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Species | D S TuckwellSummaryAffiliation: University of Manchester Country: UK Publications
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Publications
Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1D S Tuckwell
Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Biochem J 350:485-93. 2000..e. they are intimately associated with the collagen-binding site, responsive to conformational changes at the collagen-binding site and sensitive to events initiated outside the vWFA domain...
Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen familyDanny Tuckwell
2 205 Stopford Building, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
Matrix Biol 21:63-6. 2002..This study provides a framework for the evolution of the FACIT collagens which will be of value in linking NC3 domains with their functions...- A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domainD S Tuckwell
Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
FEBS Lett 400:297-303. 1997..Primary, secondary and tertiary structure analyses indicate that the region folds into a von Willebrand factor A-domain, thereby potentially placing a previously characterised module at the centre of a key functional region... - The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motifD S Tuckwell
Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
Eur J Biochem 241:732-9. 1996..By inference, these findings indicate the existence of an integrin-specific sequence motif within collagenous ligands recognised by the alpha 2 A-domain... - Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridgeD S Tuckwell
School of Biological Sciences, University of Manchester, UK
J Cell Sci 107:993-1005. 1994..In particular, these data suggest that, unlike other integrin ligands, a synthetic peptide-based approach is not suitable for the identification of collagen active sites... - The integrin alpha1 A-domain is a ligand binding site for collagens and lamininD A Calderwood
Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
J Biol Chem 272:12311-7. 1997..The values obtained were similar to those reported for intact integrin binding, suggesting that the A-domain is the major collagen binding site in the alpha1beta1 and alpha2beta1 integrins... - Protein secondary structure prediction by the analysis of variation and conservation in multiple alignmentsD S Tuckwell
School of Biological Sciences, University of Manchester, UK
Comput Appl Biosci 11:627-32. 1995..The algorithm presented here, plus the assessment of the accuracy of prediction generated by this method, should enable this predictive approach to receive informed general use... - Identification and characterization of anaerobic gut fungi using molecular methodologies based on ribosomal ITS1 and 185 rRNAJ L Brookman
School of Biological Sciences, University of Manchester, UK
Microbiology 146:393-403. 2000..DNA slot-blot analysis using ribosomal sequences is able to differentiate between gut fungal genera and thus has considerable potential for use in ecological studies of these organisms... - A novel gain-of-function mutation of the integrin alpha2 VWFA domainAlexis Aquilina
School of Biological Sciences, University of Manchester, Manchester, UK
Eur J Biochem 269:1136-44. 2002..These data indicate that residue E318 plays a novel and important role in modulating alpha2 VWFA domain--ligand binding and may be involved in the conformational changes associated with its regulation... - M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shapeJoaquin M Muriel
Department of Cell and Molecular Biology, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611, USA
Dev Biol 260:339-51. 2003..M142.2 therefore plays a major role in the assembly of the alae and the morphology of the dauer cuticle; because of its similarity to the other cut genes of the cuticle, we have named the gene cut-6... - Identification of a novel class of annexin genesVahid Khalaj
F2G Ltd, P.O. Box 1, Lankro Way, Eccles, Manchester M30 0BH, UK
FEBS Lett 562:79-86. 2004..However, bioinformatics indicated that ANXC4 is an annexin and homologues were identified in other filamentous fungi. ANXC4 therefore represents a new grouping within the annexin family... - ADAMs are present in fungi: identification of two novel ADAM genes in Aspergillus fumigatusSandra E Lavens
F2G Ltd, P O Box 1, Lankro Way, Eccles, Manchester M30 0BH, UK
FEMS Microbiol Lett 248:23-30. 2005..Recombinant ADM-B protease specifically cleaved casein and albumin while recombinant propeptide+protease was inactive. A sheddase function is therefore proposed for fungal ADAMs... - Two families of extracellular phospholipase C genes are present in aspergilliDanny Tuckwell
F2G Ltd, Lankro Way, Eccles, Manchester, UK
Mycol Res 110:1140-51. 2006..The PLC genes appear to have arisen from separate gene transfer events from bacteria or lower eukaryotes. Thus, aspergilli have acquired PLCs twice in the course of evolution...