D S Tuckwell

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1
    D S Tuckwell
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Biochem J 350:485-93. 2000
  2. ncbi request reprint Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen family
    Danny Tuckwell
    2 205 Stopford Building, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Matrix Biol 21:63-6. 2002
  3. ncbi request reprint A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain
    D S Tuckwell
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    FEBS Lett 400:297-303. 1997
  4. ncbi request reprint The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif
    D S Tuckwell
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    Eur J Biochem 241:732-9. 1996
  5. ncbi request reprint Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge
    D S Tuckwell
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 107:993-1005. 1994
  6. ncbi request reprint The integrin alpha1 A-domain is a ligand binding site for collagens and laminin
    D A Calderwood
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    J Biol Chem 272:12311-7. 1997
  7. ncbi request reprint Protein secondary structure prediction by the analysis of variation and conservation in multiple alignments
    D S Tuckwell
    School of Biological Sciences, University of Manchester, UK
    Comput Appl Biosci 11:627-32. 1995
  8. ncbi request reprint Identification and characterization of anaerobic gut fungi using molecular methodologies based on ribosomal ITS1 and 185 rRNA
    J L Brookman
    School of Biological Sciences, University of Manchester, UK
    Microbiology 146:393-403. 2000
  9. ncbi request reprint A novel gain-of-function mutation of the integrin alpha2 VWFA domain
    Alexis Aquilina
    School of Biological Sciences, University of Manchester, Manchester, UK
    Eur J Biochem 269:1136-44. 2002
  10. ncbi request reprint M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape
    Joaquin M Muriel
    Department of Cell and Molecular Biology, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611, USA
    Dev Biol 260:339-51. 2003

Collaborators

  • M J Humphries
  • S Santoso
  • R W Farndale
  • Sandra E Lavens
  • Vahid Khalaj
  • Joaquin M Muriel
  • Alexis Aquilina
  • J L Brookman
  • Nuria Rovira-Graells
  • Mike Birch
  • D A Calderwood
  • Jayne Brookman
  • Lyndsay Smith
  • Gordon J Lithgow
  • Kathryn Taylor
  • Mike Brannan
  • Iain L Johnstone
  • Michelle Korda
  • Jeffrey M Bergelson
  • G Mennim
  • M K Theodorou
  • A P Trinci
  • J Eble
  • K Kuhn

Detail Information

Publications13

  1. pmc Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1
    D S Tuckwell
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Biochem J 350:485-93. 2000
    ..e. they are intimately associated with the collagen-binding site, responsive to conformational changes at the collagen-binding site and sensitive to events initiated outside the vWFA domain...
  2. ncbi request reprint Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen family
    Danny Tuckwell
    2 205 Stopford Building, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Matrix Biol 21:63-6. 2002
    ..This study provides a framework for the evolution of the FACIT collagens which will be of value in linking NC3 domains with their functions...
  3. ncbi request reprint A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain
    D S Tuckwell
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    FEBS Lett 400:297-303. 1997
    ..Primary, secondary and tertiary structure analyses indicate that the region folds into a von Willebrand factor A-domain, thereby potentially placing a previously characterised module at the centre of a key functional region...
  4. ncbi request reprint The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif
    D S Tuckwell
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    Eur J Biochem 241:732-9. 1996
    ..By inference, these findings indicate the existence of an integrin-specific sequence motif within collagenous ligands recognised by the alpha 2 A-domain...
  5. ncbi request reprint Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge
    D S Tuckwell
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 107:993-1005. 1994
    ..In particular, these data suggest that, unlike other integrin ligands, a synthetic peptide-based approach is not suitable for the identification of collagen active sites...
  6. ncbi request reprint The integrin alpha1 A-domain is a ligand binding site for collagens and laminin
    D A Calderwood
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    J Biol Chem 272:12311-7. 1997
    ..The values obtained were similar to those reported for intact integrin binding, suggesting that the A-domain is the major collagen binding site in the alpha1beta1 and alpha2beta1 integrins...
  7. ncbi request reprint Protein secondary structure prediction by the analysis of variation and conservation in multiple alignments
    D S Tuckwell
    School of Biological Sciences, University of Manchester, UK
    Comput Appl Biosci 11:627-32. 1995
    ..The algorithm presented here, plus the assessment of the accuracy of prediction generated by this method, should enable this predictive approach to receive informed general use...
  8. ncbi request reprint Identification and characterization of anaerobic gut fungi using molecular methodologies based on ribosomal ITS1 and 185 rRNA
    J L Brookman
    School of Biological Sciences, University of Manchester, UK
    Microbiology 146:393-403. 2000
    ..DNA slot-blot analysis using ribosomal sequences is able to differentiate between gut fungal genera and thus has considerable potential for use in ecological studies of these organisms...
  9. ncbi request reprint A novel gain-of-function mutation of the integrin alpha2 VWFA domain
    Alexis Aquilina
    School of Biological Sciences, University of Manchester, Manchester, UK
    Eur J Biochem 269:1136-44. 2002
    ..These data indicate that residue E318 plays a novel and important role in modulating alpha2 VWFA domain--ligand binding and may be involved in the conformational changes associated with its regulation...
  10. ncbi request reprint M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape
    Joaquin M Muriel
    Department of Cell and Molecular Biology, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611, USA
    Dev Biol 260:339-51. 2003
    ..M142.2 therefore plays a major role in the assembly of the alae and the morphology of the dauer cuticle; because of its similarity to the other cut genes of the cuticle, we have named the gene cut-6...
  11. ncbi request reprint Identification of a novel class of annexin genes
    Vahid Khalaj
    F2G Ltd, P O Box 1, Lankro Way, Eccles, Manchester M30 0BH, UK
    FEBS Lett 562:79-86. 2004
    ..However, bioinformatics indicated that ANXC4 is an annexin and homologues were identified in other filamentous fungi. ANXC4 therefore represents a new grouping within the annexin family...
  12. ncbi request reprint ADAMs are present in fungi: identification of two novel ADAM genes in Aspergillus fumigatus
    Sandra E Lavens
    F2G Ltd, P O Box 1, Lankro Way, Eccles, Manchester M30 0BH, UK
    FEMS Microbiol Lett 248:23-30. 2005
    ..Recombinant ADM-B protease specifically cleaved casein and albumin while recombinant propeptide+protease was inactive. A sheddase function is therefore proposed for fungal ADAMs...
  13. ncbi request reprint Two families of extracellular phospholipase C genes are present in aspergilli
    Danny Tuckwell
    F2G Ltd, Lankro Way, Eccles, Manchester, UK
    Mycol Res 110:1140-51. 2006
    ..The PLC genes appear to have arisen from separate gene transfer events from bacteria or lower eukaryotes. Thus, aspergilli have acquired PLCs twice in the course of evolution...