocardial remodelling...
  14. ncbi request reprint Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA
    Karen E Porter
    Institute for Cardiovascular Research, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 61:745-55. 2004
    ..Although statins are known to reduce myocyte hypertrophy, their effect on cardiac fibroblast proliferation is unknown. The purpose of this study was to investigate the effects of simvastatin on human atrial myofibroblast proliferation...
  15. doi request reprint Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients
    Haifa A Madi
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Am J Physiol Cell Physiol 297:C1307-17. 2009
    ..In conclusion, SV-SMC from T2DM patients differ from nondiabetic SV-SMC in that they exhibit a rhomboid phenotype and are more migratory, but less proliferative, in response to serum...
  16. ncbi request reprint Endothelin-1 is an essential co-factor for beta2-adrenergic receptor-induced proliferation of human cardiac fibroblasts
    Neil A Turner
    Institute for Cardiovascular Research, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    FEBS Lett 576:156-60. 2004
    ..Furthermore, despite activation of the MAP kinase pathway, ET-1 treatment did not stimulate CF proliferation. Therefore, the role of ET-1 in this process is that of an essential co-factor acting independently of beta2-AR stimulation...
  17. ncbi request reprint Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    J Cardiovasc Pharmacol 50:458-61. 2007
    ..Our data provide strong evidence that individual statins possess differential pleiotropic effects on SV-SMC function. This may be of clinical relevance in the selection of individual statins for the treatment of CABG patients...
  18. doi request reprint Interleukin-1 has opposing effects on connective tissue growth factor and tenascin-C expression in human cardiac fibroblasts
    Azhar Maqbool
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Matrix Biol 32:208-14. 2013
    ..In conclusion, IL-1α reduced CCN2 expression and increased TNC expression in human CF. These observations are of potential value for understanding how inflammation and ECM regulation are linked at the level of the CF...
  19. ncbi request reprint Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels
    Neil A Turner
    Institute for Cardiovascular Research, University of Leeds, Leeds, UK
    FASEB J 19:804-6. 2005
    ....
  20. doi request reprint MMP-3 (5A/6A) polymorphism does not influence human smooth muscle cell invasion
    Azhar Maqbool
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    J Surg Res 175:343-9. 2012
    ..The aim of this study was to determine whether the MMP-3 5A/6A polymorphism directly influences endogenous MMP-3 expression levels and, consequently, cell invasion, in SV-derived SMC cultured from patients with different genotypes...
  21. doi request reprint The -1562C/T MMP-9 promoter polymorphism does not predict MMP-9 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patients
    Azhar Maqbool
    Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    Atherosclerosis 207:458-65. 2009
    ..Our data challenge the functional nature of the -1562C/T polymorphism and its capacity to modulate MMP-9 expression levels and SV-SMC invasion, and hence susceptibility to vascular pathologies in vivo...
  22. ncbi request reprint Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin
    Karen E Porter
    Institute for Cardiovascular Research, Academic Unit for Cardiovascular Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 64:507-15. 2004
    ..This study investigated the effect of TNFalpha on human cardiac myofibroblast proliferation, invasion and MMP-9 secretion, and determined whether these properties were modulated by simvastatin...
  23. ncbi request reprint Smooth muscle cells cultured from human saphenous vein exhibit increased proliferation, invasion, and mitogen-activated protein kinase activation in vitro compared with paired internal mammary artery cells
    Neil A Turner
    Institute for Cardiovascular Research, School of Medicine, University of Leeds, Leeds, United Kingdom
    J Vasc Surg 45:1022-8. 2007
    ..In this study we used paired cultures of SV-SMCs and IMA-SMCs from the same patients and compared their rates of proliferation, invasion, migration, and MMP-2 and MMP-9 secretion...
  24. pmc Chronic hypoxia inhibits MMP-2 activation and cellular invasion in human cardiac myofibroblasts
    Kirsten Riches
    Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds LS2 9JT, UK
    J Mol Cell Cardiol 47:391-9. 2009
    ..Regulation of these MMPs remains an attractive target for therapeutic intervention...
  25. doi request reprint Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction
    Justin F X Ainscough
    BHF Heart Research Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 81:592-600. 2009
    ..This study aimed to clarify the role of local RAS activity, specifically in the adult heart, in modulating cardiac hypertrophy and pathological remodelling...
  26. ncbi request reprint Cardiac fibroblasts: at the heart of myocardial remodeling
    Karen E Porter
    Multidisciplinary Cardiovascular Research Centre MCRC, Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS29JT, UK
    Pharmacol Ther 123:255-78. 2009
    ..We also review the evidence suggesting that certain cardiovascular drugs can reduce myocardial remodeling specifically via modulatory effects on cardiac fibroblasts...
  27. pmc Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms
    Kirsten Riches
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Int J Biochem Cell Biol 45:1776-83. 2013
    ..Circulating levels of Lp(a) are resistant to lipid-lowering strategies and hence a greater understanding of the mechanisms underlying its functional effects on SMC may provide alternative therapeutic targets. ..
  28. ncbi request reprint Chronic beta2-adrenergic receptor stimulation increases proliferation of human cardiac fibroblasts via an autocrine mechanism
    Neil A Turner
    Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, Worsley Building, University of Leeds, UK
    Cardiovasc Res 57:784-92. 2003
    ..The aim of this study was to determine whether chronic beta-adrenergic receptor (beta-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the mechanism(s) involved...
  29. ncbi request reprint Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: possible role of differential RhoA activity
    Kirsten Riches
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    Cardiovasc Revasc Med 15:141-8. 2014
    ..Smooth muscle cells (SMC) play a pivotal role in graft integration; we therefore examined the phenotype and proliferative function of IMA- and SV-SMC isolated from non-diabetic (ND) patients or those diagnosed with T2DM...
  30. doi request reprint Divergent effects of 17-β-estradiol on human vascular smooth muscle and endothelial cell function diminishes TNF-α-induced neointima formation
    Rungrat Nintasen
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 420:828-33. 2012
    ..E2 exerted distinct cell-type and function-specific modulation, the mechanisms underlying which are worthy of further detailed study...
  31. doi request reprint Statins and myocardial remodelling: cell and molecular pathways
    Karen E Porter
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Clarendon Way, Leeds, UK
    Expert Rev Mol Med 13:e22. 2011
    ..The prospects for future therapies and ongoing clinical trials are also summarised...
  32. ncbi request reprint Selective gene silencing of either MMP-2 or MMP-9 inhibits invasion of human saphenous vein smooth muscle cells
    Neil A Turner
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Atherosclerosis 193:36-43. 2007
    ..Specific manipulation of either MMP-2 or MMP-9 may therefore provide a valuable strategy for prevention of SV graft stenosis in man...
  33. ncbi request reprint Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors
    Bryony Sedgwick
    Division of Cardiovascular and Diabetes Research, School of Medicine, University of Leeds, Leeds, UK
    Cardiovasc Pathol 23:204-10. 2014
    ..As cardiac fibroblasts (CFs) are key effectors of myocardial remodeling, we investigated whether inherent phenotypic differences exist in CF derived from T2DM donors compared with cells from nondiabetic (ND) donors...
  34. doi request reprint Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia
    Pirusha Ketheeswaranathan
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, LS2 9JT, UK
    Brain Res 1418:93-103. 2011
    ..Down regulation of GLT-1 in these brain areas may impair normal clearance of synaptically-released glutamate and contribute to neural damage following focal ischemic insult...