Research Topics
| Mick TuiteSummaryAffiliation: University of Kent Country: UK Publications
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Publications
The [PSI+] prion of yeast: a problem of inheritanceMick F Tuite
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Methods 39:9-22. 2006....- Regulated translational bypass of stop codons in yeastTobias von der Haar
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
Trends Microbiol 15:78-86. 2007..Rather than being a translation 'error', stop-codon readthrough can have important effects on other cellular processes such as mRNA degradation and, in some cases, can confer a beneficial phenotype to the cell... - Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated Abeta peptides in vivoTobias von der Haar
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, UK
Neurodegener Dis 4:136-47. 2007..We conclude that we have established a useful new tool for studying the aggregation of Abeta peptides in an organism in vivo... 
Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochlorideLee J Byrne
Protein Science Group, Department of Biosciences, University of Kent, Canterbury CT2 7NJ, United Kingdom
Proc Natl Acad Sci U S A 104:11688-93. 2007..HCl requires ongoing cell division and that prions are not destroyed during or after the evident curing phase...
Fungal prions: structure, function and propagationMick F Tuite
Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Top Curr Chem 305:257-98. 2011..Much has already been learnt about prion structure, and propagation and de novo generation of the prion state through studies in yeast and these findings are reviewed here...- The prion hypothesis: from biological anomaly to basic regulatory mechanismMick F Tuite
Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Nat Rev Mol Cell Biol 11:823-33. 2010..The mechanistic similarities between prion propagation in mammals and fungi suggest that prions are not a biological anomaly but instead could be a newly appreciated and perhaps ubiquitous regulatory mechanism... - Prions remodel gene expression in yeastMick F Tuite
Kent Fungal Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Nat Cell Biol 11:241-3. 2009.... - Protein misfolding and aggregation in ageing and disease: molecular processes and therapeutic perspectivesMick F Tuite
Department of Biosciences, University of Kent, Canterbury, Kent, UK
Prion 1:116-20. 2007..Such diseases are usually characterised by the deposition of specific misfolded proteins as amyloid fibrils and hence are often referred to as the amyloidoses... - The genetic control of the formation and propagation of the [PSI+] prion of yeastMick F Tuite
Department of Biosciences, University of Kent, Canterbury, Kent, UK
Prion 1:101-9. 2007..In this Chapter we describe what has emerged from the application of classical and molecular genetic studies, to the most intensively studied of the three native yeast prions, the [PSI(+)] prion... - Cellular factors important for the de novo formation of yeast prionsMick Tuite
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Biochem Soc Trans 36:1083-7. 2008..A number of other cellular factors, in particular chaperones of the Hsp70 (heat-shock protein 70) family, are known to modify the frequency of de novo prion formation in yeast... - Propagation of yeast prionsMick F Tuite
Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Nat Rev Mol Cell Biol 4:878-90. 2003 - The [PSI+] prion of Saccharomyces cerevisiae can be propagated by an Hsp104 orthologue from Candida albicansJoanna F Zenthon
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
Eukaryot Cell 5:217-25. 2006..These findings have implications both in terms of the mechanism of inhibition of Hsp104 by GdnHCl and in the evolution of the ability of fungal species to propagate prions... - The number and transmission of [PSI] prion seeds (Propagons) in the yeast Saccharomyces cerevisiaeLee J Byrne
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, United Kingdom
PLoS ONE 4:e4670. 2009.... - Prion stabilityBrian S Cox
Department of Biosciences, University of Kent, Canterbury, Kent, UK
Prion 1:170-8. 2007..published in Nature (2006), which provides much insight into the phenotypic and genetic parameters of the numerous "variants" of prions increasingly being described in the literature... - Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeastGloria H Merritt
Kent Fungal Group and Protein Science Group, School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
Nucleic Acids Res 38:5479-92. 2010..We reassess current models of stop-codon recognition by eRF1 in the light of these new data... - Guanidine hydrochloride inhibits the generation of prion "seeds" but not prion protein aggregation in yeastFrederique Ness
Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
Mol Cell Biol 22:5593-605. 2002.... - Analysis of the generation and segregation of propagons: entities that propagate the [PSI+] prion in yeastBrian Cox
Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
Genetics 165:23-33. 2003..The implications of our findings with respect to yeast prion propagation mechanisms are discussed... - Hsp70/Hsp90 co-chaperones are required for efficient Hsp104-mediated elimination of the yeast [PSI(+)] prion but not for prion propagationBehrooz Moosavi
Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, UK
Yeast 27:167-79. 2010.... - Propagating prions in fungi and mammalsMick F Tuite
Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
Mol Cell 14:541-52. 2004..Recent studies on both mammalian and fungal prions are providing a greater understanding of the structural features that distinguish prions from non-transmissible amyloids... - Prion protein gene polymorphisms in Saccharomyces cerevisiaeCatarina G Resende
Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Mol Microbiol 49:1005-17. 2003..The expansion and contraction of DNA repeats within the RNQ1 gene may provide an evolutionary mechanism that can ensure rapid change between the [PRION+] and [prion-] states... - Transient expression of human TorsinA enhances secretion of two functionally distinct proteins in cultured Chinese hamster ovary (CHO) cellsLyne Jossé
Department of Biosciences, Centre for Molecular Processing, University of Kent, Canterbury, UK
Biotechnol Bioeng 105:556-66. 2010.... - The Candida albicans Sup35p protein (CaSup35p): function, prion-like behaviour and an associated polyglutamine length polymorphismCatarina Resende
Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Microbiology 148:1049-60. 2002..albicans identified four naturally occurring polymorphisms associated with changes in the length of the largest of the polyglutamine repeats. These findings have important implications for the evolution of fungal prion genes... - Preventing illicit liaisons in PolandPeter A Lund
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
EMBO Rep 6:1126-30. 2005 - Heterologous gene expression in yeastLee J Byrne
Department of Biosciences, University of Kent, UK
Methods Mol Biol 308:51-64. 2005 - Extraction and denaturing gel electrophoretic methodology for the analysis of yeast proteinsLee J Byrne
Department of Biosciences, University of Kent, Canterbury, Kent, UK
Methods Mol Biol 308:357-73. 2005 - Cell biology: the strain of being a prionMick F Tuite
Nature 428:265-7. 2004 - Dissection and design of yeast prionsLev Z Osherovich
Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, USA
PLoS Biol 2:E86. 2004..Using this knowledge, we have designed novel artificial prions by fusing the replication element of Sup35p to aggregation-prone sequences from other proteins, including pathogenically expanded polyglutamine... - Chaperoning prions: the cellular machinery for propagating an infectious protein?Gary W Jones
Department of Biology, National University of Ireland, Maynooth, Co Kildare Ireland
Bioessays 27:823-32. 2005.... - The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variantsIrina S Shkundina
Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
Genetics 172:827-35. 2006..These data suggest that [PSI+] variability is primarily defined by differential folding of the Sup35-PrD oligopeptide-repeat region... - Stop codon decoding in Candida albicans: from non-standard back to standardGabriela Moura
Centre for Cell Biology, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
Yeast 19:727-33. 2002..The data therefore show that the only aberrant event mediated by the ser-tRNA(CAG) is decoding of the leu-CUG codon as serine... - Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida sppSteven E Massey
Department of Biology, University of South Florida, Tampa, Florida 33620, USA
Genome Res 13:544-57. 2003..In either case, CTG reassignment had a major impact on the evolution of the coding component of the Candida spp. genome... - tRNA and protein methylase complexes mediate zymocin toxicity in yeastPatrick Studte
Institut fur Biologie, Bereich Genetik, Martin Luther Universitat, Halle Wittenberg, Weinbergweg 10, D 06120 Halle Saale, Germany
Mol Microbiol 69:1266-77. 2008..Sup35, we observe that SUP45 overexpression and sup45 mutants suppress zymocin. Intriguingly, this suppression correlates with upregulated levels of tRNA species targeted by zymocin's tRNase activity...