Laura Trinkle-Mulcahy

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Displacement affinity chromatography of protein phosphatase one (PP1) complexes
    Greg B G Moorhead
    Department of Biological Sciences, University of Calgary, 2500 University Dr, NW Calgary, AB T2N 1N4, Canada
    BMC Biochem 9:28. 2008
  2. ncbi request reprint Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors
    L Trinkle-Mulcahy
    Department of Biochemistry, The University, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    J Cell Sci 112:157-68. 1999
  3. doi request reprint Nuclear functions in space and time: gene expression in a dynamic, constrained environment
    Laura Trinkle-Mulcahy
    Centre for Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    FEBS Lett 582:1960-70. 2008
  4. ncbi request reprint Mitotic phosphatases: no longer silent partners
    Laura Trinkle-Mulcahy
    Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, UK
    Curr Opin Cell Biol 18:623-31. 2006
  5. pmc Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability
    Laura Trinkle-Mulcahy
    University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 172:679-92. 2006
  6. ncbi request reprint Toward a high-resolution view of nuclear dynamics
    Laura Trinkle-Mulcahy
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Science 318:1402-7. 2007
  7. ncbi request reprint Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells
    L Trinkle-Mulcahy
    MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland
    J Cell Sci 114:4219-28. 2001
  8. pmc Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle
    Laura Trinkle-Mulcahy
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 14:107-17. 2003
  9. ncbi request reprint Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo
    Judith E Sleeman
    University of Dundee, MSI WTB complex, School of Life Sciences, Dow Street, Dundee DD1 5EH, UK
    J Cell Sci 116:2039-50. 2003
  10. pmc FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35
    Janet Chusainow
    Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    RNA 11:1201-14. 2005

Collaborators

Detail Information

Publications22

  1. pmc Displacement affinity chromatography of protein phosphatase one (PP1) complexes
    Greg B G Moorhead
    Department of Biological Sciences, University of Calgary, 2500 University Dr, NW Calgary, AB T2N 1N4, Canada
    BMC Biochem 9:28. 2008
    ..PP1 is localized to its site of action by interacting with targeting or regulatory proteins, a majority of which contains a primary docking site referred to as the RVXF/W motif...
  2. ncbi request reprint Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors
    L Trinkle-Mulcahy
    Department of Biochemistry, The University, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    J Cell Sci 112:157-68. 1999
    ..These findings implicate the NIPP1-PP1 complex in the control of pre-mRNA splicing...
  3. doi request reprint Nuclear functions in space and time: gene expression in a dynamic, constrained environment
    Laura Trinkle-Mulcahy
    Centre for Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    FEBS Lett 582:1960-70. 2008
    ..In several cases, as highlighted here, this has turned up surprising results and has forced a re-evaluation of models for nuclear structure and gene regulation...
  4. ncbi request reprint Mitotic phosphatases: no longer silent partners
    Laura Trinkle-Mulcahy
    Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, UK
    Curr Opin Cell Biol 18:623-31. 2006
    ..These exciting advances show that protein phosphatases are not merely silent partners to kinases in regulating the control of cell division...
  5. pmc Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability
    Laura Trinkle-Mulcahy
    University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 172:679-92. 2006
    ..The data indicate that Repo-Man forms an essential complex with PP1gamma and is required for the recruitment of PP1 to chromatin...
  6. ncbi request reprint Toward a high-resolution view of nuclear dynamics
    Laura Trinkle-Mulcahy
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Science 318:1402-7. 2007
    ..Here, we review the impact of new technologies, especially in areas of fluorescence microscopy and proteomics, which are providing major insights into dynamic processes affecting both structure and function within the nucleus...
  7. ncbi request reprint Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells
    L Trinkle-Mulcahy
    MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland
    J Cell Sci 114:4219-28. 2001
    ..These data indicate that PP1 isoforms are highly mobile in cells and can be dynamically (re)localized through direct interaction with targeting subunits...
  8. pmc Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle
    Laura Trinkle-Mulcahy
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 14:107-17. 2003
    ..The changing spatio-temporal distribution of PP1gamma revealed using the stable PP1 cell lines implicates it in multiple processes, including nucleolar function, the regulation of chromosome segregation and cytokinesis...
  9. ncbi request reprint Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo
    Judith E Sleeman
    University of Dundee, MSI WTB complex, School of Life Sciences, Dow Street, Dundee DD1 5EH, UK
    J Cell Sci 116:2039-50. 2003
    ..This in vivo study indicates that SMN and coilin interact differentially with Cajal bodies and reveals parallels in the pathway for reassembly of nucleoli and Cajal bodies following mitosis...
  10. pmc FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35
    Janet Chusainow
    Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    RNA 11:1201-14. 2005
    ..The data show that FRET studies offer a valuable approach for probing interactions between pre-mRNA splicing factors in vivo...
  11. pmc Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo
    Wendy A Kimber
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 361:525-36. 2002
    ....
  12. pmc NOPdb: Nucleolar Proteome Database
    Anthony Kar Lun Leung
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nucleic Acids Res 34:D218-20. 2006
    ..g. LocusLink, OMIM and PubMed)...
  13. pmc Establishment of a protein frequency library and its application in the reliable identification of specific protein interaction partners
    Séverine Boulon
    The Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Cell Proteomics 9:861-79. 2010
    ....
  14. ncbi request reprint Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene
    A C Chang
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, UK
    Gene 240:45-55. 1999
    ..Our results establish the process by which functionally disparate ARD-1 and NIPP-1 peptides are generated from the protein-coding sequence of the same gene in human cells...
  15. ncbi request reprint Visualization of intracellular PP1 targeting through transiently and stably expressed fluorescent protein fusions
    Laura Trinkle-Mulcahy
    Division of Gene Regulation and Expression, School of Life Sciences, MSI WTB complex, University of Dundee, UK
    Methods Mol Biol 365:133-54. 2007
    ..Interactions with targeting subunits can be visualized in vivo by fluorescence resonance energy transfer (FRET), using techniques such as sensitized emission, acceptor photobleaching, or fluorescence lifetime imaging...
  16. pmc Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes
    Laura Trinkle-Mulcahy
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee, Scotland, UK
    J Cell Biol 183:223-39. 2008
    ..These data provide a specificity filter to distinguish specific protein binding partners in both quantitative and nonquantitative pull-down and immunoprecipitation experiments...
  17. pmc Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi
    P C Cheung
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 355:113-21. 2001
    ..Cell localization studies using a green fluorescent protein fusion show that TAFF1 is localized to the Golgi, and that the Golgi targeting sequence is located within the N-terminal 187 residues and not in either FYVE domain...
  18. doi request reprint Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking
    Alan R Prescott
    College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Cell Sci 127:812-27. 2014
    ..We propose that these represent a family of related vesicles, some of which play a role in snRNP biogenesis and some that might play more diverse roles in cellular RNA metabolism. ..
  19. ncbi request reprint The nucleolus
    Yun Wah Lam
    Wellcome Trust Biocentre, MSI WTB complex, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 118:1335-7. 2005
  20. ncbi request reprint The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G
    Annegret Ulke-Lemee
    Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
    Biochim Biophys Acta 1774:1339-50. 2007
    ..In ZAP3, although this domain is present, it now appears degenerate and functions to bind PP1 through an RVRW docking site located within the domain...
  21. ncbi request reprint Emerging roles of nuclear protein phosphatases
    Greg B G Moorhead
    Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary Alberta, Canada T2N 1N4
    Nat Rev Mol Cell Biol 8:234-44. 2007
    ....
  22. pmc Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis
    Paola Vagnarelli
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Nat Cell Biol 8:1133-42. 2006
    ..This activity, provisionally termed 'regulator of chromosome architecture' (RCA), cooperates with condensin to preserve the characteristic chromosome architecture during mitosis...