Michael R Trimble

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Neuropsychiatric disorders in epilepsy: some transcultural issues
    Michael R Trimble
    Department of Behavioural Neurology, Institute of Neurology, London, United Kingdom
    Epilepsia 44:21-4. 2003
  2. ncbi request reprint Classics in epilepsy and behavior: commentary
    Michael Trimble
    Institute of Neurology, University of London, National Hospital for Neurology and Neurosurgery, London, UK
    Epilepsy Behav 6:279-81. 2005
  3. ncbi request reprint Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables
    M R Trimble
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Seizure 9:249-54. 2000
  4. ncbi request reprint The role of hippocampal sclerosis in antiepileptic drug-related depression in patients with epilepsy: a study on levetiracetam
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom
    Seizure 15:405-8. 2006
  5. ncbi request reprint The importance of being seizure free: topiramate and psychopathology in epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Epilepsy Behav 4:430-4. 2003
  6. ncbi request reprint The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, England, UK
    Epilepsia 44:1573-7. 2003
  7. ncbi request reprint Topiramate and psychiatric adverse events in patients with epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Epilepsia 44:659-63. 2003
  8. ncbi request reprint Evaluation of health status in epilepsy using the EQ-5D questionnaire: a prospective, observational, 6-month study of adjunctive therapy with anti-epileptic drugs
    Caroline E Selai
    University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Curr Med Res Opin 21:733-9. 2005
  9. ncbi request reprint Topiramate and word-finding difficulties in patients with epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Neurology 60:1104-7. 2003
  10. ncbi request reprint Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Seizure 13:55-7. 2004

Detail Information

Publications51

  1. ncbi request reprint Neuropsychiatric disorders in epilepsy: some transcultural issues
    Michael R Trimble
    Department of Behavioural Neurology, Institute of Neurology, London, United Kingdom
    Epilepsia 44:21-4. 2003
    ..To review transcultural perspectives in the neuropsychiatry of epilepsy...
  2. ncbi request reprint Classics in epilepsy and behavior: commentary
    Michael Trimble
    Institute of Neurology, University of London, National Hospital for Neurology and Neurosurgery, London, UK
    Epilepsy Behav 6:279-81. 2005
  3. ncbi request reprint Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables
    M R Trimble
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Seizure 9:249-54. 2000
    ..Those with a seizure-free period before the onset of the psychiatric problem were more likely to develop a psychosis than an affective disorder...
  4. ncbi request reprint The role of hippocampal sclerosis in antiepileptic drug-related depression in patients with epilepsy: a study on levetiracetam
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom
    Seizure 15:405-8. 2006
    ..The aim of our study was to clarify whether patients with temporal lobe epilepsy (TLE) and HS were also at risk during therapy with levetiracetam (LEV)...
  5. ncbi request reprint The importance of being seizure free: topiramate and psychopathology in epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Epilepsy Behav 4:430-4. 2003
    ..We observed that psychopathology was related to seizure control in a subgroup of patients. The role of forced normalization, interlinked with interactions with other antiepileptic drugs, could be relevant...
  6. ncbi request reprint The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, England, UK
    Epilepsia 44:1573-7. 2003
    ..To clarify the role of hippocampal sclerosis (HS) in developing psychiatric and cognitive adverse events during therapy with topiramate (TPM) in patients with temporal lobe epilepsy (TLE)...
  7. ncbi request reprint Topiramate and psychiatric adverse events in patients with epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Epilepsia 44:659-63. 2003
    ..Classification, relation to TPM dosing, and outcome were evaluated to identify a patient profile at risk of developing PAEs...
  8. ncbi request reprint Evaluation of health status in epilepsy using the EQ-5D questionnaire: a prospective, observational, 6-month study of adjunctive therapy with anti-epileptic drugs
    Caroline E Selai
    University College London Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Curr Med Res Opin 21:733-9. 2005
    ..The aims of this project were to evaluate the impact of adjunctive treatment with an anti-epileptic drug (AED) on the health status of people with epilepsy and to investigate how seizure frequency affects their health status...
  9. ncbi request reprint Topiramate and word-finding difficulties in patients with epilepsy
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Neurology 60:1104-7. 2003
    ..To evaluate the prevalence of word-finding difficulties as a treatment-emergent adverse event in patients with epilepsy taking topiramate and to identify a clinical phenotype at risk...
  10. ncbi request reprint Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetam
    Marco Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Seizure 13:55-7. 2004
    ..To investigate the prevalence and psychopathological features of psychiatric adverse events (PAEs) in patients with learning disabilities (LD) in therapy with levetiracetam (LEV)...
  11. ncbi request reprint Absence of cortical gray matter abnormalities in psychosis of epilepsy: a voxel-based MRI study in patients with temporal lobe epilepsy
    NICOLAS RUSCH
    Raymond Way Research Group, Institute of Neurology, University College London, London, UK
    J Neuropsychiatry Clin Neurosci 16:148-55. 2004
    ..There were no significant cortical gray matter differences between the POE and the TLE group. Since cortical pathology is prominent in schizophrenia, POE may be a clinical entity separate from schizophrenia...
  12. ncbi request reprint Mesial temporal structures and comorbid anxiety in refractory partial epilepsy
    Parthasarathy Satishchandra
    Raymond Way Neuropsychiatry Research Group, Institute of Neurology, London, United Kingdom
    J Neuropsychiatry Clin Neurosci 15:450-2. 2003
    ..The findings indicate a role for this brain region in the genesis of anxiety...
  13. ncbi request reprint Brain activity relating to the contingent negative variation: an fMRI investigation
    Y Nagai
    Institute of Neurology, Department of Clinical and Experimental Epilepsy, London WC1N 3BG, UK
    Neuroimage 21:1232-41. 2004
    ..Moreover, these data suggest a mechanistic model whereby thalamocortical interactions regulate CNV amplitude...
  14. ncbi request reprint Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Box 77, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 116:764-8. 2005
    ..We modified the rTMS protocol in order to investigate some of the possible methodological reasons for the negative outcome in that study...
  15. ncbi request reprint Psychopathological profile in patients with severe bilateral hippocampal atrophy and temporal lobe epilepsy: evidence in support of the Geschwind syndrome?
    L Tebartz van Elst
    Institute of Neurology, University College, Queen Square, London WC1N 3BG, UK
    Epilepsy Behav 4:291-7. 2003
    ....
  16. ncbi request reprint Activity in ventromedial prefrontal cortex covaries with sympathetic skin conductance level: a physiological account of a "default mode" of brain function
    Y Nagai
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 22:243-51. 2004
    ....
  17. pmc Reliability of self-reported diagnoses in patients with neurologically unexplained symptoms
    A Schrag
    Division of Neuropsychiatry and Neuropsychology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 75:608-11. 2004
    ..However, information on past medical diagnoses is primarily obtained from patient interviews and may be inaccurate, particularly in patients with NUS...
  18. ncbi request reprint Adjunctive therapy in epilepsy: a cost-effectiveness comparison of two AEDs
    C E Selai
    Raymond Way Neuropsychiatry Unit, Institute of Neurology, Queen Square, London, UK
    Seizure 8:8-13. 1999
    ..Outcome and pharmaco-economic studies need to assess more than reduction in number of seizures. They should take into account variables important for quality of life including side-effects and adverse events...
  19. ncbi request reprint On some clinical implications of the ventral striatum and the extended amygdala. Investigations of aggression
    M R Trimble
    Institute of Neurology, Queen Square, London, England
    Ann N Y Acad Sci 877:638-44. 1999
    ..There is no difference in amygdala T2 and volumetric assessments between the groups, but a subgroup of patients are defined with aggression, left-sided amygdala atrophy, and a history of encephalitis...
  20. ncbi request reprint Quality of life pre and post epilepsy surgery
    C E Selai
    Raymond Way Neuropsychiatry Unit, Institute of Neurology, Queen Square, London, UK
    Epilepsy Res 38:67-74. 2000
    ..The results for the EQ-5D profile and the EQ-5D utility suggest that the EQ-5D is not a valid and responsive instrument for use in patients with intractable epilepsy...
  21. ncbi request reprint Repetitive transcranial magnetic stimulation for Tourette syndrome
    A Munchau
    Sobell Department of Neurophysiology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, UK
    Neurology 59:1789-91. 2002
    ..In the 12 patients who completed the trial, there was no significant improvement of symptoms after any of the rTMS conditions as assessed with the Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey...
  22. ncbi request reprint A comparative study of mismatch negativity (MMN) in epilepsy and non-epileptic seizures
    Nuri Gene-Cos
    Traumatic Stress Service, Clinical Treatment Center, Maudsley Hospital, London, UK
    Epileptic Disord 7:363-72. 2005
    ....
  23. ncbi request reprint Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorder
    Richard J Brown
    Department of Clinical Neurology, Institute of Neurology, London, UK
    Am J Psychiatry 162:899-905. 2005
    ....
  24. ncbi request reprint The insular lobe of Reil--its anatamico-functional, behavioural and neuropsychiatric attributes in humans--a review
    Bhaskara P Shelley
    Raymond Way Neuropsychiatry Research Group, Institute of Neurology, Queen Square, London, United Kingdom
    World J Biol Psychiatry 5:176-200. 2004
    ..The functional role of the insula in these disorders with particular reference to the current functional neuroimaging data has been also reviewed in this article...
  25. ncbi request reprint Clinical efficacy of galvanic skin response biofeedback training in reducing seizures in adult epilepsy: a preliminary randomized controlled study
    Yoko Nagai
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Epilepsy Behav 5:216-23. 2004
    ..Our findings highlight the potential therapeutic value of GSR biofeedback in reducing seizure frequency in patients with drug-resistant epilepsy...
  26. ncbi request reprint Pharmacokinetic Interactions between Antiepileptic and Antidepressant Drugs
    Marco Mula
    Raymond Way Neuropsychiatry Research Group, Department of Clinical Neurology, Institute of Neurology, Queen Square, London, United Kingdom
    World J Biol Psychiatry 4:21-4. 2003
    ..In this paper, the available data about the mechanisms of metabolic kinetic interactions between antidepressant and antiepileptic drugs, as well as their clinical significance, has been reviewed...
  27. pmc The functional neuroimaging correlates of psychogenic versus organic dystonia
    Anette E Schrag
    UCL Institute of Neurology, University College London, Royal Free Campus, Clinical Neurosciences, Rowland Hill Street, London, NW3 2PF, UK
    Brain 136:770-81. 2013
    ..This suggests that psychogenic and organic dystonia have different cortical and subcortical pathophysiology, while a derangement in mechanisms of motor attention may be a feature of both conditions...
  28. ncbi request reprint Long-term follow-up of topiramate and lamotrigine: a perspective on quality of life
    Stefan Kaiser
    Raymond Way Neuropsychiatry Research Unit, Institute of Neurology, London
    Seizure 11:356-60. 2002
    ..These data suggest that about one third of the patients on lamotrigine or topiramate as add-on therapy stay on the drug in the long term. These patients are likely to benefit with respect to objective and subjective outcome measures...
  29. ncbi request reprint The precuneus: a review of its functional anatomy and behavioural correlates
    Andrea E Cavanna
    Institute of Neurology, Queen Square, London WC1N3BG, UK
    Brain 129:564-83. 2006
    ....
  30. pmc Vagus nerve stimulation for treatment-resistant depression: behavioral and neural effects on encoding negative material
    Hugo D Critchley
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, Queen Square, London, UK
    Psychosom Med 69:17-22. 2007
    ..We hypothesized that the antidepressant action of VNS may emerge through corrective influences on 'negativity bias' in memory. We therefore examined the impact of VNS on emotional memory and its underlying brain activity...
  31. ncbi request reprint The amygdala and psychopathology studies in epilepsy
    Michael R Trimble
    Institute of Neurology, Queen Square, London WC1N3BG, England
    Ann N Y Acad Sci 985:461-8. 2003
    ..The main data relate to the increased size of the amygdala in patients with epilepsy and psychosis. The associations between the amygdala and affective disorders, notably dysthymia and euphoria, are also discussed...
  32. ncbi request reprint Abulia: a delphi survey of British neurologists and psychiatrists
    Lavanya Vijayaraghavan
    Raymond Way Neuropsychiatry Research Group, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 17:1052-7. 2002
    ..The information generated by this study may help to develop a working classification for disorders of diminished drive and motivation, and instruments for clinical assessment and decision making...
  33. ncbi request reprint On the use of tranquillisers in epilepsy
    Michael R Trimble
    Institute of Neurology, National Hospital for Neurology, London, UK
    Epilepsia 43:25-7. 2002
    ..It is useful in patients that have catamenial seizures, clusters of seizures, and also in the prevention of postictal syndromes. It is used in childhood epilepsy, and is also helpful in the management of febrile seizures...
  34. ncbi request reprint Epilepsy, psychosis and clozapine
    J M Langosch
    Raymond Way Neuropsychiatric Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Hum Psychopharmacol 17:115-9. 2002
    ..One patient had a reduction of non-epileptic seizures as well. In the second part of this paper, combinations of clozapine with newer and older anticonvulsants as well as their interactions and associated risks are discussed...
  35. pmc Religiosity is associated with hippocampal but not amygdala volumes in patients with refractory epilepsy
    J Wuerfel
    Raymond Way Neuropsychiatry Research Group, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 75:640-2. 2004
    ..To assess the relationship between the behavioural triad of hyper-religiosity, hypergraphia and hyposexuality in epilepsy, and volumes of the mesial temporal structures...
  36. ncbi request reprint Amygdala pathology in psychosis of epilepsy: A magnetic resonance imaging study in patients with temporal lobe epilepsy
    L Tebartz van Elst
    Raymond Way Research Group, Epilepsy Research Group, Institute of Neurology, University College London, UK
    Brain 125:140-9. 2002
    ..The finding of amygdala enlargement agrees with the observation of an association between dysphoric disorders of epilepsy and POE described nearly 100 years ago...
  37. pmc Mirtazapine increases cortical excitability in healthy controls and epilepsy patients with major depression
    A Munchau
    Sobell Department of Motor Neuroscience and Movement Disorders, Dept of Clinical and Experimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 76:527-33. 2005
    ..Epilepsy is often complicated by depression requiring antidepressant treatment. Such treatment might be proconvulsive...
  38. ncbi request reprint Clinical presentations in neuropsychiatry
    Michael R Trimble
    National Hospital for Neurology and Neurosurgery, London, UK
    Semin Clin Neuropsychiatry 7:11-7. 2002
    ..A plea is made that any future diagnostic schedules contain references to neuropsychiatric disorders and presentations...
  39. ncbi request reprint Increased amygdala volumes in female and depressed humans. A quantitative magnetic resonance imaging study
    L Tebartz van Elst
    Epilepsy Research Group, Institute of Neurology, University College London, Queen Square, London, UK
    Neurosci Lett 281:103-6. 2000
    ..008; right side: P=0.001) There was no significant finding relating to the factor aggression neither was there any significant interaction between aggression, dysthymia and gender...
  40. ncbi request reprint Psychiatric adverse events during levetiracetam therapy
    M Mula
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK
    Neurology 61:704-6. 2003
    ..PAE were not related to the titration schedule of LEV, and certain patients seem to be biologically more vulnerable...
  41. ncbi request reprint Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study
    J Serra-Mestres
    Department of Neuropsychiatry, Institute of Neurology, University College London, UK
    Acta Psychiatr Scand 109:140-6. 2004
    ..To investigate dopamine transporter binding in Gilles de la Tourette syndrome (GTS) with SPECT and [123I]FP-CIT...
  42. ncbi request reprint Functional connectivity of human premotor and motor cortex explored with repetitive transcranial magnetic stimulation
    A Munchau
    Sobell Department of Neurophysiology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 22:554-61. 2002
    ..The cortical silent period was also shortened. The implication is that rTMS at a site distant from the motor cortex can change the excitability of circuits intrinsic to the motor cortex...
  43. ncbi request reprint The psychiatric comorbidity of epilepsy
    A Gaitatzis
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, and The National Hospital for Neurology and Neurosurgery, London, UK
    Acta Neurol Scand 110:207-20. 2004
    ..Adequate recognition and treatment of psychiatric conditions in epilepsy is essential for patient management because of their considerable burden in morbidity and quality of life...
  44. ncbi request reprint Are psychiatric adverse events of antiepileptic drugs a unique entity? A study on topiramate and levetiracetam
    Marco Mula
    Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, Novara, Italy
    Epilepsia 48:2322-6. 2007
    ..To investigate the hypothesis that some patients with epilepsy are generally prone to develop psychiatric adverse events (PAEs) during antiepileptic drug (AED) therapy irrespective of the mechanism of action of the drugs...
  45. ncbi request reprint A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials
    Joyce A Cramer
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, Room 7 127, West Haven, CT 06516 2770, USA
    Epilepsy Behav 4:124-32. 2003
    ..These data support the hypothesis that some feature related to epilepsy is the cause of many behavioral events rather than the addition of a specific antiepileptic drug...
  46. doi request reprint Electroencephalographic cerebral dysrhythmic abnormalities in the trinity of nonepileptic general population, neuropsychiatric, and neurobehavioral disorders
    Bhaskara P Shelley
    Raymond Way Neuropsychiatry Research Group, Institute of Neurology at Queen Sq, London
    J Neuropsychiatry Clin Neurosci 20:7-22. 2008
    ..These EEG aberrations may be reflective of underlying morpho-functional brain abnormalities that underpin various neurobehavioral disturbances...
  47. ncbi request reprint Neuropharmacological aspects of cognitive neurorehabilitation in epilepsy
    Marco Mula
    Department of Neurology, Amedeo Avogadro University, Novara, Italy
    Behav Neurol 17:69-75. 2006
    ..This paper reviews different pharmacological aspects of cognitive neurorehabilitation in epilepsy...
  48. ncbi request reprint Use of psychotropic drugs in patients with epilepsy: interactions and seizure risk
    Marco Mula
    Department of Neurology, Amedeo Avogadro University, C so Mazzini, 18 28100 Novara, Italy
    Expert Rev Neurother 4:953-64. 2004
    ..On the other hand, the main factors that may affect choice of therapy, patients' response and compliance, when prescribing antidepressants or antipsychotic drugs, drug interactions and the potential proconvulsive risk are reviewed...
  49. ncbi request reprint Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy
    Ludger Tebartz van Elst
    Neurology 63:942-3; author reply 942-3. 2004
  50. ncbi request reprint The end of the seizure can be the beginning of the problem: Epilepsy is more than just the ictus
    Michael R Trimble
    Neurology 62:683. 2004
  51. ncbi request reprint Re: Drug-induced psychosis with levetiracetam
    Marco Mula
    Can J Psychiatry 50:948; author reply 948. 2005