Yu Kang Tu

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint A Bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, UK
    J Clin Periodontol 39:303-14. 2012
  2. doi request reprint Addressing the identification problem in age-period-cohort analysis: a tutorial on the use of partial least squares and principal components analysis
    Yu Kang Tu
    Division of Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, and Leeds Dental Institute, University of Leeds, Leeds, United Kingdom
    Epidemiology 23:583-93. 2012
  3. pmc Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
    Kuo Liong Chien
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    BMC Cardiovasc Disord 12:66. 2012
  4. ncbi request reprint The problem of analysing the relationship between change and initial value in oral health research
    Yu Kang Tu
    Leeds Dental Institute, University of Leeds, Leeds, UK
    Eur J Oral Sci 113:271-8. 2005
  5. ncbi request reprint What is the effect of adjusting for more than one measure of current body size on the relation between birthweight and blood pressure?
    Y K Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    J Hum Hypertens 20:646-57. 2006
  6. ncbi request reprint Misuses of correlation and regression analyses in orthodontic research: the problem of mathematical coupling
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
    Am J Orthod Dentofacial Orthop 130:62-8. 2006
  7. pmc Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort
    Yu Kang Tu
    Leeds Dental Institute, University of Leeds, Leeds, UK
    Heart 93:1098-103. 2007
  8. doi request reprint Assessing the impact of body size in childhood and adolescence on blood pressure: an application of partial least squares regression
    Yu Kang Tu
    Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
    Epidemiology 21:440-8. 2010
  9. doi request reprint Do bone grafts or barrier membranes provide additional treatment effects for infrabony lesions treated with enamel matrix derivatives? A network meta-analysis of randomized-controlled trials
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, Leeds, UK
    J Clin Periodontol 37:59-79. 2010
  10. ncbi request reprint Revisiting the interaction between birth weight and current body size in the foetal origins of adult disease
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, 30 32 Hyde Terrace, Leeds LS2 9LN, UK
    Eur J Epidemiol 22:565-75. 2007

Detail Information

Publications44

  1. ncbi request reprint A Bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, UK
    J Clin Periodontol 39:303-14. 2012
    ..Both have been used in conjunction with other regenerative materials. We conducted a Bayesian network meta-analysis of randomized controlled trials on treatment effects of GTR, EMD and their combination therapies...
  2. doi request reprint Addressing the identification problem in age-period-cohort analysis: a tutorial on the use of partial least squares and principal components analysis
    Yu Kang Tu
    Division of Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, and Leeds Dental Institute, University of Leeds, Leeds, United Kingdom
    Epidemiology 23:583-93. 2012
    ..We also show that the inclusion of all indicator variables provides a more consistent approach. R code for our analyses is provided in the eAppendix...
  3. pmc Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
    Kuo Liong Chien
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    BMC Cardiovasc Disord 12:66. 2012
    ..The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented...
  4. ncbi request reprint The problem of analysing the relationship between change and initial value in oral health research
    Yu Kang Tu
    Leeds Dental Institute, University of Leeds, Leeds, UK
    Eur J Oral Sci 113:271-8. 2005
    ....
  5. ncbi request reprint What is the effect of adjusting for more than one measure of current body size on the relation between birthweight and blood pressure?
    Y K Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    J Hum Hypertens 20:646-57. 2006
    ....
  6. ncbi request reprint Misuses of correlation and regression analyses in orthodontic research: the problem of mathematical coupling
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
    Am J Orthod Dentofacial Orthop 130:62-8. 2006
    ..These statistical problems are among the most common pitfalls in orthodontic research when exploring associations among clinical variables. This article will show why these problems arise and how they can be avoided and overcome...
  7. pmc Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort
    Yu Kang Tu
    Leeds Dental Institute, University of Leeds, Leeds, UK
    Heart 93:1098-103. 2007
    ..To use data from the Glasgow Alumni Cohort to investigate whether oral health in young adulthood is independently associated with later life cardiovascular disease (CVD) and cancer mortality...
  8. doi request reprint Assessing the impact of body size in childhood and adolescence on blood pressure: an application of partial least squares regression
    Yu Kang Tu
    Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
    Epidemiology 21:440-8. 2010
    ....
  9. doi request reprint Do bone grafts or barrier membranes provide additional treatment effects for infrabony lesions treated with enamel matrix derivatives? A network meta-analysis of randomized-controlled trials
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, Leeds, UK
    J Clin Periodontol 37:59-79. 2010
    ....
  10. ncbi request reprint Revisiting the interaction between birth weight and current body size in the foetal origins of adult disease
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, 30 32 Hyde Terrace, Leeds LS2 9LN, UK
    Eur J Epidemiol 22:565-75. 2007
    ..The interaction between exposure and effect modifier variables should be interpreted with caution both here and elsewhere in epidemiological analyses...
  11. doi request reprint An introduction to latent growth curve modelling for longitudinal continuous data in dental research
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, Leeds, UK
    Eur J Oral Sci 117:343-50. 2009
    ..When properly applied, latent growth curve modelling has great potential to give new directions for future longitudinal dental research...
  12. pmc The most dangerous hospital or the most dangerous equation?
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, 30 32 Hyde Terrace, Leeds, LS2 9LN, UK
    BMC Health Serv Res 7:185. 2007
    ....
  13. doi request reprint Ratio index variables or ANCOVA? Fisher's cats revisited
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    Pharm Stat 9:77-83. 2010
    ..Caution is therefore required when interpreting analyses of ratio variables whenever the underlying biological relationships among the variables involved are unspecified or unclear...
  14. ncbi request reprint Is there a temporal trend in the reported treatment efficacy of periodontal regeneration? A meta-analysis of randomized-controlled trials
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, and Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    J Clin Periodontol 35:139-46. 2008
    ....
  15. doi request reprint A structural equation modelling approach to the analysis of change
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Leeds, UK
    Eur J Oral Sci 116:291-6. 2008
    ..For the appropriate interpretation of non-randomized studies, the assumptions underlying these methods therefore need to be taken into consideration...
  16. ncbi request reprint Revisiting the relation between change and initial value: a review and evaluation
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds, UK
    Stat Med 26:443-57. 2007
    ..Furthermore, we demonstrate how each method actually answers different research questions, and how confusion arises when this is not always understood...
  17. ncbi request reprint Evaluating the quality of active-control trials in periodontal research
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Clarendon Way, Leeds, UK
    J Clin Periodontol 33:151-6. 2006
    ..The purpose of this study was to apply specific methodological criteria to evaluate the quality of active-control trials using studies that compared guided tissue regeneration (GTR) with enamel matrix derivatives (EMD)...
  18. doi request reprint Trends in the association between blood pressure and obesity in a Taiwanese population between 1996 and 2006
    Y K Tu
    Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    J Hum Hypertens 25:88-97. 2011
    ..Further research is required to investigate the impact of these intriguing changes in the associations on the risk of cardiovascular diseases in the Taiwanese population...
  19. pmc A new approach to age-period-cohort analysis using partial least squares regression: the trend in blood pressure in the Glasgow Alumni cohort
    Yu Kang Tu
    Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
    PLoS ONE 6:e19401. 2011
    ..More emphasis is then required to clarify the substantive and conceptual issues surrounding the definitions and interpretations of age, period and cohort effects...
  20. ncbi request reprint Collinearity in linear regression is a serious problem in oral health research
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Leeds, UK
    Eur J Oral Sci 112:389-97. 2004
    ..Regression analyses are useful tools in oral health research when their limitations are recognized. However, care is required in planning and it is worthwhile seeking statistical advice when formulating the study's research questions...
  21. ncbi request reprint Why evidence for the fetal origins of adult disease might be a statistical artifact: the "reversal paradox" for the relation between birth weight and blood pressure in later life
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds LS2 9LN, UK
    Am J Epidemiol 161:27-32. 2005
    ..Thus, researchers must consider the reversal paradox when adjusting for variables that lie within causal pathways...
  22. doi request reprint Partial least squares path modelling for relations between baseline factors and treatment outcomes in periodontal regeneration
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK
    J Clin Periodontol 36:984-95. 2009
    ..The simplest solution to this problem is to drop at least one of the mathematically coupled variables. However, this solution is not satisfactory when the mathematically coupled variables have distinctive clinical implications...
  23. pmc Unravelling the effects of age, period and cohort on metabolic syndrome components in a Taiwanese population using partial least squares regression
    Yu Kang Tu
    Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    BMC Med Res Methodol 11:82. 2011
    ....
  24. ncbi request reprint Problems of correlations between explanatory variables in multiple regression analyses in the dental literature
    Y K Tu
    Department of Periodontology, Division of Restorative Dentistry, Leeds Dental Institute, University of Leeds, Leeds LS2 9LU, UK
    Br Dent J 199:457-61. 2005
    ....
  25. doi request reprint Latent variable approach to correct errors in radiographic measurements
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Leeds, UK
    Eur J Oral Sci 118:642-8. 2010
    ..Whilst both LVM and CFM achieve excellent results, LVM is more flexible in handling missing values, and may provide better results when treatment effects are large...
  26. ncbi request reprint Direct and indirect effects of interdental hygiene in a clinical trial
    Y K Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Clarendon Way, Leeds, LS2 9LU, UK
    J Dent Res 87:1037-42. 2008
    ..In contrast, smokers showed less BOP at baseline but also less improvement in BOP through direct effects...
  27. ncbi request reprint The application of multilevel modeling in the analysis of longitudinal periodontal data--part II: changes in disease levels over time
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Leeds, UK
    J Periodontol 75:137-45. 2004
    ..In order to account for the hierarchical data structure, and to explore explicitly the site, tooth, and subject levels simultaneously, multilevel modeling was undertaken...
  28. ncbi request reprint Mathematical coupling can undermine the statistical assessment of clinical research: illustration from the treatment of guided tissue regeneration
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Clarendon Way, LS2 9LU, Leeds, UK
    J Dent 32:133-42. 2004
    ....
  29. ncbi request reprint The application of multilevel modeling in the analysis of longitudinal periodontal data--part I: absolute levels of disease
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Leeds, UK
    J Periodontol 75:127-36. 2004
    ..MLM was used to investigate longitudinal relationships between the outcomes of lifetime cumulative attachment loss (LCAL) and probing depth (PD) in relation to potential risk factors for periodontal disease progression...
  30. ncbi request reprint Ratio variables in regression analysis can give rise to spurious results: illustration from two studies in periodontology
    Yu Kang Tu
    Biostatistics Unit, School of Medicine, University of Leeds, 24 Hyde Terrace, LS2 9LN, Leeds, UK
    J Dent 32:143-51. 2004
    ....
  31. ncbi request reprint The relationship between baseline value and its change: problems in categorization and the proposal of a new method
    Yu Kang Tu
    Leeds Dental Institute, University of Leeds, Leeds, UK
    Eur J Oral Sci 113:279-88. 2005
    ....
  32. ncbi request reprint A multilevel modelling solution to mathematical coupling
    Andrew Blance
    Leeds Dental Institute, University of Leeds, Leeds, UK
    Stat Methods Med Res 14:553-65. 2005
    ..MLM provides a robust solution when relating change to baseline and is capable of simultaneously dealing with complex error structures and additional covariates and/or potential confounders...
  33. ncbi request reprint Statistical issues on the analysis of change in follow-up studies in dental research
    Andrew Blance
    Leeds Dental Institute, University of Leeds, Clarendon Way, Leeds, UK
    Community Dent Oral Epidemiol 35:412-20. 2007
    ..To provide an overview to the problems in study design and associated analyses of follow-up studies in dental research, particularly addressing three issues: treatment-baselineinteractions; statistical power; and nonrandomization...
  34. ncbi request reprint A Bayesian analysis of amalgam restorations in the Royal Air Force using the counting process approach with nested frailty effects
    Samuel O M Manda
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, UK
    Stat Methods Med Res 14:567-78. 2005
    ..These data have previously been analysed using a non-Bayesian approach. The Gibbs sampler, a Markov chain Monte Carlo method, is used to generate samples from the marginal posterior distribution of the parameters of this Bayesian model...
  35. pmc A comparison of different approaches to unravel the latent structure within metabolic syndrome
    Andrew Woolston
    Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
    PLoS ONE 7:e34410. 2012
    ..We propose two alternative techniques developed from cluster analysis which can achieve a clinically relevant structure, whilst maintaining intuitive advantages of clustering methodology...
  36. ncbi request reprint Commentary: is tooth loss good or bad for general health?
    Yu Kang Tu
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds Institute for Genetics, Health and Therapeutics, 30 32 Hyde Terrace, Leeds LS2 9LN, UK
    Int J Epidemiol 34:475-6. 2005
  37. pmc Do the UK government's new Quality and Outcomes Framework (QOF) scores adequately measure primary care performance? A cross-sectional survey of routine healthcare data
    Amy Downing
    Cancer Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, 30 32 Hyde Terrace, Leeds, LS2 9LN, UK
    BMC Health Serv Res 7:166. 2007
    ....
  38. ncbi request reprint Mathematical coupling: a multilevel approach
    Mark S Gilthorpe
    Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9LN, UK
    Int J Epidemiol 33:1399-400. 2004
  39. ncbi request reprint Evidence-based dentistry: a model for clinical practice
    Clóvis M Faggion
    Leeds Dental Institute and Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds
    J Dent Educ 71:825-31. 2007
    ..The use of a letter grade scale allowed an objective analysis of the quality of evidence. A checklist-driven model that assesses and applies evidence to dental practice may substantially improve dentists' decision making skill...
  40. ncbi request reprint Statistical power for analyses of changes in randomized controlled trials
    Y K Tu
    Department of Periodontology, Leeds Dental Institute, University of Leeds, Clarendon Way, Leeds, LS2 9LU, UK
    J Dent Res 84:283-7. 2005
    ..Therefore, ANCOVA should be used in preference to change score or percentage change score to reduce type II error rates...
  41. ncbi request reprint Is reduction of pocket probing depth correlated with the baseline value or is it "mathematical coupling"?
    Y K Tu
    Biostatistics Unit, Academic Unit of Epidemiology and Health Services Research, Medical School, University of Leeds, 24 Hyde Terrace, Leeds, LS2 9LN, UK
    J Dent Res 81:722-6. 2002
    ..To separate this artificial effect of mathematical coupling from the true underlying biological relationship, one must apply appropriate analytical strategies to re-evaluate previous evidence within the periodontal literature...
  42. ncbi request reprint Unexplained residuals models are not solutions to statistical modeling of the fetal origins hypothesis
    Yu Kang Tu
    J Clin Epidemiol 60:318-9; author reply 319-20. 2007
  43. ncbi request reprint Re: Relative connective tissue graft size affects root coverage treatment outcome in the envelope procedure
    Yu Kang Tu
    J Periodontol 76:1403-5. 2005
  44. ncbi request reprint What evidence is there that adjustment for adult height influences the relationship between birth weight and blood pressure?
    Rosemary F Head
    St George s, University of London, London, UK
    Ann Hum Biol 34:252-64. 2007
    ..The inverse association between birth weight and blood pressure may partly be the result of inappropriate adjustment for adult body size, but it remains unclear whether adjustment for adult height elicits this effect...