Research Topics
| M W TurnerSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Differential recognition of obligate anaerobic bacteria by human mannose-binding lectinR Townsend
Division of Genomic Medicine, University of Sheffield, United Kingdom
Clin Exp Immunol 124:223-8. 2001..The results suggest that for the species we examined, resistance to MBL binding may be associated with organisms that are more commonly pathogenic and that MBL binding to some bacteria may be phase variable...
Anti-microbial activities of mannose-binding lectinD L Jack
Academic Unit of Infection and Immunity, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
Biochem Soc Trans 31:753-7. 2003..An understanding of these basic mechanisms will be vital if we are to use purified or recombinant MBL in therapeutic applications...
Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanismK J Fidler
Infectious Diseases and Microbiology Unit, Institute of Child Health, London, UK
Thorax 64:150-5. 2009..The mechanism is uncertain, and could relate either to systemic or local effects. The aim of this study was to determine, in a large cohort of children, whether MBL is present on the airway surface in health or disease...- Mannose-binding lectin: structure, function, genetics and disease associationsM W Turner
Immunobiology Unit, Institute of Child Health, University College London, UK
Rev Immunogenet 2:305-22. 2000..These and other findings suggest that the concept of MBL as a protein involved solely in first line defence is an oversimplification and the protein should rather be viewed as having a range of activities including disease modulation... - Restricted polymorphism of the mannose-binding lectin gene of indigenous AustraliansM W Turner
Immunobiology Unit, Institute of Child Health, University College London, UK
Hum Mol Genet 9:1481-6. 2000..Its absence from the founder gene pool of indigenous Australians may also partly explain their vulnerability to intracellular infections such as tuberculosis... - Mannose-binding lectin (MBL) in health and diseaseM W Turner
Immunobiology Unit, Institute of Child Health, London, UK
Immunobiology 199:327-39. 1998..Moreover, this association was independent of age. Prospective studies are underway to address the questions raised by these findings... - Mannose-binding lectin: the pluripotent molecule of the innate immune systemM W Turner
Immunobiology Unit, Institute of Child Health, London, UK
Immunol Today 17:532-40. 1996 - The role of mannose-binding lectin in health and diseaseM W Turner
Immunobiology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Mol Immunol 40:423-9. 2003..For example, the protein appears to influence the severity of several diseases. The mechanism whereby MBL exerts such effects is unclear but one possibility is through a dose-dependent modulation of pro-inflammatory cytokines... - Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective studyO Neth
Immunobiology Unit, Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK
Lancet 358:614-8. 2001..This finding suggests that MBL infusions could represent a new therapeutic approach which would aid the management of chemotherapy-induced complications in this population of children... - Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosisD L Jack
Immunobiology Unit, Institute of Child Health, University College London, UK
Immunol Rev 180:86-99. 2001..In addition, the protein also modulates disease severity, at least in part through a complex, dose-dependent influence on cytokine production. The mechanisms and signalling pathways involved in such processes remain to be elucidated... - Molecular basis of opsonic defect in immunodeficient childrenM Sumiya
Department of Medicine, St Mary s Hospital Medical School, London, UK
Lancet 337:1569-70. 1991..Study of sixteen members of the three families showed autosomal dominant co-inheritance of the mutation and low serum MBP concentrations... - Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup BD L Jack
Immunobiology Unit, Institute of Child Health, University College, London, United Kingdom
J Infect Dis 184:1152-62. 2001..These results suggest that MBL not only is involved in complement activation but also is a potent regulator of inflammatory pathways and, as such, may affect the severity of meningococcal disease... - Mannose-binding lectin accelerates complement activation and increases serum killing of Neisseria meningitidis serogroup CD L Jack
Institute of Child Health, University College London, London, United Kingdom
J Infect Dis 184:836-45. 2001..meningitidis and can modulate complement-dependent killing of the bacterium. These findings could explain the observed susceptibility to meningococcal disease of individuals genetically deficient in MBL... - High frequencies in African and non-African populations of independent mutations in the mannose binding protein geneR J Lipscombe
Molecular Immunology Unit, Institute of Child Health, London
Hum Mol Genet 1:709-15. 1992..Our data indicate that the two mutations have arisen independently since the divergence of African and non African populations and both have attained high frequencies... - Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement depositionO Neth
Immunobiology Unit, Institute of Child Health, University College London, NHS Trust, London, United Kingdom
Infect Immun 68:688-93. 2000..Bound MBL was able to promote C4 deposition in a concentration-dependent manner. We conclude that MBL may be of importance in first-line immune defense against several important pathogens... - Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup BD L Jack
Immunobiology Unit, Institute of Child Health, London, United Kingdom
J Immunol 160:1346-53. 1998..Our results suggest that MBL may bind to and activate complement on these encapsulated organisms, and the major determinants of these effects are the LOS structure and sialylation... - The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrationsM Super
Department of Immunology, Institute of Child Health, London, England
Clin Exp Immunol 79:144-50. 1990.... - Antibodies to mannose binding lectin in patients with systemic lupus erythematosusM Y Mok
Department of Immunology and Molecular Pathology and Rheumatology, Royal Free and University College Medical School, London, UK
Lupus 13:522-8. 2004..Thus the production of anti-MBL antibodies is likely to be a specific antigen-driven process. Its role in lupus pathogenesis remains to be elucidated... - Mannose-binding lectin in innate immunity: past, present and futureR M Dommett
Infectious Diseases and Microbiology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
Tissue Antigens 68:193-209. 2006..However, in certain situations, reduced levels of circulating MBL may be beneficial to the host and this may explain the persistence of the deleterious gene polymorphisms in many population groups... - Susceptibility to infection in patients with neutropenia: the role of the innate immune systemO W Neth
Infectious Diseases and Microbiology Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
Br J Haematol 129:713-22. 2005..frequency one in 10). Here, we review the potential role of the innate immune system in determining susceptibility to infections in patients with neutropenia... - Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 allelesJ C Davies
Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney St, London, SW3 6NP, UK
Eur Respir J 24:798-804. 2004.... - Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclassesN McCloskey
Institute of Child Health, London, UK
Immunology 88:169-73. 1996..The exact mechanism for this phenomenon remains obscure but such differences should be taken into account when designing or choosing antibodies for therapeutic use... - Endotoxin immunity and the development of the systemic inflammatory response syndrome in critically ill childrenR C M Stephens
Critical Care Group, Portex Unit, Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK
Intensive Care Med 32:286-94. 2006..Because of the existing literature we defined two sub-groups according to the primary reason for ICU admission: infection and non-infection... - Assays for human mannose-binding lectinM W Turner
J Immunol Methods 276:147-9. 2003 - Mannose binding protein gene mutations associated with unusual and severe infections in adultsJ A Summerfield
Department of Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London
Lancet 345:886-9. 1995..3%). The occurrence of three homozygotes for MBP mutations among these five infected patients suggests that MBP deficiency may confer a life-long risk of infection... - Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISAM A Seelen
Department of Nephrology, C3P-29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
J Immunol Methods 296:187-98. 2005..The results demonstrate the value of these ELISA-based procedures for the functional assessment of complement deficiencies in clinical practice. The assay is now available commercially in kit form...