Elizabeth M Tunbridge

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions
    Linda M Laatikainen
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e61839. 2013
  2. pmc Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition
    L M Laatikainen
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Psychopharmacol 26:1561-8. 2012
  3. pmc Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, UK
    Neuroimage 68:49-54. 2013
  4. ncbi request reprint The role of catechol-O-methyltransferase in reward processing and addiction
    E M Tunbridge
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    CNS Neurol Disord Drug Targets 11:306-23. 2012
  5. doi request reprint Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, OX3 7JX, UK
    Curr Top Behav Neurosci 8:119-40. 2011
  6. doi request reprint Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:996-9. 2008
  7. ncbi request reprint Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain
    Elizabeth M Tunbridge
    Department of Psychiatry, Oxford University, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 144:834-9. 2007
  8. ncbi request reprint Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom, OX3 7JX
    J Neurosci 24:5331-5. 2004
  9. pmc COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition
    Sarah M Farrell
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 71:538-44. 2012
  10. pmc Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
    Tracy A Lane
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    BMC Neurosci 14:102. 2013

Collaborators

Detail Information

Publications19

  1. pmc Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions
    Linda M Laatikainen
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e61839. 2013
    ..Furthermore, they suggest that the impact of tolcapone may be greater in females than males, a finding which may be of clinical significance in terms of the efficacy and dosing of COMT inhibitors...
  2. pmc Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition
    L M Laatikainen
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Psychopharmacol 26:1561-8. 2012
    ..These findings support the therapeutic candidacy of COMT inhibition as a cognitive enhancer, and suggest that, in addition to the prefrontal cortex, the hippocampus might be a key region for mediating these effects...
  3. pmc Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, UK
    Neuroimage 68:49-54. 2013
    ....
  4. ncbi request reprint The role of catechol-O-methyltransferase in reward processing and addiction
    E M Tunbridge
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    CNS Neurol Disord Drug Targets 11:306-23. 2012
    ..In particular, it will be critical to reveal the precise neurobiological mechanisms underlying links between COMT and reward processing, and the extent to which these relate to the putative associations with addiction...
  5. doi request reprint Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, OX3 7JX, UK
    Curr Top Behav Neurosci 8:119-40. 2011
    ....
  6. doi request reprint Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:996-9. 2008
    ..The results also indicate that COMT activity may influence a broader range of biochemical pathways than hitherto appreciated...
  7. ncbi request reprint Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain
    Elizabeth M Tunbridge
    Department of Psychiatry, Oxford University, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 144:834-9. 2007
    ..The alternate gene products may be of significant functional importance, and differentially impacted by polymorphisms within the COMT gene...
  8. ncbi request reprint Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom, OX3 7JX
    J Neurosci 24:5331-5. 2004
    ..The interaction between clozapine and tolcapone may have implications for the treatment of schizophrenia...
  9. pmc COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition
    Sarah M Farrell
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 71:538-44. 2012
    ..The inverted-U relationship between cortical dopamine signaling and working memory predicts that the effects of COMT inhibition will differ according to COMT genotype...
  10. pmc Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
    Tracy A Lane
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    BMC Neurosci 14:102. 2013
    ..We also measured the same parameters in mGlu2-/- and mGlu3-/- single knockout mice...
  11. ncbi request reprint Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders
    Paul J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:3037-45. 2008
    ..Since sex differences in the genetic architecture of quantitative traits are the rule not the exception, we anticipate that additional evidence will emerge for sexual dimorphisms, not only in COMT but also in many other autosomal genes...
  12. ncbi request reprint Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 60:141-51. 2006
    ..We conclude by outlining preliminary data indicating that COMT is a promising therapeutic target for ameliorating the cognitive deficits associated with schizophrenia...
  13. ncbi request reprint Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues
    Robert D Rogers
    University Department of Psychiatry, University of Oxford, UK
    Neuropsychopharmacology 28:153-62. 2003
    ..It is possible that such a change in the cognition mediating human choice is one mechanism associated with the onset and maintenance of anhedonia and lowered mood in psychiatric illness...
  14. pmc Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP)
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropathol Appl Neurobiol 36:498-504. 2010
    ..Many variables affect mRNA measurements in post mortem human brain tissue. Brain weight has not hitherto been considered to be such a factor. This study examined whether there is any relationship between brain weight and mRNA abundance...
  15. ncbi request reprint Genetic mouse models relevant to schizophrenia: taking stock and looking forward
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Neuropharmacology 62:1164-7. 2012
    ....
  16. doi request reprint Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 69:173-9. 2011
    ..We end by making several recommendations toward a more flexible, transparent, and comprehensive approach to data presentation and analysis. We illustrate the review with examples from studies of schizophrenia and mood disorder...
  17. ncbi request reprint Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Cereb Cortex 17:1206-12. 2007
    ....
  18. pmc Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation
    Olivia A Shipton
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 31:1688-92. 2011
    ..We conclude that preventing the interaction between Aβ and tau could be a promising strategy for treating cognitive impairment in MCI and early AD...
  19. doi request reprint The catechol-O-methyltransferase gene: its regulation and polymorphisms
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, UK
    Int Rev Neurobiol 95:7-27. 2010
    ..COMT contains several functional polymorphisms and haplotypes, including the well-studied Val158Met polymorphism. Here I review the regulation of COMT and the functional polymorphisms within its sequence with respect to brain function...