Mick Tuite

Summary

Affiliation: University of Kent
Country: UK

Publications

  1. ncbi request reprint The [PSI+] prion of yeast: a problem of inheritance
    Mick F Tuite
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Methods 39:9-22. 2006
  2. ncbi request reprint Regulated translational bypass of stop codons in yeast
    Tobias von der Haar
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
    Trends Microbiol 15:78-86. 2007
  3. ncbi request reprint Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated Abeta peptides in vivo
    Tobias von der Haar
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, UK
    Neurodegener Dis 4:136-47. 2007
  4. pmc Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochloride
    Lee J Byrne
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury CT2 7NJ, United Kingdom
    Proc Natl Acad Sci U S A 104:11688-93. 2007
  5. pmc Specialized yeast ribosomes: a customized tool for selective mRNA translation
    Johann W Bauer
    Department of Cell Biology, University of Salzburg, Salzburg, Austria
    PLoS ONE 8:e67609. 2013
  6. doi request reprint Dynamic prions revealed by magic
    Mick F Tuite
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK Electronic address
    Chem Biol 21:172-3. 2014
  7. pmc Structural definition is important for the propagation of the yeast [PSI+] prion
    Ricardo Marchante
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Mol Cell 50:675-85. 2013
  8. doi request reprint The natural history of yeast prions
    Mick F Tuite
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom Electronic address
    Adv Appl Microbiol 84:85-137. 2013
  9. pmc The genetic control of the formation and propagation of the [PSI+] prion of yeast
    Mick F Tuite
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Prion 1:101-9. 2007
  10. pmc Protein misfolding and aggregation in ageing and disease: molecular processes and therapeutic perspectives
    Mick F Tuite
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Prion 1:116-20. 2007

Collaborators

  • P A Lund
  • Martin S Ridout
  • Tobias von der Haar
  • Susan Lindquist
  • Tiago Fleming Outeiro
  • Steven E Massey
  • Vitaly V Kushnirov
  • Gary W Jones
  • Gabriela R Moura
  • Lee J Byrne
  • Brian S Cox
  • Frederique Ness
  • Ricardo Marchante
  • Johann W Bauer
  • Kenneth J O'Callaghan
  • Brian Cox
  • Lyne Jossé
  • Gloria H Merritt
  • Behrooz Moosavi
  • Byron J T Morgan
  • Diana J Cole
  • Patrick Studte
  • Joanna F Zenthon
  • Irina S Shkundina
  • Lev Z Osherovich
  • Catarina G Resende
  • Paulo Ferreira
  • Catarina Resende
  • Mark J Howard
  • Michael Breitenbach
  • Olaf Haubenreisser
  • Bjoern Wimmer
  • Michelle Rowe
  • Clemens Brandl
  • Manuela Weber
  • Thomas Karl
  • Helmut Hintner
  • Alfred Klausegger
  • Jo Zenthon
  • Lore Breitenbach-Koller
  • C Mark Smales
  • Pierre Mugnier
  • Wesley R Naemi
  • Jintana Wongwigkarn
  • Helen M Webb
  • Sabrina Zink
  • Raffael Schaffrath
  • Christian Bär
  • Daniel Jablonowski
  • Michael D Ter-Avanesyan
  • Jonathan S Weissman
  • Laina Sands
  • Caroline Tinsley
  • Júlio A B Duarte
  • Steven N Parham

Detail Information

Publications36

  1. ncbi request reprint The [PSI+] prion of yeast: a problem of inheritance
    Mick F Tuite
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Methods 39:9-22. 2006
    ....
  2. ncbi request reprint Regulated translational bypass of stop codons in yeast
    Tobias von der Haar
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
    Trends Microbiol 15:78-86. 2007
    ..Rather than being a translation 'error', stop-codon readthrough can have important effects on other cellular processes such as mRNA degradation and, in some cases, can confer a beneficial phenotype to the cell...
  3. ncbi request reprint Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated Abeta peptides in vivo
    Tobias von der Haar
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, UK
    Neurodegener Dis 4:136-47. 2007
    ..We conclude that we have established a useful new tool for studying the aggregation of Abeta peptides in an organism in vivo...
  4. pmc Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochloride
    Lee J Byrne
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury CT2 7NJ, United Kingdom
    Proc Natl Acad Sci U S A 104:11688-93. 2007
    ..HCl requires ongoing cell division and that prions are not destroyed during or after the evident curing phase...
  5. pmc Specialized yeast ribosomes: a customized tool for selective mRNA translation
    Johann W Bauer
    Department of Cell Biology, University of Salzburg, Salzburg, Austria
    PLoS ONE 8:e67609. 2013
    ..Importantly, the RP L35B sub-population of specialized ribosomes leave both translation of a reporter luciferase carrying a different PTC and bulk mRNA translation largely unaltered. ..
  6. doi request reprint Dynamic prions revealed by magic
    Mick F Tuite
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK Electronic address
    Chem Biol 21:172-3. 2014
    ..By providing structural information at atomic level for two such variants of a yeast prion, Frederick and colleagues, in this issue of Chemistry & Biology, reveal how conformational flexibility can generate phenotypic diversity. ..
  7. pmc Structural definition is important for the propagation of the yeast [PSI+] prion
    Ricardo Marchante
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Mol Cell 50:675-85. 2013
    ..These findings offer a molecular explanation for the dominant-negative effects of such psi-no-more (PNM) mutations and demonstrate directly the importance of localized structural definition in prion propagation...
  8. doi request reprint The natural history of yeast prions
    Mick F Tuite
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom Electronic address
    Adv Appl Microbiol 84:85-137. 2013
    ..Prion research has now entered a new phase in which we must now consider their biological function and evolutionary significance in the natural world...
  9. pmc The genetic control of the formation and propagation of the [PSI+] prion of yeast
    Mick F Tuite
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Prion 1:101-9. 2007
    ..In this Chapter we describe what has emerged from the application of classical and molecular genetic studies, to the most intensively studied of the three native yeast prions, the [PSI(+)] prion...
  10. pmc Protein misfolding and aggregation in ageing and disease: molecular processes and therapeutic perspectives
    Mick F Tuite
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Prion 1:116-20. 2007
    ..Such diseases are usually characterised by the deposition of specific misfolded proteins as amyloid fibrils and hence are often referred to as the amyloidoses...
  11. doi request reprint Prions remodel gene expression in yeast
    Mick F Tuite
    Kent Fungal Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Nat Cell Biol 11:241-3. 2009
    ....
  12. doi request reprint Cellular factors important for the de novo formation of yeast prions
    Mick Tuite
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Biochem Soc Trans 36:1083-7. 2008
    ..A number of other cellular factors, in particular chaperones of the Hsp70 (heat-shock protein 70) family, are known to modify the frequency of de novo prion formation in yeast...
  13. pmc The prion hypothesis: from biological anomaly to basic regulatory mechanism
    Mick F Tuite
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Nat Rev Mol Cell Biol 11:823-33. 2010
    ..The mechanistic similarities between prion propagation in mammals and fungi suggest that prions are not a biological anomaly but instead could be a newly appreciated and perhaps ubiquitous regulatory mechanism...
  14. doi request reprint Fungal prions: structure, function and propagation
    Mick F Tuite
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Top Curr Chem 305:257-98. 2011
    ..Much has already been learnt about prion structure, and propagation and de novo generation of the prion state through studies in yeast and these findings are reviewed here...
  15. ncbi request reprint Propagation of yeast prions
    Mick F Tuite
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Nat Rev Mol Cell Biol 4:878-90. 2003
  16. pmc Analysis of the generation and segregation of propagons: entities that propagate the [PSI+] prion in yeast
    Brian Cox
    Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Genetics 165:23-33. 2003
    ..The implications of our findings with respect to yeast prion propagation mechanisms are discussed...
  17. pmc Prion stability
    Brian S Cox
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Prion 1:170-8. 2007
    ..published in Nature (2006), which provides much insight into the phenotypic and genetic parameters of the numerous "variants" of prions increasingly being described in the literature...
  18. pmc Guanidine hydrochloride inhibits the generation of prion "seeds" but not prion protein aggregation in yeast
    Frederique Ness
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Mol Cell Biol 22:5593-605. 2002
    ....
  19. pmc The [PSI+] prion of Saccharomyces cerevisiae can be propagated by an Hsp104 orthologue from Candida albicans
    Joanna F Zenthon
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Eukaryot Cell 5:217-25. 2006
    ..These findings have implications both in terms of the mechanism of inhibition of Hsp104 by GdnHCl and in the evolution of the ability of fungal species to propagate prions...
  20. pmc Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast
    Gloria H Merritt
    Kent Fungal Group and Protein Science Group, School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
    Nucleic Acids Res 38:5479-92. 2010
    ..We reassess current models of stop-codon recognition by eRF1 in the light of these new data...
  21. pmc The number and transmission of [PSI] prion seeds (Propagons) in the yeast Saccharomyces cerevisiae
    Lee J Byrne
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, United Kingdom
    PLoS ONE 4:e4670. 2009
    ....
  22. doi request reprint Hsp70/Hsp90 co-chaperones are required for efficient Hsp104-mediated elimination of the yeast [PSI(+)] prion but not for prion propagation
    Behrooz Moosavi
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, UK
    Yeast 27:167-79. 2010
    ....
  23. ncbi request reprint Propagating prions in fungi and mammals
    Mick F Tuite
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Mol Cell 14:541-52. 2004
    ..Recent studies on both mammalian and fungal prions are providing a greater understanding of the structural features that distinguish prions from non-transmissible amyloids...
  24. doi request reprint Transient expression of human TorsinA enhances secretion of two functionally distinct proteins in cultured Chinese hamster ovary (CHO) cells
    Lyne Jossé
    Department of Biosciences, Centre for Molecular Processing, University of Kent, Canterbury, UK
    Biotechnol Bioeng 105:556-66. 2010
    ....
  25. ncbi request reprint The Candida albicans Sup35p protein (CaSup35p): function, prion-like behaviour and an associated polyglutamine length polymorphism
    Catarina Resende
    Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Microbiology 148:1049-60. 2002
    ..albicans identified four naturally occurring polymorphisms associated with changes in the length of the largest of the polyglutamine repeats. These findings have important implications for the evolution of fungal prion genes...
  26. ncbi request reprint Prion protein gene polymorphisms in Saccharomyces cerevisiae
    Catarina G Resende
    Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Mol Microbiol 49:1005-17. 2003
    ..The expansion and contraction of DNA repeats within the RNQ1 gene may provide an evolutionary mechanism that can ensure rapid change between the [PRION+] and [prion-] states...
  27. pmc Preventing illicit liaisons in Poland
    Peter A Lund
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    EMBO Rep 6:1126-30. 2005
  28. ncbi request reprint Heterologous gene expression in yeast
    Lee J Byrne
    Department of Biosciences, University of Kent, UK
    Methods Mol Biol 308:51-64. 2005
  29. ncbi request reprint Extraction and denaturing gel electrophoretic methodology for the analysis of yeast proteins
    Kenneth J O'Callaghan
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Methods Mol Biol 308:357-73. 2005
  30. ncbi request reprint Cell biology: the strain of being a prion
    Mick F Tuite
    Nature 428:265-7. 2004
  31. pmc Dissection and design of yeast prions
    Lev Z Osherovich
    Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, USA
    PLoS Biol 2:E86. 2004
    ..Using this knowledge, we have designed novel artificial prions by fusing the replication element of Sup35p to aggregation-prone sequences from other proteins, including pathogenically expanded polyglutamine...
  32. ncbi request reprint Chaperoning prions: the cellular machinery for propagating an infectious protein?
    Gary W Jones
    Department of Biology, National University of Ireland, Maynooth, Co Kildare Ireland
    Bioessays 27:823-32. 2005
    ....
  33. pmc The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants
    Irina S Shkundina
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Genetics 172:827-35. 2006
    ..These data suggest that [PSI+] variability is primarily defined by differential folding of the Sup35-PrD oligopeptide-repeat region...
  34. pmc Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp
    Steven E Massey
    Department of Biology, University of South Florida, Tampa, Florida 33620, USA
    Genome Res 13:544-57. 2003
    ..In either case, CTG reassignment had a major impact on the evolution of the coding component of the Candida spp. genome...
  35. ncbi request reprint Stop codon decoding in Candida albicans: from non-standard back to standard
    Gabriela Moura
    Centre for Cell Biology, Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Yeast 19:727-33. 2002
    ..The data therefore show that the only aberrant event mediated by the ser-tRNA(CAG) is decoding of the leu-CUG codon as serine...
  36. doi request reprint tRNA and protein methylase complexes mediate zymocin toxicity in yeast
    Patrick Studte
    Institut fur Biologie, Bereich Genetik, Martin Luther Universitat, Halle Wittenberg, Weinbergweg 10, D 06120 Halle Saale, Germany
    Mol Microbiol 69:1266-77. 2008
    ..Sup35, we observe that SUP45 overexpression and sup45 mutants suppress zymocin. Intriguingly, this suppression correlates with upregulated levels of tRNA species targeted by zymocin's tRNase activity...